WO2009108934A3 - Ciments de phosphate de calcium injectables formulés avec des agents bioactifs et procédés de fabrication associés - Google Patents

Ciments de phosphate de calcium injectables formulés avec des agents bioactifs et procédés de fabrication associés Download PDF

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Publication number
WO2009108934A3
WO2009108934A3 PCT/US2009/035729 US2009035729W WO2009108934A3 WO 2009108934 A3 WO2009108934 A3 WO 2009108934A3 US 2009035729 W US2009035729 W US 2009035729W WO 2009108934 A3 WO2009108934 A3 WO 2009108934A3
Authority
WO
WIPO (PCT)
Prior art keywords
calcium phosphate
cememts
formulated
methods
bioactive agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2009/035729
Other languages
English (en)
Other versions
WO2009108934A2 (fr
Inventor
Hugo Pedrozo
Shuliang Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
OSTEOTHERAPEUTICS LLC
Original Assignee
OSTEOTHERAPEUTICS LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by OSTEOTHERAPEUTICS LLC filed Critical OSTEOTHERAPEUTICS LLC
Publication of WO2009108934A2 publication Critical patent/WO2009108934A2/fr
Publication of WO2009108934A3 publication Critical patent/WO2009108934A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
    • A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cette invention concerne des ciments de phosphate de calcium autodurcissants injectables qui sont appropriés pour être utilisés comme vecteurs pharmaceutiques pour administrer des compositions bioactives à des tissus calcifiés chez un sujet.
PCT/US2009/035729 2008-02-28 2009-03-02 Ciments de phosphate de calcium injectables formulés avec des agents bioactifs et procédés de fabrication associés Ceased WO2009108934A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3235708P 2008-02-28 2008-02-28
US61/032,357 2008-02-28

Publications (2)

Publication Number Publication Date
WO2009108934A2 WO2009108934A2 (fr) 2009-09-03
WO2009108934A3 true WO2009108934A3 (fr) 2009-12-03

Family

ID=41016752

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/035729 Ceased WO2009108934A2 (fr) 2008-02-28 2009-03-02 Ciments de phosphate de calcium injectables formulés avec des agents bioactifs et procédés de fabrication associés

Country Status (1)

Country Link
WO (1) WO2009108934A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130039990A1 (en) * 2010-04-30 2013-02-14 University Of Maryland, Baltimore Injectable, load-bearing cell/microbead/calcium phosphate bone paste for bone tissue engineering
JP2014500276A (ja) 2010-12-06 2014-01-09 マサチューセッツ インスティテュート オブ テクノロジー リン酸三カルシウム結合ペプチド及びその使用
US20130066327A1 (en) * 2011-09-09 2013-03-14 Håkan Engqvist Hydraulic cement compositions with low ph methods, articles and kits
US10245306B2 (en) 2012-11-16 2019-04-02 Isto Technologies Ii, Llc Flexible tissue matrix and methods for joint repair
US10179191B2 (en) 2014-10-09 2019-01-15 Isto Technologies Ii, Llc Flexible tissue matrix and methods for joint repair
CN105056298B (zh) * 2015-08-25 2018-01-02 华南理工大学 一种具有表面大孔的多孔磷酸钙微球材料、制备方法及应用
WO2020077265A1 (fr) 2018-10-12 2020-04-16 Theradaptive, Inc. Polypeptides comprenant une séquence de liaison au phosphate bêta-tricalcique et leurs utilisations
CN109437826B (zh) * 2018-11-29 2021-03-23 广州润虹医药科技股份有限公司 一种可3d打印的磷酸镁骨水泥及其制备方法和应用
BR112022020809A2 (pt) 2020-04-15 2023-02-23 Theradaptive Inc Composições e métodos para entrega terapêutica direcionada ao osso
WO2022015364A1 (fr) * 2020-07-17 2022-01-20 Zetagen Therapeutics, Inc. Méthodes et compositions de greffe osseuse au moyen d'excipients ferreux
CN114591066B (zh) * 2022-03-14 2023-03-17 卢霄 陶瓷化磷酸钙骨水泥及其制备方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020155167A1 (en) * 1995-05-19 2002-10-24 Etex Corporation Self-setting calcium phosphate pastes and related products
US20030143258A1 (en) * 2001-10-12 2003-07-31 David Knaack Bone graft
US20040137032A1 (en) * 2002-03-15 2004-07-15 Wang Francis W. Combinations of calcium phosphates, bone growth factors, and pore-forming additives as osteoconductive and osteoinductive composite bone grafts
US20050186449A1 (en) * 2004-02-19 2005-08-25 Calcitec, Inc. Method for making a porous calcium phosphate article
US20050199156A1 (en) * 2004-02-10 2005-09-15 Ibrahim Khairoun Macroporous, resorbable and injectible calcium phosphate-based cements (MCPC) for bone repair, augmentation, regeneration, and osteoporosis treatment
US20050260115A1 (en) * 2002-05-06 2005-11-24 Tas Ahmet C Method of preparing porous calcium phosphate granules
US20060233849A1 (en) * 2005-04-13 2006-10-19 Simon Bruce J Composite bone graft material

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020155167A1 (en) * 1995-05-19 2002-10-24 Etex Corporation Self-setting calcium phosphate pastes and related products
US20030143258A1 (en) * 2001-10-12 2003-07-31 David Knaack Bone graft
US20040137032A1 (en) * 2002-03-15 2004-07-15 Wang Francis W. Combinations of calcium phosphates, bone growth factors, and pore-forming additives as osteoconductive and osteoinductive composite bone grafts
US20050260115A1 (en) * 2002-05-06 2005-11-24 Tas Ahmet C Method of preparing porous calcium phosphate granules
US20050199156A1 (en) * 2004-02-10 2005-09-15 Ibrahim Khairoun Macroporous, resorbable and injectible calcium phosphate-based cements (MCPC) for bone repair, augmentation, regeneration, and osteoporosis treatment
US20050186449A1 (en) * 2004-02-19 2005-08-25 Calcitec, Inc. Method for making a porous calcium phosphate article
US20060233849A1 (en) * 2005-04-13 2006-10-19 Simon Bruce J Composite bone graft material

Also Published As

Publication number Publication date
WO2009108934A2 (fr) 2009-09-03

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