WO2009111852A3 - Procédé d'obtention d'une composition pharmaceutique à base de rétinoïdes, produit dérivé de rétinoïdes et utilisation correspondante - Google Patents

Procédé d'obtention d'une composition pharmaceutique à base de rétinoïdes, produit dérivé de rétinoïdes et utilisation correspondante Download PDF

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Publication number
WO2009111852A3
WO2009111852A3 PCT/BR2009/000072 BR2009000072W WO2009111852A3 WO 2009111852 A3 WO2009111852 A3 WO 2009111852A3 BR 2009000072 W BR2009000072 W BR 2009000072W WO 2009111852 A3 WO2009111852 A3 WO 2009111852A3
Authority
WO
WIPO (PCT)
Prior art keywords
solid lipid
lipid nanoparticles
retinoic acid
nanoparticles containing
containing retinoids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/BR2009/000072
Other languages
English (en)
Portuguese (pt)
Other versions
WO2009111852A2 (fr
Inventor
Lucas Antônio MIRANDA FERREIRA
Gisele Assis Castro Goulart
Rodrigo LAMBERT ORÉFICE
Vicente Tadeu Lopes Buono
Cleida Aprecida De Oliveira
Germán Arturo BOHÓRQUEZ MAHECHA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidade Federal de Minas Gerais
Original Assignee
Universidade Federal de Minas Gerais
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidade Federal de Minas Gerais filed Critical Universidade Federal de Minas Gerais
Publication of WO2009111852A2 publication Critical patent/WO2009111852A2/fr
Publication of WO2009111852A3 publication Critical patent/WO2009111852A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/11—Encapsulated compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Birds (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne la préparation d'une composition de nanoparticules lipidiques solides contenant des rétinoïdes et des amines lipophiles, à application cosmétique. L'invention concerne également un procédé d'obtention d'une composition à forts taux d'encapsulation d'acide rétinoïque dans les nanoparticules lipidiques solides, par formation d'une paire ionique entre l'acide rétinoïque et les amines lipophiles, ainsi que son utilisation.
PCT/BR2009/000072 2008-03-13 2009-03-13 Procédé d'obtention d'une composition pharmaceutique à base de rétinoïdes, produit dérivé de rétinoïdes et utilisation correspondante Ceased WO2009111852A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BRPI0801417-5 2008-03-13
BRPI0801417A BRPI0801417B8 (pt) 2008-03-13 2008-03-13 processo para obtenção de composição farmacêutica de retinóides, produto derivado de retinóides e uso

Publications (2)

Publication Number Publication Date
WO2009111852A2 WO2009111852A2 (fr) 2009-09-17
WO2009111852A3 true WO2009111852A3 (fr) 2009-11-12

Family

ID=41065588

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BR2009/000072 Ceased WO2009111852A2 (fr) 2008-03-13 2009-03-13 Procédé d'obtention d'une composition pharmaceutique à base de rétinoïdes, produit dérivé de rétinoïdes et utilisation correspondante

Country Status (2)

Country Link
BR (1) BRPI0801417B8 (fr)
WO (1) WO2009111852A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102352608B1 (ko) * 2018-12-04 2022-01-19 주식회사 엘지생활건강 고함량 및 서방형 레티노이드 캡슐 및 이를 포함하는 주름 개선용 조성물

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0214501A2 (fr) * 1985-09-11 1987-03-18 American Cyanamid Company Emulsions pour l'administration de médicaments peu solubles dans l'eau, ionisables basiques et hydrophobes
WO2000059475A1 (fr) * 1999-04-06 2000-10-12 Lipocine, Inc. Compositions et procedes d'administration amelioree d'agents therapeutiques hydrophobes ionisables

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0214501A2 (fr) * 1985-09-11 1987-03-18 American Cyanamid Company Emulsions pour l'administration de médicaments peu solubles dans l'eau, ionisables basiques et hydrophobes
WO2000059475A1 (fr) * 1999-04-06 2000-10-12 Lipocine, Inc. Compositions et procedes d'administration amelioree d'agents therapeutiques hydrophobes ionisables

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CASTRO G. A. ET AL.: "Development of a new solid lipid nanoparticle formulation containing retinoic acid for topical treatment of acne", J. OF MICROENCAPSULATION, vol. 24, no. 5, August 2007 (2007-08-01), pages 395 - 407 *
TROTTA M. ET AL.: "lnfluence of ion pairing on topical delivery of retinoic acid from microemulsions", J. OF CONTROLLED RELEASE, vol. 86, 2003, pages 315 - 321 *

Also Published As

Publication number Publication date
BRPI0801417B8 (pt) 2021-05-25
BRPI0801417B1 (pt) 2019-04-09
WO2009111852A2 (fr) 2009-09-17
BRPI0801417A2 (pt) 2009-11-10

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