WO2009116894A3 - Кровезаменитель с функцией переноса кислорода, фармацевтическая композиция (варианты) - Google Patents

Кровезаменитель с функцией переноса кислорода, фармацевтическая композиция (варианты) Download PDF

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Publication number
WO2009116894A3
WO2009116894A3 PCT/RU2009/000129 RU2009000129W WO2009116894A3 WO 2009116894 A3 WO2009116894 A3 WO 2009116894A3 RU 2009000129 W RU2009000129 W RU 2009000129W WO 2009116894 A3 WO2009116894 A3 WO 2009116894A3
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WO
WIPO (PCT)
Prior art keywords
blood
oxygen
blood substitute
variants
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/RU2009/000129
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English (en)
French (fr)
Other versions
WO2009116894A2 (ru
Inventor
Анна Яковлевна ГОНЧАРОВА
Владимир Константинович ПОДГОРОДНИЧЕНКО
Рахимджан Ахметджанович РОЗИЕВ
Виктор Владимирович ХОМИЧЁНОК
Анатолий Федорович ЦЫБ
Ольга Борисовна Брускова
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
OBSCHESTVO S OGRANICHENNOY OTVETSTVENNOSTJU "NAUCHNO PROIZVODSTVENNAYA KOMPANIYA "MEDBIOFARM"
Original Assignee
OBSCHESTVO S OGRANICHENNOY OTVETSTVENNOSTJU "NAUCHNO PROIZVODSTVENNAYA KOMPANIYA "MEDBIOFARM"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by OBSCHESTVO S OGRANICHENNOY OTVETSTVENNOSTJU "NAUCHNO PROIZVODSTVENNAYA KOMPANIYA "MEDBIOFARM" filed Critical OBSCHESTVO S OGRANICHENNOY OTVETSTVENNOSTJU "NAUCHNO PROIZVODSTVENNAYA KOMPANIYA "MEDBIOFARM"
Priority to EA201001469A priority Critical patent/EA017871B1/ru
Priority to UAA201012241A priority patent/UA96390C2/ru
Priority to CN2009801177114A priority patent/CN102026654A/zh
Priority to EP09723300A priority patent/EP2322207A4/en
Publication of WO2009116894A2 publication Critical patent/WO2009116894A2/ru
Publication of WO2009116894A3 publication Critical patent/WO2009116894A3/ru
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Изобретение относится к медицине, а именно к кровезаменителям на основе полигемоглобина. Изобретение может быть использовано для производства кровезамещающих растворов, сопоставимых по эффективности газового транспорта (по переносу кислорода) с эритроцитами крови человека. Предложен кровезаменитель с функцией переноса кислорода, основу которого составляет полимеризованный глутаровым альдегидом гемоглобин, полученный из крови животных, отличающийся тем, что он представляет собой сухую субстанцию и содержит не менее 90% полимеризованного гемоглобина с молекулярной массой в диапазоне 192 000 - 320 000Да, а содержание метгемоглобина в кровезаменителе составляет не более 5%.
PCT/RU2009/000129 2008-03-18 2009-03-17 Кровезаменитель с функцией переноса кислорода, фармацевтическая композиция (варианты) Ceased WO2009116894A2 (ru)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EA201001469A EA017871B1 (ru) 2008-03-18 2009-03-17 Кровезаменитель с функцией переноса кислорода, фармацевтическая композиция (варианты)
UAA201012241A UA96390C2 (ru) 2008-03-18 2009-03-17 Кровезаменитель с функцией переноса кислорода, фармацевтическая композиция (варианты)
CN2009801177114A CN102026654A (zh) 2008-03-18 2009-03-17 具有氧气转运功能的血液代用品，药物组合物(任选项)
EP09723300A EP2322207A4 (en) 2008-03-18 2009-03-17 OXYGEN TRANSMITTING BLOOD SUBSTITUTE AND PHARMACEUTICAL COMPOSITION (VARIANTS)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2008109967/15A RU2361608C1 (ru) 2008-03-18 2008-03-18 Кровезаменитель с функцией переноса кислорода, фармацевтическая композиция (варианты)
RU2008109967 2008-03-18

Publications (2)

Publication Number Publication Date
WO2009116894A2 WO2009116894A2 (ru) 2009-09-24
WO2009116894A3 true WO2009116894A3 (ru) 2009-12-23

Family

ID=41047006

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2009/000129 Ceased WO2009116894A2 (ru) 2008-03-18 2009-03-17 Кровезаменитель с функцией переноса кислорода, фармацевтическая композиция (варианты)

Country Status (7)

Country Link
EP (1) EP2322207A4 (ru)
CN (1) CN102026654A (ru)
EA (1) EA017871B1 (ru)
MY (1) MY169785A (ru)
RU (1) RU2361608C1 (ru)
UA (1) UA96390C2 (ru)
WO (1) WO2009116894A2 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3072502B1 (en) * 2015-03-25 2020-07-08 Universitätsmedizin der Johannes Gutenberg-Universität Mainz Rheological blood replacement solution and uses thereof
CN106237314A (zh) * 2016-08-30 2016-12-21 中国科学院长春应用化学研究所 一种应用于宠物失血休克急救的复苏液及其制备方法
WO2019070086A2 (en) * 2017-09-20 2019-04-11 RIM, Chang Ho BLOOD SUBSTITUTE CARRYING OXYGEN OBTAINED FROM PORK BLOOD AND METHOD OF MAKING SAME
WO2020080978A2 (ru) * 2018-10-19 2020-04-23 Рахимджан Ахметджанович РОЗИЕВ Cпособ получения кровезаменителя для применения в ветеринарии
WO2023022626A1 (ru) * 2021-08-19 2023-02-23 Рахимджан Ахметджанович РОЗИЕВ Применение полимеризованного гемоглобина для повышения эффективности химиотерапии злокачественных опухолей
WO2023022625A1 (ru) * 2021-08-19 2023-02-23 Рахимджан Ахметджанович РОЗИЕВ Применение гемоглобина полимеризованного для мобилизации крови из депо при кровопотерях
CN114146165B (zh) * 2021-12-02 2022-08-12 润方（北京）生物医药研究院有限公司 一种聚合血红蛋白在制备防治呼吸衰竭药物中的应用
CN116059324A (zh) * 2023-03-22 2023-05-05 润方(北京)生物科技有限公司 一种血红蛋白氧载体冻干粉针剂、其制备方法及应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5084558A (en) * 1987-10-13 1992-01-28 Biopure Corporation Extra pure semi-synthetic blood substitute
RU2162707C2 (ru) * 1999-03-24 2001-02-10 Российский научно-исследовательский институт гематологии и трансфузиологии Кровезаменитель - переносчик кислорода, состав для его получения и способ получения полимерного модифицированного гемоглобина
US20020025343A1 (en) * 1996-03-28 2002-02-28 Richard E. De Woskin Method and apparatus for preparing an acellular red blood cell substitute
US6506725B1 (en) * 1986-11-10 2003-01-14 Biopure Corporation Ultra pure hemoglobin solutions and blood-substitutes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464814A (en) * 1986-06-20 1995-11-07 Northfield Laboratories, Inc. Acellular red blood cell substitute
RU2132687C1 (ru) * 1996-04-23 1999-07-10 Институт высомолекулярных соединений РАН Способ получения полигемоглобина с повышенной кислородтранспортной эффективностью
RU2325924C2 (ru) * 2002-10-03 2008-06-10 Нортфилд Лэборэтериз, Инк. Способ лечения пациентов с массивной потерей крови
NZ541340A (en) * 2003-01-29 2008-04-30 Northfield Lab Polymerized hemoglobin solutions having reduced amount of tetramer and method for preparing

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6506725B1 (en) * 1986-11-10 2003-01-14 Biopure Corporation Ultra pure hemoglobin solutions and blood-substitutes
US5084558A (en) * 1987-10-13 1992-01-28 Biopure Corporation Extra pure semi-synthetic blood substitute
US20020025343A1 (en) * 1996-03-28 2002-02-28 Richard E. De Woskin Method and apparatus for preparing an acellular red blood cell substitute
RU2162707C2 (ru) * 1999-03-24 2001-02-10 Российский научно-исследовательский институт гематологии и трансфузиологии Кровезаменитель - переносчик кислорода, состав для его получения и способ получения полимерного модифицированного гемоглобина

Also Published As

Publication number Publication date
EP2322207A2 (en) 2011-05-18
CN102026654A (zh) 2011-04-20
UA96390C2 (ru) 2011-10-25
EA017871B1 (ru) 2013-03-29
RU2361608C1 (ru) 2009-07-20
MY169785A (en) 2019-05-15
WO2009116894A2 (ru) 2009-09-24
EP2322207A4 (en) 2012-04-18
EA201001469A1 (ru) 2011-02-28

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