WO2009121503A3 - Verfahren und zusammensetzung zur regeneration von gewebe mit hilfe von stamm- oder knochenmarkzellen - Google Patents

Verfahren und zusammensetzung zur regeneration von gewebe mit hilfe von stamm- oder knochenmarkzellen Download PDF

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Publication number
WO2009121503A3
WO2009121503A3 PCT/EP2009/002135 EP2009002135W WO2009121503A3 WO 2009121503 A3 WO2009121503 A3 WO 2009121503A3 EP 2009002135 W EP2009002135 W EP 2009002135W WO 2009121503 A3 WO2009121503 A3 WO 2009121503A3
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WO
WIPO (PCT)
Prior art keywords
bone marrow
stem
cells
aid
tissue
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Ceased
Application number
PCT/EP2009/002135
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English (en)
French (fr)
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WO2009121503A2 (de
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Augustinus Bader
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Individual
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Individual
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Priority to RU2010142988/15A priority Critical patent/RU2491076C2/ru
Priority to EP09726923.7A priority patent/EP2273997B1/de
Priority to CA2719437A priority patent/CA2719437A1/en
Priority to AU2009231139A priority patent/AU2009231139A1/en
Priority to CN2009801112567A priority patent/CN101980714A/zh
Priority to JP2011502260A priority patent/JP2011516436A/ja
Priority to US12/935,532 priority patent/US20110020299A1/en
Publication of WO2009121503A2 publication Critical patent/WO2009121503A2/de
Publication of WO2009121503A3 publication Critical patent/WO2009121503A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/19—Platelets; Megacaryocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Die Erfindung betrifft eine neuartige polymerisierbare Zusammensetzung bestehend im wesentlichen aus Blut oder Blutplasma, sowie Stammzellen oder Zellen des Knochenmarks, sowie ein Verfahren zur Geweberegeneration mit Hilfe solcher Zusammensetzungen. Derartige Mischungen können unter dem Einfluss endogener oder exogener Polymerisierungsfaktoren, wie Thrombin, Calcium-Ionen oder Zelldetritus zu viskosen Gelen polymerisieren, welche sehr vorteilhaft für die Entwicklung und Differenzierung der Stamm- bzw. Knochenmarkzellen zu gewebespezifischen Zellen sind. Derartige Polymerisate, die insbesondere zusätzlich Erythropoietin (EPO), oder ähnlich wirkende Wachstumsfaktoren enthalten, zeigen hervorragende Eigenschaften bei ihrem Einsatz für Geweberegeneration oder bei der Regeneration von Knochendefekten.
PCT/EP2009/002135 2008-03-31 2009-03-24 Verfahren und zusammensetzung zur regeneration von gewebe mit hilfe von stamm- oder knochenmarkzellen Ceased WO2009121503A2 (de)

Priority Applications (7)

Application Number Priority Date Filing Date Title
RU2010142988/15A RU2491076C2 (ru) 2008-03-31 2009-03-24 Способ и композиция для регенерации тканей с помощью стволовых или костномозговых клеток
EP09726923.7A EP2273997B1 (de) 2008-03-31 2009-03-24 Verfahren und zusammensetzung zur regeneration von gewebe mit hilfe von stamm- oder knochenmarkzellen
CA2719437A CA2719437A1 (en) 2008-03-31 2009-03-24 Method and composition for the regeneration of tissue with the aid of stem cells or bone-marrow cells
AU2009231139A AU2009231139A1 (en) 2008-03-31 2009-03-24 Method and composition for regenerating tissue with the aid of stem or bone marrow cells
CN2009801112567A CN101980714A (zh) 2008-03-31 2009-03-24 借助干细胞或骨髓细胞进行组织再生的方法和组合物
JP2011502260A JP2011516436A (ja) 2008-03-31 2009-03-24 幹細胞又は骨髄細胞を用いる組織の再生のための方法及び組成物
US12/935,532 US20110020299A1 (en) 2008-03-31 2009-03-24 Method and composition for the regeneration of tissue with the aid of stem cells or bone marrow cells

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08006238 2008-03-31
EP08006238.3 2008-03-31

Publications (2)

Publication Number Publication Date
WO2009121503A2 WO2009121503A2 (de) 2009-10-08
WO2009121503A3 true WO2009121503A3 (de) 2009-11-26

Family

ID=41103846

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Application Number Title Priority Date Filing Date
PCT/EP2009/002135 Ceased WO2009121503A2 (de) 2008-03-31 2009-03-24 Verfahren und zusammensetzung zur regeneration von gewebe mit hilfe von stamm- oder knochenmarkzellen

Country Status (8)

Country Link
US (1) US20110020299A1 (de)
EP (1) EP2273997B1 (de)
JP (1) JP2011516436A (de)
CN (1) CN101980714A (de)
AU (1) AU2009231139A1 (de)
CA (1) CA2719437A1 (de)
RU (1) RU2491076C2 (de)
WO (1) WO2009121503A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110280838A1 (en) * 2007-12-27 2011-11-17 Advanced Technologies And Regenerative Medicine, Llc Treatment of intervertebral disc degeneration using human umbilical cord tissue-derived cells
WO2011153512A2 (en) * 2010-06-03 2011-12-08 Indiana University Research And Technology Corporation Use of compounds with thrombopoietic activity to promote bone growth and healing
US20150065425A1 (en) * 2013-09-02 2015-03-05 Muffin Incorporated Products comprising an extracellular matrix material and osteogenic protein
CN104524636B (zh) * 2014-12-19 2017-06-16 中国人民解放军第四军医大学 通过定向诱导骨髓间充质干细胞获得组织工程软骨的方法
RU2614665C1 (ru) * 2015-12-18 2017-03-28 федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) Способ стимуляции репаративного ангиогенеза и регенерации соединительной ткани, при её повреждении, методом генной терапии с использованием видоспецифичных генов белковых факторов vegf и fgf2, в ветеринарии, и генетическая конструкция для реализации заявленного способа
CN106581772B (zh) * 2016-12-02 2020-02-18 四川大学华西医院 携带G-CSF缓释系统的Fibrin-HA水凝胶及其制备方法和用途
KR101772449B1 (ko) 2016-12-27 2017-08-30 주식회사 하이센스바이오 신규한 펩타이드
RU2687007C2 (ru) * 2017-09-12 2019-05-06 Общество с ограниченной ответственностью "Клеточные Системы" Способ биотехнологического восстановления кожного покрова аллогенными стволовыми клетками человека
JP7110360B2 (ja) 2017-10-09 2022-08-01 テルモ ビーシーティー バイオテクノロジーズ，エルエルシー 凍結乾燥方法
KR101943978B1 (ko) 2017-12-28 2019-01-30 주식회사 하이센스바이오 신규한 펩타이드
RU2669726C1 (ru) * 2018-01-10 2018-10-15 Диана Малхазовна Обидняк Способ повышения эффективности вспомогательных репродуктивных технологий у пациенток с повторными неэффективными попытками имплантации
CN113597532B (zh) 2019-03-14 2023-02-17 泰尔茂比司特生物技术有限公司 冻干容器填充固定装置、系统及使用方法
RU2747589C1 (ru) * 2019-12-09 2021-05-11 Руслан Яверович Атлуханов Способ лечения повреждения мениска коленного сустава
CN116712597B (zh) * 2023-06-12 2026-04-17 广州正源生物技术有限公司 一种复合生物敷料及其制备方法和应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6541024B1 (en) * 1996-04-19 2003-04-01 Osiris Therapeutics, Inc. Regeneration and augmentation of bone using mesenchymal stem cells
WO2004001023A2 (de) * 2002-06-20 2003-12-31 Bionethos Holding Gmbh Verfahren und vorrichtung zur vermehrung und differenzierung von zellen in anwesenheit von wachstumsfaktoren und einer biologischen matrix oder trägerstruktur
US20040191215A1 (en) * 2003-03-25 2004-09-30 Michael Froix Compositions for induction of a therapeutic response
WO2005063965A1 (de) * 2003-12-30 2005-07-14 Bionethos Holding Gmbh Verfahren zur regeneration von gewebe
WO2005070450A2 (de) * 2004-01-23 2005-08-04 Epoplus Gmbh & Co. Kg Verwendung von niedrig dosiertem erythropoietin zur behandlung von akuter oder chronischer niereninsuffizienz und zur behandlung von wunden

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000018885A1 (en) * 1998-09-29 2000-04-06 Gamida Cell Ltd. Methods of controlling proliferation and differentiation of stem and progenitor cells
ITRM20060289A1 (it) * 2006-05-31 2007-12-01 Ranieri Cancedda Bio membrana ingegnerizzata osteo angiogenica e suoi usi per la rigenerazione di tessuto osseo

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6541024B1 (en) * 1996-04-19 2003-04-01 Osiris Therapeutics, Inc. Regeneration and augmentation of bone using mesenchymal stem cells
WO2004001023A2 (de) * 2002-06-20 2003-12-31 Bionethos Holding Gmbh Verfahren und vorrichtung zur vermehrung und differenzierung von zellen in anwesenheit von wachstumsfaktoren und einer biologischen matrix oder trägerstruktur
US20040191215A1 (en) * 2003-03-25 2004-09-30 Michael Froix Compositions for induction of a therapeutic response
WO2005063965A1 (de) * 2003-12-30 2005-07-14 Bionethos Holding Gmbh Verfahren zur regeneration von gewebe
WO2005070450A2 (de) * 2004-01-23 2005-08-04 Epoplus Gmbh & Co. Kg Verwendung von niedrig dosiertem erythropoietin zur behandlung von akuter oder chronischer niereninsuffizienz und zur behandlung von wunden

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KINOSHITA KAZUHIKO ET AL: "Promoted new bone formation in maxillary distraction osteogenesis using a tissue-engineered osteogenic material", JOURNAL OF CRANIOFACIAL SURGERY, BURLINGTON, CA, vol. 19, no. 1, 1 January 2008 (2008-01-01), pages 80 - 87, XP009123049, ISSN: 1049-2275 *
YAMADA YOICHI ET AL: "A novel approach to periodontal tissue regeneration with mesenchymal stem cells and platelet-rich plasma using tissue engineering technology: A clinical case report", THE INTERNATIONAL JOURNAL OF PERIODONTICS & RESTORATIVE DENTISTRY, QUINTESSENCE PUBL, vol. 26, no. 4, 1 August 2006 (2006-08-01), pages 363 - 369, XP001525060, ISSN: 0198-7569 *

Also Published As

Publication number Publication date
EP2273997B1 (de) 2016-01-13
JP2011516436A (ja) 2011-05-26
RU2010142988A (ru) 2012-05-10
CA2719437A1 (en) 2009-10-08
EP2273997A2 (de) 2011-01-19
RU2491076C2 (ru) 2013-08-27
US20110020299A1 (en) 2011-01-27
WO2009121503A2 (de) 2009-10-08
AU2009231139A1 (en) 2009-10-08
CN101980714A (zh) 2011-02-23

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