ATE523592T1 - Dehydratisierte chitosan-nanopartikel - Google Patents

Dehydratisierte chitosan-nanopartikel

Info

Publication number
ATE523592T1
ATE523592T1 AT08758308T AT08758308T ATE523592T1 AT E523592 T1 ATE523592 T1 AT E523592T1 AT 08758308 T AT08758308 T AT 08758308T AT 08758308 T AT08758308 T AT 08758308T AT E523592 T1 ATE523592 T1 AT E523592T1
Authority
AT
Austria
Prior art keywords
nanoparticles
dehydrated
particles
nucleic acid
chitosan nanoparticles
Prior art date
Application number
AT08758308T
Other languages
English (en)
Inventor
Jorgen Kjems
Kenneth Alan Howard
Flemming Besenbacher
Morten Ystergaard Andersen
Original Assignee
Univ Aarhus
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Aarhus filed Critical Univ Aarhus
Application granted granted Critical
Publication of ATE523592T1 publication Critical patent/ATE523592T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0041Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5161Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111General methods applicable to biologically active non-coding nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00Applications; Uses
    • C12N2320/50Methods for regulating/modulating their activity
    • C12N2320/51Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
AT08758308T 2007-07-06 2008-07-04 Dehydratisierte chitosan-nanopartikel ATE523592T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200701004 2007-07-06
PCT/DK2008/050171 WO2009006905A1 (en) 2007-07-06 2008-07-04 Dehydrated chitosan nanoparticles

Publications (1)

Publication Number Publication Date
ATE523592T1 true ATE523592T1 (de) 2011-09-15

Family

ID=39790018

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08758308T ATE523592T1 (de) 2007-07-06 2008-07-04 Dehydratisierte chitosan-nanopartikel

Country Status (7)

Country Link
US (1) US20110033547A1 (de)
EP (1) EP2164964B1 (de)
AT (1) ATE523592T1 (de)
CA (1) CA2729923A1 (de)
DK (1) DK2164964T3 (de)
ES (1) ES2376200T3 (de)
WO (1) WO2009006905A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100272813A1 (en) 2007-07-23 2010-10-28 Aarhus Universitet Nanoparticle-mediated treatment for inflammatory diseases
JP5804453B2 (ja) * 2009-05-14 2015-11-04 国立大学法人 東京大学 結晶性ポリオール微粒子及びその調製方法
WO2013042125A2 (en) * 2011-09-21 2013-03-28 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Nano delivery systems
US20130122096A1 (en) * 2011-11-14 2013-05-16 Silenseed Ltd. Compositions for drug delivery and methods of manufacturing and using same
EP2806896B1 (de) 2012-01-27 2018-01-03 F. Hoffmann-La Roche AG Kovalent an kleinmolekülige integrinantagonisten gebundenes chitosan für gezielte abgabe
GB201220675D0 (en) * 2012-11-16 2013-01-02 Univ Singapore Process and materials for medical applications
US20160130606A1 (en) * 2013-06-10 2016-05-12 Polyvalor, Société En Commandite Freeze-dried polyelectrolyte complexes that maintain size and biological activity
WO2015123778A1 (en) * 2014-02-20 2015-08-27 Polyvalor, Limited Partnership Freeze-dried polymer compositions for mixing with platelet rich plasma to form implants for tissue repair and/or compositions for therapeutic intra-articular injections
CN105031746B (zh) * 2015-09-10 2017-11-03 李健 一种壳聚糖携载siRNA涂层血管支架及其制备方法
GB201520600D0 (en) 2015-11-23 2016-01-06 Univ Leuven Kath Treatment of central nervous tumours
MX2018013122A (es) 2016-04-26 2019-03-28 Viaqua Therapeutics Ltd Composiciones y procedimientos para tratar infecciones viricas en gambas.
EP3585364B1 (de) 2017-02-24 2021-04-28 The Regents of the University of California Partikeltropfenstrukturen und verfahren zur herstellung und verwendung davon
CN107875400B (zh) * 2017-11-20 2020-10-30 南通大学 一种壳-核结构的siRNA仿病毒递送系统及应用
KR20240019077A (ko) 2021-04-14 2024-02-14 파틸리온 바이오사이언스 코포레이션 나노규모 반응 챔버 및 이를 사용하는 방법
PE20241353A1 (es) 2021-11-09 2024-07-03 Viaqua Therapeutics Ltd Composiciones para acuicultura

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE216264T1 (de) * 1996-07-10 2002-05-15 West Pharm Serv Drug Res Ltd Gentherapiesystem zur zielung des endotheliums
JP2003265171A (ja) * 2002-03-15 2003-09-24 Koike Kagaku Kk 遺伝子ドライパウダー及びその調製方法並びに遺伝子ドライパウダーの調製装置
EP1898833A2 (de) * 2005-06-03 2008-03-19 Biohesion, Inc. Mit einer hitzestabilen und chemisch resistenten polypeptidschicht beschichtete goldoberflächen und anwendungen davon
US20070299043A1 (en) * 2005-10-03 2007-12-27 Hunter William L Anti-scarring drug combinations and use thereof
DOP2006000268A (es) * 2005-12-22 2007-07-31 Pfizer Prod Inc Agentes antibacterianos
JP2007224012A (ja) * 2006-01-30 2007-09-06 Fujifilm Corp 酵素架橋したタンパク質ナノ粒子
CA2652530A1 (en) * 2006-05-24 2007-11-29 Advanced In Vitro Cell Technologies, S.L. Nanoparticles of chitosan and hyaluronan for the administration of active molecules
US20100092572A1 (en) * 2007-01-29 2010-04-15 Peter Kaeuper Chitosan-based colloidal particles for rna delivery

Also Published As

Publication number Publication date
EP2164964A1 (de) 2010-03-24
WO2009006905A1 (en) 2009-01-15
CA2729923A1 (en) 2009-01-15
US20110033547A1 (en) 2011-02-10
EP2164964B1 (de) 2011-09-07
ES2376200T3 (es) 2012-03-09
DK2164964T3 (da) 2011-12-05

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