ATE523592T1 - Dehydratisierte chitosan-nanopartikel - Google Patents

Dehydratisierte chitosan-nanopartikel

Info

Publication number
ATE523592T1
ATE523592T1 AT08758308T AT08758308T ATE523592T1 AT E523592 T1 ATE523592 T1 AT E523592T1 AT 08758308 T AT08758308 T AT 08758308T AT 08758308 T AT08758308 T AT 08758308T AT E523592 T1 ATE523592 T1 AT E523592T1
Authority
AT
Austria
Prior art keywords
nanoparticles
dehydrated
particles
nucleic acid
chitosan nanoparticles
Prior art date
Application number
AT08758308T
Other languages
English (en)
Inventor
Jorgen Kjems
Kenneth Alan Howard
Flemming Besenbacher
Morten Ystergaard Andersen
Original Assignee
Univ Aarhus
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Aarhus filed Critical Univ Aarhus
Application granted granted Critical
Publication of ATE523592T1 publication Critical patent/ATE523592T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity
    • C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT08758308T 2007-07-06 2008-07-04 Dehydratisierte chitosan-nanopartikel ATE523592T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200701004 2007-07-06
PCT/DK2008/050171 WO2009006905A1 (en) 2007-07-06 2008-07-04 Dehydrated chitosan nanoparticles

Publications (1)

Publication Number Publication Date
ATE523592T1 true ATE523592T1 (de) 2011-09-15

Family

ID=39790018

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08758308T ATE523592T1 (de) 2007-07-06 2008-07-04 Dehydratisierte chitosan-nanopartikel

Country Status (7)

Country Link
US (1) US20110033547A1 (de)
EP (1) EP2164964B1 (de)
AT (1) ATE523592T1 (de)
CA (1) CA2729923A1 (de)
DK (1) DK2164964T3 (de)
ES (1) ES2376200T3 (de)
WO (1) WO2009006905A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100272813A1 (en) 2007-07-23 2010-10-28 Aarhus Universitet Nanoparticle-mediated treatment for inflammatory diseases
JP5804453B2 (ja) * 2009-05-14 2015-11-04 国立大学法人 東京大学 結晶性ポリオール微粒子及びその調製方法
RU2014112958A (ru) * 2011-09-21 2015-10-27 Йиссум Ресерч Девелопмент Компани оф де Хебрю Юниверсити оф Джерусалем Лтд. Наносистемы доставки для мирнк
US20130122096A1 (en) * 2011-11-14 2013-05-16 Silenseed Ltd. Compositions for drug delivery and methods of manufacturing and using same
EP2806896B1 (de) 2012-01-27 2018-01-03 F. Hoffmann-La Roche AG Kovalent an kleinmolekülige integrinantagonisten gebundenes chitosan für gezielte abgabe
GB201220675D0 (en) * 2012-11-16 2013-01-02 Univ Singapore Process and materials for medical applications
CA2915131A1 (en) * 2013-06-10 2014-12-18 Polyvalor, Societe En Commandite Freeze-dried polyelectrolyte complexes that maintain size and biological activity
ES2904359T3 (es) 2014-02-20 2022-04-04 Ortho Regenerative Tech Inc Composiciones poliméricas liofilizadas para mezclar con plasma rico en plaquetas para formar implantes para la reparación de tejidos y/o composiciones para inyecciones terapéuticas intraarticulares
CN105031746B (zh) * 2015-09-10 2017-11-03 李健 一种壳聚糖携载siRNA涂层血管支架及其制备方法
GB201520600D0 (en) 2015-11-23 2016-01-06 Univ Leuven Kath Treatment of central nervous tumours
BR112018071997A2 (pt) 2016-04-26 2019-02-12 Viaqua Therapeutics Ltd nanopartícula de quitosana-rna, nanopartícula de quitosana-dsrna, composição nutracêutica, crustáceo criado em cativeiro, e método de tratamento ou prevenção de uma doença ou condição em um crustáceo criado em cativeiro associado a um vírus patogênico
DK4218738T3 (da) 2017-02-24 2024-11-11 Univ California Partikeldråbestrukturer og fremgangsmåder til fremstilling og anvendelse af disse
CN107875400B (zh) * 2017-11-20 2020-10-30 南通大学 一种壳-核结构的siRNA仿病毒递送系统及应用
US20250264477A1 (en) 2021-04-14 2025-08-21 Partillion Bioscience Corporation Nanoscale reaction chambers and methods of using the same
CN118679256A (zh) 2021-11-09 2024-09-20 微而广治疗有限公司 用于水产养殖的组合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69712110T2 (de) * 1996-07-10 2002-12-12 West Pharmaceutical Services Drug Delivery & Clinical Research Centre Ltd., Nottingham Zusammensetzungen zur einführung von genen in epithelzellen
JP2003265171A (ja) * 2002-03-15 2003-09-24 Koike Kagaku Kk 遺伝子ドライパウダー及びその調製方法並びに遺伝子ドライパウダーの調製装置
US20060286142A1 (en) * 2005-06-03 2006-12-21 Biohesion, Inc. Gold surfaces coated with a thermostable chemically resistant polypeptide layer and applications thereof
US20070299043A1 (en) * 2005-10-03 2007-12-27 Hunter William L Anti-scarring drug combinations and use thereof
DOP2006000268A (es) * 2005-12-22 2007-07-31 Pfizer Prod Inc Agentes antibacterianos
JP2007224012A (ja) * 2006-01-30 2007-09-06 Fujifilm Corp 酵素架橋したタンパク質ナノ粒子
EP2026772A1 (de) * 2006-05-24 2009-02-25 Advanced In Vitro Cell Technologies, S.A. Nanoteilchen aus chitosan und hyaluronan zur verabreichung von aktiven molekülen
EP2125030A2 (de) * 2007-01-29 2009-12-02 Medipol S.A. Kolloidale partikel auf chitosan-basis zur rna-abgabe

Also Published As

Publication number Publication date
CA2729923A1 (en) 2009-01-15
DK2164964T3 (da) 2011-12-05
ES2376200T3 (es) 2012-03-09
EP2164964B1 (de) 2011-09-07
WO2009006905A1 (en) 2009-01-15
EP2164964A1 (de) 2010-03-24
US20110033547A1 (en) 2011-02-10

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