WO2009131423A3 - 신규 ａ형 간염 바이러스의 항원 유전자 및 상기 유전자로 형질전환된 식물체 - Google Patents

신규 ａ형 간염 바이러스의 항원 유전자 및 상기 유전자로 형질전환된 식물체 Download PDF

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Publication number
WO2009131423A3
WO2009131423A3 PCT/KR2009/002173 KR2009002173W WO2009131423A3 WO 2009131423 A3 WO2009131423 A3 WO 2009131423A3 KR 2009002173 W KR2009002173 W KR 2009002173W WO 2009131423 A3 WO2009131423 A3 WO 2009131423A3
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WO
WIPO (PCT)
Prior art keywords
gene
hepatitis
virus antigen
transformed plants
virus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2009/002173
Other languages
English (en)
French (fr)
Other versions
WO2009131423A2 (ko
Inventor
정인식
김경일
이종민
이현호
손동화
김원용
이희영
정호용
정하영
황보전
유기현
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MEDIKAN Inc
Kyung Hee University
Original Assignee
MEDIKAN Inc
Kyung Hee University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by MEDIKAN Inc, Kyung Hee University filed Critical MEDIKAN Inc
Publication of WO2009131423A2 publication Critical patent/WO2009131423A2/ko
Publication of WO2009131423A3 publication Critical patent/WO2009131423A3/ko
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

본 발명은 신규 A형 간염 바이러스의 항원 유전자 및 상기 유전자로 형질전환된 식물체에 관한 것으로, 보다 구체적으로는, 유전자 코돈 최적화에 의해 합성된 신규 A형 간염 바이러스의 항원 유전자, 상기 유전자를 함유하는 재조합벡터 및 상기 재조합벡터로 형질전환된 식물체에 관한 것이다. 본 발명에 따르면, 합성 A형 간염 바이러스의 항원 유전자를 사용하면 높은 효율로 재조합 A형 간염 백신 소재를 제조할 수 있으며, A형 간염 바이러스 항원을 발현하는 형질전환 식물체는 기능성 식품 소재와 구강 복용성 백신 소재로 유용하다.
PCT/KR2009/002173 2008-04-25 2009-04-24 신규 ａ형 간염 바이러스의 항원 유전자 및 상기 유전자로 형질전환된 식물체 Ceased WO2009131423A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2008-0038483 2008-04-25
KR1020080038483A KR101012830B1 (ko) 2008-04-25 2008-04-25 신규 ａ형 간염 바이러스의 항원 유전자 및 상기 유전자로형질전환된 식물체

Publications (2)

Publication Number Publication Date
WO2009131423A2 WO2009131423A2 (ko) 2009-10-29
WO2009131423A3 true WO2009131423A3 (ko) 2009-12-23

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ID=41217299

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Application Number Title Priority Date Filing Date
PCT/KR2009/002173 Ceased WO2009131423A2 (ko) 2008-04-25 2009-04-24 신규 ａ형 간염 바이러스의 항원 유전자 및 상기 유전자로 형질전환된 식물체

Country Status (2)

Country Link
KR (1) KR101012830B1 (ko)
WO (1) WO2009131423A2 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101635672B1 (ko) 2014-05-28 2016-07-01 경희대학교 산학협력단 Ａ형 간염 바이러스 백신 소재 단백질 3ｄ2 및 백신 조성물
KR101635673B1 (ko) 2014-05-28 2016-07-01 경희대학교 산학협력단 Ａ형 간염 바이러스 백신 소재 단백질 ｖｐ1-3ｎ 및 백신 조성물

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5484719A (en) * 1991-08-26 1996-01-16 Edible Vaccines, Inc. Vaccines produced and administered through edible plants
KR20050100365A (ko) * 2003-01-31 2005-10-18 센트로 데 인제니에리아 제네티카 와이 바이오테크놀로지아 식물세포로부터 얻은 재조합 간염 에이 바이러스 항원
KR20060013000A (ko) * 2004-08-05 2006-02-09 정인식 Ｂｃｔｖ 레플리콘을 함유하는 식물 발현벡터

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100861923B1 (ko) * 2006-12-07 2008-10-09 메디칸(주) 바이러스 항원 발현 재조합 벡터로 형질전환된 곤충세포를 이용한 ａ형 간염 바이러스 항원의 제조방법

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5484719A (en) * 1991-08-26 1996-01-16 Edible Vaccines, Inc. Vaccines produced and administered through edible plants
KR20050100365A (ko) * 2003-01-31 2005-10-18 센트로 데 인제니에리아 제네티카 와이 바이오테크놀로지아 식물세포로부터 얻은 재조합 간염 에이 바이러스 항원
KR20060013000A (ko) * 2004-08-05 2006-02-09 정인식 Ｂｃｔｖ 레플리콘을 함유하는 식물 발현벡터

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KIRSTEN B. J. SCHOLTEN ET AL.: "Codon modification of T cell receptors allows enhanced functional expression in transgenic human T cells.", CLINICAL IMMUNOLOGY, vol. 119, 2 February 2006 (2006-02-02), pages 135 - 145 *

Also Published As

Publication number Publication date
KR20090112784A (ko) 2009-10-29
WO2009131423A2 (ko) 2009-10-29
KR101012830B1 (ko) 2011-02-10

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WO2009131423A3 (ko) 신규 ａ형 간염 바이러스의 항원 유전자 및 상기 유전자로 형질전환된 식물체

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