WO2009132313A3 - Dérivés de morphinane d’acides organiques et inorganiques - Google Patents

Dérivés de morphinane d’acides organiques et inorganiques Download PDF

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Publication number
WO2009132313A3
WO2009132313A3 PCT/US2009/041722 US2009041722W WO2009132313A3 WO 2009132313 A3 WO2009132313 A3 WO 2009132313A3 US 2009041722 W US2009041722 W US 2009041722W WO 2009132313 A3 WO2009132313 A3 WO 2009132313A3
Authority
WO
WIPO (PCT)
Prior art keywords
organic
inorganic acids
morphinan derivatives
disclosed
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2009/041722
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English (en)
Other versions
WO2009132313A2 (fr
Inventor
Amy Qi Han
Yakov Rotshteyn
Virendra Kumar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Progenics Pharmaceuticals Inc
Original Assignee
Progenics Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Progenics Pharmaceuticals Inc filed Critical Progenics Pharmaceuticals Inc
Publication of WO2009132313A2 publication Critical patent/WO2009132313A2/fr
Publication of WO2009132313A3 publication Critical patent/WO2009132313A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne de nouveaux dérivés de morphinane 4,5-époxy-14-substitués d’acides organiques et inorganiques. L’invention porte également sur des compositions pharmaceutiques contenant ces composés et sur des procédés d’utilisations pharmaceutiques et des synthèses desdits composés. Ces composés sont utiles, entre autres, en tant que modulateurs des récepteurs opioïdes.
PCT/US2009/041722 2008-04-25 2009-04-24 Dérivés de morphinane d’acides organiques et inorganiques Ceased WO2009132313A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US4799608P 2008-04-25 2008-04-25
US61/047,996 2008-04-25
US5511508P 2008-05-21 2008-05-21
US61/055,115 2008-05-21

Publications (2)

Publication Number Publication Date
WO2009132313A2 WO2009132313A2 (fr) 2009-10-29
WO2009132313A3 true WO2009132313A3 (fr) 2010-02-18

Family

ID=41217443

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/041722 Ceased WO2009132313A2 (fr) 2008-04-25 2009-04-24 Dérivés de morphinane d’acides organiques et inorganiques

Country Status (1)

Country Link
WO (1) WO2009132313A2 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2340832A1 (fr) * 2009-12-23 2011-07-06 Universität Innsbruck Composés de morphine-6-one pour le traitement ou la prévention des maladies neurodégénératives
PH12012501552A1 (en) * 2010-01-29 2017-04-26 Toray Industries Therapeutic or prophylactic agent for biliary diseases
EP2658523A1 (fr) * 2010-12-28 2013-11-06 Euro-Celtique S.A. Combinaison d'un agoniste des opioïdes et d'un antagoniste des opioïdes dans le traitement de la maladie de parkinson
ES2692885T3 (es) 2011-10-03 2018-12-05 Johnson Matthey Plc Proceso para preparar buprenorfina
US8637538B1 (en) 2012-12-14 2014-01-28 Trevi Therapeutics, Inc. Methods for treatment of pruritis
US8987289B2 (en) 2012-12-14 2015-03-24 Trevi Therapeutics, Inc. Methods for treating pruritus
US20140179727A1 (en) 2012-12-14 2014-06-26 Trevi Therapeutics, Inc. Methods for treating pruritus
ES2784690T3 (es) 2013-12-05 2020-09-29 Univ Bath Nuevos compuestos opioides y sus usos
CN105985348B (zh) * 2015-02-12 2019-02-01 正大天晴药业集团股份有限公司 一种溴甲基纳曲酮的制备方法
US10799496B2 (en) 2018-07-13 2020-10-13 Alkermes Pharma Ireland Limited Naphthylenyl compounds for long-acting injectable compositions and related methods
WO2020012245A1 (fr) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Promédicaments de thiénothiophène-naltrexone pour compositions injectables à action prolongée
IL318587A (en) 2018-07-23 2025-03-01 Trevi Therapeutics Inc Treatment of chronic cough, shortness of breath and wheezing
US10975099B2 (en) 2018-11-05 2021-04-13 Alkermes Pharma Ireland Limited Thiophene compounds for long-acting injectable compositions and related methods
IL294601A (en) 2020-01-10 2022-09-01 Trevi Therapeutics Inc Methods of administration of nalbuphine
CN114702510B (zh) * 2022-05-05 2023-06-30 重庆华邦胜凯制药有限公司 一种利福布汀氧化杂质的制备方法
EP4688749A2 (fr) * 2023-04-04 2026-02-11 Board of Regents, The University of Texas System Procédés de synthèse de 14-beta-aminomorphanes et de sels de ceux-ci

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995031463A1 (fr) * 1994-05-18 1995-11-23 Astra Aktiebolag Nouveaux composes antagonistes
WO2004005294A2 (fr) * 2002-07-03 2004-01-15 Alcasynn Pharmaceuticals Gmbh Derives de morphinane et leurs sels d'ammonium quaternaire substitues en position 14, procede de production de ces composes et leur utilisation
EP1595541A1 (fr) * 2004-05-12 2005-11-16 Alcasynn Pharmaceuticals Gmbh Utilisation d'antagonistes aux récepteurs opioides pour prévenir et/ou traiter les maladies associées à la cible calcineurine
US20060063792A1 (en) * 2004-09-17 2006-03-23 Adolor Corporation Substituted morphinans and methods of their use

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995031463A1 (fr) * 1994-05-18 1995-11-23 Astra Aktiebolag Nouveaux composes antagonistes
WO2004005294A2 (fr) * 2002-07-03 2004-01-15 Alcasynn Pharmaceuticals Gmbh Derives de morphinane et leurs sels d'ammonium quaternaire substitues en position 14, procede de production de ces composes et leur utilisation
EP1595541A1 (fr) * 2004-05-12 2005-11-16 Alcasynn Pharmaceuticals Gmbh Utilisation d'antagonistes aux récepteurs opioides pour prévenir et/ou traiter les maladies associées à la cible calcineurine
US20060063792A1 (en) * 2004-09-17 2006-03-23 Adolor Corporation Substituted morphinans and methods of their use

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ALICE S. ET AL.: "14-beta-[(p-nitrocinnamoyl)amino]morphinones, 14-beta-[(p- nitrocinnamoyl)amino]-7,8-dihydromorphinones, and their codeinone analogs:synthesis and receptor activity", JOURNAL OF MEDICINAL CHEMISTRY, vol. 36, no. 21, 1993, pages 3154 - 3160 *
DAVID R. ET AL.: "Structural Determinants of Opioid Activity in Derivatives of 14- Aminomorphinones: Effects of Changes to the Chain Linking of the C14-Amino Group to the Aryl Ring", JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, no. 20, 2006, pages 6104 - 6110 *
GUILLERMO R. ET AL.: "OSAR study on the antinociceptive activity of some morphinans", CHEMICAL BIOLOGY & DRUG DESIGN, vol. 70, no. 1, 2007, pages 53 - 64 *

Also Published As

Publication number Publication date
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