WO2009135910A3 - Modulateurs de mcam dans le traitement de l'acné, de dermatite séborrhéique ou d'hyperséborrhée - Google Patents

Modulateurs de mcam dans le traitement de l'acné, de dermatite séborrhéique ou d'hyperséborrhée Download PDF

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Publication number
WO2009135910A3
WO2009135910A3 PCT/EP2009/055555 EP2009055555W WO2009135910A3 WO 2009135910 A3 WO2009135910 A3 WO 2009135910A3 EP 2009055555 W EP2009055555 W EP 2009055555W WO 2009135910 A3 WO2009135910 A3 WO 2009135910A3
Authority
WO
WIPO (PCT)
Prior art keywords
hyperseborrhoea
acne
treatment
mcam
modulators
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2009/055555
Other languages
English (en)
Other versions
WO2009135910A2 (fr
Inventor
Jérôme AUBERT
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Galderma Research and Development SNC
Original Assignee
Galderma Research and Development SNC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Research and Development SNC filed Critical Galderma Research and Development SNC
Priority to EP09742128A priority Critical patent/EP2285987A2/fr
Publication of WO2009135910A2 publication Critical patent/WO2009135910A2/fr
Publication of WO2009135910A3 publication Critical patent/WO2009135910A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/20—Dermatological disorders

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne un procédé in vitro ou in vivo permettant de cribler des composés candidats pour la prévention ou le traitement curatif de l'acné, de la dermatite séborrhéique ou de troubles cutanés associés à l'hyperséborrhée. Ce procédé consiste à déterminer la capacité d'un composé de moduler l'expression ou l'activité de la molécule d'adhérence cellulaire du mélanome (MCAM). L'invention concerne aussi l'utilisation des modulateurs de l'expression ou de l'activité de cette protéine, pour le traitement de l'acné, de la dermite séborrhéique ou de troubles cutanés associés à l'hyperséborrhée. L'invention concerne enfin des procédés de diagnostic in vitro ou/et de pronostic in vitro de ces pathologies.
PCT/EP2009/055555 2008-05-07 2009-05-07 Modulateurs de mcam dans le traitement de l'acné, de dermatite séborrhéique ou d'hyperséborrhée Ceased WO2009135910A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP09742128A EP2285987A2 (fr) 2008-05-07 2009-05-07 Modulateurs de mcam dans le traitement de l'acné, de dermatite séborrhéique ou d'hyperséborrhée

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US7160208P 2008-05-07 2008-05-07
US61/071,602 2008-05-07
FR0857706 2008-11-13
FR0857706A FR2938337A1 (fr) 2008-11-13 2008-11-13 Modulateurs de mcam dans le traitement de l'acne, d'une dermatite seborrheique ou de l'hyperseborrhee

Publications (2)

Publication Number Publication Date
WO2009135910A2 WO2009135910A2 (fr) 2009-11-12
WO2009135910A3 true WO2009135910A3 (fr) 2009-12-23

Family

ID=40875197

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/055555 Ceased WO2009135910A2 (fr) 2008-05-07 2009-05-07 Modulateurs de mcam dans le traitement de l'acné, de dermatite séborrhéique ou d'hyperséborrhée

Country Status (3)

Country Link
EP (1) EP2285987A2 (fr)
FR (1) FR2938337A1 (fr)
WO (1) WO2009135910A2 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050054832A1 (en) * 2002-03-01 2005-03-10 Xencor, Inc. Optimized Fc variants and methods for their generation
WO2005053632A2 (fr) * 2003-12-01 2005-06-16 Galderma Research & Development, S.N.C. Utilisation d'activateurs de recepteurs ppar en cosmetique et dermatologie

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2904003B1 (fr) * 2006-07-19 2008-09-05 Galderma Res & Dev S N C Snc Modulateurs du transporteur abcd3 dans le traitement de l'acne ou de l'hyperseborrhee
FR2904004B1 (fr) * 2006-07-19 2008-09-05 Galderma Res & Dev S N C Snc Modulateurs de scarb-1 dans le traitement de l'acne ou de l'hyperseborrhee

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050054832A1 (en) * 2002-03-01 2005-03-10 Xencor, Inc. Optimized Fc variants and methods for their generation
WO2005053632A2 (fr) * 2003-12-01 2005-06-16 Galderma Research & Development, S.N.C. Utilisation d'activateurs de recepteurs ppar en cosmetique et dermatologie

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF INVESTIGATIVE DERMATOLOGY (INTERNATIONAL INVESTIGATIVE DERMATOLOGY MEETING; KYOTO, JAPAN; MAY 14, 2008), vol. 128, no. Suppl. 1, 1 April 2008 (2008-04-01), Cambridge MA USA, pages S147 - S149, XP002536487 *

Also Published As

Publication number Publication date
EP2285987A2 (fr) 2011-02-23
WO2009135910A2 (fr) 2009-11-12
FR2938337A1 (fr) 2010-05-14

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