WO2009146152A3 - Composés non myélosuppresseurs, leurs compositions pharmaceutiques, et procédés de traitement - Google Patents

Composés non myélosuppresseurs, leurs compositions pharmaceutiques, et procédés de traitement Download PDF

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Publication number
WO2009146152A3
WO2009146152A3 PCT/US2009/039679 US2009039679W WO2009146152A3 WO 2009146152 A3 WO2009146152 A3 WO 2009146152A3 US 2009039679 W US2009039679 W US 2009039679W WO 2009146152 A3 WO2009146152 A3 WO 2009146152A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
mtcs
methods
pharmaceutical compositions
myelosuppressive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2009/039679
Other languages
English (en)
Other versions
WO2009146152A2 (fr
Inventor
James P. Snyder
Ana A. Alcaraz
David George Ian Kingston
Qiao-hong CHEN
Thota Ganesh
Paraskevi Giannakakou
Susan Bane
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Emory University
Cornell University
Virginia Tech Intellectual Properties Inc
Research Foundation of the State University of New York
Original Assignee
Emory University
Cornell University
Virginia Tech Intellectual Properties Inc
Research Foundation of the State University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emory University, Cornell University, Virginia Tech Intellectual Properties Inc, Research Foundation of the State University of New York filed Critical Emory University
Publication of WO2009146152A2 publication Critical patent/WO2009146152A2/fr
Publication of WO2009146152A3 publication Critical patent/WO2009146152A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L’invention concerne des composés de ciblage de microtubule qui sont myéloépargnants. En particulier, les MTC de l’invention sont structurellement conçus pour présenter une spécificité pour l’inhibition d’isotypes de b-tubuline qui ne sont pas liés à la myélosuppression associée à d’autres MTC connus. L’invention concerne en outre des compositions pharmaceutiques incorporant les MTC de l’invention et des procédés de traitement du cancer au moyen des MTC. L’invention concerne en outre également diverses analyses pour identifier des composés myéloépargnants et déterminer si de tels composés sont indiqués ou non pour être utilisés avec des patients spécifiques.
PCT/US2009/039679 2008-04-04 2009-04-06 Composés non myélosuppresseurs, leurs compositions pharmaceutiques, et procédés de traitement Ceased WO2009146152A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US12306708P 2008-04-04 2008-04-04
US61/123,067 2008-04-04
US8166108P 2008-07-17 2008-07-17
US61/081,661 2008-07-17

Publications (2)

Publication Number Publication Date
WO2009146152A2 WO2009146152A2 (fr) 2009-12-03
WO2009146152A3 true WO2009146152A3 (fr) 2010-01-21

Family

ID=41377876

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/039679 Ceased WO2009146152A2 (fr) 2008-04-04 2009-04-06 Composés non myélosuppresseurs, leurs compositions pharmaceutiques, et procédés de traitement

Country Status (1)

Country Link
WO (1) WO2009146152A2 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999054319A1 (fr) * 1998-04-21 1999-10-28 Bristol-Myers Squibb Company Derives d'epothilone modifies en position 12,13
WO2002098868A1 (fr) * 2001-06-01 2002-12-12 Bristol-Myers Squibb Company Derives d'epothilone

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999054319A1 (fr) * 1998-04-21 1999-10-28 Bristol-Myers Squibb Company Derives d'epothilone modifies en position 12,13
WO2002098868A1 (fr) * 2001-06-01 2002-12-12 Bristol-Myers Squibb Company Derives d'epothilone

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHEN, Q.-H. ET AL.: "DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF BRIDGED EPOTHILONE D ANALOGUES", ORGANIC &BIOMOLECULA CHEMISTRY, vol. 6, December 2008 (2008-12-01), pages 4542 - 4552 *
CHEN, S.-H. ET AL.: "NOVEL C-4 PACLITAXEL(TAXOL) ANALOGS: POTENT ANTITUMOR AGENTS", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 5, no. 22, 1995, pages 2741 - 2746 *
REGUEIRO-REN, A. ET AL.: "SYNTHESIS AND BIOLOGICAL ACTIVITY OF NOVEL EPOTHILONE AZIRIDINES", ORGANIC LETTERS, vol. 3, no. 17, 2001, pages 2693 - 2696 *

Also Published As

Publication number Publication date
WO2009146152A2 (fr) 2009-12-03

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