WO2010007565A2 - Vêtement d'administration de médicament - Google Patents

Vêtement d'administration de médicament Download PDF

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Publication number
WO2010007565A2
WO2010007565A2 PCT/IB2009/053005 IB2009053005W WO2010007565A2 WO 2010007565 A2 WO2010007565 A2 WO 2010007565A2 IB 2009053005 W IB2009053005 W IB 2009053005W WO 2010007565 A2 WO2010007565 A2 WO 2010007565A2
Authority
WO
WIPO (PCT)
Prior art keywords
drug delivery
drug
delivery device
dispenser
garment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2009/053005
Other languages
English (en)
Other versions
WO2010007565A3 (fr
Inventor
Roelf Kassies
Giovanni Nisato
Wilhelmus H. N. M. Van Mensvoort
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
Original Assignee
Koninklijke Philips Electronics NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips Electronics NV filed Critical Koninklijke Philips Electronics NV
Publication of WO2010007565A2 publication Critical patent/WO2010007565A2/fr
Publication of WO2010007565A3 publication Critical patent/WO2010007565A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0097—Medicinal compositions released by microdevices, e.g. microelectromechanical systems [MEMS], microdevices comprising chips or microdevices on silicon
    • A—HUMAN NECESSITIES
    • A41—WEARING APPAREL
    • A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D13/00—Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches
    • A41D13/12—Surgeons' or patients' gowns or dresses
    • A41D13/1236—Patients' garments
    • A41D13/1281—Patients' garments with incorporated means for medical monitoring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A61M2005/3022—Worn on the body, e.g. as patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14212—Pumping with an aspiration and an expulsion action

Definitions

  • the present invention relates to a drug delivery device comprising a garment carrying a drug dispenser.
  • drugs While most drugs are delivered orally, a substantial number of drugs cannot be administered in such a way.
  • the treatments of diabetes, genetic disorders, and novel cancer treatments drugs are typically based on (poly)peptides, which are destroyed in the gastro-intestinal tract.
  • the preferred delivery route is usually injection, and appropriate formulations need to be developed or tuned to optimize therapeutic effect, which can be highly dependent on the patient and can vary during time.
  • transdermal drug delivery One of the methods for realizing a continuous delivery of medication is transdermal drug delivery.
  • passive patches are often used for delivering medication through the skin by passive diffusion. These patches often use adhesives to adhere to the skin. This can cause skin irritation.
  • Active transdermal systems also exist, using various kinds of physical principles to enhance the drug transport through the skin.
  • a drug delivery device comprising a garment comprising at least one pocket encasing at least one drug dispenser with an outlet in line with an opening in the pocket.
  • the garment can for example wholly or partly be made of a stretchable fabric.
  • Suitable fabrics or textiles are cotton, polyester or polyamide textile, linen, wool or mixtures thereof.
  • the drug dispenser can for example comprise one or more jet dispensers, for instance thermal droplet jet dispensers, which are particularly suitable for low speed jetting, or piezoelectric droplet dispensers, which can also be used for high speed jetting (above 30 m/s).
  • High speeds jet dispensers are particularly suitable for intradermal or subcutaneous administration, requiring the medicament to be shot through the skin barrier.
  • Low speed injectors can be used for topical or transdermal administration, when the medicament passes the skin by diffusion.
  • a combination of high speed and low speed jet dispensers can be used.
  • jet dispensers a wide range of drug molecules can be dispensed. The use of such inkjet-related technology jet dispensers, allows careful and accurate control of distribution of the medicament to the target.
  • Exact dosing of the medicament can be achieved.
  • an activating pulse induces movement of a piezoelectric transducer changing the volume of a chamber containing liquid to be jetted.
  • the volume change of the chamber generates pressure for propelling a drop out of a nozzle.
  • the velocity of the jetted drops can be increased.
  • Passing the nozzles the medicament can be accelerated to a velocity which is sufficient to penetrate the patient skin.
  • the velocity can be increased to more than 30 m/s, e.g., to a velocity of 50 - 150 m/s.
  • the jets can be generated by actuators located at each individual nozzle, e.g., by piezo actuators, or by a central pressure generating system in combination with electronically controlled valves.
  • the nozzles of the jet dispenser can have any suitably sized opening, e.g., having a diameter of 30 - 200 ⁇ m, for instance about 50 ⁇ m.
  • the drug dispenser can comprise one or more iontophoretic dispensers and / or micro-needles coupled to a reservoir and a pump.
  • a stretchable fabric can be used to apply a pressure on the drug delivery device to maintain the micro-needles inserted in the stratum corneum.
  • the drug delivery device can have a replaceable part comprising a skin contacting section with the one or more nozzles, and a permanent part comprising a connection section for connection of the replaceable part, e.g. by insertion.
  • the replaceable part can for example be a replaceable cartridge encasing the drug reservoir.
  • the power module and control unit can be located in the permanent part.
  • the cartridges are refillable.
  • the opening in the pocket can be defined by a rim or edge attached to the drug dispenser.
  • the garment can be designed to enclose a body part, and for instance be a sock, an underpants, a legging, a panty, a shirt, a T-shirt, a pullover, a cap, etc.
  • the garmen can be designed to lay or hang over a body part, like a scarf or waistcoat, e.g., being carried by a strap or belt.
  • the drug delivery device can be provided with a wireless communication module and a signal emitter / receiver, such as an antenna.
  • the wireless module 32 can for example be a
  • the drug delivery device can for instance be used for parenteral drug administration, such as transdermal or needle- free subcutaneous application.
  • the device can for instance be used with the treatment of diabetes for delivery of insulin or GLP-I analogues. It can also be used with the treatment of neurodegenerative diseases, such as Parkinson's disease for the delivery of dopamine receptor agonists; with the treatment of multiple sclerosis for the delivery of interferone; with pain management as a patient controlled analgesia (PCA) device; or with the treatment of cancer, e.g., for the delivery of therapeutic agents based on monoclonal antibodies.
  • PCA patient controlled analgesia
  • Fig. 1 shows two embodiments of a drug delivery device according to the present invention
  • Fig. 2a shows in cross section a pocket with a drug dispenser as used in the drug delivery devices of Fig. 1;
  • Fig. 2b shows a further embodiment of a drug delivery devices according to the invention
  • Fig. 2c shows a further alterative embodiment of a drug delivery devices according to the invention
  • Fig 3 shows a further alternative embodiment of a drug delivery device according to the present invention
  • Fig. 4 shows a further alternative embodiment of a drug delivery device according to the present invention
  • Fig. 5 shows a further alternative embodiment of a drug delivery device according to the present invention.
  • Figure 1 shows a first drug delivery device 1 comprising a sock 2 worn by a user 3.
  • the sock comprises a pocket 4 encasing a drug dispenser (see Figure 2A).
  • a second drug delivery device 11 comprising an underpants 12 worn by a user 13 is also shown in the Figure 1 and is also provided with a pocket 14 comprising a drug dispenser (see Figure 2A).
  • the pockets 4, 14 comprise a fabric cover 5, 15 sewed along its edges 6, 16 to the sock 2 or the underpants 12 respectively.
  • the upper edge 7, 17 of the pocket 4, 14 is left open, so the contents of the pocket 4, 14 can be taken out or put back in if and when so desired.
  • FIG 2a shows in cross section the drug dispenser 20a contained within the pocket 4 of sock 2 of Figure 1.
  • An identical dispenser 20a can be used within pocket 14 of underpants 12 of Figure 1.
  • the fabric cover 5 covers an opening 21 in the sock 2.
  • the drug dispenser 20a comprises a replaceable drug reservoir 22a, shaped as a cartridge which can be clicked onto a permanent part 22a' encasing a jet injection control unit 24, a wireless communication module 25 and an antenna 26 for receiving remote control commands and for exchanging information with a remote receiver.
  • the replaceable drug reservoir 22a On its side facing the skin of user 3, the replaceable drug reservoir 22a is provided with a jet nozzle 23a, operatively connected to the jet injection control unit 24 within the permanent part 22a'.
  • the jet nozzle 23a is located within the scope of opening 21 in sock 2.
  • the injection control unit 24 can be programmed to activate the nozzle 23a to jet a dose of the contained drug according to a predetermined time pattern.
  • Edge 27 of the opening 21 in the sock 2 is attached to the wall of the reservoir 22a, for instance by gluing.
  • a circular rim 28a surrounds the nozzle 23a to maintain a distance between the nozzle 23a and the patient's skin 3.
  • Figures 2b and 2c show alternative embodiments which differ from the embodiment of Figure 2a in that a different dispenser type is used. Parts of these embodiments which are the same as corresponding parts of the embodiment in Figure 2 A are indicated with the same reference numbers.
  • Figure 2b shows an embodiment 20b having a bulge 28b contacting the patients skin 3.
  • the bulge 28b is provided with an array of micro-needles 23b for dispensing the drug from drug reservoir 22b.
  • the stretchable fabric of cover 5 gently presses the microneedles 23b into the stratum corneum of the patients skin 3.
  • the embodiment of Figure 2c comprises a drug reservoir 22c with iontophoretic electrodes 23c for dispensing the drug.
  • the iontophoretic electrodes 23c are linked to a power source 29 under the control of control unit 24.
  • Figures 3, 4 and 5 shows further possible embodiments 31, 41, 51 of drug delivery devices according to the invention.
  • the devices 31, 41, 51 hang over the skin of a patient 3 and are in contact with the skin of the patient 3 by the effect of gravity and by outer garment worn over the devices 31, 41, 51.
  • the drug delivery device 31 in Figure 3 comprises a fabric section 32 having a pocket stitched on its side contacting the patient 3.
  • the fabric section 32 is carried by a chain or band 33 hanging around the neck of patient 3.
  • drug delivery device 41 is shaped as a scarf 42 hanging over the shoulders of the patient 3.
  • drug delivery device 51 is designed as a waistcoat, with a fabric section 52 hanging over the lower back of a patient 3, carried by a belt 53 hanging around the neck and over the shoulders of the patient 3.
  • the fabric section 52 comprises a pocket cover with an opening through which a jet nozzle of a drug dispenser is directed to the patient 3.

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Textile Engineering (AREA)
  • Details Of Garments (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

L'invention concerne un dispositif d'administration de médicament (1, 11, 31, 41, 51) comportant un vêtement (2, 12, 32, 42, 52), du type chaussette, T-shirt, ou slip, comportant au moins une poche (4, 14) renfermant au moins un distributeur de médicament (20a, 20b, 20c) avec une sortie (23a, 23b, 23c), du type buse à jet, alignée sur une ouverture (21) dans la poche. Le vêtement (2, 12) est réalisé au moins partiellement en un tissu extensible. Quand le vêtement est porté, la sortie peut faire face à la peau d'un patient et l'administration de médicament peut avoir lieu.
PCT/IB2009/053005 2008-07-18 2009-07-10 Vêtement d'administration de médicament Ceased WO2010007565A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08160679 2008-07-18
EP08160679.0 2008-07-18

Publications (2)

Publication Number Publication Date
WO2010007565A2 true WO2010007565A2 (fr) 2010-01-21
WO2010007565A3 WO2010007565A3 (fr) 2010-03-11

Family

ID=41128049

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2009/053005 Ceased WO2010007565A2 (fr) 2008-07-18 2009-07-10 Vêtement d'administration de médicament

Country Status (1)

Country Link
WO (1) WO2010007565A2 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013136176A1 (fr) * 2012-03-13 2013-09-19 Becton Dickinson France Dispositif d'injection muni d'une partie d'administration de médicament miniaturisée
US20140350442A1 (en) * 2011-08-19 2014-11-27 Amorepacific Corporation Facial massager
WO2015031938A1 (fr) * 2013-09-03 2015-03-12 Savage Jacqueline Sarah Système portable d'administration de fluide en intraveineuse
WO2015198060A1 (fr) * 2014-06-25 2015-12-30 Hid-In Limited Vêtement destiné à retenir des dispositifs médicaux
CN106110490A (zh) * 2016-06-21 2016-11-16 唐晨 一种软囊微喷式微针透皮给药的方法及装置
WO2017156022A1 (fr) 2016-03-11 2017-09-14 Elwha Llc Systèmes de distribution d'un médicament à un sujet et procédés associés

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087864A (en) * 1976-12-30 1978-05-09 Larry D. LaBove Dispensing vest for patients receiving hyperalimentation treatment
DE19810951B4 (de) * 1998-03-13 2005-09-29 Ciba Speciality Chemicals Holding Inc. Verwendung eines textilen Materials als transdermales Abgabesystem sowie Verfahren zu seiner Herstellung
GB0405552D0 (en) * 2004-03-12 2004-04-21 Magnet Attraction Ltd Methods for the targetted delivery of biological molecules
EP2056902A1 (fr) * 2006-08-21 2009-05-13 Koninklijke Philips Electronics N.V. Dispositif d'administration de médicaments avec actionneur piézo-électrique

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140350442A1 (en) * 2011-08-19 2014-11-27 Amorepacific Corporation Facial massager
US10111805B2 (en) * 2011-08-19 2018-10-30 Amorepacific Corporation Facial massager
US10010676B2 (en) 2012-03-13 2018-07-03 Becton Dickinson France Method of manufacture for a miniaturized drug delivery device
WO2013136176A1 (fr) * 2012-03-13 2013-09-19 Becton Dickinson France Dispositif d'injection muni d'une partie d'administration de médicament miniaturisée
US10080843B2 (en) 2012-03-13 2018-09-25 Becton Dickinson France Method of manufacture for a miniaturized drug delivery device
US9844631B2 (en) 2012-03-13 2017-12-19 Becton Dickinson France Injection device having a miniaturized drug delivery portion
WO2015031938A1 (fr) * 2013-09-03 2015-03-12 Savage Jacqueline Sarah Système portable d'administration de fluide en intraveineuse
AU2014317795B2 (en) * 2013-09-03 2019-05-30 Jacqueline Sarah SAVAGE Wearable intravenous fluid delivery system
WO2015198060A1 (fr) * 2014-06-25 2015-12-30 Hid-In Limited Vêtement destiné à retenir des dispositifs médicaux
US20170258995A1 (en) * 2016-03-11 2017-09-14 Elwha Llc Systems for dispensing a medicament to a subject and related methods
WO2017156022A1 (fr) 2016-03-11 2017-09-14 Elwha Llc Systèmes de distribution d'un médicament à un sujet et procédés associés
CN108778395A (zh) * 2016-03-11 2018-11-09 埃尔瓦有限公司 用于将药物分配给受试者的系统和相关方法
US10758673B2 (en) * 2016-03-11 2020-09-01 Elwha Llc Systems for dispensing a medicament to a subject and related methods
CN106110490A (zh) * 2016-06-21 2016-11-16 唐晨 一种软囊微喷式微针透皮给药的方法及装置

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