WO2010053329A2 - Nouveau lipide cationique dérivé d'oligopeptides, procédé de préparation de celui-ci et système d'administration comprenant celui-ci - Google Patents

Nouveau lipide cationique dérivé d'oligopeptides, procédé de préparation de celui-ci et système d'administration comprenant celui-ci Download PDF

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Publication number
WO2010053329A2
WO2010053329A2 PCT/KR2009/006567 KR2009006567W WO2010053329A2 WO 2010053329 A2 WO2010053329 A2 WO 2010053329A2 KR 2009006567 W KR2009006567 W KR 2009006567W WO 2010053329 A2 WO2010053329 A2 WO 2010053329A2
Authority
WO
WIPO (PCT)
Prior art keywords
delivery system
nucleic acid
same
cationic lipid
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2009/006567
Other languages
English (en)
Korean (ko)
Other versions
WO2010053329A3 (fr
Inventor
오유경
이한영
한수은
심가용
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Korea University Research and Business Foundation
SNU R&DB Foundation
Original Assignee
Korea University Research and Business Foundation
SNU R&DB Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Korea University Research and Business Foundation, SNU R&DB Foundation filed Critical Korea University Research and Business Foundation
Publication of WO2010053329A2 publication Critical patent/WO2010053329A2/fr
Publication of WO2010053329A3 publication Critical patent/WO2010053329A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B1/00—Nanostructures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne un nouveau lipide cationique dérivé d'oligopeptides, un procédé de préparation de celui-ci et un système d'administration d'acide nucléique comprenant celui-ci. Le lipide cationique de l'invention est utilisé pour préparer le système d'administration d'acide nucléique. Le lipide cationique de l'invention  peut être préparé et purifié à l'aide d'un procédé simple qui présente des avantages économiques accrus en vue d'une production de masse. De plus, le système d'administration d'acide nucléique comprenant le lipide cationique de l'invention permet non seulement d'accroître considérablement l'efficacité de médicaments oligonucléotidiques vecteurs tels que l'acide ribonucléique, le petit ARN interférent, un oligonucléotide antisens, un aptamère d'acide nucléique et analogue dans des cellules, mais aussi de réduire la cytotoxicité. Le système d'administration d'acide nucléique de l'invention permet par conséquent d'améliorer les effets thérapeutiques de traitements à base d'acide nucléique.
PCT/KR2009/006567 2008-11-10 2009-11-10 Nouveau lipide cationique dérivé d'oligopeptides, procédé de préparation de celui-ci et système d'administration comprenant celui-ci Ceased WO2010053329A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020080111275A KR100909786B1 (ko) 2008-11-10 2008-11-10 올리고 펩티드를 수식한 신규한 양이온성 지질, 그의 제조 방법 및 그를 포함하는 전달체
KR10-2008-0111275 2008-11-10

Publications (2)

Publication Number Publication Date
WO2010053329A2 true WO2010053329A2 (fr) 2010-05-14
WO2010053329A3 WO2010053329A3 (fr) 2010-08-19

Family

ID=41338037

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/006567 Ceased WO2010053329A2 (fr) 2008-11-10 2009-11-10 Nouveau lipide cationique dérivé d'oligopeptides, procédé de préparation de celui-ci et système d'administration comprenant celui-ci

Country Status (2)

Country Link
KR (1) KR100909786B1 (fr)
WO (1) WO2010053329A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103760428A (zh) * 2014-01-24 2014-04-30 上海同耀通信技术有限公司 人体组织液的模拟液
CN109414451A (zh) * 2016-05-16 2019-03-01 德克萨斯大学系统董事会 用于作为纳米粒递送tRNA的组合物及其使用方法
US12357580B2 (en) 2018-06-19 2025-07-15 The Board Of Regents Of The University Of Texas System Lipid nanoparticle compositions for delivery of mRNA and long nucleic acids

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011116152A2 (fr) * 2010-03-16 2011-09-22 Sanford -Burnham Medical Research Institute Administration d'agents par le biais de l'utilisation de nanoparticules interférentes
US12509552B2 (en) * 2021-04-08 2025-12-30 The Curators Of The University Of Missouri Lipidated poly(amino acid) nanostructures

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2533209B1 (fr) * 1982-09-22 1985-11-08 Centre Nat Rech Scient Lipopeptides, leur obtention et leur application comme emulsifiants
KR100807060B1 (ko) * 2007-08-28 2008-02-25 고려대학교 산학협력단 신규한 양이온성 지질, 그의 제조 방법 및 그를 포함하는전달체

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103760428A (zh) * 2014-01-24 2014-04-30 上海同耀通信技术有限公司 人体组织液的模拟液
CN109414451A (zh) * 2016-05-16 2019-03-01 德克萨斯大学系统董事会 用于作为纳米粒递送tRNA的组合物及其使用方法
EP3458074A4 (fr) * 2016-05-16 2020-01-22 The Board of Regents of The University of Texas System Compositions destinées à l'administration d'arnt sous la forme de nanoparticules et procédé d'utilisation associé
AU2017268272B2 (en) * 2016-05-16 2021-09-23 The Board Of Regents Of The University Of Texas System Compositions for the delivery of tRNA as nanoparticles and methods of use therewith
AU2017268272C1 (en) * 2016-05-16 2022-05-05 The Board Of Regents Of The University Of Texas System Compositions for the delivery of tRNA as nanoparticles and methods of use therewith
CN115919769A (zh) * 2016-05-16 2023-04-07 德克萨斯大学系统董事会 用于作为纳米粒递送tRNA的组合物及其使用方法
EP4393549A3 (fr) * 2016-05-16 2024-10-09 The Board of Regents of the University of Texas System Compositions pour l'administration d'arnt en tant que nanoparticules et procédés d'utilisation associés
US12357580B2 (en) 2018-06-19 2025-07-15 The Board Of Regents Of The University Of Texas System Lipid nanoparticle compositions for delivery of mRNA and long nucleic acids

Also Published As

Publication number Publication date
WO2010053329A3 (fr) 2010-08-19
KR100909786B1 (ko) 2009-07-29

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