WO2010053335A3 - 난용성 약물의 나노입자를 포함하는 분말의 제조방법, 그에 의해 제조된 분말 및 이를 포함하는 약학적 조성물 - Google Patents

난용성 약물의 나노입자를 포함하는 분말의 제조방법, 그에 의해 제조된 분말 및 이를 포함하는 약학적 조성물 Download PDF

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Publication number
WO2010053335A3
WO2010053335A3 PCT/KR2009/006585 KR2009006585W WO2010053335A3 WO 2010053335 A3 WO2010053335 A3 WO 2010053335A3 KR 2009006585 W KR2009006585 W KR 2009006585W WO 2010053335 A3 WO2010053335 A3 WO 2010053335A3
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insoluble drug
powder
nanoparticles
pharmaceutical composition
solution
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Ceased
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PCT/KR2009/006585
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English (en)
French (fr)
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WO2010053335A2 (ko
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배준호
이혁
홍덕기
이종휘
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Amorepacific Corp
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Amorepacific Corp
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Priority to US13/127,957 priority Critical patent/US20110212169A1/en
Priority to CN2009801511834A priority patent/CN102256597A/zh
Publication of WO2010053335A2 publication Critical patent/WO2010053335A2/ko
Publication of WO2010053335A3 publication Critical patent/WO2010053335A3/ko
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)

Abstract

본 발명은 난용성 약물의 나노입자를 포함하는 분말의 제조방법, 그에 의해 제조된 분말 및 이를 포함하는 약학적 조성물에 관한 것이다. 본 발명의 제조방법 은 표면 안정화제의 존재 하에 나노입자화된 난용성 약물의 균질화된 분산 용액을 제공하는 단계, 균질화된 분산 용액과 수용성 분산제 용액을 혼합하는 단계, 및 결 과로서 얻어진 혼합 용액을 건조시켜 분말을 회수하는 단계를 포함한다. 본 발명의 제조방법에 의한 난용성 약물의 나노입자를 포함하는 분말은 수용 액에 재분산시 난용성 약물이 나노수준의 입자크기를 유지하면서,약물의 용해도와 용출속도가 증가하여 향상된 생체이용률을 나타내므로, 난용성 약물의 경구 투여 또는 비경구 투여를 목적으로 하는 제형 개발에 유용하게 활용될 수 있다.
PCT/KR2009/006585 2008-11-10 2009-11-10 난용성 약물의 나노입자를 포함하는 분말의 제조방법, 그에 의해 제조된 분말 및 이를 포함하는 약학적 조성물 Ceased WO2010053335A2 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US13/127,957 US20110212169A1 (en) 2008-11-10 2009-11-10 METHOD FOR PRODUCING POWDER CONTAINING NANOPARTICULATED SPARINGLY SOLUBLE DRUG, POWDER PRODUCED THEREBY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME (As Amended)
CN2009801511834A CN102256597A (zh) 2008-11-10 2009-11-10 制备含有不溶性药物的纳米颗粒的粉末的方法、由此制备的粉末以及含有该粉末的药物组合物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020080111205A KR20100052262A (ko) 2008-11-10 2008-11-10 난용성 약물의 나노입자를 포함하는 분말의 제조방법, 그에의해 제조된 분말 및 이를 포함하는 약학적 조성물
KR10-2008-0111205 2008-11-10

Publications (2)

Publication Number Publication Date
WO2010053335A2 WO2010053335A2 (ko) 2010-05-14
WO2010053335A3 true WO2010053335A3 (ko) 2010-09-10

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PCT/KR2009/006585 Ceased WO2010053335A2 (ko) 2008-11-10 2009-11-10 난용성 약물의 나노입자를 포함하는 분말의 제조방법, 그에 의해 제조된 분말 및 이를 포함하는 약학적 조성물

Country Status (4)

Country Link
US (1) US20110212169A1 (ko)
KR (1) KR20100052262A (ko)
CN (1) CN102256597A (ko)
WO (1) WO2010053335A2 (ko)

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CN102342912A (zh) * 2010-08-02 2012-02-08 中国科学院上海药物研究所 坎地沙坦酯纳米乳及其制备方法
KR101218428B1 (ko) * 2010-08-26 2013-01-03 영남대학교 산학협력단 막유화법을 이용한 실리마린 경구용 고형제제 조성물 및 그 제조방법
CN102048702B (zh) * 2010-12-03 2012-05-23 山东大学 一种联苯双酯纳米结晶制剂及其制备方法
FR2987268B1 (fr) 2012-02-28 2014-07-11 Ammtek Formulations liquides de sulfamides hypoglycemiants
CN103284952A (zh) * 2012-02-29 2013-09-11 北京万生药业有限责任公司 一种含有非诺贝特的药物组合物
JP2015527372A (ja) 2012-08-22 2015-09-17 ゼノポート，インコーポレイティド 副作用を低減させるモノメチルフマレートおよびそのプロドラッグの投与方法
US20140348915A9 (en) 2012-08-22 2014-11-27 Xenoport, Inc. Oral Dosage Forms of Methyl Hydrogen Fumarate and Prodrugs Thereof
CN102895185B (zh) * 2012-11-05 2015-03-25 西安德天药业股份有限公司 一种联苯双酯速释微丸及其制备方法和应用
CN102920654B (zh) * 2012-11-14 2014-04-23 沈阳药科大学 缬沙坦喷雾干燥纳米混悬剂及其制备方法
WO2014160633A1 (en) 2013-03-24 2014-10-02 Xenoport, Inc. Pharmaceutical compositions of dimethyl fumarate
TW201516020A (zh) 2013-09-06 2015-05-01 Xenoport Inc （ｎ，ｎ－二乙基胺甲醯基）甲基（２ｅ）丁－２－烯－１，４－二酸甲酯之晶形、合成方法及用途
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KR20240151747A (ko) * 2022-03-08 2024-10-18 (주)씨앤팜 도세탁셀 또는 이의 약학적으로 허용 가능한 염을 포함하는 약학적 조성물 및 이의 제조방법
CN114886856A (zh) * 2022-06-09 2022-08-12 山西辅仁恒峰药业有限公司 一种奥司他韦纳米干混悬剂的制备方法及应用
KR20250052834A (ko) * 2023-10-12 2025-04-21 주식회사 다산제약 프란루카스트의 생체이용률이 개선된 약제학적 조성물 및 그 제조방법
KR102756809B1 (ko) * 2023-10-13 2025-01-22 표재성 난용성 진세노사이드의 수용해도를 높인 조성물, 이를 이용한 화장품조성물 및 건강기능식품

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US20110212169A1 (en) 2011-09-01
WO2010053335A2 (ko) 2010-05-14
CN102256597A (zh) 2011-11-23
KR20100052262A (ko) 2010-05-19

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