WO2010056041A3 - 허혈 또는 허혈 재관류에 의해 유발되는 심장질환의 치료 및 예방을 위한 약제 조성물 - Google Patents

허혈 또는 허혈 재관류에 의해 유발되는 심장질환의 치료 및 예방을 위한 약제 조성물 Download PDF

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Publication number
WO2010056041A3
WO2010056041A3 PCT/KR2009/006622 KR2009006622W WO2010056041A3 WO 2010056041 A3 WO2010056041 A3 WO 2010056041A3 KR 2009006622 W KR2009006622 W KR 2009006622W WO 2010056041 A3 WO2010056041 A3 WO 2010056041A3
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WO
WIPO (PCT)
Prior art keywords
pharmaceutical composition
ischemia
treating
diseases caused
heart diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2009/006622
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English (en)
French (fr)
Other versions
WO2010056041A2 (ko
Inventor
박명규
곽태환
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mazence Inc
Original Assignee
Mazence Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mazence Inc filed Critical Mazence Inc
Publication of WO2010056041A2 publication Critical patent/WO2010056041A2/ko
Publication of WO2010056041A3 publication Critical patent/WO2010056041A3/ko
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

본 발명은 (a) 약리학적 유효량의 화학식 1 또는 2의 화합물, 약제학적으로 허용되는 그것의 염, 프로드럭, 용매화물 또는 이성질체, 및 (b) 약제학적으로 허용되는 담체, 희석제, 또는 부형제, 또는 이들의 조합을 포함하는, 허혈 또는 허혈 재관류에 의해 유발되는 심장질환의 치료 및 예방용 약제 조성물을 제공한다.
PCT/KR2009/006622 2008-11-13 2009-11-11 허혈 또는 허혈 재관류에 의해 유발되는 심장질환의 치료 및 예방을 위한 약제 조성물 Ceased WO2010056041A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2008-0112784 2008-11-13
KR20080112784 2008-11-13

Publications (2)

Publication Number Publication Date
WO2010056041A2 WO2010056041A2 (ko) 2010-05-20
WO2010056041A3 true WO2010056041A3 (ko) 2010-08-26

Family

ID=42170516

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/006622 Ceased WO2010056041A2 (ko) 2008-11-13 2009-11-11 허혈 또는 허혈 재관류에 의해 유발되는 심장질환의 치료 및 예방을 위한 약제 조성물

Country Status (2)

Country Link
KR (1) KR20100054098A (ko)
WO (1) WO2010056041A2 (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9394285B2 (en) 2013-03-15 2016-07-19 Pfizer Inc. Indole and indazole compounds that activate AMPK

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101401253B1 (ko) * 2012-03-06 2014-05-29 연세대학교 산학협력단 Ｐｃｓｋ9 발현 억제를 통한 저밀도지단백 수용체 증가 유도용 조성물
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08113555A (ja) * 1994-10-14 1996-05-07 Japan Tobacco Inc ２−アミノ−３−ハロゲノ−１，４−ナフトキノン誘導体及びその医薬用途
US5969163A (en) * 1996-02-20 1999-10-19 Wisconsin Alumni Research Foundation Ortho-quinone derivatives, novel synthesis therefor, and their use in the inhibition of neoplastic cell growth
KR20060092106A (ko) * 2005-02-16 2006-08-22 주식회사 케이티앤지 비만, 당뇨, 대사성 질환, 퇴행성 질환 및 미토콘드리아이상 질환의 치료 또는 예방을 위한 약제 조성물
KR20080039361A (ko) * 2006-02-15 2008-05-07 주식회사 엠디바이오알파 산화환원 효소에 의해 ｎａｄ（ｐ）／ｎａｄ（ｐ）ｈ비율을 조절하는 방법
KR20080099174A (ko) * 2007-05-07 2008-11-12 주식회사 머젠스 비만, 당뇨, 대사성 질환, 퇴행성 질환 및 미토콘드리아이상 질환의 치료 또는 예방을 위한 나프토퀴논계 약제조성물
KR20090073381A (ko) * 2007-12-31 2009-07-03 주식회사 머젠스 심장질환의 치료 및 예방을 위한 약제 조성물

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08113555A (ja) * 1994-10-14 1996-05-07 Japan Tobacco Inc ２−アミノ−３−ハロゲノ−１，４−ナフトキノン誘導体及びその医薬用途
US5969163A (en) * 1996-02-20 1999-10-19 Wisconsin Alumni Research Foundation Ortho-quinone derivatives, novel synthesis therefor, and their use in the inhibition of neoplastic cell growth
KR20060092106A (ko) * 2005-02-16 2006-08-22 주식회사 케이티앤지 비만, 당뇨, 대사성 질환, 퇴행성 질환 및 미토콘드리아이상 질환의 치료 또는 예방을 위한 약제 조성물
KR20080039361A (ko) * 2006-02-15 2008-05-07 주식회사 엠디바이오알파 산화환원 효소에 의해 ｎａｄ（ｐ）／ｎａｄ（ｐ）ｈ비율을 조절하는 방법
KR20080099174A (ko) * 2007-05-07 2008-11-12 주식회사 머젠스 비만, 당뇨, 대사성 질환, 퇴행성 질환 및 미토콘드리아이상 질환의 치료 또는 예방을 위한 나프토퀴논계 약제조성물
KR20090073381A (ko) * 2007-12-31 2009-07-03 주식회사 머젠스 심장질환의 치료 및 예방을 위한 약제 조성물

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"Effects of 2-chloro-3-(4-cyanophenylamino)-1,4-naphthoquinone(NQ-Y15) on normar and lschemic/reperfused rat hearts", KOREAN JOURNAL OF PHARMACY, vol. 41, no. 6, 1997, pages 829 - 836 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9394285B2 (en) 2013-03-15 2016-07-19 Pfizer Inc. Indole and indazole compounds that activate AMPK

Also Published As

Publication number Publication date
WO2010056041A2 (ko) 2010-05-20
KR20100054098A (ko) 2010-05-24

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