WO2010059976A1 - Procédés et appareils de remplacement d'articulations biologiques en utilisant une substance minérale osseuse en suspension - Google Patents

Procédés et appareils de remplacement d'articulations biologiques en utilisant une substance minérale osseuse en suspension Download PDF

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Publication number
WO2010059976A1
WO2010059976A1 PCT/US2009/065388 US2009065388W WO2010059976A1 WO 2010059976 A1 WO2010059976 A1 WO 2010059976A1 US 2009065388 W US2009065388 W US 2009065388W WO 2010059976 A1 WO2010059976 A1 WO 2010059976A1
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WIPO (PCT)
Prior art keywords
mineral substance
bone mineral
implant
suspended state
setting process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2009/065388
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English (en)
Inventor
Robert J. Daley
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Individual
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Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2010059976A1 publication Critical patent/WO2010059976A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30907—Nets or sleeves applied to surface of prostheses or in cement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0095—Packages or dispensers for prostheses or other implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
    • A61F2002/30042—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis made from both cured and uncured parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30072—Coating made of plastically deformable or self-moulding material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools for implanting artificial joints
    • A61F2002/4631—Special tools for implanting artificial joints the prosthesis being specially adapted for being cemented
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00952—Coating, pre-coating or prosthesis-covering structure made of bone cement, e.g. pre-applied PMMA cement mantle

Definitions

  • the present application relates in general to joint replacement surgery and more specifically to methods and apparatus for replacing biological joints, but applies also to the fixation of any solid implant for use in dental or orthopaedic applications.
  • a surgeon When a surgeon performs a joint replacement (e.g., a hip replacement), he must attach one or more implants to one or more bones. For example, in a total knee replacement, the surgeon typically attaches two or three different implants to two or three different bones. These implants are typically made of metal, plastic, or ceramic in any combination and are attached in one of two ways.
  • Bone cement is typically an acrylic material dispensed as a powder and a liquid, that is mixed as is any other cement.
  • the powder contains polymethyl methacrylate, (or similar type material) a filler, plasticizer, and polymerization initiator.
  • the liquid monomer may be methyl methacrylate with an inhibitor and an activator.
  • the polymerization phase of the cement (e.g., the hardness of the cement from liquid to solid) is different for each implant.
  • the bone cement is more polymerized and firmer for later placed implants.
  • each implant is not placed with the bone cement at the ideal consistency.
  • complications can occur(e.g. crack propagation from the voids in the cement mantle).
  • the excess must be cleaned out. If any cement is missed, that excess cement may cause wearing complications for the artificial joint and the patient by interposing third body wear and causing abrasive wear to the implant.
  • each implant is manufactured with a rough contact surface such as a porous surface.
  • This roughened surface may also be coated with a very thin bone mineral substance layer, e.g. hydroxyapatite or other calcium mineral substances, that is applied and is hardened into a solid layer on the implant substrate. The bone grows into this layer, and no bone cement is needed.
  • the present disclosure provides methods and apparatus for replacing biological joints that solve all of these problems.
  • an ideal amount of bone mineral substance is applied to the implant prior to going in to the operating room.
  • the setting (e.g., hardening) process is suspended with the bone mineral substance in a semi solid-liquid stage ,e.g. doughy state, by a manufacturing process such as a coating and/or a chemical.
  • the setting process may be suspended and then resumed using by freezing and then thawing the bone mineral substance.
  • the setting process is resumed.
  • the bone mineral substance does not need to be applied in the operating room, and the surgeon does not need to "race the clock.”
  • Each implant is placed with the ideal amount of bone mineral substance in the ideal consistency, in the ideal distribution on the implant. The surgeon is able to open the implant package and implant the prosthesis with confidence that fixation is achieved without the inherent problems of the mixing of the bone mineral substance in the operating room.
  • FIG. 1 is a flowchart of an example method of replacing a biological joint.
  • FIG. 2 is diagram illustrating a portion of an implant including bone mineral substance in a pre-suspended setting state.
  • FIG. 3 is diagram illustrating a portion of an implant including bone mineral substance in a suspended setting state.
  • FIG. 4 is diagram illustrating a portion of an implant including bone mineral substance in a resumed setting state.
  • FIG. 1 a flowchart of an example process 100 for replacing biological joints is presented in FIG. 1.
  • process 100 is described with reference to the flowchart illustrated in FIG. 1 , it will be appreciated that many other methods of performing the acts associated with process 100 may be used. For example, the order of many of the steps may be changed, some of the steps described may be optional, and additional steps may be included.
  • the methods disclosed herein also apply to the fixation of any solid implant for use in dental or orthopaedic applications.
  • the process 100 begins when an ideal amount of bone mineral substance is applied to the implant prior to going in to the operating room (block 102).
  • An example of a portion 200 of an implant 202 including bone mineral substance 204 in such a pre-suspended setting state (e.g., 25% setting) is illustrated in FIG. 2.
  • the bone mineral substance may be applied in the factory.
  • the setting process is suspended with a manufacturing process, coating and/or a chemical (block 104).
  • a manufacturing process, coating and/or a chemical block 104
  • An example of a portion 300 of an implant including bone mineral substance in such a suspended setting state (e.g., 50% setting) is illustrated in FIG. 3.
  • a plastic seal similar to plastic food wrap such as polyvinylidene chloride or low density polyethylene, may be used to prevent air from reaching the bone mineral substance.
  • the entire end of the implant may be submerged in a chemical to suspend the setting process.
  • the setting process is resumed (block 108).
  • An example of a portion 400 of an implant including a bone mineral substance in such a resumed setting state (e.g., 75% setting) is illustrated in FIG. 4.
  • the surgeon or an assistant may peel off a plastic coating in the operating room right before each implant is attached to the patient.
  • the entire end of the implant may be submerged in a chemical to resume the setting process.

Landscapes

  • Health & Medical Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

La présente divulgation propose des procédés et des appareils de remplacement d'articulations biologiques, mais concerne également la fixation de tout implant massif destiné à être utilisé dans des applications dentaires ou orthopédiques. De manière générale, on applique une quantité idéale de substance minérale osseuse sur l'implant avant d'entrer en salle d'opération. Ensuite, le processus de solidification (par exemple par séchage) est arrêté à l'aide d'un revêtement et/ou d'un agent chimique. Lorsque le ou les implants sont nécessaires dans la salle d'opération, le processus de solidification est repris. De cette manière, la substance minérale osseuse ne doit pas être appliquée dans la salle d'opération, le chirurgien ne doit pas "se presser" et chaque implant est placé avec la quantité idéale de substance minérale osseuse qui présente la consistance idéale.
PCT/US2009/065388 2008-11-20 2009-11-20 Procédés et appareils de remplacement d'articulations biologiques en utilisant une substance minérale osseuse en suspension Ceased WO2010059976A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11652808P 2008-11-20 2008-11-20
US61/116,528 2008-11-20
US12/544,684 2009-08-20
US12/544,684 US20100125303A1 (en) 2008-11-20 2009-08-20 Methods and apparatus for replacing biological joints using bone mineral substance in a suspended state

Publications (1)

Publication Number Publication Date
WO2010059976A1 true WO2010059976A1 (fr) 2010-05-27

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Country Status (2)

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US (1) US20100125303A1 (fr)
WO (1) WO2010059976A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5015180A (en) * 1989-03-01 1991-05-14 Minnesota Mining And Manufacturing Company Dental article containing light-curable paste
EP0806192A2 (fr) * 1996-05-11 1997-11-12 Heraeus Kulzer GmbH Produit semi-fini pour la fabrication de précision d'une prothèse à implanter
US5810584A (en) * 1997-04-04 1998-09-22 Ormco Corporation Orthodontic appliances (brackets) having pre-applied adhesive
US7131836B1 (en) * 2002-11-01 2006-11-07 Tp Orthodontics, Inc. Bracket with bilayer base configured to produce a control value

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2718228A (en) * 1952-09-26 1955-09-20 Henri Georges Van Steenbrugghe Artificial femoral heads in prostheses
US3616841A (en) * 1967-10-30 1971-11-02 Energy Research And Generation Method of making an inorganic reticulated foam structure
US3816952A (en) * 1969-02-19 1974-06-18 Ethyl Corp Preparation of metal foams with viscosity increasing gases
US3605123A (en) * 1969-04-29 1971-09-20 Melpar Inc Bone implant
CA962806A (en) * 1970-06-04 1975-02-18 Ontario Research Foundation Surgical prosthetic device
US3790365A (en) * 1971-06-21 1974-02-05 Ethyl Corp Method of making metal foams by sequential expansion
CH568753A5 (fr) * 1973-08-31 1975-11-14 Oscobal Ag
US3906550A (en) * 1973-12-27 1975-09-23 William Rostoker Prosthetic device having a porous fiber metal structure
DE2620907C3 (de) * 1976-05-12 1984-09-20 Battelle-Institut E.V., 6000 Frankfurt Verankerung für hochbelastete Endoprothesen
US4081866A (en) * 1977-02-02 1978-04-04 Howmedica, Inc. Total anatomical knee prosthesis
CH622423A5 (fr) * 1977-10-12 1981-04-15 Sulzer Ag
FR2429589A1 (fr) * 1978-06-29 1980-01-25 Ceraver Tige en titane ou alliage de titane pour fixation sans ciment dans un os long pour prothese
US4281420A (en) * 1979-02-15 1981-08-04 Raab S Bone connective prostheses adapted to maximize strength and durability of prostheses-bone cement interface; and methods of forming same
US4365359A (en) * 1979-02-15 1982-12-28 Raab S PMMA Coated bone connective prostheses and method of forming same
DE2928007A1 (de) * 1979-07-11 1981-01-15 Riess Guido Dr Knochen-implantatkoerper fuer prothesen und knochenverbindungsstuecke sowie verfahren zu seiner herstellung
US4283799A (en) * 1979-09-10 1981-08-18 Massachusetts Institute Of Technology Pre-coated body implant
US4491987A (en) * 1979-09-24 1985-01-08 Clemson University Method of orthopedic implantation and implant product
CH648748A5 (de) * 1981-02-19 1985-04-15 Sulzer Ag Gerader, blattartiger schaft einer gelenkendoprothese.
US4549319A (en) * 1982-08-03 1985-10-29 United States Medical Corporation Artificial joint fixation to bone
US4834756A (en) * 1982-02-18 1989-05-30 Pfizer Hospital Products Group, Inc. Bone prosthesis with porous coating
US4514865A (en) * 1982-04-19 1985-05-07 Harris William H Stemmed femoral component for the human hip
DE8237288U1 (de) * 1982-05-03 1985-09-12 Waldemar Link Gmbh & Co, 2000 Hamburg Femorale Hüftgelenkprothese
CH656525A5 (de) * 1982-10-15 1986-07-15 Sulzer Ag Verankerungsschaft fuer die verankerung einer gelenkendoprothese.
DE3301415A1 (de) * 1983-01-18 1984-07-19 Robert Bosch Gmbh, 7000 Stuttgart Endoprothesenschaft
US4566138A (en) * 1983-03-08 1986-01-28 Zimmer, Inc. Prosthetic device with spacers
US4554686A (en) * 1984-02-29 1985-11-26 Technical Research Associates, Inc. Polymethylmethacrylate bone cements and methods for preparing such bone cements
US4626392A (en) * 1984-03-28 1986-12-02 Ngk Spark Plug Co., Ltd. Process for producing ceramic body for surgical implantation
US4608052A (en) * 1984-04-25 1986-08-26 Minnesota Mining And Manufacturing Company Implant with attachment surface
US4657941A (en) * 1984-11-29 1987-04-14 Dentsply Research & Development Corp. Biologically compatible adhesive containing a phosphorus adhesion promoter and a sulfinic accelerator
US4715860A (en) * 1985-08-23 1987-12-29 The Regents Of The University Of California Porous acetabular hip resurfacing
US4735625A (en) * 1985-09-11 1988-04-05 Richards Medical Company Bone cement reinforcement and method
JPS62202884A (ja) * 1986-02-28 1987-09-07 工業技術院長 生体代替セラミツク材料
US4795472A (en) * 1987-01-28 1989-01-03 Zimmer, Inc. Prosthesis with enhanced surface finish
USD339634S (en) * 1987-08-24 1993-09-21 Zimmer, Inc. Proximal portion of a femoral hip stem prothesis
US6228116B1 (en) * 1987-12-22 2001-05-08 Walter J. Ledergerber Tissue expander
US5108436A (en) * 1988-09-29 1992-04-28 Collagen Corporation Implant fixation
US5147403A (en) * 1989-03-15 1992-09-15 United States Gypsum Company Prosthesis implantation method
SE465571B (sv) * 1989-04-10 1991-09-30 Stiftelsen Ct Foer Dentaltekni Saett att framstaella ett sammansatt keramiskt material med bioaktiva egenskaper
US5246530A (en) * 1990-04-20 1993-09-21 Dynamet Incorporated Method of producing porous metal surface
US5116380A (en) * 1991-02-28 1992-05-26 Zimmer, Inc. Prosthetic implant with spacers having tapered trailing edges
US5163963A (en) * 1991-02-28 1992-11-17 Zimmer, Inc. Prosthetic implant with spacers having tapered trailing edges
JP3064470B2 (ja) * 1991-04-19 2000-07-12 杉郎 大谷 人工補填補綴材料
GR1002517B (el) * 1991-09-30 1997-01-23 Johnson & Johnson Orthopaedics Inc. Προσθεση ισχιου.
US5507833A (en) * 1992-02-10 1996-04-16 Kim-Med, Inc. Hip replacement system and method for implanting the same
US5282861A (en) * 1992-03-11 1994-02-01 Ultramet Open cell tantalum structures for cancellous bone implants and cell and tissue receptors
US5370698A (en) * 1992-04-16 1994-12-06 Clemson University Isoelastic implants with improved anchorage means
US5281251A (en) * 1992-11-04 1994-01-25 Alcan International Limited Process for shape casting of particle stabilized metal foam
US5507832B1 (en) * 1993-10-26 1999-07-27 Howmedica Prosthesis with integral proximal spacer
US5509935A (en) * 1994-02-16 1996-04-23 Wright Medical Technology, Inc. Intramedullary implant with optimized geometric stiffness
US5538514A (en) * 1994-04-07 1996-07-23 Zimmer, Inc. Method for forming bone cement to an implant
US5489022A (en) * 1994-04-19 1996-02-06 Sabin Corporation Ultraviolet light absorbing and transparent packaging laminate
US6302913B1 (en) * 1994-05-24 2001-10-16 Implico B.V. Biomaterial and bone implant for bone repair and replacement
US5614206A (en) * 1995-03-07 1997-03-25 Wright Medical Technology, Inc. Controlled dissolution pellet containing calcium sulfate
AU6423796A (en) * 1995-08-29 1997-03-06 Johnson & Johnson Professional, Inc. Bone prosthesis with protected coating for penetrating bone intergrowth
US6050815A (en) * 1996-03-15 2000-04-18 3M Innovative Properties Company Precoated dental cement
EP0891195B1 (fr) * 1996-12-30 2005-06-15 Xenon Research Inc. Prothese perfectionnee pour jonction avec l'os et son procede de fabrication
US5874123A (en) * 1997-01-24 1999-02-23 Park; Joon B. Precoated polymeric prosthesis and process for making same
US6136029A (en) * 1997-10-01 2000-10-24 Phillips-Origen Ceramic Technology, Llc Bone substitute materials
US6296667B1 (en) * 1997-10-01 2001-10-02 Phillips-Origen Ceramic Technology, Llc Bone substitutes
US6214049B1 (en) * 1999-01-14 2001-04-10 Comfort Biomedical, Inc. Method and apparatus for augmentating osteointegration of prosthetic implant devices
WO1999030632A1 (fr) * 1997-12-18 1999-06-24 Comfort Biomedical, Inc. Croissance osseuse d'implants prothetiques et autres
US6136229A (en) * 1998-10-15 2000-10-24 Alliedsignal Inc. Method for the mechanochemical preparation of high performance ceramics
EP1000691A3 (fr) * 1998-11-16 2002-07-03 Johnson & Johnson Professional, Inc. Superfinition de composants d'implants polymériques
US6558422B1 (en) * 1999-03-26 2003-05-06 University Of Washington Structures having coated indentations
US6203844B1 (en) * 1999-04-01 2001-03-20 Joon B. Park Precoated polymeric prosthesis and process for making same
US6790228B2 (en) * 1999-12-23 2004-09-14 Advanced Cardiovascular Systems, Inc. Coating for implantable devices and a method of forming the same
US6827740B1 (en) * 1999-12-08 2004-12-07 Gary K. Michelson Spinal implant surface configuration
US7115143B1 (en) * 1999-12-08 2006-10-03 Sdgi Holdings, Inc. Orthopedic implant surface configuration
US6361566B1 (en) * 2000-03-10 2002-03-26 Bashar Al-Hafez Hip prosthesis
US6800245B1 (en) * 2000-11-28 2004-10-05 Vita Special Purpose Corporation Sterile polymerizable systems and kits and methods of their manufacture and use
US6652591B2 (en) * 2000-12-14 2003-11-25 Depuy Orthopaedics, Inc. Prosthesis with feature aligned to trabeculae
WO2002083188A2 (fr) * 2001-04-16 2002-10-24 Cassidy James J Structures denses/poreuses utilisees comme substituts osseux
CA2449433A1 (fr) * 2001-06-20 2003-01-03 Microvention, Inc. Dispositifs medicaux a gainages polymeres integraux ou partiels et procedes de fabrication
WO2003034937A2 (fr) * 2001-10-24 2003-05-01 Raab S Prothese de jonction avec l'os et son procede de fabrication
US6596338B2 (en) * 2001-10-24 2003-07-22 Howmedica Osteonics Corp. Antibiotic calcium phosphate coating
US7374420B2 (en) * 2003-12-19 2008-05-20 3M Innovative Properties Company Multi-layer adhesives and methods for bonding orthodontic appliances to tooth structure
US7534271B2 (en) * 2004-01-22 2009-05-19 Smith + Nephew Femoral hip prosthesis and method of implantation
US20050278012A1 (en) * 2004-06-10 2005-12-15 Design & Performance - Cyprus Limited Protected stent delivery system and packaging

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5015180A (en) * 1989-03-01 1991-05-14 Minnesota Mining And Manufacturing Company Dental article containing light-curable paste
EP0806192A2 (fr) * 1996-05-11 1997-11-12 Heraeus Kulzer GmbH Produit semi-fini pour la fabrication de précision d'une prothèse à implanter
US5810584A (en) * 1997-04-04 1998-09-22 Ormco Corporation Orthodontic appliances (brackets) having pre-applied adhesive
US7131836B1 (en) * 2002-11-01 2006-11-07 Tp Orthodontics, Inc. Bracket with bilayer base configured to produce a control value

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