WO2010077101A3 - 신규한 티아졸리딘디온 유도체 및 그의 용도 - Google Patents

신규한 티아졸리딘디온 유도체 및 그의 용도 Download PDF

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Publication number
WO2010077101A3
WO2010077101A3 PCT/KR2009/007995 KR2009007995W WO2010077101A3 WO 2010077101 A3 WO2010077101 A3 WO 2010077101A3 KR 2009007995 W KR2009007995 W KR 2009007995W WO 2010077101 A3 WO2010077101 A3 WO 2010077101A3
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WO
WIPO (PCT)
Prior art keywords
thiazolidinedione derivative
novel thiazolidinedione
chemical formula
following chemical
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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PCT/KR2009/007995
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English (en)
French (fr)
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WO2010077101A2 (ko
WO2010077101A4 (ko
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조훈
무영
최철희
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Chosun University Industry Academic Cooperation Foundation
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Chosun University Industry Academic Cooperation Foundation
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42310414&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2010077101(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chosun University Industry Academic Cooperation Foundation filed Critical Chosun University Industry Academic Cooperation Foundation
Priority to US13/142,924 priority Critical patent/US8637558B2/en
Priority to EP09836422.7A priority patent/EP2383263B1/en
Priority to KR1020117017782A priority patent/KR101172638B1/ko
Publication of WO2010077101A2 publication Critical patent/WO2010077101A2/ko
Publication of WO2010077101A3 publication Critical patent/WO2010077101A3/ko
Publication of WO2010077101A4 publication Critical patent/WO2010077101A4/ko
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 하기 화학식 1로 표시되는 신규 화합물 및 그의 용도에 관한 것이다. 보다 구체적으로 본 발명은 하기 화학식 1로 표시되는 신규한 티아졸리딘디온 유도체 및 이를 포함하는 약학적 조성물에 관한 것이다. 본 발명에 따른 하기 화학식 1의 신규한 티아졸리딘디온 유도체는 프로스타글란딘을 분해하는 15-하이드록시프로스타글란딘 탈수소화효소(15-PGDH)를 억제하는 활성을 나타내므로 심혈관계질환, 위장질환 및 신장질환을 예방 또는 치료하는데 효과적으로 사용될 수 있고, 탈모의 예방 및 발모 촉진에 효과적으로 사용될 수 있을 뿐만 아니라 골형성 촉진 및 화상 치료에도 효과적으로 사용할 수 있다.
PCT/KR2009/007995 2008-12-30 2009-12-30 신규한 티아졸리딘디온 유도체 및 그의 용도 Ceased WO2010077101A2 (ko)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US13/142,924 US8637558B2 (en) 2008-12-30 2009-12-30 Thiazolidinedione derivative and use thereof
EP09836422.7A EP2383263B1 (en) 2008-12-30 2009-12-30 Novel thiazolidinedione derivative and use thereof
KR1020117017782A KR101172638B1 (ko) 2008-12-30 2009-12-30 신규한 티아졸리딘디온 유도체 및 그의 용도

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20080136921 2008-12-30
KR10-2008-0136921 2008-12-30
KR10-2009-0055326 2009-06-22
KR20090055326 2009-06-22

Publications (3)

Publication Number Publication Date
WO2010077101A2 WO2010077101A2 (ko) 2010-07-08
WO2010077101A3 true WO2010077101A3 (ko) 2010-10-21
WO2010077101A4 WO2010077101A4 (ko) 2011-01-13

Family

ID=42310414

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/007995 Ceased WO2010077101A2 (ko) 2008-12-30 2009-12-30 신규한 티아졸리딘디온 유도체 및 그의 용도

Country Status (4)

Country Link
US (1) US8637558B2 (ko)
EP (1) EP2383263B1 (ko)
KR (1) KR101172638B1 (ko)
WO (1) WO2010077101A2 (ko)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013158649A1 (en) * 2012-04-16 2013-10-24 Case Western Reserve University Compositions and methods of modulating 15-pgdh activity
US9801863B2 (en) 2012-04-16 2017-10-31 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for modulating hematopoietic stem cells and hematopoiesis
WO2016144958A1 (en) 2015-03-08 2016-09-15 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for treating fibrosis
WO2014062811A2 (en) * 2012-10-16 2014-04-24 New York University METHOD OF TREATING CANCER WITH MODULATORS OF SCFSkp2
US9789116B2 (en) 2013-10-15 2017-10-17 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity
JP2018511616A (ja) * 2015-04-14 2018-04-26 ケース ウエスタン リザーブ ユニバーシティ 短鎖デヒドロゲナーゼ活性を調節する組成物および方法
KR102660070B1 (ko) * 2015-07-21 2024-04-24 이뮤노젠 아이엔씨 세포독성 벤조다이아제핀 유도체의 제조 방법
KR101843927B1 (ko) * 2015-10-27 2018-03-30 주식회사 이에이치엘바이오 15-pgdh 억제제를 처리한 세포 또는 그것의 배양물을 포함하는 조성물과 그의 용도
WO2017074043A1 (ko) * 2015-10-27 2017-05-04 주식회사 이에이치엘바이오 15-pgdh 억제제를 처리한 세포 또는 그것의 배양물을 포함하는 조성물과 그의 용도
KR101817287B1 (ko) 2016-01-08 2018-01-10 조선대학교 산학협력단 티아졸리딘디온 유도체 및 그의 용도
CN109475565B (zh) 2016-04-05 2021-11-02 免疫传感器公司 cGAS拮抗剂化合物
EP3484473A4 (en) 2016-07-18 2020-03-18 Case Western Reserve University INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY TO PROMOTE NEUROGENESIS AND INHIBIT NERVOUS DEATH
WO2018102552A1 (en) 2016-11-30 2018-06-07 Case Western Reserve University Combinations of 15-pgdh inhibitors with corcosteroids and/or tnf inhibitors and uses thereof
US11718589B2 (en) 2017-02-06 2023-08-08 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase
US11426420B2 (en) * 2017-04-07 2022-08-30 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for treating coronary disorders
KR101912142B1 (ko) * 2018-01-04 2018-10-29 주식회사 이에이치엘바이오 15-pgdh 억제제를 처리한 세포 또는 그것의 배양물을 포함하는 조성물과 그의 용도
KR102921276B1 (ko) 2018-11-21 2026-02-03 케이스 웨스턴 리저브 유니버시티 단쇄 데히드로게나아제 활성을 조절하는 조성물 및 방법

Citations (5)

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Publication number Priority date Publication date Assignee Title
WO2000018746A1 (en) * 1998-09-30 2000-04-06 Roche Diagnostics Gmbh Thiazolidine derivatives for the treatment and prevention of metabolic bone disorders
WO2004093803A2 (en) * 2003-04-16 2004-11-04 Pintex Pharmaceuticals, Inc. Photochemotherapeutic compounds for use in treatment of pin1-associated states
US20070065472A1 (en) * 2005-06-28 2007-03-22 L'oreal Benzyl-1,3-thiazolidine-2,4-dione compounds for stimulating or inducing the growth and/or for reducing the loss of keratin fibers
US20070071699A1 (en) * 2005-06-28 2007-03-29 L'oreal Benzylidene-1,3-thiazolidine-2,4-dione compounds for promoting and/or inducing and/or stimulating the pigmentation of keratin materials and/or for limiting their depigmentation and/or whitening
WO2008109727A1 (en) * 2007-03-07 2008-09-12 Janssen Pharmaceutica N.V. Substituted phenoxy thiazolidinediones as estrogen related receptor-alpha modulators

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Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000018746A1 (en) * 1998-09-30 2000-04-06 Roche Diagnostics Gmbh Thiazolidine derivatives for the treatment and prevention of metabolic bone disorders
WO2004093803A2 (en) * 2003-04-16 2004-11-04 Pintex Pharmaceuticals, Inc. Photochemotherapeutic compounds for use in treatment of pin1-associated states
US20070065472A1 (en) * 2005-06-28 2007-03-22 L'oreal Benzyl-1,3-thiazolidine-2,4-dione compounds for stimulating or inducing the growth and/or for reducing the loss of keratin fibers
US20070071699A1 (en) * 2005-06-28 2007-03-29 L'oreal Benzylidene-1,3-thiazolidine-2,4-dione compounds for promoting and/or inducing and/or stimulating the pigmentation of keratin materials and/or for limiting their depigmentation and/or whitening
WO2008109727A1 (en) * 2007-03-07 2008-09-12 Janssen Pharmaceutica N.V. Substituted phenoxy thiazolidinediones as estrogen related receptor-alpha modulators

Non-Patent Citations (1)

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Title
See also references of EP2383263A4 *

Also Published As

Publication number Publication date
US20110269954A1 (en) 2011-11-03
WO2010077101A2 (ko) 2010-07-08
KR101172638B1 (ko) 2012-08-08
EP2383263A2 (en) 2011-11-02
EP2383263A4 (en) 2012-08-22
KR20110107358A (ko) 2011-09-30
WO2010077101A4 (ko) 2011-01-13
EP2383263B1 (en) 2014-04-16
US8637558B2 (en) 2014-01-28

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