WO2010092500A3 - Procédé de préparation du tartrate de toltérodine - Google Patents

Procédé de préparation du tartrate de toltérodine Download PDF

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Publication number
WO2010092500A3
WO2010092500A3 PCT/IB2010/050384 IB2010050384W WO2010092500A3 WO 2010092500 A3 WO2010092500 A3 WO 2010092500A3 IB 2010050384 W IB2010050384 W IB 2010050384W WO 2010092500 A3 WO2010092500 A3 WO 2010092500A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
tolterodine tartrate
methylphenyl
methoxy
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2010/050384
Other languages
English (en)
Other versions
WO2010092500A2 (fr
Inventor
Ravi Ponnaiah
Sanjay Desai
Chankrakant Chunilal Shah
Kalpesh Shantibhai Patel
Viral Maheshbhai Parekh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alembic Ltd
Original Assignee
Alembic Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alembic Ltd filed Critical Alembic Ltd
Publication of WO2010092500A2 publication Critical patent/WO2010092500A2/fr
Publication of WO2010092500A3 publication Critical patent/WO2010092500A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255—Tartaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C07C51/31—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation of cyclic compounds with ring-splitting
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La présente invention concerne un procédé de préparation du L-tartrate de (+)-(R)-toltérodine, comprenant une étape d'amination de l'hydroxyle protégé du 3-(2-méthoxy-5-méthylphényl)-3-phényl-propanol de formule (V) avec la diisopropylamine en présence d'eau afin d'obtenir la N,N-diisopropyl-3-(2-méthoxy-5-méthylphényl)-3-phénylpropyl-amine de formule (VI).
PCT/IB2010/050384 2009-02-12 2010-01-28 Procédé de préparation du tartrate de toltérodine Ceased WO2010092500A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN312/MUM/2009 2009-02-12
IN312MU2009 2009-02-12

Publications (2)

Publication Number Publication Date
WO2010092500A2 WO2010092500A2 (fr) 2010-08-19
WO2010092500A3 true WO2010092500A3 (fr) 2010-12-02

Family

ID=42244871

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2010/050384 Ceased WO2010092500A2 (fr) 2009-02-12 2010-01-28 Procédé de préparation du tartrate de toltérodine

Country Status (1)

Country Link
WO (1) WO2010092500A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017137955A1 (fr) * 2016-02-14 2017-08-17 Celestis Pharmaceuticals Pvt. Ltd. Nouveau (r) et 3-(2-(allyloxy)-5-méthylphényl)-n,n-diisopropyl-3- phénylpropan-1-amine racémique et son utilisation pour la synthèse de (r) et de 2-(3- (diisopropylamino)-1-phénylpropyl)-4-(hydroxyméthyl)phénol racémique

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003014060A1 (fr) * 2001-08-03 2003-02-20 Ranbaxy Laboratories Limited Procede de preparation de tolterodine
WO2005061432A1 (fr) * 2003-12-24 2005-07-07 Cipla Limited Tolterodine, compositions et leurs utilisations, et preparations desdites compositions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5382600A (en) 1988-01-22 1995-01-17 Pharmacia Aktiebolag 3,3-diphenylpropylamines and pharmaceutical compositions thereof
KR20000057548A (ko) 1996-12-13 2000-09-25 알프레드 엘. 미첼슨 광학적 전송물질 및 결합재
EP1603862A1 (fr) 2003-03-06 2005-12-14 Ranbaxy Laboratories Limited Derives de 3,3-diarylpropylamine et procedes permettant de les isoler

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003014060A1 (fr) * 2001-08-03 2003-02-20 Ranbaxy Laboratories Limited Procede de preparation de tolterodine
WO2005061432A1 (fr) * 2003-12-24 2005-07-07 Cipla Limited Tolterodine, compositions et leurs utilisations, et preparations desdites compositions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
K. SRINIVAS ET AL.: "An improved, scalable, and impurity-free process for tolterodine tartrate", ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 9, 23 April 2005 (2005-04-23), pages 314 - 318, XP002602375 *

Also Published As

Publication number Publication date
WO2010092500A2 (fr) 2010-08-19

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