WO2010113176A3 - Nouveaux copolymères pour système d'administration à libération contrôlée - Google Patents

Nouveaux copolymères pour système d'administration à libération contrôlée Download PDF

Info

Publication number
WO2010113176A3
WO2010113176A3 PCT/IN2010/000204 IN2010000204W WO2010113176A3 WO 2010113176 A3 WO2010113176 A3 WO 2010113176A3 IN 2010000204 W IN2010000204 W IN 2010000204W WO 2010113176 A3 WO2010113176 A3 WO 2010113176A3
Authority
WO
WIPO (PCT)
Prior art keywords
controlled release
delivery system
copolymers
release delivery
vinylcaprolactam
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2010/000204
Other languages
English (en)
Other versions
WO2010113176A2 (fr
Inventor
Vidhya Rangaswamy
Tejraj Malleshappa Aminabhavi
Vadde Ramesh Babu
Raghavendra Chaluvayya Mundargi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Reliance Life Sciences Pvt Ltd
Original Assignee
Reliance Life Sciences Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reliance Life Sciences Pvt Ltd filed Critical Reliance Life Sciences Pvt Ltd
Publication of WO2010113176A2 publication Critical patent/WO2010113176A2/fr
Publication of WO2010113176A3 publication Critical patent/WO2010113176A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F226/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C08F226/06—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a heterocyclic ring containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/04—Acids; Metal salts or ammonium salts thereof
    • C08F220/06—Acrylic acid; Methacrylic acid; Metal salts or ammonium salts thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
    • C08F222/02—Acids; Metal salts or ammonium salts thereof, e.g. maleic acid or itaconic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne des copolymères de poly(acide méthacrylique-co-N-vinylcaprolactame) sensibles au pH, nommés P(MAA-co-VCL). L'invention concerne en particulier la synthèse d'un copolymère de poly(acide méthacrylique-co-N-vinylcaprolactame) et son application pour l'administration orale, sensible au pH, de principes actifs in vitro et in vivo. L'invention décrit en particulier des microparticules contenant les copolymères pour la libération contrôlée d'un médicament administré. L'invention décrit également des méthodes d'administration de médicament au tractus gastro-intestinal inférieur, permettant d'éviter ce faisant une exposition aux acides de l'estomac, ainsi que des méthodes de traitement du diabète à l'aide de particules prévues pour l'administration d'insuline à libération contrôlée.
PCT/IN2010/000204 2009-03-31 2010-03-30 Nouveaux copolymères pour système d'administration à libération contrôlée Ceased WO2010113176A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN857/MUM/2009 2009-03-31
IN857MU2009 2009-03-31

Publications (2)

Publication Number Publication Date
WO2010113176A2 WO2010113176A2 (fr) 2010-10-07
WO2010113176A3 true WO2010113176A3 (fr) 2010-11-18

Family

ID=42740388

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2010/000204 Ceased WO2010113176A2 (fr) 2009-03-31 2010-03-30 Nouveaux copolymères pour système d'administration à libération contrôlée

Country Status (1)

Country Link
WO (1) WO2010113176A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108066313B (zh) * 2017-12-29 2021-02-19 成都恒瑞制药有限公司 一种盐酸二甲双胍包合物的制备方法
CN114431339B (zh) * 2022-02-14 2023-06-27 浙江汇能生物股份有限公司 一种低添加增稳微囊化二甲酸钾饲料添加剂及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0130080A1 (fr) * 1983-06-27 1985-01-02 Johnson & Johnson Products Inc. Adhésif sensible à la pression
WO1990012041A1 (fr) * 1989-04-07 1990-10-18 Gaf Chemicals Corporation Polymerisation par precipitation de copolymeres d'un lactame de vinyl et d'un acide carboxylique polymerisable dans un solvant d'hydrocarbure aliphatique
WO1999056782A1 (fr) * 1998-05-01 1999-11-11 Minnesota Mining And Manufacturing Company Composition d'administration de medicaments a microspheres adhesives
WO2001091729A1 (fr) * 2000-05-30 2001-12-06 Basf Aktiengesellschaft Formulation a base d'heparine, de glycosaminoglycane ou d'heparinoide et utilisation de ladite formulation et base de la formulation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2117492C1 (ru) 1997-07-03 1998-08-20 Закрытое акционерное общество "ПОЛИСТОМ" Ранозаживляющее и остеопластическое средство (варианты)
US6110434A (en) 1998-02-25 2000-08-29 Alumitech Of Cleveland, Inc. Recovery of products from non-metallic products derived from aluminum dross

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0130080A1 (fr) * 1983-06-27 1985-01-02 Johnson & Johnson Products Inc. Adhésif sensible à la pression
WO1990012041A1 (fr) * 1989-04-07 1990-10-18 Gaf Chemicals Corporation Polymerisation par precipitation de copolymeres d'un lactame de vinyl et d'un acide carboxylique polymerisable dans un solvant d'hydrocarbure aliphatique
WO1999056782A1 (fr) * 1998-05-01 1999-11-11 Minnesota Mining And Manufacturing Company Composition d'administration de medicaments a microspheres adhesives
WO2001091729A1 (fr) * 2000-05-30 2001-12-06 Basf Aktiengesellschaft Formulation a base d'heparine, de glycosaminoglycane ou d'heparinoide et utilisation de ladite formulation et base de la formulation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DAMGE ET AL: "Oral delivery of insulin associated to polymeric nanoparticles in diabetic rats", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL LNKD- DOI:10.1016/J.JCONREL.2006.10.023, vol. 117, no. 2, 30 January 2007 (2007-01-30), pages 163 - 170, XP005864305, ISSN: 0168-3659 *

Also Published As

Publication number Publication date
WO2010113176A2 (fr) 2010-10-07

Similar Documents

Publication Publication Date Title
WO2010113177A3 (fr) Systèmes d'administration d'insuline par voie orale pour contrôler le diabète
Maher et al. Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic
NZ607189A (en) Materials and methods for improving gastrointestinal function
WO2010062688A3 (fr) Forme galénique pour insertion dans la bouche
WO2008084504A3 (fr) Composition pharmaceutique d'inhibiteurs du récepteur de l'angiotensine ii
IN2012DN01216A (fr)
WO2009017716A3 (fr) Formes médicamenteuses de rétention gastrique pulsatile
WO2010103365A3 (fr) Composition à libération lente d'un agent thérapeutique
EA201100313A1 (ru) Способ доставки фармацевтической композиции пациенту, нуждающемуся в этом
WO2011107755A3 (fr) Administration immédiate / retardée de médicament
GB2491327A (en) Delayed prolonged drug delivery
WO2011112229A3 (fr) Préparations d'agent thérapeutique pour une administration dans une lumière du tractus intestinal à l'aide d'un dispositif d'administration de médicament avalable
GB2458229A8 (en) Magnetic carrier and medical preparation for controllable delivery and release of active substances, a method of production and method of treatment using ther
EP2329810A4 (fr) Système d'administration de médicament à rétention gastrique, procédé de préparation et son utilisation
EP2515992A4 (fr) Dispositif d'administration de médicament avalable et procédés d'administration de médicament
WO2007111958A3 (fr) Procédé et compositions pour potentialiser des médicaments à l'aide d'aliments thérapeutiques à base d'acides aminés
WO2010036918A3 (fr) Récepteur intracellulaire d'adn
WO2011116139A3 (fr) Compositions pharmaceutiques améliorées et procédés d'administration
WO2008030830A3 (fr) Composition à libération prolongée et son procédé d'utilisation
WO2010005980A8 (fr) Tacrolimus pour traitement amélioré de patients transplantés
WO2013049749A3 (fr) Vecteurs dépendant du ph pour libération ciblée de produits pharmaceutiques dans le tube digestif, compositions préparées à partir de ceux-ci, et leur fabrication et leur utilisation
EA201170529A1 (ru) Система доставки лекарственного препарата с замедленным высвобождением
TN2009000476A1 (en) Slow release pharmaceutical composition made of microparticles
JP2013510169A5 (fr)
WO2010090494A3 (fr) Utilisation médicale de dérivés d'acide 5-benzylaminosalicylique ou de sels correspondants

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 10740758

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 10740758

Country of ref document: EP

Kind code of ref document: A2