WO2010143972A3 - Particules sensibles à l'énergie pour l'administration de médicament comprenant des lipides formant une structure non lamellaire - Google Patents

Particules sensibles à l'énergie pour l'administration de médicament comprenant des lipides formant une structure non lamellaire Download PDF

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Publication number
WO2010143972A3
WO2010143972A3 PCT/NO2010/000218 NO2010000218W WO2010143972A3 WO 2010143972 A3 WO2010143972 A3 WO 2010143972A3 NO 2010000218 W NO2010000218 W NO 2010000218W WO 2010143972 A3 WO2010143972 A3 WO 2010143972A3
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WO
WIPO (PCT)
Prior art keywords
forming lipids
drug delivery
structure forming
sensitive drug
inverted structure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/NO2010/000218
Other languages
English (en)
Other versions
WO2010143972A2 (fr
Inventor
Cecilia Leal Lauten
Karen Sibylla RØGNVALDSSON
Sigrid L. Fossheim
Esben A. Nilssen
Tove J. Evjen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Epitarget AS
Original Assignee
Epitarget AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epitarget AS filed Critical Epitarget AS
Publication of WO2010143972A2 publication Critical patent/WO2010143972A2/fr
Publication of WO2010143972A3 publication Critical patent/WO2010143972A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne des nouvelles particules sensibles à l'énergie acoustique transportant un médicament et comprenant des lipides formant une structure non lamellaire. L'invention porte également sur l'utilisation de ces particules et les procédés correspondants. Les particules transportant un médicament s'accumulent dans le tissu cible malade et libèrent efficacement leur charge utile à l'exposition d'une énergie acoustique.
PCT/NO2010/000218 2009-06-08 2010-06-08 Particules sensibles à l'énergie pour l'administration de médicament comprenant des lipides formant une structure non lamellaire Ceased WO2010143972A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NO20092196 2009-06-08
NO20092196 2009-06-08

Publications (2)

Publication Number Publication Date
WO2010143972A2 WO2010143972A2 (fr) 2010-12-16
WO2010143972A3 true WO2010143972A3 (fr) 2011-09-29

Family

ID=42536416

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NO2010/000218 Ceased WO2010143972A2 (fr) 2009-06-08 2010-06-08 Particules sensibles à l'énergie pour l'administration de médicament comprenant des lipides formant une structure non lamellaire

Country Status (1)

Country Link
WO (1) WO2010143972A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011078695A2 (fr) * 2009-12-22 2011-06-30 Epitarget As Particules d'administration de médicament acoustiquement sensibles comprenant de faibles concentrations de phosphatidyléthanolamine
US11331272B2 (en) * 2017-01-18 2022-05-17 Temasek Life Sciences Laboratory Limited Hyperstabilized liposomes increase targeting of mitotic cells

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004053118A1 (fr) * 2002-12-12 2004-06-24 Protech Research Pty Ltd Traitement de levures
WO2008120998A2 (fr) * 2007-03-30 2008-10-09 Epitarget As Particules administrant des médicaments acoustiquement sensibles
WO2009075583A1 (fr) * 2007-12-10 2009-06-18 Epitarget As Utilisation de particules comprenant un alcool
WO2009075582A2 (fr) * 2007-12-10 2009-06-18 Epitarget As Particules acoustiquement sensibles administrant des médicaments comprenant des lipides formant des structures non lamellaires

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050019266A1 (en) 1997-05-06 2005-01-27 Unger Evan C. Novel targeted compositions for diagnostic and therapeutic use

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004053118A1 (fr) * 2002-12-12 2004-06-24 Protech Research Pty Ltd Traitement de levures
WO2008120998A2 (fr) * 2007-03-30 2008-10-09 Epitarget As Particules administrant des médicaments acoustiquement sensibles
WO2009075583A1 (fr) * 2007-12-10 2009-06-18 Epitarget As Utilisation de particules comprenant un alcool
WO2009075582A2 (fr) * 2007-12-10 2009-06-18 Epitarget As Particules acoustiquement sensibles administrant des médicaments comprenant des lipides formant des structures non lamellaires

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
FERIL L B ET AL: "Ultrasound enhances liposome-mediated gene transfection", ULTRASONICS: SONOCHEMISTRY, BUTTERWORTH-HEINEMANN, GB, vol. 12, no. 6, 1 August 2005 (2005-08-01), pages 489 - 493, XP004857720, ISSN: 1350-4177, DOI: DOI:10.1016/J.ULTSONCH.2004.06.006 *

Also Published As

Publication number Publication date
WO2010143972A2 (fr) 2010-12-16

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