WO2011004175A2 - Compositions antimicrobiennes topiques visqueuses - Google Patents

Compositions antimicrobiennes topiques visqueuses Download PDF

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Publication number
WO2011004175A2
WO2011004175A2 PCT/GB2010/051027 GB2010051027W WO2011004175A2 WO 2011004175 A2 WO2011004175 A2 WO 2011004175A2 GB 2010051027 W GB2010051027 W GB 2010051027W WO 2011004175 A2 WO2011004175 A2 WO 2011004175A2
Authority
WO
WIPO (PCT)
Prior art keywords
constituent
compositions
topical antimicrobial
topical
antimicrobial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2010/051027
Other languages
English (en)
Other versions
WO2011004175A3 (fr
Inventor
Willard Burt
James Steven Clayton
Richard John Kosturko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Reckitt and Colman Overseas Ltd
Original Assignee
Reckitt and Colman Overseas Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reckitt and Colman Overseas Ltd filed Critical Reckitt and Colman Overseas Ltd
Publication of WO2011004175A2 publication Critical patent/WO2011004175A2/fr
Publication of WO2011004175A3 publication Critical patent/WO2011004175A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/12—Preparations containing hair conditioners
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Definitions

  • topical antimicrobial compositions according to the first aspect of the invention which exhibits at least 3 log kill efficacy, preferably at least 4 log kill efficacy at 60 seconds contact time of at least two, preferably at least three and most preferably at least four of
  • a preferred class of nonionic surfactants include amine oxide compounds including one or more of those which may be described in one or more of the following of the four general classes: (i) alkyl di (lower alkyl) amine oxides in which the alkyl group has about 6-24 carbon atoms, and can be straight or branched chain, saturated or unsaturated, and the lower alkyl groups include between 1 and 7 carbon atoms, e.g., octyl dimethyl amine oxide, lauryl dimethyl amine oxide, myristyl dimethyl amine oxide, and those in which the alkyl group is a mixture of different amine oxides, such as dimethyl cocoamine oxide, dimethyl (hydrogenated tallow) amine oxide, and myristyl/palmityl dimethyl amine oxide; (ii) alkyl di (hydroxy lower alkyl) amine oxides in which the alkyl group has about 6-22 carbon atoms, and can be straight or branched chain, saturated or unsaturated,
  • the antimicrobial agent constituent may include one or more organic acids providing an antimicrobial benefit.
  • organic acids are those which generally include at least one carbon atom, and include at least one carboxyl group (— COOH) in its structure. Derivatives of said organic acids are also contemplated to be useful.
  • Exemplary organic acid include linear aliphatic acids such as acetic acid; dicarboxylic acids, acidic amino acids, and hydroxy acids such as glycolic acid, lactic acid, hydroxyacrylic acid, alpha-hydroxybutyric acid, glyceric acid, malic acid, tartaric acid and citric acid, as well as acid salts of these organic acids.
  • one or more polyols may also function as an organic solvent.
  • oxyethylenated/oxypropylenated compounds are used, and the amount of oxyalkylenated compound in the composition of the invention may range, for example, on an active material weight basis, from 0.1% to 20% preferably from 0.25% to 10% by weight relative to the total weight of the composition of which it forms a part.
  • R and R' represent, independently of each other, hydrogen or a saturated or unsaturated, linear or branched, hydroxylated or non-hydroxylated alkyl chain containing from 1 to 30 carbon atoms and preferably from 12 to 22 carbon atoms, or an aryl chain, with the proviso that R and R' are not simultaneously hydrogen.
  • polypropylene glycol ethers are condensates of polyethylene glycol and/or polypropylene glycol with one or more fatty alcohols. These are compounds of formula:
  • R and R' represent, independently of each other, hydrogen or a saturated or unsaturated, linear or branched, hydroxylated or non-hydroxylated alkyl chain containing from 1 to 30 carbon atoms and preferably from 12 to 22 carbon atoms, or an aryl chain, with the proviso that R and R' are not simultaneously hydrogen.
  • a preferred oxyalkylenated compound of the topical compositions are polyethylene glycol diesters such as polyethylene glycol distearates ethoxylated with 50 - 350 units ethylene oxide.
  • a preferred material is Stepan PEG 6000 DS, described to be a polyethylene glycol distearate ethoxylated with 150 units of ethylene oxide.
  • a second constituent of the ternary thickening system of the invention is a fatty alkanolamides examples of which include but are not limited to: cocamide MEA, cocamide DEA, soyamide DEA, lauramide DEA, oleamide MIPA, stearamide MEA, myristamide MEA, lauramide MEA, capramide DEA, ricinoleamide DEA, myristamide DEA, stearamide DEA, oleylamide DEA, tallowamide DEA, lauramide MIPA, tallowamide MEA, isostearamide DEA, isostearamide MEA, and mixtures thereof.
  • the third constituent of the ternary thickening system of the invention are benzophenone compounds and/or derivatives thereof e.g., 2-hydroxy-4-methoxy benzophenone, 2-hydroxy-4-methoxy-4'-methyl benzophenone, n-hexyl 2- (4- diethylamino-2-hydroxybenzoyl)benzoate and 2,2'-dihydroxy-4-methoxy benzophenone as well as those materials currently marketed under the UVINUL tradename by BASF.
  • benzophenone compounds and/or derivatives thereof e.g., 2-hydroxy-4-methoxy benzophenone, 2-hydroxy-4-methoxy-4'-methyl benzophenone, n-hexyl 2- (4- diethylamino-2-hydroxybenzoyl)benzoate and 2,2'-dihydroxy-4-methoxy benzophenone as well as those materials currently marketed under the UVINUL tradename by BASF.
  • the ternary thickening system advantageously present in the topical antimicrobial compositions described herein, or in other compositions, e.g., hard surface cleaning and/or disinfecting compositions according to further embodiments of the invention, and preferably this ternary thickening system is present in the absence of clays or clay thickeners, polyacrylate thickeners or polysaccharide based thickeners.
  • the pH is, in order of increasing preference is not more than 6, 5.9, 5.8, 5.6, 5.7 and 5.5.
  • Particularly preferred pH values those in the range of from 4.5 - 5.5, and more preferably between 5 - 5.5 Further preferred pH values are disclosed with reference to one or more of the Example compositions.
  • Preferred topical antimicrobial compositions of the invention are those which, according to a third aspect of the invention there are provided topical antimicrobial compositions according to the first or second aspects of the invention which exhibits at least 3 log kill efficacy, preferably at least 4 log kill efficacy and especially preferably at least 4 log kill efficacy at 60 seconds contact time of at least two, preferably at least three and most preferably at least four of microorganisms selected from the group consisting of: S. aureus, E. coli, P. aeruginosa and E.hirae, according to the protocols of prEN 12054.
  • the topical antimicrobial compositions of the invention may include one or more further optional constituents which may be used to impart one or more desired esthetic or technical benefits to the said compositions.
  • one or more of the following recited optional constituents may be considered as essential constituents according to a particular preferred embodiment.
  • Topical antimicrobial compositions of the invention may include one or more constituents, particularly may include one or more essential oils which are selected to provide a so-called "aromatherapy benefit" to the user.
  • essential oils are frequently extracted from naturally occurring botanical sources such as flowers, stems, leaves, roots and barks of aromatic plants. While essential oils may be used singly, it is also common to utilize blends of essential oils in order to provide a conjunctive aroma benefit, and possibly a therapeutic benefit as well.
  • fragrance compositions which may also include one or more essential oils, frequently, due to their potency, essential oils are often supplied dispersed in a liquid carrier such as in one or more organic solvents in which the essential oils are dissolved or dispersed.
  • Preferred essential oils providing an aromatherapy benefit include one or more selected from chamomile oil, lavendin oil, lavender oil, grapefruit oil, lemon oil, line oil, mandarin orange oil, orange flower oil and orange oil. When present, these one or more essential oils providing an aromatherapy benefit are present in an amount about 0.00001 wt. % to about 1 wt. %, based on the total weight of the composition. It is to be understood that these one or more essential oils providing an aromatherapy benefit may be used with our without the optional fragrancing constituent recited previously and may be used wholly or partially in place of said fragrancing constituent.
  • the topical antimicrobial compositions may include one or more vitamins, non-limiting examples which include vitamin A, any of the B vitamins, vitamin C, such as L-ascorbic acid, vitamin D, such as ergocalciferol and cholecarciferol; vitamin E, such as one or more tocopherols, e.g., alpha- tocopherol, beta-tocopherol, Such vitamins, when present, may be included in effective amounts, advantageously from 0.0001 - 2%wt.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne des compositions antimicrobiennes se prêtant particulièrement à une application sur l'épiderme, par exemple sur les mains, les bras, les jambes, le visage, le cuir chevelu, et d'autres parties du corps qui présentent de préférence un pH acide. Les compositions présentent un taux de destruction d'au moins 3 log, de préférence un taux de destruction d'au moins 4 log à un temps de contact de 60 secondes d'au moins deux, de préférence d'au moins trois et idéalement d'au moins quatre microorganismes choisis dans le groupe constitué par : S. aureus, E. coli, P. aeruginosa et E.hirae, selon les protocoles de la technique connue EN 12054. Les compositions sont largement aqueuses et présentent, de préférence, une viscosité d'au moins 500 cPs à 25° C, et un pH de 4,5-5,5. L'invention porte également sur des procédés de fabrication des compositions antimicrobiennes topiques et sur des procédés pour leur utilisation. En outre, ces compositions sont utiles dans le traitement de surfaces dures et molles inanimées.
PCT/GB2010/051027 2009-07-09 2010-06-22 Compositions antimicrobiennes topiques visqueuses Ceased WO2011004175A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0911951.2A GB0911951D0 (en) 2009-07-09 2009-07-09 Viscous topical antimicrobial compositions
GB0911951.2 2009-07-09

Publications (2)

Publication Number Publication Date
WO2011004175A2 true WO2011004175A2 (fr) 2011-01-13
WO2011004175A3 WO2011004175A3 (fr) 2011-04-21

Family

ID=41022415

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2010/051027 Ceased WO2011004175A2 (fr) 2009-07-09 2010-06-22 Compositions antimicrobiennes topiques visqueuses

Country Status (2)

Country Link
GB (1) GB0911951D0 (fr)
WO (1) WO2011004175A2 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10959933B1 (en) 2020-06-01 2021-03-30 The Procter & Gamble Company Low pH skin care composition and methods of using the same
US11110049B2 (en) 2017-06-23 2021-09-07 The Procter & Gamble Company Composition and method for improving the appearance of skin
US11583488B2 (en) 2020-06-01 2023-02-21 The Procter & Gamble Company Method of improving penetration of a vitamin B3 compound into skin
US11622963B2 (en) 2018-07-03 2023-04-11 The Procter & Gamble Company Method of treating a skin condition

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2974134A (en) 1957-12-02 1961-03-07 Universal Oil Prod Co Surface active glucose ethers
US3219656A (en) 1963-08-12 1965-11-23 Rohm & Haas Alkylpolyalkoxyalkyl glucosides and process of preparation therefor
US3598865A (en) 1968-02-07 1971-08-10 Atlas Chem Ind Polyglycosides and process of preparing mono and polyglycosides
US3640998A (en) 1969-06-18 1972-02-08 Richard C Mansfield Alkylene oxide adducts of alkyloligosaccharides and their mixtures with alkylene oxide adducts of bord alkyl glucosides and alkanols
US3707535A (en) 1969-07-24 1972-12-26 Atlas Chem Ind Process for preparing mono- and polyglycosides
US3772269A (en) 1969-07-24 1973-11-13 Ici America Inc Glycoside compositions and process for the preparation thereof
US3839318A (en) 1970-09-27 1974-10-01 Rohm & Haas Process for preparation of alkyl glucosides and alkyl oligosaccharides
US3974138A (en) 1972-12-15 1976-08-10 Ici United States Inc. Method of preparing butyl polyglycosides
US4223129A (en) 1978-09-01 1980-09-16 A. E. Staley Manufacturing Company Continuous process for making alkyl aldosides from starch or other carbohydrates
US4528106A (en) 1983-11-14 1985-07-09 Olin Corporation Glucoside surfactants

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EP0651051A3 (fr) * 1993-10-29 1996-02-28 Clorox Co Produit de nettoyage sous forme de gel à base d'hypochlorite.
US7482021B1 (en) * 2001-05-11 2009-01-27 Tison Kelley H Two-sided wipe for cleaning and drying a skin surface
US20040228811A1 (en) * 2003-05-13 2004-11-18 Kimberly-Clark Worldwide, Inc. Sunscreen wipes having high sunscreen formulation transfer rate
US7740876B2 (en) * 2006-05-23 2010-06-22 Isp Investments Inc. Antimicrobial composition of 3-iodo-2-propynylbutyl carbamate and 1,3-butylene glycol as solvent
TR200701489A2 (tr) * 2007-03-09 2008-10-21 Vai̇zoğlu Orhan Kozmetik formülasyonlar
US7824662B2 (en) * 2007-06-06 2010-11-02 Arizona Sunwash LLC Body wash with sunscreen
GB0802189D0 (en) * 2008-02-07 2008-03-12 Reckitt Benckiser Inc Topical antimicrobial compositions

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2974134A (en) 1957-12-02 1961-03-07 Universal Oil Prod Co Surface active glucose ethers
US3219656A (en) 1963-08-12 1965-11-23 Rohm & Haas Alkylpolyalkoxyalkyl glucosides and process of preparation therefor
US3598865A (en) 1968-02-07 1971-08-10 Atlas Chem Ind Polyglycosides and process of preparing mono and polyglycosides
US3640998A (en) 1969-06-18 1972-02-08 Richard C Mansfield Alkylene oxide adducts of alkyloligosaccharides and their mixtures with alkylene oxide adducts of bord alkyl glucosides and alkanols
US3707535A (en) 1969-07-24 1972-12-26 Atlas Chem Ind Process for preparing mono- and polyglycosides
US3772269A (en) 1969-07-24 1973-11-13 Ici America Inc Glycoside compositions and process for the preparation thereof
US3839318A (en) 1970-09-27 1974-10-01 Rohm & Haas Process for preparation of alkyl glucosides and alkyl oligosaccharides
US3974138A (en) 1972-12-15 1976-08-10 Ici United States Inc. Method of preparing butyl polyglycosides
US4223129A (en) 1978-09-01 1980-09-16 A. E. Staley Manufacturing Company Continuous process for making alkyl aldosides from starch or other carbohydrates
US4528106A (en) 1983-11-14 1985-07-09 Olin Corporation Glucoside surfactants

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11110049B2 (en) 2017-06-23 2021-09-07 The Procter & Gamble Company Composition and method for improving the appearance of skin
US11622963B2 (en) 2018-07-03 2023-04-11 The Procter & Gamble Company Method of treating a skin condition
US10959933B1 (en) 2020-06-01 2021-03-30 The Procter & Gamble Company Low pH skin care composition and methods of using the same
US11583488B2 (en) 2020-06-01 2023-02-21 The Procter & Gamble Company Method of improving penetration of a vitamin B3 compound into skin
US11911498B2 (en) 2020-06-01 2024-02-27 The Procter & Gamble Company Low pH skin care composition and methods of using the same

Also Published As

Publication number Publication date
WO2011004175A3 (fr) 2011-04-21
GB0911951D0 (en) 2009-08-19

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