WO2011051976A3 - Procédé amélioré de préparation de la forme i du bisulfate de clopidogrel - Google Patents

Procédé amélioré de préparation de la forme i du bisulfate de clopidogrel Download PDF

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Publication number
WO2011051976A3
WO2011051976A3 PCT/IN2010/000710 IN2010000710W WO2011051976A3 WO 2011051976 A3 WO2011051976 A3 WO 2011051976A3 IN 2010000710 W IN2010000710 W IN 2010000710W WO 2011051976 A3 WO2011051976 A3 WO 2011051976A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
clopidogrel
clopidogrel bisulfate
bisulfate form
free base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2010/000710
Other languages
English (en)
Other versions
WO2011051976A2 (fr
Inventor
Ramakoteswara Rao Jetti
Aggi Rami Reddy Bommareddy
Anjaneya Raju Indukuri
Debashish Datta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mylan Laboratories Ltd
Original Assignee
Matrix Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matrix Laboratories Ltd filed Critical Matrix Laboratories Ltd
Publication of WO2011051976A2 publication Critical patent/WO2011051976A2/fr
Publication of WO2011051976A3 publication Critical patent/WO2011051976A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne un procédé amélioré de préparation de la forme I du bisulfate de clopidogrel à partir d'une base exempte de clopidogrel, la base exempte de clopidogrel étant isolée à partir d'un sel d'addition d'acide de clopidogrel.
PCT/IN2010/000710 2009-10-30 2010-10-29 Procédé amélioré de préparation de la forme i du bisulfate de clopidogrel Ceased WO2011051976A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2637/CHE/2009 2009-10-30
IN2637CH2009 2009-10-30

Publications (2)

Publication Number Publication Date
WO2011051976A2 WO2011051976A2 (fr) 2011-05-05
WO2011051976A3 true WO2011051976A3 (fr) 2011-07-14

Family

ID=43607938

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2010/000710 Ceased WO2011051976A2 (fr) 2009-10-30 2010-10-29 Procédé amélioré de préparation de la forme i du bisulfate de clopidogrel

Country Status (1)

Country Link
WO (1) WO2011051976A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2818540A1 (fr) * 2013-06-26 2014-12-31 Barokes PTY Ltd. Récipient de boisson revêtu d'une couche de resvératrol
CN104211714B (zh) * 2014-08-14 2016-09-14 广东东阳光药业有限公司 一种血小板聚集抑制剂的制备方法
KR101710922B1 (ko) 2015-06-03 2017-02-28 경동제약 주식회사 클로피도그렐 황산염 결정형 i형의 제조방법

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005100364A1 (fr) * 2004-04-19 2005-10-27 Krka, Tovarna Zdravil, D.D. Novo Mesto Procedes pour la preparation de clopidogrel hydrogenosulfate de forme polymorphe i
WO2007102037A2 (fr) * 2006-03-09 2007-09-13 Richter Gedeon Nyrt. PROCÉDÉ DE SYNTHÈSE DE LA FORME POLYMORPHIQUE I DE L'HYDROGÉNOSULFATE DE (S)-(+)-MÉTHYL-α-(2-CHLOROPHÉNYL)-6,7-DIHYDRO-THIÉNO-[3,2-c]PYRIDINE-5(4H)-ACÉTATE
WO2008034912A2 (fr) * 2006-09-22 2008-03-27 Krka, Tovarna Zdravil, D.D., Novo Mesto Procédé de synthèse du clopidogrel et nouvelles formes de sels pharmaceutiquement acceptables de celui-ci
WO2008118030A1 (fr) * 2007-03-23 2008-10-02 Tomasz Kozluk Procédé de préparation de la forme 1 polymorphe pure d'hydrogénosulfate de clopidogrel

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2623810B2 (fr) 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
FR2779726B1 (fr) 1998-06-15 2001-05-18 Sanofi Sa Forme polymorphe de l'hydrogenosulfate de clopidogrel
US6767913B2 (en) 2001-12-18 2004-07-27 Teva Pharmaceutical Industries Ltd. Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
CZ297472B6 (cs) 2002-08-27 2006-12-13 Zentiva, A.S. Zpusob výroby clopidogrelu hydrogensulfátu krystalické formy I
WO2004048385A2 (fr) 2002-11-28 2004-06-10 Instytut Farmaceutyczny Procede de preparation de la forme cristalline 1 du clopidogrel hydrogene sulfate
US20060047121A1 (en) 2004-09-01 2006-03-02 Sawant Kamlesh D Novel process for preparation of clopidogrel bisulfate polymorph - Form I

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005100364A1 (fr) * 2004-04-19 2005-10-27 Krka, Tovarna Zdravil, D.D. Novo Mesto Procedes pour la preparation de clopidogrel hydrogenosulfate de forme polymorphe i
WO2007102037A2 (fr) * 2006-03-09 2007-09-13 Richter Gedeon Nyrt. PROCÉDÉ DE SYNTHÈSE DE LA FORME POLYMORPHIQUE I DE L'HYDROGÉNOSULFATE DE (S)-(+)-MÉTHYL-α-(2-CHLOROPHÉNYL)-6,7-DIHYDRO-THIÉNO-[3,2-c]PYRIDINE-5(4H)-ACÉTATE
WO2008034912A2 (fr) * 2006-09-22 2008-03-27 Krka, Tovarna Zdravil, D.D., Novo Mesto Procédé de synthèse du clopidogrel et nouvelles formes de sels pharmaceutiquement acceptables de celui-ci
WO2008118030A1 (fr) * 2007-03-23 2008-10-02 Tomasz Kozluk Procédé de préparation de la forme 1 polymorphe pure d'hydrogénosulfate de clopidogrel

Also Published As

Publication number Publication date
WO2011051976A2 (fr) 2011-05-05

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