WO2011053018A2 - Testeur de diagnostic dermatologique à aiguille pour l'identification d'allergène - Google Patents

Testeur de diagnostic dermatologique à aiguille pour l'identification d'allergène Download PDF

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Publication number
WO2011053018A2
WO2011053018A2 PCT/KR2010/007481 KR2010007481W WO2011053018A2 WO 2011053018 A2 WO2011053018 A2 WO 2011053018A2 KR 2010007481 W KR2010007481 W KR 2010007481W WO 2011053018 A2 WO2011053018 A2 WO 2011053018A2
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WO
WIPO (PCT)
Prior art keywords
needle
skin
diagnostic
sheet
compartment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2010/007481
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English (en)
Korean (ko)
Other versions
WO2011053018A3 (fr
Inventor
김도위
김진우
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Individual
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2011053018A2 publication Critical patent/WO2011053018A2/fr
Publication of WO2011053018A3 publication Critical patent/WO2011053018A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0233—Pointed or sharp biopsy instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/32—Surgical cutting instruments
    • A61B17/3209—Incision instruments
    • A61B17/32093—Incision instruments for skin incisions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0035—Vaccination diagnosis other than by injuring the skin, e.g. allergy test patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/20—Surgical instruments, devices or methods for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function

Definitions

  • the present invention relates to a skin diagnostic tester for diagnosing allergens, and more particularly to a needle-type skin diagnostic tester for diagnosing allergens for accurate reading of results.
  • the skin test is used as the most basic diagnostic method to search for allergens of allergic diseases, and it is widely used to search for allergens in a non-invasive way.
  • Allergy refers to hypersensitivity caused by immunological mechanisms and is mediated by antibodies or cells.
  • a person sensitized to an allergen produces a specific immunoglobulin E antibody (IgE) that reacts with the allergen.
  • IgE immunoglobulin E antibody
  • This specific antibody is bound to the surface of mast cells that spread throughout our body.
  • allergens enter through the skin during skin tests, they bind to the allergens and release various chemical media such as histamine from mast cells.
  • Various secreted chemical media cause immediate swelling and erythema reactions by actions such as vasodilation and increased permeability. This response peaks 15 to 20 minutes after the test. At this time, the size of the swelling and redness is measured with a ruler, and when the size of the swelling is 3 mm or more, it is regarded as a sensitized state.
  • a long time interval between the first reagent drop time and the last reagent drop time may cause a problem in that the time error is increased when reading the result.
  • a dropper for reagent dropping and a syringe needle for skin irritation should be prepared for each reagent type, and reagents are required when dropping reagents on the skin with a dropper. In many cases, the above-mentioned amount is dipped, and there is a problem that an expensive reagent is wasted.
  • the present invention has been proposed to solve the above problems of the conventionally proposed methods, and includes various types of diagnostic reagents used in skin reaction tests and needles for skin irritation, thereby reducing the time error to obtain accurate results. It is an object of the present invention to provide a needle-type skin diagnostic tester for diagnosing allergens that can be read and can reduce costs by reducing waste of instruments and reagents used in skin reaction tests.
  • a needle-type skin diagnostic tester for allergen diagnosis a needle-type skin diagnostic tester for allergen diagnosis
  • a diagnostic sheet attached to the skin having a compartment accommodating the diagnostic aid
  • It is characterized in that it comprises a wound-forming sheet is provided with a needle to contact the diagnostic sheet to burst the compartment, the diagnostic aid therein is deposited on the skin and wound on the skin to cause skin irritation.
  • the wound sheet is.
  • the needle may be rotatably coupled to the diagnostic sheet such that the needle ruptures the compartment and damages the skin.
  • the diagnostic sheet Preferably, the diagnostic sheet,
  • An adhesive layer disposed on an upper portion of the compartment and coated with an adhesive on an edge of the compartment;
  • a cover layer detachably attached to an upper portion of the adhesive layer may be further provided to protect the adhesive layer.
  • the wound sheet is,
  • a cover member detachably attached to an upper portion of the wound sheet may be further provided to protect the needle.
  • the needle Preferably, the needle, the needle, and
  • It may be composed of a needle body that is attached to one surface of the wound sheet to invade the skin to burst the compartment and cause skin irritation is 0.05 to 1.5mm.
  • the needle Preferably, the needle, the needle, and
  • It may consist of microneedles.
  • the compartment is provided with a plurality, so that each can accommodate different diagnostic aids,
  • the needle may be provided in plural numbers corresponding to the plurality of compartments, respectively, so as to burst the plurality of compartments and cause skin irritation.
  • the diagnostic aid More preferably, the diagnostic aid,
  • House dust mites, pollen, animal hair, food, fungi, insects, allergens solutions of drugs and metals, a positive control of the histamine solution, a negative control of the antigen diluent may be included.
  • a needle-type skin diagnostic tester for diagnosing allergens is provided with various types of diagnostic reagents used for skin reaction tests and needles for skin stimulation, thereby reducing accurate time readings.
  • the cost can be reduced by reducing the waste of instruments and reagents used in skin reaction tests.
  • FIG. 1 is a view showing a state of use of the needle-type skin diagnostic tester for diagnosing allergens according to an embodiment of the present invention.
  • Figure 2 is a perspective view of a needle-type skin diagnostic tester for allergen diagnosis according to an embodiment of the present invention.
  • Figure 3 is a perspective view of a needle-type skin diagnostic tester for diagnosing allergens according to another embodiment of the present invention.
  • Figure 4 is a perspective view of the folded state of the diagnostic sheet and the wound sheet of the needle-type skin diagnostic tester for diagnosing allergens according to another embodiment of the present invention.
  • FIG. 5 is an enlarged cross-sectional view of a portion A of FIG. 2.
  • FIG. 6 is an enlarged cross-sectional view of a portion B of FIG. 2.
  • Figure 7 is a cross-sectional view of the folded state of the diagnostic sheet and the wound sheet of the needle-type skin diagnostic tester for diagnosing allergens according to another embodiment of the present invention.
  • compartment 220 diagnostic aid
  • adhesion layer 240 cover layer
  • the needle-type skin diagnostic tester 100 for diagnosing allergens according to an embodiment of the present invention may be used for a skin reaction test, which is a test for identifying IgE antibodies against specific allergens.
  • the test antigen solution, the positive control solution and the negative control solution are instilled into the forearm or the forearm of the arm, and then the needle is irritated by puncturing the drop site with an injection needle.
  • the skin diagnostic tester 100 of the present invention is allergen and It is equipped with a needle for skin irritation so that the IgE antibody to the allergen can be identified by simply attaching it to the forearm of the back or arm.
  • Figure 2 is a perspective view of a needle-type skin diagnostic tester for diagnosing allergens according to an embodiment of the present invention.
  • the needle-type skin diagnostic tester for diagnosing allergens according to an embodiment of the present invention the diagnostic sheet 200 for receiving the diagnostic aid 220 and wound generation causing the skin irritation It may be composed of a sheet (300).
  • the diagnostic sheet 200 is provided with a compartment 210 to receive the diagnostic aid 220 inside the compartment 210 and to be attached to the skin to deliver the diagnostic aid 220 to the skin, and to generate a wound sheet 300.
  • the needle-type skin diagnostic tester for diagnosing allergens includes a diagnosis sheet 200 and a wound creation sheet 300.
  • the needle 310 is diagnosed.
  • the needle 310 may injure the skin and cause skin irritation.
  • the correct amount of the diagnostic aid 220 is embedded in the diagnostic sheet 200, when the diagnostic aid 220 is dropped onto the skin with the dropper, the expensive diagnostic aid 220 may not be dipped in an amount more than necessary. It is not wasted and can save cost.
  • FIG 3 is a perspective view of a needle-type skin diagnostic tester for diagnosing allergens according to another embodiment of the present invention
  • Figure 4 is a diagnostic sheet of the needle-type skin diagnostic tester for diagnosing allergens according to another embodiment of the present invention
  • the wound sheet 300 is folded to the diagnostic sheet 200 so that the needle 310 bursts the compartment 210 of the diagnostic sheet 200 and wounds the skin. It may be rotatably coupled to the diagnostic sheet (200). In this case, when the wound generating sheet 300 is rotated and folded to the diagnostic sheet 200, the needle 310 drops the diagnostic aid 220, and then causes a skin irritation by injuring the skin. In addition, the drip site of the diagnosis aid 220 and the stimulation site of the needle 310 may be exactly matched to increase the accuracy of the diagnosis.
  • a plurality of compartments 210 may be provided to accommodate different diagnostic aids 220, respectively. Since a plurality of compartments 210 of the diagnostic sheet 200 may be provided to accommodate various types of diagnostic aids 220, various types of allergens may be easily tested at one time.
  • a plurality of needles 310 may be provided so as to burst each of the plurality of compartments 210 and cause skin irritation.
  • the needle 310 of the wound-causing sheet 300 bursts each of the plurality of compartments 210 and stimulates skin irritated by the compartments 210. Should be induced. Therefore, a plurality of needles 310 of the wound-causing sheet 300 should be disposed in abutting position when folded with the compartment 210 of the diagnostic sheet 200.
  • the test can be started multiple times at the same time to confirm the time You can do exactly that. As such, when the time check is accurate and the time error is reduced, the result of the skin test can be read more accurately.
  • the dropper for dropping and the syringe needle for skin irritation should be prepared for each type of diagnostic aid 220 to prevent cross reaction.
  • the skin diagnostic tester of the present invention may include various types of diagnostic aids 220 and needles 310 for skin stimulation, thereby preventing waste of instruments such as dropper and syringe needles, thereby reducing costs.
  • the diagnostic sheet 200 is attached to the skin and serves to deliver the diagnostic aid 220 provided in the compartment 210 to the skin.
  • 5 is an enlarged cross-sectional view of a portion A of FIG. 3.
  • Diagnosis sheet 200 as shown in Figure 5, is disposed on the upper portion of the compartment 210 and the adhesive layer 230 coated with an adhesive on the edge of the compartment 210; And a cover layer 240 detachably attached to the adhesive layer 230 to protect the adhesive layer 230.
  • the adhesive layer 230 coated with the adhesive on the edge of the compartment 210 serves to fix the diagnostic sheet 200 to the skin, and the compartment 210 of the diagnostic sheet 200 is a wound creation sheet 300.
  • the cover layer 240 detachably attached on the adhesive layer 230, the adhesive layer 230 to protect the adhesive layer 230 until the use of the needle-type skin diagnostic tester for diagnosing allergens, and when removed, to improve skin adhesion It plays a role.
  • the diagnostic sheet 200 may further include at least one circular grid line around the needle 310 to check the degree to which the needle 310 causes skin irritation.
  • the skin test result is skin stimulation and after 15-20 minutes, the swelling and redness reaction site is measured with a ruler to determine the sensitized condition in the case of 3 mm or more.
  • a circular grid line around the needle 310 is provided separately. It is convenient because there is no need to prepare a ruler, and the grid lines are separated from the magnetic pole position at regular intervals so that accurate results can be confirmed when measuring.
  • the diagnostic sheet 200 and the wound sheet 300 is preferably a transparent material, the grid line is any of the diagnostic sheet 200 and the wound sheet 300 One or both of the diagnostic sheet 200 and the wound sheet 300 may be provided.
  • FIG. 6 is an enlarged cross-sectional view of part B of FIG. 3.
  • the wound sheet 300 may further include a cover member 320 detachably attached to the upper portion of the wound sheet 300 to protect the needle 310.
  • the wound sheet 300 is provided with a needle 310, the cover member 320 that can protect the needle 310 before the test is required.
  • the cover member 320 should be detachably provided so as to be removable when the skin diagnostic tester is used, and can be combined by various means such as adhesives, protrusions, and locking grooves.
  • the wound sheet 300 may be made of a transparent material so that the skin is visible when the wound sheet 300 is folded to the diagnostic sheet (200).
  • the test procedure such as the combination of the wound sheet 300 and the diagnostic sheet 200, the bursting of the compartment 210 and the skin irritation of the needle 310 can be visually confirmed, thereby improving accuracy in reading the test results. have.
  • the needle 310 serves to induce skin irritation by breaking the skin 210 by popping the compartment 210 of the diagnostic sheet 200 onto the skin, and then injuring the skin.
  • 7 is a cross-sectional view of a folded state of the diagnostic sheet 200 and the wound sheet 300 of the needle-type skin diagnostic tester for diagnosing allergens according to another embodiment of the present invention.
  • the needle 310 is attached to one surface of the wound-generating sheet 300 to rupture the compartment 210 and cause skin irritation, so that the depth of the needle 310 is 0.05 to 1.5 mm. Sieve.
  • Needle 310 of the wound sheet 300 is wound when the wound sheet 300 is folded on the diagnostic sheet 200, the needle (since the opening of the compartment 210 of the diagnostic sheet 200, and then wound the skin)
  • the length of 310 should be longer than the thickness of the diagnostic sheet (200).
  • the depth penetrated through the diagnostic sheet 200 and invaded by the skin becomes 0.05 to 1.5 mm, it can pass through the stratum corneum and give effective stimulation to the test. .
  • the needle is stimulated with a skin stimulation needle, the deviation occurs every time the test can give pain to the skin feeling unpleasant, but the needle 310 of the skin diagnostic tester of the present invention has a certain length, so the test is performed without deviation of pain can do.
  • the needle 310 may be composed of microneedles.
  • the needle 310 is a microneedle having an outer diameter, an inner diameter, and a length of several hundred micro-size needles, the needle 310 can injure the skin without pain when the needle 310 causes skin irritation, and thus the needle-equipped type for allergen diagnosis.
  • the use of a skin diagnostic tester becomes more convenient.
  • Diagnostic aid 220 serves to search for the causative antigen through the skin reaction test.
  • the diagnostic aid 220 may include any one of house dust mites, pollen, animal hair, food, mold, insects, allergens of drugs and metals, positive control histamine solution, negative control diluent. Almost all allergens consist of proteins, so any protein can be an allergen. In addition, substances other than proteins are combined with incomplete antigens (hapten) of small protein structure in the body to become allergens.
  • the test should be performed with a negative control, which should not respond to anyone, and a histamine solution, a positive control that causes swelling and redness in all, and the swelling produced by the histamine solution has a diameter of 3 mm or less or no redness. In case there is no reproducibility of the test.
  • the skin diagnosis tester 100 may be composed of a diagnostic sheet 200 and a wound sheet 300.
  • the diagnostic sheet 200 is provided with a compartment 210 for accommodating the diagnostic aid 220, and an adhesive layer 230 coated with an adhesive on an edge of the compartment 210 so as to be easily adhered to the skin at an upper portion of the compartment 210.
  • the wound sheet 300 is provided with a needle 310 that causes irritation to the skin, and a cover member 320 detachably attached to the upper portion of the wound sheet 300 to protect the needle 310 is further provided. Can be.
  • the wound sheet 300 may be rotatably coupled to the diagnostic sheet (200).
  • the cover layer 240 of the diagnostic sheet 200 is separated from the skin diagnostic tester 100, and then the adhesive layer 230 of the diagnostic sheet 200 is attached to the skin.
  • the cover member 320 of the wound sheet 300 is separated to expose the needle 310 of the wound sheet 300.
  • the needle 310 of the wound sheet 300 bursts the compartment 210 of the diagnostic sheet 200 to make the diagnosis aid 220 therein. ) Is applied to the skin, and then the needle 310 hurts the skin to cause skin irritation.
  • the needle 310 hurts the skin to cause skin irritation.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne un testeur de diagnostic dermatologique à aiguille pour l'identification d'allergène. Plus spécifiquement, ce testeur comprend: une feuille de diagnostic à fixer sur la peau, comportant un compartiment de stockage d'aide au diagnostic; et une feuille de création d'incision comportant une aiguille qui s'enfonce dans le compartiment, lorsque la feuille de diagnostic est mise en contact, afin que l'aide au diagnostic s'égoutte sur la peau et qu'une incision soit pratiquée dans la peau pour induire une stimulation dermatologique. Le testeur selon l'invention a des aiguilles pour différents types de réactifs de diagnostic à utiliser dans un test de réaction dermatologique et pour stimuler la peau. Cette configuration permet de fournir un résultat précis en réduisant les erreurs liées à la durée et en réduisant le recours inutile à des instruments et des réactifs incorporés dans le test de réaction dermatologique, ce qui réduit les coûts.
PCT/KR2010/007481 2009-10-28 2010-10-28 Testeur de diagnostic dermatologique à aiguille pour l'identification d'allergène Ceased WO2011053018A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020090103098A KR20110046205A (ko) 2009-10-28 2009-10-28 알레르겐 진단을 위한 바늘 구비형 피부 진단용 시험기
KR10-2009-0103098 2009-10-28

Publications (2)

Publication Number Publication Date
WO2011053018A2 true WO2011053018A2 (fr) 2011-05-05
WO2011053018A3 WO2011053018A3 (fr) 2011-11-03

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PCT/KR2010/007481 Ceased WO2011053018A2 (fr) 2009-10-28 2010-10-28 Testeur de diagnostic dermatologique à aiguille pour l'identification d'allergène

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KR (1) KR20110046205A (fr)
WO (1) WO2011053018A2 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8469900B2 (en) 2011-11-30 2013-06-25 Lincoln Diagnostics, Inc. Allergy testing device and method of testing for allergies
US9011350B2 (en) 2011-11-30 2015-04-21 Lincoln Diagnostics, Inc. Allergy testing device and method of testing for allergies
WO2021158927A1 (fr) 2020-02-07 2021-08-12 Dupont Nutrition Biosciences Aps Compositions alimentaires pour la santé animale
WO2022115906A1 (fr) * 2020-12-04 2022-06-09 Stefan Mazy Appareil de collecte d'échantillons de peau mini-invasif
EP4095152A2 (fr) 2016-03-04 2022-11-30 Danisco US Inc. Promoteurs modifiés de gènes ribosomiques pour la production de protéines dans des microorganismes
CN117295454A (zh) * 2021-05-07 2023-12-26 艾哈迈德·艾哈迈德 过敏皮肤测试装置、方法和套件

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101455615B1 (ko) * 2013-09-12 2014-10-28 (주)비엔에스메디븐스 폴더식 스킨패치 보관 케이스
KR101878414B1 (ko) * 2016-08-12 2018-07-13 연세대학교 산학협력단 마이크로니들 패치, 이의 제조방법 및 이를 이용한 알레르기 질환 진단방법
KR102118446B1 (ko) * 2016-08-18 2020-06-03 손원일 알러지 진단 시약의 농도가 변화되는 알러지 진단 부착 패드
KR102099319B1 (ko) 2016-08-18 2020-04-09 손원일 확대 렌즈를 구비하는 알러지 진단 부착 패드
KR102099318B1 (ko) 2016-08-18 2020-04-09 손원일 투명 윈도우를 구비하는 알러지 진단 부착 패드
US11266344B2 (en) 2016-09-21 2022-03-08 Samsung Electronics Co., Ltd. Method for measuring skin condition and electronic device therefor
KR102538549B1 (ko) 2020-11-19 2023-05-30 (의료)길의료재단 항원이 미탑재된 마이크로니들 패치 및 이를 포함하는 피부단자 시험 판독 시스템
KR102531152B1 (ko) 2020-11-19 2023-05-09 (의료)길의료재단 항원이 탑재된 마이크로니들 패치 및 이를 포함하는 피부단자 시험 판독 시스템

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US5104620A (en) * 1990-07-30 1992-04-14 Wiley Fred R Disposable allergy skin testing kit
AU2003243750A1 (en) * 2002-06-25 2004-01-06 Sung-Yun Kwon Rapidly dissolving micro-perforator for drug delivery and other applications
EP2163203A1 (fr) * 2005-02-24 2010-03-17 Gerhard Schindlbeck Dispositif pour examiner une réaction allergique
WO2007008824A2 (fr) * 2005-07-11 2007-01-18 Infotonics Technology Center, Inc. Systeme de test d'allergie avec effraction minimale

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8469900B2 (en) 2011-11-30 2013-06-25 Lincoln Diagnostics, Inc. Allergy testing device and method of testing for allergies
US9011350B2 (en) 2011-11-30 2015-04-21 Lincoln Diagnostics, Inc. Allergy testing device and method of testing for allergies
US9504418B2 (en) 2011-11-30 2016-11-29 Lincoln Diagnostics, Inc. Allergy testing device and method of testing for allergies
US10470698B2 (en) 2011-11-30 2019-11-12 Lincoln Diagnostics, Inc. Allergy testing device and method of testing for allergies
US11529092B2 (en) 2011-11-30 2022-12-20 Lincoln Diagnostics, Inc. Allergy testing device and method of testing for allergies
EP4095152A2 (fr) 2016-03-04 2022-11-30 Danisco US Inc. Promoteurs modifiés de gènes ribosomiques pour la production de protéines dans des microorganismes
WO2021158927A1 (fr) 2020-02-07 2021-08-12 Dupont Nutrition Biosciences Aps Compositions alimentaires pour la santé animale
WO2022115906A1 (fr) * 2020-12-04 2022-06-09 Stefan Mazy Appareil de collecte d'échantillons de peau mini-invasif
CN117295454A (zh) * 2021-05-07 2023-12-26 艾哈迈德·艾哈迈德 过敏皮肤测试装置、方法和套件

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WO2011053018A3 (fr) 2011-11-03
KR20110046205A (ko) 2011-05-04

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