WO2012017166A3 - Traitement d'une pathologie liee a un effet excessif du tnf par un compose de benzene sulfonamide - Google Patents

Traitement d'une pathologie liee a un effet excessif du tnf par un compose de benzene sulfonamide Download PDF

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Publication number
WO2012017166A3
WO2012017166A3 PCT/FR2011/051742 FR2011051742W WO2012017166A3 WO 2012017166 A3 WO2012017166 A3 WO 2012017166A3 FR 2011051742 W FR2011051742 W FR 2011051742W WO 2012017166 A3 WO2012017166 A3 WO 2012017166A3
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WO
WIPO (PCT)
Prior art keywords
tnf
pathological condition
benzenesulfonamide
compound treatment
excessive effect
Prior art date
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Ceased
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PCT/FR2011/051742
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English (en)
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WO2012017166A2 (fr
Inventor
Jean-François ZAGURY
Matthieu Montes
Hadley Mouhsine
Hélène GUILLEMAIN
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Vaxconsulting
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Vaxconsulting
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Filing date
Publication date
Application filed by Vaxconsulting filed Critical Vaxconsulting
Priority to EP11754705.9A priority Critical patent/EP2595620A2/fr
Priority to US13/811,144 priority patent/US8975399B2/en
Priority to CA2805206A priority patent/CA2805206A1/fr
Publication of WO2012017166A2 publication Critical patent/WO2012017166A2/fr
Publication of WO2012017166A3 publication Critical patent/WO2012017166A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D237/30—Phthalazines
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
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    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
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    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
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    • A—HUMAN NECESSITIES
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Abstract

ou l'un de ses sels d'addition avec les acides pharmaceutiquement acceptables, pour son utilisation dans une méthode de traitement d'une pathologie lie un effet excessif du TNF-alpha et pour son utilisation dans une méthode de traitement du corps humain ou animal comme inhibiteur direct du TNF alpha.
PCT/FR2011/051742 2010-07-19 2011-07-19 Traitement d'une pathologie liee a un effet excessif du tnf par un compose de benzene sulfonamide Ceased WO2012017166A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP11754705.9A EP2595620A2 (fr) 2010-07-19 2011-07-19 Traitement d'une pathologie liee a un effet excessif du tnf par un compose de benzene sulfonamide
US13/811,144 US8975399B2 (en) 2010-07-19 2011-07-19 Benzenesulfon amide-compound treatment of a pathological condition linked to an excessive effect of TNF
CA2805206A CA2805206A1 (fr) 2010-07-19 2011-07-19 Traitement d'une pathologie liee a un effet excessif du tnf par un compose de benzene sulfonamide

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR1055867 2010-07-19
FR1055867A FR2962649B1 (fr) 2010-07-19 2010-07-19 Traitement d'une pathologie liee a un effet excessif du tnf par un compose de benzene sulfonamide
US201161443132P 2011-02-15 2011-02-15
US61/443,132 2011-02-15

Publications (2)

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WO2012017166A2 WO2012017166A2 (fr) 2012-02-09
WO2012017166A3 true WO2012017166A3 (fr) 2012-07-19

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PCT/FR2011/051742 Ceased WO2012017166A2 (fr) 2010-07-19 2011-07-19 Traitement d'une pathologie liee a un effet excessif du tnf par un compose de benzene sulfonamide

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Country Link
US (1) US8975399B2 (fr)
EP (1) EP2595620A2 (fr)
CA (1) CA2805206A1 (fr)
FR (1) FR2962649B1 (fr)
WO (1) WO2012017166A2 (fr)

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* Cited by examiner, † Cited by third party
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JP5906244B2 (ja) 2010-09-13 2016-04-20 マイクロバイオティックス・インコーポレーテッド 哺乳類細胞中へのウイルスの侵入の阻害剤
PL3021839T3 (pl) * 2013-07-18 2021-12-20 Baylor College Of Medicine Kompozycje do leczenia zwłóknienia
WO2015010106A1 (fr) * 2013-07-18 2015-01-22 Baylor College Of Medicine Procédés et compositions pour la prévention d'une réaction allergique
CA2918071C (fr) * 2013-07-18 2022-04-26 Baylor College Of Medicine Methodes et compositions de traitement de l'atrophie musculaire, de la faiblesse musculaire, et/ou de la cachexie
WO2015130947A1 (fr) * 2014-02-26 2015-09-03 Howard University Utilisation de dérivés benzène-sulfonamides comme inhibiteurs de l'intégrase du vih
US9839625B2 (en) * 2014-11-06 2017-12-12 Northwestern University Inhibition of cancer cell motility
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