WO2012021800A3 - Inhibiteurs de la caspase utilisés comme agents thérapeutiques contre une lésion neurale ou d'organe et pour l'imagerie - Google Patents

Inhibiteurs de la caspase utilisés comme agents thérapeutiques contre une lésion neurale ou d'organe et pour l'imagerie Download PDF

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Publication number
WO2012021800A3
WO2012021800A3 PCT/US2011/047579 US2011047579W WO2012021800A3 WO 2012021800 A3 WO2012021800 A3 WO 2012021800A3 US 2011047579 W US2011047579 W US 2011047579W WO 2012021800 A3 WO2012021800 A3 WO 2012021800A3
Authority
WO
WIPO (PCT)
Prior art keywords
neural
therapeutics
imaging
caspase inhibitors
organ injury
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2011/047579
Other languages
English (en)
Other versions
WO2012021800A2 (fr
Inventor
Kevin Ka-Wang Wang
Zhiqun Zhang
Xue-Min Cheng
Bradley Caprathe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Banyan Biomarkers Inc
Original Assignee
Banyan Biomarkers Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyan Biomarkers Inc filed Critical Banyan Biomarkers Inc
Publication of WO2012021800A2 publication Critical patent/WO2012021800A2/fr
Publication of WO2012021800A3 publication Critical patent/WO2012021800A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des composés, des sels pharmaceutiquement acceptables de ceux-ci, et des compositions utiles comme inhibiteurs de la caspase. Certains composés sont également utiles pour le traitement d'une lésion neurale ou d'organe. D'autres composés sont utiles comme agents d'imagerie neurale ou spécifique d'organes.
PCT/US2011/047579 2010-08-13 2011-08-12 Inhibiteurs de la caspase utilisés comme agents thérapeutiques contre une lésion neurale ou d'organe et pour l'imagerie Ceased WO2012021800A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37370010P 2010-08-13 2010-08-13
US61/373,700 2010-08-13

Publications (2)

Publication Number Publication Date
WO2012021800A2 WO2012021800A2 (fr) 2012-02-16
WO2012021800A3 true WO2012021800A3 (fr) 2012-05-24

Family

ID=45568215

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/047579 Ceased WO2012021800A2 (fr) 2010-08-13 2011-08-12 Inhibiteurs de la caspase utilisés comme agents thérapeutiques contre une lésion neurale ou d'organe et pour l'imagerie

Country Status (1)

Country Link
WO (1) WO2012021800A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2737774A1 (fr) 2008-09-19 2010-03-25 Henry Ford Health System Procedes, systemes et compositions pour inhiber les calpaines
US10100037B2 (en) * 2013-03-15 2018-10-16 The Board Of Trustees Of The Leland Stanford Junior University Activity-based probe compounds, compositions, and methods of use
US10570173B2 (en) 2015-01-22 2020-02-25 The Board Of Trustees Of The Leland Stanford Junior University Protease-activated contrast agents for in vivo imaging
TW201739734A (zh) 2016-05-11 2017-11-16 Chia Tai Tianqing Pharmaceutical Group Co Ltd Caspase抑制劑及其藥物組合物、用途和治療方法
ES2964985T3 (es) 2016-12-23 2024-04-10 Univ Leland Stanford Junior Compuestos sonda basados en actividad, composiciones y métodos de uso
KR102669535B1 (ko) 2017-03-30 2024-05-24 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 생체 내 이미징을 위한 프로테아제 활성화 조영제
CN109748843B (zh) * 2017-11-06 2022-11-11 正大天晴药业集团股份有限公司 Caspase抑制剂及其药物组合物、用途和治疗方法
EP4545075A1 (fr) * 2022-06-23 2025-04-30 Goryo Chemical, Inc. Inhibiteur de calpaïne

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020042376A1 (en) * 1998-07-02 2002-04-11 Karanewsky Donald S. C-terminal modified oxamyl dipeptides as inhibitors of the ICE-ced-3 family of cysteine proteases
WO2007007162A1 (fr) * 2005-07-11 2007-01-18 Pfizer Limited Nouvelle combinaison d'un anticorps anti-madcam et d'un inhibiteur de caspase anti-fibrotique pour le traitement de la fibrose du foie

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020042376A1 (en) * 1998-07-02 2002-04-11 Karanewsky Donald S. C-terminal modified oxamyl dipeptides as inhibitors of the ICE-ced-3 family of cysteine proteases
WO2007007162A1 (fr) * 2005-07-11 2007-01-18 Pfizer Limited Nouvelle combinaison d'un anticorps anti-madcam et d'un inhibiteur de caspase anti-fibrotique pour le traitement de la fibrose du foie

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LINTON, STEVEN D. ET AL.: "Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS., vol. 14, 2004, pages 2685 - 2691, XP002510183, DOI: doi:10.1016/J.BMCL.2003.12.106 *

Also Published As

Publication number Publication date
WO2012021800A2 (fr) 2012-02-16

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