WO2012023623A3 - Agent pour le traitement du syndrome de hunter - Google Patents

Agent pour le traitement du syndrome de hunter Download PDF

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Publication number
WO2012023623A3
WO2012023623A3 PCT/JP2011/068815 JP2011068815W WO2012023623A3 WO 2012023623 A3 WO2012023623 A3 WO 2012023623A3 JP 2011068815 W JP2011068815 W JP 2011068815W WO 2012023623 A3 WO2012023623 A3 WO 2012023623A3
Authority
WO
WIPO (PCT)
Prior art keywords
hunter syndrome
treatment
agent
brain
sulphatase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2011/068815
Other languages
English (en)
Japanese (ja)
Other versions
WO2012023623A2 (fr
Inventor
義勝 衞藤
孝 樋口
十也 大橋
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JCR Pharmaceuticals Co Ltd
Original Assignee
JCR Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JCR Pharmaceuticals Co Ltd filed Critical JCR Pharmaceuticals Co Ltd
Publication of WO2012023623A2 publication Critical patent/WO2012023623A2/fr
Publication of WO2012023623A3 publication Critical patent/WO2012023623A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/06—Sulfuric ester hydrolases (3.1.6)
    • C12Y301/06013—Iduronate-2-sulfatase (3.1.6.13)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La présente invention concerne un procédé pour distribuer de l'iduronate-2-sulfatase humaine dans le cerveau d'un patient afin de prévenir la progression d'une lésion cérébrale chez des patients ayant le syndrome de Hunter. Le procédé est caractérisé en ce qu'un agent de traitement contenant de l'iduronate-2-sulfatase humaine est administré dans le cerveau d'un patient ayant le syndrome de Hunter.
PCT/JP2011/068815 2010-08-19 2011-08-15 Agent pour le traitement du syndrome de hunter Ceased WO2012023623A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2010-200310 2010-08-19
JP2010200310 2010-08-19

Publications (2)

Publication Number Publication Date
WO2012023623A2 WO2012023623A2 (fr) 2012-02-23
WO2012023623A3 true WO2012023623A3 (fr) 2012-04-12

Family

ID=45605484

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2011/068815 Ceased WO2012023623A2 (fr) 2010-08-19 2011-08-15 Agent pour le traitement du syndrome de hunter

Country Status (2)

Country Link
JP (1) JP2012062312A (fr)
WO (1) WO2012023623A2 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6073783B2 (ja) 2010-06-25 2017-02-01 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド ヘパランｎ−スルファターゼのｃｎｓ送達のための方法および組成物
HRP20191923T1 (hr) 2010-06-25 2020-01-10 Shire Human Genetic Therapies, Inc. Postupci i sastavi za isporuku arilsulfataze a u cns
LT2588130T (lt) 2010-06-25 2016-12-12 Shire Human Genetic Therapies, Inc. Terapinės priemonės pristatymas cns
PT3103469T (pt) 2010-06-25 2021-03-04 Shire Human Genetic Therapies Administração de agentes terapêuticos no snc
KR20230159646A (ko) * 2010-06-25 2023-11-21 샤이어 휴먼 지네틱 테라피즈 인크. 이듀로네이트-2-설파타제의 cns 전달을 위한 방법들 및 조성물들
US20140377244A1 (en) 2011-12-23 2014-12-25 Shire Human Genetic Therapies, Inc. Stable formulations for cns delivery of arylsulfatase a
EP3088518A4 (fr) 2013-12-25 2017-09-20 JCR Pharmaceuticals Co., Ltd. Nouvel anticorps anti-récepteur de transferrine qui traverse la barrière hémato-encéphalique
EA039366B1 (ru) 2015-06-24 2022-01-19 Джей Си Ар ФАРМАСЬЮТИКАЛЗ КО., ЛТД. Антитело к рецептору трансферрина человека, проникающее через гематоэнцефалический барьер
AU2016283344B2 (en) 2015-06-24 2022-08-04 Jcr Pharmaceuticals Co., Ltd. Fusion protein containing BDNF
PL3397270T3 (pl) 2015-12-30 2024-08-19 Green Cross Corporation Kompozycje do zastosowania w leczeniu zespołu huntera
KR102497564B1 (ko) 2016-12-26 2023-02-07 제이씨알 파마 가부시키가이샤 혈액뇌관문을 통과하는 신규한 항인간 트랜스페린 수용체 항체
CA3297793A1 (en) 2016-12-26 2026-03-02 Kagoshima University Antibody which binds to myelin oligodendrocyte glycoprotein
CA3052936A1 (fr) 2016-12-26 2018-07-05 Jcr Pharmaceuticals Co., Ltd. Proteine de fusion de bdnf et anticorps du recepteur de la transferrine anti-humain
KR102671857B1 (ko) * 2018-05-30 2024-06-04 주식회사 녹십자 대뇌 측뇌실 투여에 의해 헌터증후군을 치료하기 위한 방법 및 조성물
JP7397444B2 (ja) 2018-06-26 2023-12-13 協和キリン株式会社 コンドロイチン硫酸プロテオグリカン－５に結合する抗体
TWI857959B (zh) 2018-06-26 2024-10-11 日商協和麒麟股份有限公司 與細胞黏著分子3 結合之抗體

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009525963A (ja) * 2006-01-20 2009-07-16 ジェンザイム・コーポレーション リソソーム蓄積症のための脳室内酵素の輸送

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7442372B2 (en) * 2003-08-29 2008-10-28 Biomarin Pharmaceutical Inc. Delivery of therapeutic compounds to the brain and other tissues

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009525963A (ja) * 2006-01-20 2009-07-16 ジェンザイム・コーポレーション リソソーム蓄積症のための脳室内酵素の輸送

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
COOK, A.M. ET AL.: "Intracerebroventricular administration of drugs", PHARMACOTHERAPY, vol. 29, no. 7, 2009, pages 832 - 45, XP009147777, DOI: doi:10.1592/phco.29.7.832 *
IDENSHI KUMIKAE MUKO TATOSHO II-GATA CHIRYOZAI ELAPRASE TENTEKI SEICHUEKI 6MG TENPU BUNSHO, 2008 *
PAN, J. ET AL.: "Widespread correction of brain pathology in Hunter mice after an intracerebral injection of idursulfase", ACTA PAEDIATRICA, vol. 97, no. 457, 2008, pages 103 *
TAKASHI HIGUCHI ET AL.: "MPSII-gata Knockout Mouse de no Noshitsu Nai Koso Chiryo ni Kansuru Kenkyu", JAPANESE JOURNAL FOR INHERITED METABOLIC DISEASES, vol. 26, no. 2, 24 September 2010 (2010-09-24), pages 82 *

Also Published As

Publication number Publication date
WO2012023623A2 (fr) 2012-02-23
JP2012062312A (ja) 2012-03-29

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