WO2012103016A3 - Patchs transdermiques à libération prolongée associant un bêta-agoniste et un anticholinergique et leurs procédés d'utilisation - Google Patents

Patchs transdermiques à libération prolongée associant un bêta-agoniste et un anticholinergique et leurs procédés d'utilisation Download PDF

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Publication number
WO2012103016A3
WO2012103016A3 PCT/US2012/022233 US2012022233W WO2012103016A3 WO 2012103016 A3 WO2012103016 A3 WO 2012103016A3 US 2012022233 W US2012022233 W US 2012022233W WO 2012103016 A3 WO2012103016 A3 WO 2012103016A3
Authority
WO
WIPO (PCT)
Prior art keywords
anticholinergic
transdermal patches
beta agonist
extended
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2012/022233
Other languages
English (en)
Other versions
WO2012103016A2 (fr
Inventor
Larry J. Caldwell
Sadanobu Shirai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CSI GmbH
Original Assignee
CSI GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CSI GmbH filed Critical CSI GmbH
Priority to EP12739786.7A priority Critical patent/EP2667861A4/fr
Publication of WO2012103016A2 publication Critical patent/WO2012103016A2/fr
Publication of WO2012103016A3 publication Critical patent/WO2012103016A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne des patchs transdermiques à libération prolongée associant un bêta-agoniste et un anticholinergique. Ces patchs transdermiques présentent une matrice adhésive qui contient à la fois un bêta-agoniste, par exemple du tulobutérol, et un anticholinergique, par exemple de la scopolamine, ladite matrice étant conçue pour être stable au stockage et assurer une libération prolongée du bêta-agoniste et de l'anticholinergique. D'autres aspects de l'invention concernent des procédés d'utilisation desdits patchs transdermiques, par exemple pour le traitement d'affections pulmonaires, telles que la broncho-pneumopathie chronique obstructive (BPCO).
PCT/US2012/022233 2011-01-26 2012-01-23 Patchs transdermiques à libération prolongée associant un bêta-agoniste et un anticholinergique et leurs procédés d'utilisation Ceased WO2012103016A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP12739786.7A EP2667861A4 (fr) 2011-01-26 2012-01-23 Patchs transdermiques à libération prolongée associant un bêta-agoniste et un anticholinergique et leurs procédés d'utilisation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161436489P 2011-01-26 2011-01-26
US61/436,489 2011-01-26

Publications (2)

Publication Number Publication Date
WO2012103016A2 WO2012103016A2 (fr) 2012-08-02
WO2012103016A3 true WO2012103016A3 (fr) 2012-09-20

Family

ID=46581346

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/022233 Ceased WO2012103016A2 (fr) 2011-01-26 2012-01-23 Patchs transdermiques à libération prolongée associant un bêta-agoniste et un anticholinergique et leurs procédés d'utilisation

Country Status (2)

Country Link
EP (1) EP2667861A4 (fr)
WO (1) WO2012103016A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102017127433A1 (de) * 2017-11-21 2019-05-23 Lts Lohmann Therapie-Systeme Ag TTS auf Basis von klebenden Weichmacher-Polymer-Matrices

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0439180A2 (fr) * 1990-01-26 1991-07-31 LTS LOHMANN THERAPIE-SYSTEME GmbH & CO.KG Système thérapeutique transdermique pour l'agent actif tulobuterol
US6117447A (en) * 1997-12-12 2000-09-12 Nitto Denko-Corporation Percutaneous absorption type preparation
WO2005046600A2 (fr) * 2003-11-07 2005-05-26 Nexmed Holdings, Inc. Systeme d'application de tulobuterol transdermique, procede et composition correspondants
US20050220852A1 (en) * 2003-06-20 2005-10-06 Teikoku Seiyaku Co., Ltd Adhesive patch containing tulobuterol

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4436741A (en) * 1975-12-08 1984-03-13 Alza Corporation Method for administering scopolamine transdermally
TWI239252B (en) * 2003-12-31 2005-09-11 Ind Tech Res Inst A patch and the manufacturing method of the same
DE102004059674B4 (de) * 2004-12-10 2010-05-06 Acino Ag Transdermales System zur Abgabe von Scopolamin

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0439180A2 (fr) * 1990-01-26 1991-07-31 LTS LOHMANN THERAPIE-SYSTEME GmbH & CO.KG Système thérapeutique transdermique pour l'agent actif tulobuterol
US6117447A (en) * 1997-12-12 2000-09-12 Nitto Denko-Corporation Percutaneous absorption type preparation
US20050220852A1 (en) * 2003-06-20 2005-10-06 Teikoku Seiyaku Co., Ltd Adhesive patch containing tulobuterol
WO2005046600A2 (fr) * 2003-11-07 2005-05-26 Nexmed Holdings, Inc. Systeme d'application de tulobuterol transdermique, procede et composition correspondants

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
K. AKAMATSU ET AL.: "Improvement of pulmonary function and dyspnea by tiotropium in COPD patients using a transdermal beta2-agonist", PULMONARY PHARMACOLOGY & THERAPEUTICS, vol. 20, 2007, pages 701 - 707, XP022268380 *
M. ICHINOSE ET AL.: "Additive effects of transdermal tulobuterol to inhaled tiotropium in patients with COPD", RESPIRATORY MEDICINE, vol. 104, 2010, pages 267 - 274, XP026850307 *
See also references of EP2667861A4 *

Also Published As

Publication number Publication date
EP2667861A4 (fr) 2014-07-16
WO2012103016A2 (fr) 2012-08-02
EP2667861A2 (fr) 2013-12-04

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