WO2012103240A3 - Agents de liaison à un récepteur - Google Patents

Agents de liaison à un récepteur Download PDF

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Publication number
WO2012103240A3
WO2012103240A3 PCT/US2012/022583 US2012022583W WO2012103240A3 WO 2012103240 A3 WO2012103240 A3 WO 2012103240A3 US 2012022583 W US2012022583 W US 2012022583W WO 2012103240 A3 WO2012103240 A3 WO 2012103240A3
Authority
WO
WIPO (PCT)
Prior art keywords
domains
agonists
antagonists
chimeric
receptor type
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2012/022583
Other languages
English (en)
Other versions
WO2012103240A2 (fr
Inventor
Thomas M. Barnes
Jinzhao Hou
Bracken M. King
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Carisma Therapeutics Inc
Original Assignee
Eleven Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eleven Biotherapeutics Inc filed Critical Eleven Biotherapeutics Inc
Publication of WO2012103240A2 publication Critical patent/WO2012103240A2/fr
Publication of WO2012103240A3 publication Critical patent/WO2012103240A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des régions de la cytokine n'intervenant pas naturellement et pouvant être utilisées, entre autres, pour moduler la sensibilité de la signalisation cellulaire, pour traiter des troubles et pour détecter et/ou lier à des récepteurs cellulaires, ainsi que d'autres agents. Des exemples de régions de la cytokine peuvent contenir des restes aminoacides provenant d'au moins deux régions de la cytokine apparentées, par exemple, des caractéristiques de liaison à un récepteur, des caractéristiques de surface, des brins bêta et des boucles provenant d'au moins deux régions de la cytokine apparentées.
PCT/US2012/022583 2011-01-25 2012-01-25 Agents de liaison à un récepteur Ceased WO2012103240A2 (fr)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US201161436184P 2011-01-25 2011-01-25
US201161436178P 2011-01-25 2011-01-25
US61/436,184 2011-01-25
US61/436,178 2011-01-25
US201161493966P 2011-06-06 2011-06-06
US201161493967P 2011-06-06 2011-06-06
US61/493,967 2011-06-06
US61/493,966 2011-06-06
US201161513521P 2011-07-29 2011-07-29
US201161513472P 2011-07-29 2011-07-29
US61/513,472 2011-07-29
US61/513,521 2011-07-29

Publications (2)

Publication Number Publication Date
WO2012103240A2 WO2012103240A2 (fr) 2012-08-02
WO2012103240A3 true WO2012103240A3 (fr) 2012-10-26

Family

ID=46581384

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/022583 Ceased WO2012103240A2 (fr) 2011-01-25 2012-01-25 Agents de liaison à un récepteur

Country Status (1)

Country Link
WO (1) WO2012103240A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10059764B2 (en) 2014-01-10 2018-08-28 Anaptysbio, Inc. Antibodies directed against interleukin-33 (IL-33) and methods of making and using

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2952394T3 (es) 2010-07-29 2023-10-31 Buzzard Pharmaceuticals AB Antagonistas quiméricos del receptor IL-1 de tipo I
SG10201606218WA (en) * 2011-07-29 2016-09-29 Eleven Biotherapeutics Inc Purified Proteins
EP2968468B1 (fr) 2013-03-13 2021-07-14 Buzzard Pharmaceuticals AB Formulations de cytokine chimérique pour administration oculaire
WO2015138844A1 (fr) 2014-03-13 2015-09-17 Eleven Biotherapeutics, Inc. Procédés pour la production de formulations de protéines cytokine chimériques stables dans des récipients du type à soufflage/remplissage/fermeture
RU2582569C2 (ru) * 2014-07-24 2016-04-27 Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт особо чистых биопрепаратов" Федерального медико-биологического агентства Днк, кодирующая полноразмерный антагонист рецептора интерлейкина-36 человека, днк, кодирующая полноразмерный антагонист рецептора интерлейкина-36 человека с с-концевым полигистидиновым тагом, плазмидный экспрессионный вектор (варианты), штамм бактерий escherichia coli bl21 star[de3] (рет-il36raf), - продуцент полноразмерного рецепторного антагониста интерлейкина-36 и штамм бактерий escherichia coli bl21 star[de3] (pet-il36raf-his), - продуцент полноразмерного рецепторного антагониста интерлейкина-36 с с-концевым полигистидиновым тагом
CR20170240A (es) 2014-11-10 2018-04-03 Genentech Inc Anticuerpos anti-interleucina-33 y sus usos
JP7231326B2 (ja) 2014-11-10 2023-03-01 ジェネンテック， インコーポレイテッド Ｉｌ－３３媒介性障害のための治療及び診断方法
PE20230252A1 (es) 2020-03-13 2023-02-07 Genentech Inc Anticuerpos anti-interleucina-33 y sus usos de estos

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WO1998047921A1 (fr) * 1997-04-21 1998-10-29 Schering Corporation Cytokines de mammifere; reactifs et procedes connexes
US7700318B2 (en) * 2004-08-25 2010-04-20 Amprotein Corporation Chimeric polypeptide and use thereof
WO2010081091A2 (fr) * 2009-01-09 2010-07-15 Schepens Eye Research Institute Compositions thérapeutiques pour le traitement de troubles de la cornée
WO2012016203A1 (fr) * 2010-07-29 2012-02-02 Eleven Biotherapeutics, Inc. Agonistes et antagonistes du récepteur chimérique d'il-1 de type i

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US7700318B2 (en) * 2004-08-25 2010-04-20 Amprotein Corporation Chimeric polypeptide and use thereof
WO2010081091A2 (fr) * 2009-01-09 2010-07-15 Schepens Eye Research Institute Compositions thérapeutiques pour le traitement de troubles de la cornée
WO2012016203A1 (fr) * 2010-07-29 2012-02-02 Eleven Biotherapeutics, Inc. Agonistes et antagonistes du récepteur chimérique d'il-1 de type i

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10059764B2 (en) 2014-01-10 2018-08-28 Anaptysbio, Inc. Antibodies directed against interleukin-33 (IL-33) and methods of making and using

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Publication number Publication date
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