WO2012104823A3 - Composés pyridopyrimidinones dans le traitement de maladies neurodégénératives - Google Patents

Composés pyridopyrimidinones dans le traitement de maladies neurodégénératives Download PDF

Info

Publication number
WO2012104823A3
WO2012104823A3 PCT/IB2012/050514 IB2012050514W WO2012104823A3 WO 2012104823 A3 WO2012104823 A3 WO 2012104823A3 IB 2012050514 W IB2012050514 W IB 2012050514W WO 2012104823 A3 WO2012104823 A3 WO 2012104823A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
neurodegenerative diseases
pyridopyrimidinone compounds
pyridopyrimidinone
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2012/050514
Other languages
English (en)
Other versions
WO2012104823A2 (fr
Inventor
Stefan Frentzel
Paolo Paganetti
Christoph WIESSNER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of WO2012104823A2 publication Critical patent/WO2012104823A2/fr
Publication of WO2012104823A3 publication Critical patent/WO2012104823A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La présente invention concerne des composés pyridopyrimidinones de la formule (I) en vue de leur utilisation dans le traitement de maladies neurodégénératives.
PCT/IB2012/050514 2011-02-04 2012-02-03 Composés pyridopyrimidinones dans le traitement de maladies neurodégénératives Ceased WO2012104823A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161439740P 2011-02-04 2011-02-04
US61/439,740 2011-02-04

Publications (2)

Publication Number Publication Date
WO2012104823A2 WO2012104823A2 (fr) 2012-08-09
WO2012104823A3 true WO2012104823A3 (fr) 2012-11-29

Family

ID=45757030

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2012/050514 Ceased WO2012104823A2 (fr) 2011-02-04 2012-02-03 Composés pyridopyrimidinones dans le traitement de maladies neurodégénératives

Country Status (1)

Country Link
WO (1) WO2012104823A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3119019C (fr) 2015-12-10 2024-06-11 Ptc Therapeutics, Inc. Composes et methodes pour traiter la maladie de huntington
EP4151627A1 (fr) * 2017-06-05 2023-03-22 PTC Therapeutics, Inc. Composés permettant de traiter la maladie de huntington
CN111182898B (zh) 2017-06-28 2024-04-16 Ptc医疗公司 用于治疗亨廷顿氏病的方法
CN111163838B (zh) 2017-06-28 2023-03-28 Ptc医疗公司 用于治疗亨廷顿氏病的方法
BR112020019373A2 (pt) 2018-03-27 2020-12-29 Ptc Therapeutics, Inc. Compostos para o tratamento da doença de hutington
IL279688B2 (en) 2018-06-27 2025-01-01 Ptc Therapeutics Inc Heterocyclic and heteroaryl compounds for the treatment of Huntington's disease
WO2020005882A1 (fr) 2018-06-27 2020-01-02 Ptc Therapeutics, Inc. Composés hétéroaryles pour le traitement de la maladie de huntington
KR20210038845A (ko) 2018-06-27 2021-04-08 피티씨 테라퓨틱스, 인크. 헌팅턴병 치료를 위한 헤테로아릴 화합물
CN109846886A (zh) * 2019-03-26 2019-06-07 中国医学科学院基础医学研究所 Nvp-hsp990在制备治疗癫痫的药物中的用途
CA3139821A1 (fr) 2019-05-13 2020-11-19 Ptc Therapeutics, Inc. Composes pour le traitement de la maladie de huntington
CN111214473B (zh) * 2020-02-14 2022-02-01 中国人民解放军陆军军医大学 Hsp990在制备抗轮状病毒药物中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007041362A1 (fr) * 2005-09-30 2007-04-12 Novartis Ag 2-amino-7,8-dihydro-6h-pyrido[4,3-d] pyrimidine-5-ones
US20100022635A1 (en) * 2008-07-28 2010-01-28 University Of Kansas Heat shock protein 90 inhibitor dosing methods

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004078163A2 (fr) 2003-02-28 2004-09-16 Transform Pharmaceuticals, Inc. Compositions pharmaceutiques a base d'un co-cristal
AR075180A1 (es) 2009-01-29 2011-03-16 Novartis Ag Formulaciones orales solidas de una pirido-pirimidinona

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007041362A1 (fr) * 2005-09-30 2007-04-12 Novartis Ag 2-amino-7,8-dihydro-6h-pyrido[4,3-d] pyrimidine-5-ones
US20100022635A1 (en) * 2008-07-28 2010-01-28 University Of Kansas Heat shock protein 90 inhibitor dosing methods

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHAUDHURY SUBHABRATA ET AL: "Hsp90 as a target for drug developement", CHEMMEDCHEM, WILEY - VCH VERLAG., WEINHEIM, DE, vol. 1, no. 12, 1 December 2006 (2006-12-01), pages 1331 - 1340, XP002467848, ISSN: 1860-7179, DOI: 10.1002/CMDC.200600112 *
LABBADIA JOHN ET AL: "Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease.", THE JOURNAL OF CLINICAL INVESTIGATION AUG 2011 LNKD- DOI:10.1172/JCI57413 PUBMED:21785217, vol. 121, no. 8, August 2011 (2011-08-01), pages 3306 - 3319, XP002684227, ISSN: 1558-8238 *
M. WAZA ET AL: "Alleviating Neurodegeneration by an Anticancer Agent: An Hsp90 Inhibitor (17-AAG)", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 1086, no. 1, 1 November 2006 (2006-11-01), pages 21 - 34, XP055039394, ISSN: 0077-8923, DOI: 10.1196/annals.1377.012 *

Also Published As

Publication number Publication date
WO2012104823A2 (fr) 2012-08-09

Similar Documents

Publication Publication Date Title
ZA201402424B (en) 1- arylcarbonyl -4 - oxy - piperidine compounds useful for the treatment of neurodegenerative diseases
AU2016202437A1 (en) Organic compositions to treat HSF1-related diseases
ZA201403795B (en) Formulations for the treatment of diabetes
AP2014007533A0 (en) Substituted benzylindazoles for use as BUB1 kinaseinhibitors in the treatment of hyperproliferative diseases
GB201021103D0 (en) New compounds for the treatment of neurodegenerative diseases
IL228786A0 (en) A new compound used to treat degenerative and inflammatory diseases
IL231835A0 (en) Pyrrolopyrimidine compounds for cancer treatment
ME03042B (fr) Composés et compositions pour le traitement de maladies parasitaires
MX349224B (es) Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa.
EP2665706A1 (fr) Nouveaux 4-amino-n-hydroxy-benzamides en tant qu'inhibiteurs de hdac pour le traitement du cancer
WO2013178322A8 (fr) Dérivés de spiro-tetrahydro-benzothiophène utilisés pour traiter les maladies neurodégénératives
HK1201067A1 (en) Sialic acid analogs
GB201107985D0 (en) Process
HUP1100290A2 (en) Combination compositions for the treatment of proliferative diseases
IL234796B (en) Compounds for the treatment of diseases related to ischemia-reperfusion
WO2013030654A8 (fr) Procédés de préparation du (r)-2-acétamido-n-benzyl-3-méthoxypropionamide et de ses intermédiaires
HK1196953A1 (zh) 用於治療糖尿病的製劑
HK1182092A (en) Arylosulfonamides for the treatment of cns diseases
AU2012903365A0 (en) Compounds for the treatment of mTOR pathway related diseases
GB201119533D0 (en) Compounds for the treatment of neoplasia
HK1197236B (en) Compounds for the treatment of addiction
GB201106970D0 (en) Compounds for the treatment of clostridium difficile-associated disease
GB201106972D0 (en) Compounds for the treatment of clostridium difficile-associated disease
AU2011903969A0 (en) Compositions for treating skin conditions
GB201106981D0 (en) Compounds for the treatment of clostridium difficle-associated disease

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12705717

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 12705717

Country of ref document: EP

Kind code of ref document: A2