WO2012104823A3 - Composés pyridopyrimidinones dans le traitement de maladies neurodégénératives - Google Patents

Composés pyridopyrimidinones dans le traitement de maladies neurodégénératives Download PDF

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Publication number
WO2012104823A3
WO2012104823A3 PCT/IB2012/050514 IB2012050514W WO2012104823A3 WO 2012104823 A3 WO2012104823 A3 WO 2012104823A3 IB 2012050514 W IB2012050514 W IB 2012050514W WO 2012104823 A3 WO2012104823 A3 WO 2012104823A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
neurodegenerative diseases
pyridopyrimidinone compounds
pyridopyrimidinone
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2012/050514
Other languages
English (en)
Other versions
WO2012104823A2 (fr
Inventor
Stefan Frentzel
Paolo Paganetti
Christoph WIESSNER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of WO2012104823A2 publication Critical patent/WO2012104823A2/fr
Publication of WO2012104823A3 publication Critical patent/WO2012104823A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La présente invention concerne des composés pyridopyrimidinones de la formule (I) en vue de leur utilisation dans le traitement de maladies neurodégénératives.
PCT/IB2012/050514 2011-02-04 2012-02-03 Composés pyridopyrimidinones dans le traitement de maladies neurodégénératives Ceased WO2012104823A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161439740P 2011-02-04 2011-02-04
US61/439,740 2011-02-04

Publications (2)

Publication Number Publication Date
WO2012104823A2 WO2012104823A2 (fr) 2012-08-09
WO2012104823A3 true WO2012104823A3 (fr) 2012-11-29

Family

ID=45757030

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2012/050514 Ceased WO2012104823A2 (fr) 2011-02-04 2012-02-03 Composés pyridopyrimidinones dans le traitement de maladies neurodégénératives

Country Status (1)

Country Link
WO (1) WO2012104823A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL294124B2 (en) 2015-12-10 2024-02-01 Ptc Therapeutics Inc Methods for treating huntington's disease
US11407753B2 (en) * 2017-06-05 2022-08-09 Ptc Therapeutics, Inc. Compounds for treating Huntington's disease
WO2019005993A1 (fr) * 2017-06-28 2019-01-03 Ptc Therapeutics, Inc. Méthodes de traitement de la maladie de huntington
US11382918B2 (en) 2017-06-28 2022-07-12 Ptc Therapeutics, Inc. Methods for treating Huntington's Disease
MX2020009957A (es) 2018-03-27 2021-01-15 Ptc Therapeutics Inc Compuestos para el tratamiento de enfermedad de hungtinton.
EP3814360B8 (fr) 2018-06-27 2024-11-06 PTC Therapeutics, Inc. Composés hétéroaryl pour traiter la maladie de huntington
PL3814357T3 (pl) 2018-06-27 2024-09-16 Ptc Therapeutics, Inc. Związki heterocykliczne i heteroarylowe do leczenia choroby huntingtona
EP3814345B8 (fr) 2018-06-27 2024-10-30 PTC Therapeutics, Inc. Composés aryl et hétérocycliques pour traiter la maladie de huntington
CN109846886A (zh) * 2019-03-26 2019-06-07 中国医学科学院基础医学研究所 Nvp-hsp990在制备治疗癫痫的药物中的用途
WO2020231977A1 (fr) 2019-05-13 2020-11-19 Ptc Therapeutics, Inc. Composés pour le traitement de la maladie de huntington
CN111214473B (zh) * 2020-02-14 2022-02-01 中国人民解放军陆军军医大学 Hsp990在制备抗轮状病毒药物中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007041362A1 (fr) * 2005-09-30 2007-04-12 Novartis Ag 2-amino-7,8-dihydro-6h-pyrido[4,3-d] pyrimidine-5-ones
US20100022635A1 (en) * 2008-07-28 2010-01-28 University Of Kansas Heat shock protein 90 inhibitor dosing methods

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007524596A (ja) 2003-02-28 2007-08-30 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド 共結晶医薬組成物
AR075180A1 (es) 2009-01-29 2011-03-16 Novartis Ag Formulaciones orales solidas de una pirido-pirimidinona

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007041362A1 (fr) * 2005-09-30 2007-04-12 Novartis Ag 2-amino-7,8-dihydro-6h-pyrido[4,3-d] pyrimidine-5-ones
US20100022635A1 (en) * 2008-07-28 2010-01-28 University Of Kansas Heat shock protein 90 inhibitor dosing methods

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHAUDHURY SUBHABRATA ET AL: "Hsp90 as a target for drug developement", CHEMMEDCHEM, WILEY - VCH VERLAG., WEINHEIM, DE, vol. 1, no. 12, 1 December 2006 (2006-12-01), pages 1331 - 1340, XP002467848, ISSN: 1860-7179, DOI: 10.1002/CMDC.200600112 *
LABBADIA JOHN ET AL: "Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease.", THE JOURNAL OF CLINICAL INVESTIGATION AUG 2011 LNKD- DOI:10.1172/JCI57413 PUBMED:21785217, vol. 121, no. 8, August 2011 (2011-08-01), pages 3306 - 3319, XP002684227, ISSN: 1558-8238 *
M. WAZA ET AL: "Alleviating Neurodegeneration by an Anticancer Agent: An Hsp90 Inhibitor (17-AAG)", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 1086, no. 1, 1 November 2006 (2006-11-01), pages 21 - 34, XP055039394, ISSN: 0077-8923, DOI: 10.1196/annals.1377.012 *

Also Published As

Publication number Publication date
WO2012104823A2 (fr) 2012-08-09

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