WO2012108676A3 - 피부미백, 항산화 및 ｐｐａｒ 활성을 갖는 신규 화합물 및 이의 의학적 용도 - Google Patents

피부미백, 항산화 및 ｐｐａｒ 활성을 갖는 신규 화합물 및 이의 의학적 용도 Download PDF

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Publication number
WO2012108676A3
WO2012108676A3 PCT/KR2012/000898 KR2012000898W WO2012108676A3 WO 2012108676 A3 WO2012108676 A3 WO 2012108676A3 KR 2012000898 W KR2012000898 W KR 2012000898W WO 2012108676 A3 WO2012108676 A3 WO 2012108676A3
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Prior art keywords
skin
whitening
oxidizing
activity
medical use
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Ceased
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PCT/KR2012/000898
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English (en)
French (fr)
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WO2012108676A2 (ko
Inventor
정해영
박민희
정기웅
김진아
박지영
박윤정
문형룡
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University Industry Cooperation Foundation of Pusan National University
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University Industry Cooperation Foundation of Pusan National University
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Publication of WO2012108676A2 publication Critical patent/WO2012108676A2/ko
Publication of WO2012108676A3 publication Critical patent/WO2012108676A3/ko
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/02—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides
    • C07C245/06—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings
    • C07C245/08—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings with the two nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings, e.g. azobenzene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

본 발명은 피부미백, 항산화 및 PPAR 활성을 갖는 신규 화합물 및 이의 의학적 용도에 관한 것으로, 본 발명에 따른 화합물들은 티로시나아제를 억제하는 피부미백 활성을 지니므로 피부미백용 약학조성물 또는 화장품에 유용하게 사용될 수 있고, 항산화 활성을 지니므로 피부노화 등의 예방 또는 치료에 유용하게 사용될 수 있으며, 또한 PPAR 활성 특히, PPARα 및 PPARγ 활성을 지니므로 비만, 대사성 질환 또는 심혈관계 질환을 예방하고 치료하는 데에 유용한 약학조성물 또는 건강식품으로 사용될 수 있다.
PCT/KR2012/000898 2011-02-09 2012-02-08 피부미백, 항산화 및 ｐｐａｒ 활성을 갖는 신규 화합물 및 이의 의학적 용도 Ceased WO2012108676A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2011-0011545 2011-02-09
KR1020110011545A KR101334466B1 (ko) 2011-02-09 2011-02-09 피부미백, 항산화 및 ｐｐａｒ 활성을 갖는 신규 화합물 및 이의 의학적 용도

Publications (2)

Publication Number Publication Date
WO2012108676A2 WO2012108676A2 (ko) 2012-08-16
WO2012108676A3 true WO2012108676A3 (ko) 2012-12-20

Family

ID=46639049

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/000898 Ceased WO2012108676A2 (ko) 2011-02-09 2012-02-08 피부미백, 항산화 및 ｐｐａｒ 활성을 갖는 신규 화합물 및 이의 의학적 용도

Country Status (2)

Country Link
KR (1) KR101334466B1 (ko)
WO (1) WO2012108676A2 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102858576B1 (ko) 2021-05-18 2025-09-12 부산대학교 산학협력단 신규 화합물 및 이를 유효성분으로 함유하는 병원성 미생물의 생물막 형성 또는 병독성 억제용 조성물
KR20250047103A (ko) 2023-09-26 2025-04-03 부산대학교 산학협력단 머캅토 작용기를 가지는 화합물을 포함하는 미백용 조성물

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008082169A1 (en) * 2006-12-28 2008-07-10 Industrial Cooperation Foundation Chonbuk National University Stilbene derivatives for adp-ribosyl cyclase inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7220286B2 (en) 2004-01-13 2007-05-22 L'oreal Sa Cationic direct triazo dyes, dye composition comprising them and process for dyeing keratin fibres using it
US8987474B2 (en) 2006-04-07 2015-03-24 University Of South Florida Inhibition of Shp2/PTPN11 protein tyrosine phosphatase by NSC-87877, NSC-117199 and their analogs
WO2008097504A2 (en) 2007-02-02 2008-08-14 Redpoint Bio Corporation Use of a trpm5 inhibitor to regulate insulin and glp-1 release

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008082169A1 (en) * 2006-12-28 2008-07-10 Industrial Cooperation Foundation Chonbuk National University Stilbene derivatives for adp-ribosyl cyclase inhibitors

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
NICO SMIT ET AL.: "The Hunt for Natural Skin Whitening Agents.", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES., vol. 10, no. 12, 2009, pages 5326 - 5349 *
SHIGERU OAE ET AL.: "A New Rearrangement Reaction of Azoxybenzene with Arenesulfonyl Chloride.", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 44, no. 9, 1971, pages 2495 - 2501 *
YOVANI MARRERO-PONCE ET AL.: "Prediction of Tyrosinase Inhibition Activity Using Atom-Based Bilinear Indices.", CHEMMEDCHEM, vol. 2, no. 4, April 2007 (2007-04-01), pages 449 - 478 *

Also Published As

Publication number Publication date
KR20120091652A (ko) 2012-08-20
WO2012108676A2 (ko) 2012-08-16
KR101334466B1 (ko) 2013-11-29

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