WO2012121485A3 - Procédé pour induire la migration in vivo de cellules souches - Google Patents

Procédé pour induire la migration in vivo de cellules souches Download PDF

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Publication number
WO2012121485A3
WO2012121485A3 PCT/KR2012/000618 KR2012000618W WO2012121485A3 WO 2012121485 A3 WO2012121485 A3 WO 2012121485A3 KR 2012000618 W KR2012000618 W KR 2012000618W WO 2012121485 A3 WO2012121485 A3 WO 2012121485A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell
treatment
tissue
damaged
inducing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2012/000618
Other languages
English (en)
Korean (ko)
Other versions
WO2012121485A2 (fr
Inventor
이진우
박민성
김윤희
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tegoscience Inc
Original Assignee
Tegoscience Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020120001563A external-priority patent/KR101466811B1/ko
Application filed by Tegoscience Inc filed Critical Tegoscience Inc
Priority to JP2013557637A priority Critical patent/JP5828916B2/ja
Priority to EP12754399.9A priority patent/EP2684575B1/fr
Priority to CN201280011945.2A priority patent/CN103561788B/zh
Priority to US14/003,364 priority patent/US9220757B2/en
Publication of WO2012121485A2 publication Critical patent/WO2012121485A2/fr
Publication of WO2012121485A3 publication Critical patent/WO2012121485A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La présente invention concerne une composition implantable pour traiter un tissu endommagé et un procédé pour induire une migration in vivo d'une cellule pour le traitement d'une région de tissu endommagée. La présente invention traite le tissu endommagé par induction/promotion de l'écotropisme d'une cellule pour la génération de tissu par implantation d'un échafaudage biodégradable ayant été mis en réaction avec des facteurs chimiotactiques (par exemple, IL-8 ou MIP-3α) à un emplacement endommagé (par exemple, un cartilage articulaire ou la peau). Par conséquent, la composition de la présente invention peut non seulement être appliquée au traitement d'un tissu osseux endommagé, un cartilage articulaire, ou un tissu cutané plus commodément et efficacement par comparaison à la technologie conventionnelle, mais peut également être utilisée en tant qu'agent de supplément de traitement utile dans le traitement de cellules utilisant une cellule allogénique en permettant l'utilisation efficace de ressources cellulaires pour le traitement, les ressources cellulaires étant extrêmement limitées.
PCT/KR2012/000618 2011-03-08 2012-01-26 Procédé pour induire la migration in vivo de cellules souches Ceased WO2012121485A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2013557637A JP5828916B2 (ja) 2011-03-08 2012-01-26 幹細胞のインビボ移動誘導方法
EP12754399.9A EP2684575B1 (fr) 2011-03-08 2012-01-26 Procédé pour induire la migration in vivo de cellules souches
CN201280011945.2A CN103561788B (zh) 2011-03-08 2012-01-26 干细胞的体内迁移诱导方法
US14/003,364 US9220757B2 (en) 2011-03-08 2012-01-26 Method for inducing in vivo migration of stem cell

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2011-0020221 2011-03-08
KR20110020221 2011-03-08
KR1020120001563A KR101466811B1 (ko) 2011-03-08 2012-01-05 줄기세포의 인 비보(ｉｎ ｖｉｖｏ) 이동 유도방법
KR10-2012-0001563 2012-01-05

Publications (2)

Publication Number Publication Date
WO2012121485A2 WO2012121485A2 (fr) 2012-09-13
WO2012121485A3 true WO2012121485A3 (fr) 2012-12-13

Family

ID=46798614

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/000618 Ceased WO2012121485A2 (fr) 2011-03-08 2012-01-26 Procédé pour induire la migration in vivo de cellules souches

Country Status (1)

Country Link
WO (1) WO2012121485A2 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008088381A2 (fr) * 2007-01-08 2008-07-24 Bioform Medical, Inc. Compositions d'implantation pour une utilisation dans l'augmentation de tissu

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008088381A2 (fr) * 2007-01-08 2008-07-24 Bioform Medical, Inc. Compositions d'implantation pour une utilisation dans l'augmentation de tissu

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DAISUKE INOKUMA ET AL.: "CTACK/CCL27 Accelerates Skin Regeneration via Accumulation of Bone Marrow-Derived Keratinocytes", STEM CELLS, vol. 24, no. 12, 12 December 2006 (2006-12-12), pages 2810 - 2816, XP055122837 *
JOCHEN RINGE ET AL.: "Towards in situ tissu repair : Human mesenchymal stem cells express chemokine receptors CXCR1, CXCR2 and CCR2, and migrate upon stimulation with CXCL8 but not CCL2", JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 101, no. 1, 1 May 2007 (2007-05-01), pages 135 - 146, XP055050679 *
See also references of EP2684575A4 *
VALERIA SORDI ET AL.: "Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic islets", BLOOD, vol. 106, no. 2, 15 July 2005 (2005-07-15), pages 419 - 427, XP003019019 *

Also Published As

Publication number Publication date
WO2012121485A2 (fr) 2012-09-13

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