WO2012122522A3 - Mise en culture d'un prélèvement d'une communauté microbienne intestinale - Google Patents

Mise en culture d'un prélèvement d'une communauté microbienne intestinale Download PDF

Info

Publication number
WO2012122522A3
WO2012122522A3 PCT/US2012/028600 US2012028600W WO2012122522A3 WO 2012122522 A3 WO2012122522 A3 WO 2012122522A3 US 2012028600 W US2012028600 W US 2012028600W WO 2012122522 A3 WO2012122522 A3 WO 2012122522A3
Authority
WO
WIPO (PCT)
Prior art keywords
microbial community
gut microbial
cultured
collection
cultured collection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2012/028600
Other languages
English (en)
Other versions
WO2012122522A2 (fr
Inventor
Jeffrey I GORDON
Jeremiah J. FAITH
Nathan P. MCNULTY
Federico E. REY
Andrew Goodman
George KALLSTROM
Venessa RIDAURA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Washington University in St Louis WUSTL
Original Assignee
University of Washington
Washington University in St Louis WUSTL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington, Washington University in St Louis WUSTL filed Critical University of Washington
Publication of WO2012122522A2 publication Critical patent/WO2012122522A2/fr
Priority to US14/022,000 priority Critical patent/US20140045744A1/en
Anticipated expiration legal-status Critical
Publication of WO2012122522A3 publication Critical patent/WO2012122522A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/105Murine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Cette invention concerne la mise en culture de prélèvements d'une communauté microbienne intestinale, des modèles comprenant ces cultures, et leurs méthodes d'utilisation.
PCT/US2012/028600 2011-03-09 2012-03-09 Mise en culture d'un prélèvement d'une communauté microbienne intestinale Ceased WO2012122522A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US14/022,000 US20140045744A1 (en) 2011-03-09 2013-09-09 Cultured collection of gut microbial community

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201161450741P 2011-03-09 2011-03-09
US61/450,741 2011-03-09
US201161485887P 2011-05-13 2011-05-13
US61/485,887 2011-05-13
US201161497663P 2011-06-16 2011-06-16
US61/497,663 2011-06-16

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US14/022,000 Continuation-In-Part US20140045744A1 (en) 2011-03-09 2013-09-09 Cultured collection of gut microbial community

Publications (2)

Publication Number Publication Date
WO2012122522A2 WO2012122522A2 (fr) 2012-09-13
WO2012122522A3 true WO2012122522A3 (fr) 2014-04-24

Family

ID=46798844

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/028600 Ceased WO2012122522A2 (fr) 2011-03-09 2012-03-09 Mise en culture d'un prélèvement d'une communauté microbienne intestinale

Country Status (2)

Country Link
US (1) US20140045744A1 (fr)
WO (1) WO2012122522A2 (fr)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9457077B2 (en) 2009-11-18 2016-10-04 Katherine Rose Kovarik Method and system for targeting the microbiome to promote health and treat allergic and inflammatory diseases
US9585920B2 (en) 2011-02-04 2017-03-07 Katherine Rose Kovarik Method and system for treating cancer cachexia
DK3564357T3 (da) 2010-02-01 2022-06-20 Rebiotix Inc Bakterieterapi mod clostridium difficile colitis
US12279989B2 (en) 2011-02-04 2025-04-22 Seed Health, Inc. Method and system for increasing beneficial bacteria and decreasing pathogenic bacteria in the oral cavity
US10086018B2 (en) 2011-02-04 2018-10-02 Joseph E. Kovarik Method and system for reducing the likelihood of colorectal cancer in a human being
US10111913B2 (en) 2011-02-04 2018-10-30 Joseph E. Kovarik Method of reducing the likelihood of skin cancer in an individual human being
US11844720B2 (en) 2011-02-04 2023-12-19 Seed Health, Inc. Method and system to reduce the likelihood of dental caries and halitosis
US10835560B2 (en) 2013-12-20 2020-11-17 Joseph E. Kovarik Reducing the likelihood of skin cancer in an individual human being
US10940169B2 (en) 2015-11-30 2021-03-09 Joseph E. Kovarik Method for reducing the likelihood of developing cancer in an individual human being
US11951139B2 (en) 2015-11-30 2024-04-09 Seed Health, Inc. Method and system for reducing the likelihood of osteoporosis
US10548761B2 (en) 2011-02-04 2020-02-04 Joseph E. Kovarik Method and system for reducing the likelihood of colorectal cancer in a human being
US9730967B2 (en) 2011-02-04 2017-08-15 Katherine Rose Kovarik Method and system for treating cancer cachexia
US11357722B2 (en) 2011-02-04 2022-06-14 Seed Health, Inc. Method and system for preventing sore throat in humans
US10314865B2 (en) 2011-02-04 2019-06-11 Katherine Rose Kovarik Method and system for treating cancer and other age-related diseases by extending the healthspan of a human
US10245288B2 (en) 2011-02-04 2019-04-02 Joseph E. Kovarik Method and system for reducing the likelihood of developing NASH in an individual diagnosed with non-alcoholic fatty liver disease
US11998479B2 (en) 2011-02-04 2024-06-04 Seed Health, Inc. Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure
US10687975B2 (en) 2011-02-04 2020-06-23 Joseph E. Kovarik Method and system to facilitate the growth of desired bacteria in a human's mouth
US12257272B2 (en) 2015-12-24 2025-03-25 Seed Health, Inc. Method and system for reducing the likelihood of developing depression in an individual
US10583033B2 (en) 2011-02-04 2020-03-10 Katherine Rose Kovarik Method and system for reducing the likelihood of a porphyromonas gingivalis infection in a human being
US11273187B2 (en) 2015-11-30 2022-03-15 Joseph E. Kovarik Method and system for reducing the likelihood of developing depression in an individual
US10010568B2 (en) 2011-02-04 2018-07-03 Katherine Rose Kovarik Method and system for reducing the likelihood of a spirochetes infection in a human being
US11191665B2 (en) 2011-02-04 2021-12-07 Joseph E. Kovarik Method and system for reducing the likelihood of a porphyromonas gingivalis infection in a human being
US10085938B2 (en) 2011-02-04 2018-10-02 Joseph E. Kovarik Method and system for preventing sore throat in humans
US10842834B2 (en) 2016-01-06 2020-11-24 Joseph E. Kovarik Method and system for reducing the likelihood of developing liver cancer in an individual diagnosed with non-alcoholic fatty liver disease
US11523934B2 (en) 2011-02-04 2022-12-13 Seed Health, Inc. Method and system to facilitate the growth of desired bacteria in a human's mouth
US11951140B2 (en) 2011-02-04 2024-04-09 Seed Health, Inc. Modulation of an individual's gut microbiome to address osteoporosis and bone disease
US12533312B2 (en) 2011-02-04 2026-01-27 Seed Health, Inc. Method and system for preventing sore throat in humans
US10512661B2 (en) 2011-02-04 2019-12-24 Joseph E. Kovarik Method and system for reducing the likelihood of developing liver cancer in an individual diagnosed with non-alcoholic fatty liver disease
US9987224B2 (en) 2011-02-04 2018-06-05 Joseph E. Kovarik Method and system for preventing migraine headaches, cluster headaches and dizziness
US11419903B2 (en) 2015-11-30 2022-08-23 Seed Health, Inc. Method and system for reducing the likelihood of osteoporosis
US8841071B2 (en) * 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
EP2859119A2 (fr) * 2012-06-12 2015-04-15 Institute for Systems Biology Composition d'arn complexe de liquides corporels
US8906668B2 (en) 2012-11-23 2014-12-09 Seres Health, Inc. Synergistic bacterial compositions and methods of production and use thereof
SG11201503966PA (en) 2012-11-23 2015-06-29 Seres Health Inc Synergistic bacterial compositions and methods of production and use thereof
US10973861B2 (en) 2013-02-04 2021-04-13 Seres Therapeutics, Inc. Compositions and methods
JP2016509003A (ja) 2013-02-04 2016-03-24 セレス セラピューティクス インコーポレイテッド 組成物および方法
US20160000837A1 (en) * 2013-02-18 2016-01-07 Washington University Compositions and methods to alter gut microbial fermentation using sulfate-reducing bacteria
WO2014145958A2 (fr) 2013-03-15 2014-09-18 Seres Health, Inc. Compositions microbiennes et procédés associés basés sur un réseau
US9694039B2 (en) 2013-06-05 2017-07-04 Rebiotix, Inc. Microbiota restoration therapy (MRT), compositions and methods of manufacture
US9782445B2 (en) 2013-06-05 2017-10-10 Rebiotix, Inc. Microbiota restoration therapy (MRT), compositions and methods of manufacture
US9511099B2 (en) 2013-06-05 2016-12-06 Rebiotix, Inc. Microbiota restoration therapy (MRT), compositions and methods of manufacture
US9511100B2 (en) 2013-06-05 2016-12-06 Rebiotix, Inc. Microbiota restoration therapy (MRT), compositions and methods of manufacture
KR102099503B1 (ko) 2013-06-05 2020-04-09 리바이오틱스, 인코퍼레이티드 미생물상 복원 요법(mrt) 조성물
US10383901B2 (en) 2013-06-05 2019-08-20 Rebiotix, Inc. Microbiota restoration therapy (MRT), compositions and methods of manufacture
WO2015066625A1 (fr) * 2013-11-01 2015-05-07 Washington University Méthodes pour établir et restaurer la fonction normale du microbiote intestinal chez un sujet en ayant besoin
WO2015074054A1 (fr) * 2013-11-18 2015-05-21 The Trustees Of Columbia University In The City Of New York Amélioration de la santé microbienne dans l'intestin de mammifères
CN105979952B (zh) 2013-11-25 2022-04-08 赛里斯治疗公司 协同细菌组合物以及其制造方法和用途
US9956282B2 (en) 2013-12-16 2018-05-01 Seres Therapeutics, Inc. Bacterial compositions and methods of use thereof for treatment of immune system disorders
US11213552B2 (en) 2015-11-30 2022-01-04 Joseph E. Kovarik Method for treating an individual suffering from a chronic infectious disease and cancer
US11826388B2 (en) 2013-12-20 2023-11-28 Seed Health, Inc. Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation
US12005085B2 (en) 2013-12-20 2024-06-11 Seed Health, Inc. Probiotic method and composition for maintaining a healthy vaginal microbiome
US11998574B2 (en) 2013-12-20 2024-06-04 Seed Health, Inc. Method and system for modulating an individual's skin microbiome
US11833177B2 (en) 2013-12-20 2023-12-05 Seed Health, Inc. Probiotic to enhance an individual's skin microbiome
US12329783B2 (en) 2013-12-20 2025-06-17 Seed Health, Inc. Method and system to improve the health of a person's skin microbiome
US11672835B2 (en) 2013-12-20 2023-06-13 Seed Health, Inc. Method for treating individuals having cancer and who are receiving cancer immunotherapy
US11980643B2 (en) 2013-12-20 2024-05-14 Seed Health, Inc. Method and system to modify an individual's gut-brain axis to provide neurocognitive protection
US11642382B2 (en) 2013-12-20 2023-05-09 Seed Health, Inc. Method for treating an individual suffering from bladder cancer
US12246043B2 (en) 2013-12-20 2025-03-11 Seed Health, Inc. Topical application to treat acne vulgaris
US11026982B2 (en) 2015-11-30 2021-06-08 Joseph E. Kovarik Method for reducing the likelihood of developing bladder or colorectal cancer in an individual human being
US12318377B2 (en) 2013-12-20 2025-06-03 Seed Health, Inc. Method and system for reducing the likelihood of a porphyromonas gingivalis infection in a human being
US11969445B2 (en) 2013-12-20 2024-04-30 Seed Health, Inc. Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH
US11529379B2 (en) 2013-12-20 2022-12-20 Seed Health, Inc. Method and system for reducing the likelihood of developing colorectal cancer in an individual human being
US11839632B2 (en) 2013-12-20 2023-12-12 Seed Health, Inc. Topical application of CRISPR-modified bacteria to treat acne vulgaris
CA2935254A1 (fr) * 2014-02-20 2015-08-27 MicroBiome Therapeutics LLC Fibre de gousse de soja activee
EP3134509B1 (fr) 2014-04-23 2026-01-21 Cornell University Modulation du stockage des graisses chez un sujet par modification des niveaux de population de christensenellaceae dans le tractus gastro-intestinal
WO2016007544A1 (fr) * 2014-07-11 2016-01-14 Matatu, Inc. Utilisation d'un microbiome intestinal comme prédicteur de croissance ou de santé d'un animal
CN107206030B (zh) 2014-12-08 2020-11-17 Gi生物群系公司 包含生酸拟杆菌作为有效成分的用于预防或治疗代谢性疾病的药学组合物
US10799539B2 (en) 2015-06-09 2020-10-13 Rebiotix, Inc. Microbiota restoration therapy (MRT) compositions and methods of manufacture
US10828340B2 (en) 2015-06-09 2020-11-10 Rebiotix, Inc. Microbiota restoration therapy (MRT) compositions and methods of manufacture
ES2889902T3 (es) 2015-06-09 2022-01-14 Rebiotix Inc Métodos de fabricación de composiciones para terapia de restauración de la microbiota (TRM)
US10905726B2 (en) 2015-06-09 2021-02-02 Rebiotix, Inc. Microbiota restoration therapy (MRT) compositions and methods of manufacture
US10851399B2 (en) 2015-06-25 2020-12-01 Native Microbials, Inc. Methods, apparatuses, and systems for microorganism strain analysis of complex heterogeneous communities, predicting and identifying functional relationships and interactions thereof, and selecting and synthesizing microbial ensembles based thereon
US9938558B2 (en) 2015-06-25 2018-04-10 Ascus Biosciences, Inc. Methods, apparatuses, and systems for analyzing microorganism strains from complex heterogeneous communities, predicting and identifying functional relationships and interactions thereof, and selecting and synthesizing microbial ensembles based thereon
PY1639434A (es) 2015-06-25 2018-08-01 Ascus Biosciences Inc Procedimientos, aparatos y sistemas para el analisis de cepas de microorganismos provinientes de comunidades complejas y heterogenas. prediccion e identificacion de relaciones..//.
WO2017053446A2 (fr) * 2015-09-21 2017-03-30 The Regents Of The University Of California Détection d'agents pathogènes utilisant un séquençage de nouvelle génération
GB201518364D0 (en) 2015-10-16 2015-12-02 Genome Res Ltd Methods associated with a database that stores a plurality of reference genomes
US12239706B2 (en) 2015-11-30 2025-03-04 Seed Health, Inc. Method and system for protecting monarch butterflies from pesticides
US10933128B2 (en) 2015-11-30 2021-03-02 Joseph E. Kovarik Method and system for protecting honey bees from pesticides
US10675347B2 (en) 2015-11-30 2020-06-09 Joseph E. Kovarik Method and system for protecting honey bees from fipronil pesticides
US10086024B2 (en) 2015-11-30 2018-10-02 Joseph E. Kovarik Method and system for protecting honey bees, bats and butterflies from neonicotinoid pesticides
US11529412B2 (en) 2015-11-30 2022-12-20 Seed Health, Inc. Method and system for protecting honey bees from pesticides
US10568916B2 (en) 2015-11-30 2020-02-25 Joseph E. Kovarik Method and system for protecting honey bees, bats and butterflies from neonicotinoid pesticides
MX392304B (es) 2016-01-07 2025-03-24 Native Microbials Inc Métodos para mejorar la producción de leche mediante la administración de consorcios microbianos.
US20190139628A1 (en) * 2016-04-27 2019-05-09 Arc Bio, Llc Machine learning techniques for analysis of structural variants
US20180030403A1 (en) 2016-07-28 2018-02-01 Bobban Subhadra Devices, systems and methods for the production of humanized gut commensal microbiota
WO2018039089A1 (fr) * 2016-08-20 2018-03-01 Gregg John Malcolm Hall Méthodes d'utilisation et compositions contre l'obésité
AU2017388535A1 (en) 2016-12-28 2019-07-25 Native Microbials, Inc. Methods, apparatuses, and systems for microorganism strain analysis of complex heterogeneous communities with tracer analytics, determination of functional relationships and interactions thereof, and synthesis of microbial ensembles including dosed microbial ensembles and inoculative microbial ensembles
CA3048246A1 (fr) 2016-12-28 2018-07-05 Ascus Biosciences, Inc. Procedes, appareils, et systemes permettant d'analyser des souches completes de micro-organismes dans des communautes heterogenes complexes, de determiner leurs interactions et re lations fonctionnelles, et d'identifier et de synthetiser des modificateurs bioreactifs bases sur ceux-ci
UY37708A (es) 2017-04-28 2018-10-31 Ascus Biosciences Inc Métodos para complementar dietas con alto consumo de granos y/o alto valor energético en rumiantes, mediante la administración de un bioensamble sintético de microbios, o cepas purificadas de los mismos
EP3668527A1 (fr) 2017-08-14 2020-06-24 Seres Therapeutics, Inc. Compositions et méthodes de traitement de la maladie cholestatique
TWI629607B (zh) * 2017-08-15 2018-07-11 極諾生技股份有限公司 建立腸道菌數據庫的方法和相關檢測系統
BR112020008552A2 (pt) 2017-10-30 2020-12-29 Seres Therapeutics, Inc. métodos e composições para tratamento de resistência a antibiótico
EP3520799A1 (fr) * 2018-02-06 2019-08-07 European Molecular Biology Laboratory Modèle in vitro du microbiome intestinal humain et ses utilisations dans l'analyse de l'impact de substances xénobiotiques
US20190352712A1 (en) * 2018-05-04 2019-11-21 Shoreline Biome, Llc Multiple Specific/Nonspecific Primers for PCR of a Complex Gene Pool
CN109055517A (zh) * 2018-07-27 2018-12-21 成都大熊猫繁育研究基地 一种基于肠道微生物检测获得大熊猫饲喂食物配方的方法以及饲喂方法
WO2020055547A2 (fr) 2018-08-18 2020-03-19 Seed Health, Inc. Procédés et compositions pour la santé d'abeilles mellifères
WO2020176564A1 (fr) 2019-02-26 2020-09-03 The Regents Of The University Of Colorado, A Body Corporate Méthode et composition de traitement de troubles gastro-intestinaux inflammatoires
US20220235352A1 (en) * 2019-06-06 2022-07-28 Tata Consultancy Services Limited Method and system for identification of target sites in protein coding regions for combating pathogens
CN111368920B (zh) * 2020-03-05 2024-03-05 中南大学 基于量子孪生神经网络的二分类方法及其人脸识别方法
US20230212640A1 (en) * 2020-06-02 2023-07-06 The Trustees Of Princeton University Quantitative screen for the assessment of inter-individual variability in drug metabolism by the human gut microbiome
US20220208375A1 (en) * 2020-12-29 2022-06-30 Kpn Innovations, Llc. System and method for generating a digestive disease functional program

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040091893A1 (en) * 2001-11-27 2004-05-13 Jeffrey Gordon Method for studying the effects of commensal microflora on mammalian intestine and treatments of gastrointestinal-associated disease based thereon
US20050239706A1 (en) * 2003-10-31 2005-10-27 Washington University In St. Louis Modulation of fiaf and the gastrointestinal microbiota as a means to control energy storage in a subject
US20100008949A1 (en) * 2008-07-08 2010-01-14 South Dakota State University Vaccine for porcine post-weaning diarrhea caused by enterotoxigenic escherichia coli
US20100172874A1 (en) * 2006-12-18 2010-07-08 The Washington University Gut microbiome as a biomarker and therapeutic target for treating obesity or an obesity related disorder

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040091893A1 (en) * 2001-11-27 2004-05-13 Jeffrey Gordon Method for studying the effects of commensal microflora on mammalian intestine and treatments of gastrointestinal-associated disease based thereon
US20050239706A1 (en) * 2003-10-31 2005-10-27 Washington University In St. Louis Modulation of fiaf and the gastrointestinal microbiota as a means to control energy storage in a subject
US20100172874A1 (en) * 2006-12-18 2010-07-08 The Washington University Gut microbiome as a biomarker and therapeutic target for treating obesity or an obesity related disorder
US20100008949A1 (en) * 2008-07-08 2010-01-14 South Dakota State University Vaccine for porcine post-weaning diarrhea caused by enterotoxigenic escherichia coli

Also Published As

Publication number Publication date
WO2012122522A2 (fr) 2012-09-13
US20140045744A1 (en) 2014-02-13

Similar Documents

Publication Publication Date Title
WO2012122522A3 (fr) Mise en culture d'un prélèvement d'une communauté microbienne intestinale
WO2013177133A3 (fr) Génération de cellules ips humaines par un arn de synthèse auto-réplicatif
WO2013046060A9 (fr) Papier et procédés de fabrication du papier
SG11201400466TA (en) Eukaryotic organisms and methods for producing 1,3-butanediol
GB201115280D0 (en) Antibodies, uses and methods
EP2545441A4 (fr) Recherche guidée sur la base d'un modèle de demande
SG10201600618QA (en) Microorganisms and methods for producing 2,4-pentadienoate, butadiene, propylene, 1,3-butanediol and related alcohols
EP2580692A4 (fr) Pipeline d'interrogation
WO2011133504A3 (fr) Nanozymes, procédés de production de nanozymes, et procédés d'utilisation de nanozymes
WO2012178091A3 (fr) Procédé d'association d'utilisateurs ayant des intérêts similaires
EP2652141A4 (fr) Microorganismes et procédés pour la production de 1,4-cyclohexanediméthanol
ZA201305410B (en) Multistage polymer dispersions,method for producing same,and use thereof
WO2014127351A3 (fr) Compositions et procédés pour modifier la fermentation microbienne intestinale en utilisant des bactéries réduisant les sulfates
PL2650358T3 (pl) Mikroorganizm o ulepszonej zdolności wytwarzania ornityny i sposób wytwarzania ornityny z jego użyciem
ZA201406381B (en) Levoisovalerylspiramycin i,ii,iii,and preparations,preparations methods and uses thereof
WO2013011368A9 (fr) Nouveaux mutants il-17r-ecd
EP2562197A4 (fr) Copolymère comprenant de l'anthracène et du benzosélénadiazole, son procédé de préparation et ses utilisations
HK1202070A1 (zh) 用於肿瘤免疫疗法的疫苗
EP2763528B8 (fr) Préparation pesticide et procédé de production
IL231065A0 (en) Cancer antigen-bearing microorganisms, preparations containing them and their uses
EP2634183B8 (fr) Procédé de préparation de 1,3,5-trioxane
EP2634182B8 (fr) Procédé de préparation de 1,3,5-trioxane
WO2014198913A3 (fr) Nouvel isolat de piscirickettsia salmonis
AU2020202162A1 (en) Microorganisms for producing 1,4-butanediol and methods related thereto
Kulisz Recycling and culture

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12755740

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 12755740

Country of ref document: EP

Kind code of ref document: A2