WO2012128508A3 - 광견병 바이러스를 중화시킬 수 있는 결합 분자 - Google Patents

광견병 바이러스를 중화시킬 수 있는 결합 분자 Download PDF

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Publication number
WO2012128508A3
WO2012128508A3 PCT/KR2012/001902 KR2012001902W WO2012128508A3 WO 2012128508 A3 WO2012128508 A3 WO 2012128508A3 KR 2012001902 W KR2012001902 W KR 2012001902W WO 2012128508 A3 WO2012128508 A3 WO 2012128508A3
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WO
WIPO (PCT)
Prior art keywords
rabies virus
binding molecules
neutralizing
molecules capable
animals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2012/001902
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English (en)
French (fr)
Other versions
WO2012128508A2 (ko
Inventor
장신재
김판겸
홍혜진
김성현
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celltrion Inc
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Celltrion Inc
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Filing date
Publication date
Application filed by Celltrion Inc filed Critical Celltrion Inc
Priority to CN201280013315.9A priority Critical patent/CN103492419B/zh
Publication of WO2012128508A2 publication Critical patent/WO2012128508A2/ko
Publication of WO2012128508A3 publication Critical patent/WO2012128508A3/ko
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

본 발명은 광견병 바이러스를 중화시킬 수 있는 결합 분자에 관한 것으로, 더욱 상세하게 본 발명의 결합 분자는 개, 소, 몽구스, 박쥐, 스컹크 및 늑대와 같은 개체에서 유래한 광견병 바이러스를 대상으로 중화하는 능력을 가지고 있으므로, 광범위한 개체에서 유래한 광견병 바이러스에 감염된 환자를 치료하는데 유용하게 이용될 수 있다.
PCT/KR2012/001902 2011-03-18 2012-03-16 광견병 바이러스를 중화시킬 수 있는 결합 분자 Ceased WO2012128508A2 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201280013315.9A CN103492419B (zh) 2011-03-18 2012-03-16 可中和狂犬病病毒的结合分子

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20110024332 2011-03-18
KR10-2011-0024332 2011-03-18

Publications (2)

Publication Number Publication Date
WO2012128508A2 WO2012128508A2 (ko) 2012-09-27
WO2012128508A3 true WO2012128508A3 (ko) 2012-12-27

Family

ID=46879865

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/001902 Ceased WO2012128508A2 (ko) 2011-03-18 2012-03-16 광견병 바이러스를 중화시킬 수 있는 결합 분자

Country Status (3)

Country Link
KR (1) KR101388680B1 (ko)
CN (1) CN103492419B (ko)
WO (1) WO2012128508A2 (ko)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2537345B2 (ja) * 1984-04-25 1996-09-25 トランスジ−ン ソシエテ アノニム 狂犬病に対するワクチン及びその製造法
JP2004528803A (ja) * 2000-05-16 2004-09-24 トーマス・ジェファーソン・ユニバーシティー 狂犬病ウイルス特異的ヒトモノクローナル中和抗体及び核酸及び関連する方法
KR20070044807A (ko) * 2004-05-27 2007-04-30 크루셀 홀란드 비.브이. 광견병 바이러스를 중화시킬 수 있는 결합 분자 및 그 용도
KR20100006868A (ko) * 2008-07-10 2010-01-22 대한민국(관리부서 : 농림수산식품부 국립수의과학검역원) 면역크로마토그라피를 이용한 광견병 항체 신속 검출진단키트 및 면역크로마토그라피를 이용한 광견병 항체진단방법
JP2010085126A (ja) * 2008-09-29 2010-04-15 Adtec Kk 狂犬病ウイルス中和抗体価判定具および狂犬病ウイルス中和抗体価の測定方法
JP2011050269A (ja) * 2009-08-31 2011-03-17 Evec Inc 狂犬病ウイルスに対するヒト抗体ならびにその医薬組成物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1355253A (zh) * 2000-11-29 2002-06-26 中国预防医学科学院病毒学研究所 人源抗狂犬病毒中和性基因工程抗体
CN101100663B (zh) * 2006-07-05 2011-08-24 华北制药集团新药研究开发有限责任公司 重组人抗狂犬病毒单克隆抗体的制备方法
CN101560255B (zh) * 2009-04-22 2012-05-23 南京医科大学 抗狂犬病病毒单克隆抗体及其应用

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2537345B2 (ja) * 1984-04-25 1996-09-25 トランスジ−ン ソシエテ アノニム 狂犬病に対するワクチン及びその製造法
JP2004528803A (ja) * 2000-05-16 2004-09-24 トーマス・ジェファーソン・ユニバーシティー 狂犬病ウイルス特異的ヒトモノクローナル中和抗体及び核酸及び関連する方法
KR20070044807A (ko) * 2004-05-27 2007-04-30 크루셀 홀란드 비.브이. 광견병 바이러스를 중화시킬 수 있는 결합 분자 및 그 용도
KR20100006868A (ko) * 2008-07-10 2010-01-22 대한민국(관리부서 : 농림수산식품부 국립수의과학검역원) 면역크로마토그라피를 이용한 광견병 항체 신속 검출진단키트 및 면역크로마토그라피를 이용한 광견병 항체진단방법
JP2010085126A (ja) * 2008-09-29 2010-04-15 Adtec Kk 狂犬病ウイルス中和抗体価判定具および狂犬病ウイルス中和抗体価の測定方法
JP2011050269A (ja) * 2009-08-31 2011-03-17 Evec Inc 狂犬病ウイルスに対するヒト抗体ならびにその医薬組成物

Also Published As

Publication number Publication date
CN103492419A (zh) 2014-01-01
KR101388680B1 (ko) 2014-04-28
CN103492419B (zh) 2015-11-25
KR20120107050A (ko) 2012-09-28
WO2012128508A2 (ko) 2012-09-27

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