WO2012128530A3 - Dérivés de 2-méthyl-2-alkyl-6-amido-2h-benzopyrane ayant une activité anticancéreuse - Google Patents

Dérivés de 2-méthyl-2-alkyl-6-amido-2h-benzopyrane ayant une activité anticancéreuse Download PDF

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Publication number
WO2012128530A3
WO2012128530A3 PCT/KR2012/001971 KR2012001971W WO2012128530A3 WO 2012128530 A3 WO2012128530 A3 WO 2012128530A3 KR 2012001971 W KR2012001971 W KR 2012001971W WO 2012128530 A3 WO2012128530 A3 WO 2012128530A3
Authority
WO
WIPO (PCT)
Prior art keywords
amido
alkyl
methyl
benzopyran derivatives
cancer activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2012/001971
Other languages
English (en)
Korean (ko)
Other versions
WO2012128530A2 (fr
Inventor
공영대
김정엽
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KOREA HEALTH INDUSTRY DEVELOPMENT INSTITUTE
Industry Academic Cooperation Foundation of Dongguk University
Korea Health Industry Development Institute
Original Assignee
KOREA HEALTH INDUSTRY DEVELOPMENT INSTITUTE
Industry Academic Cooperation Foundation of Dongguk University
Korea Health Industry Development Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KOREA HEALTH INDUSTRY DEVELOPMENT INSTITUTE, Industry Academic Cooperation Foundation of Dongguk University, Korea Health Industry Development Institute filed Critical KOREA HEALTH INDUSTRY DEVELOPMENT INSTITUTE
Publication of WO2012128530A2 publication Critical patent/WO2012128530A2/fr
Publication of WO2012128530A3 publication Critical patent/WO2012128530A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des dérivés inédits de 2-méthyl-2-alkyl-6-amido-2H-benzopyrane présentant une remarquable activité inhibitrice contre l'expression du gène cible du facteur NF-KB, ainsi que des sels pharmaceutiquement acceptables de ceux-ci, un procédé de préparation dudit composé et l'utilisation dudit composé en tant qu'agent anticancéreux.
PCT/KR2012/001971 2011-03-21 2012-03-20 Dérivés de 2-méthyl-2-alkyl-6-amido-2h-benzopyrane ayant une activité anticancéreuse Ceased WO2012128530A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020110025075A KR101071359B1 (ko) 2011-03-21 2011-03-21 항암 활성을 가지는 2-메틸-2-알킬-6-아미도-2ｈ-벤조피란 유도체
KR10-2011-0025075 2011-03-21

Publications (2)

Publication Number Publication Date
WO2012128530A2 WO2012128530A2 (fr) 2012-09-27
WO2012128530A3 true WO2012128530A3 (fr) 2012-12-27

Family

ID=45032515

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/001971 Ceased WO2012128530A2 (fr) 2011-03-21 2012-03-20 Dérivés de 2-méthyl-2-alkyl-6-amido-2h-benzopyrane ayant une activité anticancéreuse

Country Status (2)

Country Link
KR (1) KR101071359B1 (fr)
WO (1) WO2012128530A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111233809B (zh) * 2020-01-16 2021-12-03 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） 一种Millepachine-CA-4衍生物及其制备方法和应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100429609B1 (ko) * 1999-10-21 2004-05-03 동부한농화학 주식회사 벤조피라닐 구아니딘 유도체, 그의 제조방법 및 그를포함하는 약학적 조성물
KR100704009B1 (ko) * 2005-08-30 2007-04-04 한국화학연구원 염증억제 활성을 가지는6-알킬아미노-2-메틸-2'-(ｎ-메틸치환술폰아미도)메틸-2ｈ-1-벤조피란 유도체
KR20090022398A (ko) * 2007-08-30 2009-03-04 한국화학연구원 2-메틸-2'-하이드록시메틸-6-아미도벤조피란 유도체 또는 약제학적으로 허용 가능한 그의 염을 유효성분으로 함유하는 알레르기 질환 치료제
KR20090022070A (ko) * 2007-08-29 2009-03-04 한국화학연구원 2-메틸-2'-하이드록시메틸-6-아미도 벤조피란 유도체 및약제학적으로 허용 가능한 그의 염, 그의 제조방법, 그를유효성분으로 함유하는 산화스트레스 억제용 조성물 및그를 이용한 약리학적인 용도
KR20110012090A (ko) * 2009-07-29 2011-02-09 한국화학연구원 2-메틸-2ｈ-크로멘-2-카르복사미드 화합물

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5164509A (en) * 1990-11-26 1992-11-17 E. R. Squibb & Sons, Inc. Benzodiazolo analogs

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100429609B1 (ko) * 1999-10-21 2004-05-03 동부한농화학 주식회사 벤조피라닐 구아니딘 유도체, 그의 제조방법 및 그를포함하는 약학적 조성물
KR100704009B1 (ko) * 2005-08-30 2007-04-04 한국화학연구원 염증억제 활성을 가지는6-알킬아미노-2-메틸-2'-(ｎ-메틸치환술폰아미도)메틸-2ｈ-1-벤조피란 유도체
KR20090022070A (ko) * 2007-08-29 2009-03-04 한국화학연구원 2-메틸-2'-하이드록시메틸-6-아미도 벤조피란 유도체 및약제학적으로 허용 가능한 그의 염, 그의 제조방법, 그를유효성분으로 함유하는 산화스트레스 억제용 조성물 및그를 이용한 약리학적인 용도
KR20090022398A (ko) * 2007-08-30 2009-03-04 한국화학연구원 2-메틸-2'-하이드록시메틸-6-아미도벤조피란 유도체 또는 약제학적으로 허용 가능한 그의 염을 유효성분으로 함유하는 알레르기 질환 치료제
KR20110012090A (ko) * 2009-07-29 2011-02-09 한국화학연구원 2-메틸-2ｈ-크로멘-2-카르복사미드 화합물

Also Published As

Publication number Publication date
KR101071359B1 (ko) 2011-10-07
WO2012128530A2 (fr) 2012-09-27

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