WO2012141445A3 - 만성 ｂ형 간질환 환자의 간세포암 발병 위험도 분석 및 예측방법 - Google Patents

만성 ｂ형 간질환 환자의 간세포암 발병 위험도 분석 및 예측방법 Download PDF

Info

Publication number
WO2012141445A3
WO2012141445A3 PCT/KR2012/002436 KR2012002436W WO2012141445A3 WO 2012141445 A3 WO2012141445 A3 WO 2012141445A3 KR 2012002436 W KR2012002436 W KR 2012002436W WO 2012141445 A3 WO2012141445 A3 WO 2012141445A3
Authority
WO
WIPO (PCT)
Prior art keywords
hepatoma
hepatitis type
predicting
onset
gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2012/002436
Other languages
English (en)
French (fr)
Other versions
WO2012141445A2 (ko
Inventor
천지용
장정원
박영민
신수경
유왕돈
김수옥
홍선표
김석준
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genematrix Inc
Original Assignee
Genematrix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genematrix Inc filed Critical Genematrix Inc
Publication of WO2012141445A2 publication Critical patent/WO2012141445A2/ko
Publication of WO2012141445A3 publication Critical patent/WO2012141445A3/ko
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

본 발명은 만성 B형 간질환 환자군과 만성 B형 간질환으로부터 간세포암으로 진행된 환자군에 감염된 B형 간염 바이러스의 X 유전자 및 프리코어/코어 유전자 상에서 돌연변이의 발생빈도가 증가되는 돌연변이 양상을 다양한 분자유전학적 분석법을 통해 분석한 후, 간세포암 발병과 독립적으로 연관된 X 유전자 및 프리코어/코어 유전자 상의 간세포암 예측용 마커들을 도출하고, 이러한 간세포암 예측용 마커들의 돌연변이 패턴, 즉 돌연변이 누적 개수 및/또는 조합을 이용하여 만성 B형 간질환 환자의 간세포암 발병 위험도를 고감도 및 높은 특이도로 분석 및 예측하는 방법을 제공한다.
PCT/KR2012/002436 2011-04-12 2012-04-02 만성 ｂ형 간질환 환자의 간세포암 발병 위험도 분석 및 예측방법 Ceased WO2012141445A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020110033944A KR101394973B1 (ko) 2011-04-12 2011-04-12 만성 ｂ형 간질환 환자의 간세포암 발병 위험도 분석 및 예측방법
KR10-2011-0033944 2011-04-12

Publications (2)

Publication Number Publication Date
WO2012141445A2 WO2012141445A2 (ko) 2012-10-18
WO2012141445A3 true WO2012141445A3 (ko) 2013-03-07

Family

ID=47009800

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/002436 Ceased WO2012141445A2 (ko) 2011-04-12 2012-04-02 만성 ｂ형 간질환 환자의 간세포암 발병 위험도 분석 및 예측방법

Country Status (2)

Country Link
KR (1) KR101394973B1 (ko)
WO (1) WO2012141445A2 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103451319B (zh) * 2013-08-22 2015-08-05 中国人民解放军第四军医大学 Hbv b基因型1799g＞c突变作为分子标记的应用及试剂盒
CN110184350B (zh) * 2019-05-29 2023-06-16 阿吉安(福州)基因医学检验实验室有限公司 用于预测乙肝患者肝癌易感性的引物、探针及试剂盒
CN111613324B (zh) * 2020-05-15 2025-02-07 上海中医药大学附属岳阳中西医结合医院 一种机器学习模型高通量分析乙型肝炎病毒基因组rt/s区序列特征预测肝癌风险的方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHO, E. Y. ET AL.: "Association between hepatitis B virus X gene mutations and clinical status in patients with chronic hepatitis B infection", GUT AND LIVER, vol. 5, no. 1, March 2011 (2011-03-01), pages 70 - 76 *
JANG, J. W. ET AL.: "Mutational complex genotype of the hepatitis B virus X /precore regions as a novel predictive marker for hepatocellular carcinoma", CANCER SCI., vol. 103, no. 2, February 2012 (2012-02-01), pages 296 - 304 *
LIU, S. ET AL.: "Associations between hepatitis B virus mutations and the risk of hepatocellular carcinoma a meta-analysis", J. NATL. CANCER INST., vol. 101, 2009, pages 1066 - 1082 *
YIN, J. ET AL.: "Association between the various mutations in viral corepromoter region to different stages of hepatitis B, ranging of asymptomatic carrier state to hepatocellular carcinoma", AM. J. GASTROENTEROL, vol. 106, January 2011 (2011-01-01), pages 81 - 92 *

Also Published As

Publication number Publication date
WO2012141445A2 (ko) 2012-10-18
KR20120116294A (ko) 2012-10-22
KR101394973B1 (ko) 2014-05-15

Similar Documents

Publication Publication Date Title
Sahoo et al. Alternative measures of environmental technology structure in DEA: An application
GB2511690A (en) Detecting malware using stored patterns
Garcia et al. Comparative dynamics and distribution of influenza drug resistance acquisition to protein m2 and neuraminidase inhibitors
EA202092900A2 (ru) Мутационный анализ днк в плазме для детектирования рака
WO2012018387A3 (en) Compositions and methods for discovery of causative mutations in genetic disorders
EP2819671A4 (en) INHIBITORS OF HEPATITIS B VIRUS WITH COVALENT CLOSED CIRCULAR DNA PREPARATION AND ITS USE METHOD
WO2012104340A3 (en) Markers of melanoma and uses thereof
EP2856373A4 (en) SYSTEM AND METHOD FOR PREDICTING THE RETAINING STRENGTH
EP2888349A4 (en) SYSTEM, DEVICE AND METHOD FOR MULTIPLEX DETECTION WITH HIGH THROUGHPUT
BR112012001931A2 (pt) métodos para diagnosticar ou prever o resultado de hepatite c em pacientes infectados com hcv
EP2842221A4 (en) CURRENT TRANSFORMER SYSTEM, DAMPING SYSTEM AND METHOD FOR OPERATING A CURRENT TRANSFORMER SYSTEM
PH12014500063A1 (en) Methods and nucleic acids for determining the prognosis of a cancer subject
WO2012093340A3 (en) Viral diagnostics
EP2764660A4 (en) DISTRIBUTED SYSTEM AND METHOD FOR RETRIEVING AND DISMISSING SOUGHT INTERNET HOSTS
WO2011163116A3 (en) CHRONIC LYMPHOCYTIC LEUKEMIA MODELED IN MOUSE BY TARGETED miR-29 EXPRESSION
WO2012125712A3 (en) Lung tumor classifier for current and former smokers
CA2863106A1 (en) Hbv immunocomplexes for response prediction and therapy monitoring of chronic hbv patients
ZA201305947B (en) Method,system and computer program to provide fares detection from rules attributes
WO2012141445A3 (ko) 만성 ｂ형 간질환 환자의 간세포암 발병 위험도 분석 및 예측방법
WO2012054681A3 (en) Methods for selecting medications for treating patients having attention-deficit hyperactivity disorder
EP2860619A4 (en) METHOD, SYSTEM AND TOUCH SCREEN DEVICE FOR DISABLING THE SCREEN
EP2921968A4 (en) HARD DISK SYSTEM OPERATION, STORAGE SYSTEM AND PROCESSOR
EP2713286A4 (en) SEARCH PROCEDURE AND SYSTEM FOR COMMUNITY PARTICIPANTS
EP2661505A4 (en) SYSTEM AND METHOD FOR DETERMINING CANCER PROGENNESS AND PREDICTING RESPONSE TO THERAPY
WO2014023808A3 (en) Method for evaluating a cancer patient for propensity to respond to a therapy

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12770779

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 12770779

Country of ref document: EP

Kind code of ref document: A2