WO2012148188A2 - Utilisation d'une technique d'analyse d'image pour une image élastographique d'un col de l'utérus afin d'évaluer l'état du col de l'utérus d'une femme enceinte - Google Patents

Utilisation d'une technique d'analyse d'image pour une image élastographique d'un col de l'utérus afin d'évaluer l'état du col de l'utérus d'une femme enceinte Download PDF

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WO2012148188A2
WO2012148188A2 PCT/KR2012/003235 KR2012003235W WO2012148188A2 WO 2012148188 A2 WO2012148188 A2 WO 2012148188A2 KR 2012003235 W KR2012003235 W KR 2012003235W WO 2012148188 A2 WO2012148188 A2 WO 2012148188A2
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cervix
image
area
information
cervical
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Korean (ko)
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WO2012148188A3 (fr
WO2012148188A9 (fr
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황한성
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University Industry Cooperation Corporation of Konkuk University
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University Industry Cooperation Corporation of Konkuk University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Clinical applications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Clinical applications
    • A61B8/0866—Clinical applications involving foetal diagnosis; pre-natal or peri-natal diagnosis of the baby
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/485—Diagnostic techniques involving measuring strain or elastic properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/5215—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data
    • A61B8/5223—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for extracting a diagnostic or physiological parameter from medical diagnostic data
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T11/00—Two-dimensional [2D] image generation
    • G06T11/40—Filling planar surfaces by adding surface attributes, e.g. adding colours or textures
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing

Definitions

  • the present invention relates to the use of an image analysis method for cervical elasticity images to evaluate the cervical state of the mother, and more specifically, to the cervix to evaluate the state of the cervix in the mother
  • an imaging analyzer By performing elastography and analyzing the obtained elastographic imaging data using an imaging analyzer, it is possible to exclude the subjective judgment of the observer and to obtain objective numerical data on the state of the cervix. will be.
  • the size of the cervix (the remaining amount) and the degree of aging (hardness) should be evaluated.
  • the existing Bishop score is based on this, but it is difficult to evaluate when the score is low and is very subjective.
  • the cervical length is relatively objective, but because it only covers the length of the cervix, it can be said that it is difficult to evaluate the exact state.
  • the present invention has been made to solve the above problems and the object of the present invention is to provide a new means for evaluating the cervical condition of the mother.
  • the present invention comprises the steps of: a) obtaining an image of the cervix with suffocating ultrasound;
  • the image of the cervix obtained by the choking ultrasound is preferably a black and white two-dimensional image, but is not limited thereto.
  • the elastic ultrasound image is gray, but the liquid is white and the solid is black.
  • the softest part of the ultrasound image is white and its numerical value is 255, the hard part is black and the numerical value preferably corresponds to 0. It is not limited.
  • the image analysis step is to determine the area ratio of the area having a pixel value of less than 80 of the entire area of the selected ultrasound image overlapped in the ultrasound image as the hard part area of the cervix Preferably, but not limited to.
  • the present invention provides a method for providing information on cesarean section predictive predictive maternal delivery using information on the state of the cervix of the present invention.
  • the information on the cervical state is preferably characterized in that the area of the hard area of the cervix,
  • the area of the hard part of the cervix is more preferably set to a cut-off value (192.4mm 2 ), but is not limited thereto.
  • the present invention provides a method for providing information on the induction of delivery using the information on the state of the cervix of the present invention and not delivering within 24 hours.
  • the information on the cervical state is preferably the area of the hard area of the cervix
  • the area of the hard part of the cervix is preferably 184.7 mm 2 but the cut-off value (cut-off value) is not limited thereto.
  • the specific numerical method for the image of the elastic ultrasonic wave used in the present invention is that the numerical technique by the image analysis of the elastic image is not yet used in all other fields and may be a technique that can be applied in other clinical fields as well as gynecology. It is not limited to the above two examples used to give the following examples.
  • the ultrasound imaging analysis of the cervix presented in the present invention can be called a breakthrough in this respect, and no one has tried yet.
  • the ultrasonographic analysis of the present invention is the first attempt in the cervix, and if this successfully reflects the state of the cervix,
  • Figure 1 is a photograph and description of the elasticity (elasticity) and strain (Strain) that is the basic principle of elastography.
  • Figure 3 is an elastography picture of the cervix obtained in black and white.
  • Figure 4 is an elastography picture of the cervix obtained in color.
  • 5 is a gray scale image (left) and a black and white elastography image (right).
  • FIG. 6 is a diagram illustrating a process of overlapping the same region on the right elastoscan image after setting an area in the left cervical image.
  • FIG. 7 is a diagram showing the hard area of the cervix measured by the image analyzer (red area) and the data for the area (lower part figure).
  • Figure 8 is a graph showing the correlation between cervical length (cervical length) and cervical area (cervical area).
  • Figure 9 is a graph showing the correlation between the cervical length (cervical length) and the hard area of the cervix (hard area of cervix).
  • 10 is a graph showing the correlation between the Bishop score and the cervial area.
  • 11 is a graph showing the correlation between the Bishop score and the hard area of cervix.
  • Figure 12 is a factor predicting that natural delivery among inpatient mothers failed to deliver by cesarean section for induction of labor, cervical area (CxArea), cervical hard area (CxHardArea), cervical length ( Cxlength)
  • CxArea cervical area
  • CxHardArea cervical hard area
  • Cxlength cervical length
  • Figure 13 is an example of applying a model that predicts not to deliver within 24 hours.
  • the present invention is to use the elastography using asphyxiation ultrasound to determine the degree of aging of the cervix in the mother, and to objectively quantify the simple imaging data obtained by using an image analyzer for clinical use.
  • the present invention is a prospective study aimed at people who underwent suffocating ultrasound to measure cervical length in pregnant women who visited obstetrics and gynecology. Excludes cases of intrauterine fetal death, fetal malformation, conventional surgical uterine surgery or active labor.
  • the gestational age is determined on the basis of the final normal menstrual date (LNMP), but is determined by ultrasound in the first trimester and compared with the crown-rump length (CRL).
  • Cervical length and elastography were measured by two different professional ultrasound users who did not know the mother's Bishop score, and one ultrasound user obtained two ultrasound pictures of the same mother. The mother performs an ultrasound in the position of the dorsal lithotomy position after emptying the bladder.
  • the instrument obtains a 2D image of the cervix using an ultrasonic device to measure the cervical length, and obtains an ultrasound image screen at the same position as the image.
  • the elastographic image was grayed out, the amniotic fluid was white, and the hardest areas, such as bones, were measured in black.
  • Elastography uses elasticity, which is the ratio of strain to applied stress.
  • the stress actually applied is difficult to measure in the clinic, but is mostly constant, and only the strain is measured and imaged.
  • the elastographic image obtained by the elastic ultrasound is not objective in expressing the intensity of the cervix as it is measured only by the image from white to black.
  • the image analysis is performed by extracting only the image in the area selected by the cervix from the elastographic image obtained.
  • Various programs can be used for image analysis. Any program can be used.
  • the analysis calculates the area of the area over the selected area that exhibits a certain intensity and measures how the clinical features change according to the area of the area.
  • Elastography is measured in the same phase as taking an image of a conventional cervix (Fig. 2). Images obtained by Elastography range from black and white to color (see FIGS. 3 and 4).
  • Imaging analysis is performed on the elastography region selected in FIG.
  • the selected red area represents the area corresponding to the relatively hard area in the cervix.
  • Area Fraction The area ratio of the area having a pixel value of less than 80 among all the areas set in FIG. 6. In other words, 17.4% means the area ratio of the portion of the total set area (area of the cervix) having an intensity value of less than 80 (1/3 or more).
  • Area ROI Area of the entire area set in FIG. 6
  • Hard area of cervix Area ROI and Area Fraction can be used to calculate the area of a region consisting of pixels with intensity values less than 80 (ie, the area of a relatively hard area).
  • Elastography calculates the area of cervix and the area of hard area and compares it with the length of cervix and Bishop score.
  • induction of induction and delivery within 24 hours is a clinically important moment for the mother.
  • the mother before the induction of labor can know in advance whether there is a possibility of surgery due to natural delivery failure, or if you know in advance that you need to give more than one day of induction, you can reduce the unnecessary treatment to the mother and cut the cost In addition to the benefits, you will be able to give birth safely.
  • the measurement of the cervical area and the hard part of the cervix was used to predict the successful delivery of mothers of induced labor and the likelihood of delivery within 24 hours, compared with the existing cervix and Bishop score.
  • a total of 48 mothers were included, except for fertility mothers, pregnancy addiction, fetal malformations, maternal diabetes, and twins. All the procedures were carried out with the consent of the mother, and there was no mother's benefit from the test or the mother's disadvantage due to the test, and the procedure of the test was explained.
  • Table 1 shows the Elastographic data and the predictive value of cesarean section for clinical variables.
  • the highest sensitivity and specificity for predicting caesarean section of CxHardArea of cervix with highest AUC was 192.4mm 2 .
  • the sensitivity was 83.3%, specificity 75.0%, positive predictive value 52.6%, and negative predictive value 93.1%.
  • Table 2 shows the Elastographic data and the predictive value of cesarean section for clinical variables.

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Abstract

La présente invention concerne l'utilisation d'une technique d'analyse d'image pour une image élastographique d'un col de l'utérus afin d'évaluer l'état du col de l'utérus d'une femme enceinte. Plus particulièrement, la présente invention concerne l'utilisation d'une technique d'analyse d'image, qui implique la mise en œuvre d'une élastographie sur un col de l'utérus afin d'évaluer l'état du col de l'utérus d'une femme enceinte, et l'analyse des données d'imagerie élastographique obtenues au moyen de l'élastographie en utilisant un analyseur d'images, afin d'obtenir ainsi des données numériques objectives sur l'état du col de l'utérus et qui permet de s'affranchir du jugement subjectif d'un observateur.
PCT/KR2012/003235 2011-04-29 2012-04-26 Utilisation d'une technique d'analyse d'image pour une image élastographique d'un col de l'utérus afin d'évaluer l'état du col de l'utérus d'une femme enceinte Ceased WO2012148188A2 (fr)

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KR1020110040618A KR101250456B1 (ko) 2011-04-29 2011-04-29 산모의 자궁경부 상태를 평가하기 위하여 자궁경부 탄성 이미지에 대한 이미지 분석기법의 활용
KR10-2011-0040618 2011-04-29

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108135570A (zh) * 2015-10-20 2018-06-08 三星麦迪森株式会社 超声成像设备和超声成像设备的控制方法
EP3351181A1 (fr) * 2017-01-18 2018-07-25 Samsung Medison Co., Ltd. Appareil d'imagerie par ultrasons et procédé d'affichage d'images ultrasonores
EP3851053A1 (fr) * 2020-01-17 2021-07-21 Samsung Medison Co., Ltd. Appareil d'imagerie à ultrasons

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KR102356719B1 (ko) 2014-12-01 2022-01-27 삼성메디슨 주식회사 초음파 영상 장치 및 그 동작 방법
KR102361612B1 (ko) * 2014-12-16 2022-02-10 삼성메디슨 주식회사 초음파 진단장치 및 그에 따른 초음파 진단 장치의 동작 방법
US11250564B2 (en) * 2019-12-19 2022-02-15 GE Precision Healthcare LLC Methods and systems for automatic measurement of strains and strain-ratio calculation for sonoelastography
KR102482468B1 (ko) * 2020-08-11 2022-12-28 연세대학교 산학협력단 조산에 대한 정보 제공 방법 및 이를 적용한 디바이스
KR102823321B1 (ko) * 2022-01-17 2025-06-19 연세대학교 산학협력단 자궁 경부에 대한 정보 제공 방법 및 이를 이용한 자궁 경부에 대한 정보 제공용 디바이스

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US7297116B2 (en) * 2003-04-21 2007-11-20 Wisconsin Alumni Research Foundation Method and apparatus for imaging the cervix and uterine wall
JP4455003B2 (ja) * 2003-10-14 2010-04-21 株式会社日立メディコ 超音波診断装置
US20070161905A1 (en) 2006-01-12 2007-07-12 Gynesonics, Inc. Intrauterine ultrasound and method for use
KR101023659B1 (ko) * 2008-10-29 2011-03-25 주식회사 메디슨 다수의 분할 화면을 디스플레이하는 초음파 시스템
JP2010124946A (ja) * 2008-11-26 2010-06-10 Ge Medical Systems Global Technology Co Llc 超音波診断装置及びプログラム
KR20100091271A (ko) * 2009-02-10 2010-08-19 주식회사 메디슨 다중 뷰 디스플레이를 이용하여 대상체 정보를 제공하는 초음파 시스템 및 방법

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108135570A (zh) * 2015-10-20 2018-06-08 三星麦迪森株式会社 超声成像设备和超声成像设备的控制方法
EP3364881A4 (fr) * 2015-10-20 2019-07-10 Samsung Medison Co., Ltd. Appareil d'imagerie par ultrasons et son procédé de commande
US11219429B2 (en) 2015-10-20 2022-01-11 Samsung Medison Co., Ltd. Ultrasound imaging apparatus and controlling method for the same
EP3351181A1 (fr) * 2017-01-18 2018-07-25 Samsung Medison Co., Ltd. Appareil d'imagerie par ultrasons et procédé d'affichage d'images ultrasonores
US11013494B2 (en) 2017-01-18 2021-05-25 Samsung Medison Co., Ltd. Ultrasound imaging apparatus and ultrasound image display method
EP3851053A1 (fr) * 2020-01-17 2021-07-21 Samsung Medison Co., Ltd. Appareil d'imagerie à ultrasons

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KR101250456B1 (ko) 2013-04-08
KR20120122455A (ko) 2012-11-07
WO2012148188A9 (fr) 2013-03-21

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