WO2012148247A3 - 올레아놀린산 아세테이트를 유효성분으로 포함하는 tlr 및 il-6 매개성 질환예방 또는 치료용 약학적 조성물 - Google Patents

올레아놀린산 아세테이트를 유효성분으로 포함하는 tlr 및 il-6 매개성 질환예방 또는 치료용 약학적 조성물 Download PDF

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WO2012148247A3
WO2012148247A3 PCT/KR2012/003383 KR2012003383W WO2012148247A3 WO 2012148247 A3 WO2012148247 A3 WO 2012148247A3 KR 2012003383 W KR2012003383 W KR 2012003383W WO 2012148247 A3 WO2012148247 A3 WO 2012148247A3
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tlr
preventing
mediated diseases
pharmaceutical composition
active ingredient
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WO2012148247A2 (ko
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노문철
이우송
오현미
김영민
류영배
박수진
이승웅
조경오
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Korea Research Institute of Bioscience and Biotechnology
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Priority to US14/114,559 priority Critical patent/US20140179780A1/en
Priority to EP12776128.6A priority patent/EP2823819B1/en
Priority to CN201280032711.6A priority patent/CN103648502B/zh
Priority to JP2014508299A priority patent/JP5932972B2/ja
Publication of WO2012148247A2 publication Critical patent/WO2012148247A2/ko
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Abstract

본 발명은 올레아놀린산 아세테이트(oleanolic acid acetate) 또는 이의 약학적으로 허용되는 염을 유효성분으로 포함하는 TLR 및 IL-6 매개성 질환의 예방 또는 치료용 약학적 조성물, 및 상기 화합물 또는 염을 포함하는 적소두 추출물 또는 이의 분획물을 유효성분으로 포함하는 TLR 및 IL-6 매개성 질환의 예방 또는 치료용 약학적 조성물에 관한 것이다. 본 발명의 적소두 추출물 또는 화합물은 오랫동안 천연약재로서 사용되어온 천연물에서 유래되어 부작용이 없으면서도, dsRNA 및 ssRNA의 합성 유사체인 Poly(I:C)와 Poly(I)에 의해 유도되는 TLR-3 및 TLR-7의 활성저해 및 NF-κB를 포함하는 신호전달 경로를 차단하고, IL-6에 의해 활성화되는 염증관련 전사인자인 STAT3의 전사활성 및 인산화를 저해함으로써, TLR 및 IL-6 매개성 질환, 예컨대 아토피성 피부염 또는 관절염 등의 예방 또는 치료제의 개발에 널리 활용될 수 있을 것이다.
PCT/KR2012/003383 2011-04-29 2012-04-30 올레아놀린산 아세테이트를 유효성분으로 포함하는 tlr 및 il-6 매개성 질환예방 또는 치료용 약학적 조성물 Ceased WO2012148247A2 (ko)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US14/114,559 US20140179780A1 (en) 2011-04-29 2012-04-30 Pharmaceutical composition containing oleanolic acid acetate as an active ingredient for preventing or treating tlr- or il-6-mediated diseases
EP12776128.6A EP2823819B1 (en) 2011-04-29 2012-04-30 Oleanolic acid acetate as an active ingredient for preventing or treating tlr- or il-6-mediated diseases
CN201280032711.6A CN103648502B (zh) 2011-04-29 2012-04-30 包含齐墩果酸乙酸酯作为有效成分的预防或者治疗tlr及il‑6介导疾病的药物组合物
JP2014508299A JP5932972B2 (ja) 2011-04-29 2012-04-30 オレアノール酸アセテートを有効成分として含むｔｌｒ及びｉｌ−６媒介性疾患の予防又は治療用の薬学的組成物

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2011-0041189 2011-04-29
KR20110041189 2011-04-29
KR10-2011-0098547 2011-09-28
KR1020110098547A KR101178947B1 (ko) 2011-04-29 2011-09-28 올레아놀린산 아세테이트를 유효성분으로 포함하는 ｔｌｒ 및 ｉｌ-6 매개성 질환 예방 또는 치료용 약학적 조성물

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WO2012148247A2 WO2012148247A2 (ko) 2012-11-01
WO2012148247A3 true WO2012148247A3 (ko) 2013-01-24

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PCT/KR2012/003383 Ceased WO2012148247A2 (ko) 2011-04-29 2012-04-30 올레아놀린산 아세테이트를 유효성분으로 포함하는 tlr 및 il-6 매개성 질환예방 또는 치료용 약학적 조성물

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US (1) US20140179780A1 (ko)
EP (1) EP2823819B1 (ko)
JP (1) JP5932972B2 (ko)
KR (3) KR101178947B1 (ko)
CN (2) CN108143737B (ko)
WO (1) WO2012148247A2 (ko)

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CN103768078B (zh) * 2012-10-22 2019-02-05 北京大学 三萜衍生物及其抗流感用途
JP6446269B2 (ja) * 2012-12-06 2018-12-26 協和発酵バイオ株式会社 アジュバント用二重鎖リボ核酸
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WO2017014502A1 (ko) * 2015-07-17 2017-01-26 한국생명공학연구원 해당화 꽃 추출물을 유효성분으로 포함하는 il-6 매개성 질환의 예방 또는 치료용 약학적 조성물
KR101737277B1 (ko) 2016-10-04 2017-05-18 한국생명공학연구원 올레아놀린산 아세테이트를 유효성분으로 포함하는 약제에 의해 유발되는 신장독성의 예방, 개선 또는 치료용 조성물
CN106619654A (zh) * 2016-12-27 2017-05-10 广西中医药大学 齐墩果酸在制备治疗痛风药物中的应用
KR101957632B1 (ko) * 2017-06-30 2019-03-12 한국생명공학연구원 섬유화증 예방, 개선 또는 치료용 조성물
KR101935371B1 (ko) 2018-05-17 2019-01-07 부산대학교 산학협력단 말톨, 이소소이아말로사이드 i 또는 이들의 혼합물을 유효성분으로 함유하는 아토피성 피부염 예방 또는 치료용 조성물
KR101978761B1 (ko) * 2018-08-22 2019-05-15 (주)휴벳 반려동물용 보조사료 및 이의 제조방법
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EP2823819A2 (en) 2015-01-14
KR101271562B1 (ko) 2013-06-11
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JP5932972B2 (ja) 2016-06-08
US20140179780A1 (en) 2014-06-26
EP2823819A4 (en) 2015-12-23
CN108143737A (zh) 2018-06-12
KR20120122870A (ko) 2012-11-07
CN103648502A (zh) 2014-03-19
CN108143737B (zh) 2020-11-24
KR20120124361A (ko) 2012-11-13
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