WO2012149097A3 - Dérivés de guanidylimidazole et de guanidylimidazoline en tant qu'agents anti-malaria, leur synthèse et leurs procédés d'utilisation - Google Patents

Dérivés de guanidylimidazole et de guanidylimidazoline en tant qu'agents anti-malaria, leur synthèse et leurs procédés d'utilisation Download PDF

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Publication number
WO2012149097A3
WO2012149097A3 PCT/US2012/035105 US2012035105W WO2012149097A3 WO 2012149097 A3 WO2012149097 A3 WO 2012149097A3 US 2012035105 W US2012035105 W US 2012035105W WO 2012149097 A3 WO2012149097 A3 WO 2012149097A3
Authority
WO
WIPO (PCT)
Prior art keywords
derivatives
methods
guanidylimidazoline
guanidylimidazole
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2012/035105
Other languages
English (en)
Other versions
WO2012149097A2 (fr
Inventor
Ai J. Lin
Michael P. Kozar
Micahel T. O'NEIL
Liang Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
United States Department of the Army
Original Assignee
United States Department of the Army
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by United States Department of the Army filed Critical United States Department of the Army
Publication of WO2012149097A2 publication Critical patent/WO2012149097A2/fr
Anticipated expiration legal-status Critical
Publication of WO2012149097A3 publication Critical patent/WO2012149097A3/fr
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne de nouveaux dérivés de guanidylimidazole et dérivés de guanidylimidazoline, des procédés de fabrication de ces composés, des compositions les contenant et des procédés d'utilisation de ceux-ci pour prévenir, traiter ou inhiber la malaria chez un sujet.
PCT/US2012/035105 2011-04-26 2012-04-26 Dérivés de guanidylimidazole et de guanidylimidazoline en tant qu'agents anti-malaria, leur synthèse et leurs procédés d'utilisation Ceased WO2012149097A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161517858P 2011-04-26 2011-04-26
US61/517,858 2011-04-26

Publications (2)

Publication Number Publication Date
WO2012149097A2 WO2012149097A2 (fr) 2012-11-01
WO2012149097A3 true WO2012149097A3 (fr) 2014-05-01

Family

ID=47073059

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/035105 Ceased WO2012149097A2 (fr) 2011-04-26 2012-04-26 Dérivés de guanidylimidazole et de guanidylimidazoline en tant qu'agents anti-malaria, leur synthèse et leurs procédés d'utilisation

Country Status (1)

Country Link
WO (1) WO2012149097A2 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050148645A1 (en) * 2003-11-21 2005-07-07 Lin Ai J. 2-Guanidinylimidazolidinedione compounds and methods of making and using thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050148645A1 (en) * 2003-11-21 2005-07-07 Lin Ai J. 2-Guanidinylimidazolidinedione compounds and methods of making and using thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JAIN ET AL.: "Antimalarial Activities of Ring-Substituted Bioimidazoles.", BIOORGANIC AND MEDICINAL CHEMISTRY, vol. 12, 2002, pages 1701 - 1704 *
SUH ET AL.: "Novel Potent Antagonists of Transient Receptor Potential Channel, Vanilloid Subfamily Member 1: Structure-Activity Relationship of 1,3-Diarylalkyl Thioureas Possessing New Vanilloid Equivalents.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, 2005, pages 5823 - 5836 *

Also Published As

Publication number Publication date
WO2012149097A2 (fr) 2012-11-01

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