WO2012149226A3 - Caractérisation à base d'imagerie par résonance magnétique (irm) d'une obstruction microvasculaire en réponse à une hypothermie thérapeutique après un infarctus aigu du myocarde - Google Patents

Caractérisation à base d'imagerie par résonance magnétique (irm) d'une obstruction microvasculaire en réponse à une hypothermie thérapeutique après un infarctus aigu du myocarde Download PDF

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Publication number
WO2012149226A3
WO2012149226A3 PCT/US2012/035307 US2012035307W WO2012149226A3 WO 2012149226 A3 WO2012149226 A3 WO 2012149226A3 US 2012035307 W US2012035307 W US 2012035307W WO 2012149226 A3 WO2012149226 A3 WO 2012149226A3
Authority
WO
WIPO (PCT)
Prior art keywords
subject
reducing
microvascular
myocardial infarction
therapeutic hypothermia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2012/035307
Other languages
English (en)
Other versions
WO2012149226A2 (fr
Inventor
Rohan Dharmakumar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cedars Sinai Medical Center
Original Assignee
Cedars Sinai Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cedars Sinai Medical Center filed Critical Cedars Sinai Medical Center
Publication of WO2012149226A2 publication Critical patent/WO2012149226A2/fr
Publication of WO2012149226A3 publication Critical patent/WO2012149226A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/10—Cooling bags, e.g. ice-bags
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room
    • A61B5/004—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
    • A61B5/0044—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the heart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/12—Devices for heating or cooling internal body cavities
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/563—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution of moving material, e.g. flow contrast angiography
    • G01R33/56366—Perfusion imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2576/00—Medical imaging apparatus involving image processing or analysis
    • A61B2576/02—Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part
    • A61B2576/023—Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part for the heart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/12—Devices for heating or cooling internal body cavities
    • A61F2007/126—Devices for heating or cooling internal body cavities for invasive application, e.g. for introducing into blood vessels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5602—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution by filtering or weighting based on different relaxation times within the sample, e.g. T1 weighting using an inversion pulse
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H30/00—ICT specially adapted for the handling or processing of medical images
    • G16H30/40—ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Thermal Sciences (AREA)
  • Cardiology (AREA)
  • Signal Processing (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention porte sur des procédés pour réduire des obstructions microvasculaires, réduire des obstructions microvasculaires hémorragiques et/ou réduire une lésion due à une reperfusion consécutivement à une ischémie chez un sujet en ayant besoin par utilisation d'une hypothermie thérapeutique et surveillance du résultat de l'intervention avec une norme d'imagerie non invasive.
PCT/US2012/035307 2011-04-29 2012-04-26 Caractérisation à base d'imagerie par résonance magnétique (irm) d'une obstruction microvasculaire en réponse à une hypothermie thérapeutique après un infarctus aigu du myocarde Ceased WO2012149226A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161481001P 2011-04-29 2011-04-29
US61/481,001 2011-04-29

Publications (2)

Publication Number Publication Date
WO2012149226A2 WO2012149226A2 (fr) 2012-11-01
WO2012149226A3 true WO2012149226A3 (fr) 2013-01-03

Family

ID=47073074

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/035307 Ceased WO2012149226A2 (fr) 2011-04-29 2012-04-26 Caractérisation à base d'imagerie par résonance magnétique (irm) d'une obstruction microvasculaire en réponse à une hypothermie thérapeutique après un infarctus aigu du myocarde

Country Status (1)

Country Link
WO (1) WO2012149226A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10471094B2 (en) 2013-08-05 2019-11-12 Cedars-Sinai Medical Center Methods for reducing ischemia-reperfusion injury via targeted control of blood gases

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040167467A1 (en) * 2003-02-21 2004-08-26 Kent Harrison Delivering cooled fluid to sites inside the body
US20070014764A1 (en) * 2005-07-18 2007-01-18 Andrew Levy Reduction in myocardial infarction size
US20100168649A1 (en) * 2006-08-02 2010-07-01 Osprey Medical, Inc. Microvascular obstruction detection and therapy
US20110184384A1 (en) * 2007-11-27 2011-07-28 Abbott Cardiovascular Systems Inc. Blood Vessel Permeability-Enhancement For The Treatment Of Vascular Diseases

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040167467A1 (en) * 2003-02-21 2004-08-26 Kent Harrison Delivering cooled fluid to sites inside the body
US20070014764A1 (en) * 2005-07-18 2007-01-18 Andrew Levy Reduction in myocardial infarction size
US20100168649A1 (en) * 2006-08-02 2010-07-01 Osprey Medical, Inc. Microvascular obstruction detection and therapy
US20110184384A1 (en) * 2007-11-27 2011-07-28 Abbott Cardiovascular Systems Inc. Blood Vessel Permeability-Enhancement For The Treatment Of Vascular Diseases

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HALE ET AL.: "Mild Hypothermia as a Cardioprotective Approach for Acute Myocardial Infarction: Laboratory to Clinical Application.", JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, vol. 16, no. 2, 13 December 2010 (2010-12-13), pages 131 - 139, Retrieved from the Internet <URL:http://cpt.sagepub.com/content/16/2/131.short> [retrieved on 20120707] *
SELIMOGLU ET AL.: "A practical and effective approach for the prevention of ischemia- reperfusion injury after acute myocardial infarction: pressure-regulated tepid blood reperfusion.", HEART SURGERY FORUM, vol. 10, no. 4, 2007, pages E309 - E314, Retrieved from the Internet <URL:http://www.ncbi.nlm.nih.gov/pubmed/17599881> [retrieved on 20120707] *

Also Published As

Publication number Publication date
WO2012149226A2 (fr) 2012-11-01

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