WO2012151272A3 - Vaccination avec des lymphocytes t à l'aide de vecteurs viraux par rupture épidermique mécanique - Google Patents

Vaccination avec des lymphocytes t à l'aide de vecteurs viraux par rupture épidermique mécanique Download PDF

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Publication number
WO2012151272A3
WO2012151272A3 PCT/US2012/036114 US2012036114W WO2012151272A3 WO 2012151272 A3 WO2012151272 A3 WO 2012151272A3 US 2012036114 W US2012036114 W US 2012036114W WO 2012151272 A3 WO2012151272 A3 WO 2012151272A3
Authority
WO
WIPO (PCT)
Prior art keywords
vaccine
mechanically disrupted
viral vectors
virus
via mechanical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2012/036114
Other languages
English (en)
Other versions
WO2012151272A2 (fr
Inventor
Thomas S. Kupper
Luzheng Liu
Rachael A. Clark
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TremRx Inc
Original Assignee
TremRx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/099,235 external-priority patent/US8691502B2/en
Application filed by TremRx Inc filed Critical TremRx Inc
Publication of WO2012151272A2 publication Critical patent/WO2012151272A2/fr
Publication of WO2012151272A3 publication Critical patent/WO2012151272A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Dans la présente invention, on utilise des virus atténués déficients en termes de réplication tels que des virus de la vaccine pour livrer un antigène exogène viral, bactérien, parasite ou tumoral à un tissu épidermique tel que la peau, les poumons ou le tractus gastrointestinal, qui a été mécaniquement rompu, suivant une quantité efficace pour éliciter ou stimuler une réponse immune médiée par la cellule. Le tissu épidermique peut être mécaniquement rompu au moyen d'un dispositif tel qu'une aiguille de scarification ou un dispositif abrasif. L'épiderme peut être mécaniquement rompu avant, en même temps ou immédiatement après l'administration du vaccin. Le vaccin peut être utilisé pour induire une immunité contre un agent pathogène, tel qu'un virus, une bactérie ou un parasite ou encore contre un cancer chez un individu qui est déjà atteint d'un cancer ou présente un risque de le développer. Dans certains modes de réalisation, une molécule de costimulation, un facteur de croissance, un adjuvant et/ou une cytokine est administré avant, en même temps ou après le vaccin viral. Dans certains modes de réalisation, la molécule de costimulation est co-exprimée avec l'antigène par le virus.
PCT/US2012/036114 2011-05-02 2012-05-02 Vaccination avec des lymphocytes t à l'aide de vecteurs viraux par rupture épidermique mécanique Ceased WO2012151272A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13/099,235 2011-05-02
US13/099,235 US8691502B2 (en) 2008-10-31 2011-05-02 T-cell vaccination with viral vectors via mechanical epidermal disruption

Publications (2)

Publication Number Publication Date
WO2012151272A2 WO2012151272A2 (fr) 2012-11-08
WO2012151272A3 true WO2012151272A3 (fr) 2012-12-27

Family

ID=46168616

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/036114 Ceased WO2012151272A2 (fr) 2011-05-02 2012-05-02 Vaccination avec des lymphocytes t à l'aide de vecteurs viraux par rupture épidermique mécanique

Country Status (1)

Country Link
WO (1) WO2012151272A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190336552A1 (en) 2016-05-30 2019-11-07 Astellas Pharma Inc. Genetically engineered vaccinia viruses
WO2017209053A1 (fr) 2016-05-30 2017-12-07 アステラス製薬株式会社 Nouveau virus de la vaccine génétiquement modifié
EP3858369A4 (fr) 2018-09-26 2022-07-20 Astellas Pharma Inc. Thérapie anticancéreuse dans laquelle un virus de la vaccine oncolytique et un inhibiteur des points de contrôle immunitaire sont utilisés en combinaison, et composition pharmaceutique et médicament combiné utilisés dans celle-ci
WO2023077147A2 (fr) * 2021-11-01 2023-05-04 Pellis Therapeutics, Inc. Vaccins à lymphocytes t pour patients présentant une immunité humorale réduite
US20230364227A1 (en) * 2022-05-12 2023-11-16 Pellis Therapeutics, Inc. Poxvirus adjuvant for t-cell vaccination
CN114748627B (zh) * 2022-05-13 2023-10-27 中国医学科学院北京协和医院 可溶性cd58在胰腺癌预防和治疗中的应用

Citations (4)

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Publication number Priority date Publication date Assignee Title
EP0180490A1 (fr) * 1984-09-12 1986-05-07 AGENCE NATIONALE DE VALORISATION DE LA RECHERCHE (A.N.V.A.R.) Etablissement public de droit français Molécule synthétique contenant une pluralité d'épitopes distincts, procédé pour son obtention et application à la production de polyvaccins
GB2322130A (en) * 1997-02-13 1998-08-19 Secr Defence Simian herpes B virus glycoprotein D and its use in recombinant viral vaccines
WO2005103303A2 (fr) * 2004-04-13 2005-11-03 Alza Corporation Appareil et procede d'administration transdermique de multiples vaccins
US7378101B2 (en) * 2001-12-21 2008-05-27 Pfizer, Inc. Vaccine for periodontal disease

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US4603112A (en) 1981-12-24 1986-07-29 Health Research, Incorporated Modified vaccinia virus
DE10399032I1 (de) 1987-08-28 2004-01-29 Health Research Inc Rekombinante Viren.
CA1340203C (fr) 1987-09-16 1998-12-15 Noboru Yanagida Virus de la variole aviaire, recombinant
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WO1991019803A1 (fr) 1990-06-19 1991-12-26 Applied Biotechnology, Incorporated Particules virales autoassemblees defectueuses qui ne se propagent pas d'elles-memes
US6045802A (en) 1994-10-03 2000-04-04 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Enhanced immune response to an antigen by a composition of a recombinant virus expressing the antigen with a recombinant virus expressing an immunostimulatory molecule
UA68327C2 (en) 1995-07-04 2004-08-16 Gsf Forschungszentrum Fur Unwe A recombinant mva virus, an isolated eukaryotic cell, infected with recombinant mva virus, a method for production in vitro of polypeptides with use of said cell, a method for production in vitro of virus parts (variants), vaccine containing the recombinant mva virus, a method for immunization of animals
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EP0180490A1 (fr) * 1984-09-12 1986-05-07 AGENCE NATIONALE DE VALORISATION DE LA RECHERCHE (A.N.V.A.R.) Etablissement public de droit français Molécule synthétique contenant une pluralité d'épitopes distincts, procédé pour son obtention et application à la production de polyvaccins
GB2322130A (en) * 1997-02-13 1998-08-19 Secr Defence Simian herpes B virus glycoprotein D and its use in recombinant viral vaccines
US7378101B2 (en) * 2001-12-21 2008-05-27 Pfizer, Inc. Vaccine for periodontal disease
WO2005103303A2 (fr) * 2004-04-13 2005-11-03 Alza Corporation Appareil et procede d'administration transdermique de multiples vaccins

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