WO2012166554A8 - Conduits en matière de matrice extracellulaire et procédés de fabrication et d'utilisation de ces conduits - Google Patents

Conduits en matière de matrice extracellulaire et procédés de fabrication et d'utilisation de ces conduits Download PDF

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Publication number
WO2012166554A8
WO2012166554A8 PCT/US2012/039450 US2012039450W WO2012166554A8 WO 2012166554 A8 WO2012166554 A8 WO 2012166554A8 US 2012039450 W US2012039450 W US 2012039450W WO 2012166554 A8 WO2012166554 A8 WO 2012166554A8
Authority
WO
WIPO (PCT)
Prior art keywords
methods
extracellular matrix
making
same
matrix material
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2012/039450
Other languages
English (en)
Other versions
WO2012166554A3 (fr
WO2012166554A2 (fr
Inventor
Robert G. Matheny
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cormatrix Cardiovascular Inc
Original Assignee
Cormatrix Cardiovascular Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BR112013030482A priority Critical patent/BR112013030482A2/pt
Priority to KR1020137031538A priority patent/KR20140145954A/ko
Priority to SG2013083167A priority patent/SG194878A1/en
Priority to EP12793466.9A priority patent/EP2714068B1/fr
Priority to AU2012262554A priority patent/AU2012262554B2/en
Priority to JP2014512122A priority patent/JP2014519379A/ja
Application filed by Cormatrix Cardiovascular Inc filed Critical Cormatrix Cardiovascular Inc
Priority to CA2835859A priority patent/CA2835859A1/fr
Publication of WO2012166554A2 publication Critical patent/WO2012166554A2/fr
Priority to IL229287A priority patent/IL229287B/en
Anticipated expiration legal-status Critical
Publication of WO2012166554A8 publication Critical patent/WO2012166554A8/fr
Publication of WO2012166554A3 publication Critical patent/WO2012166554A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2415—Manufacturing methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3633—Extracellular matrix [ECM]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/16—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using chemical substances
    • A61L2/20—Gaseous substances, e.g. vapours
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/20—Materials or treatment for tissue regeneration for reconstruction of the heart, e.g. heart valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Manufacturing & Machinery (AREA)
  • Prostheses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • External Artificial Organs (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention porte sur des conduits en matière à matrice extracellulaire (ECM). L'invention a pour objet des procédés de régénération de valvules atrioventriculaires destinés à remplacer des valvules atrioventriculaires défectueuses dans le cœur d'un sujet en utilisant des conduits en matière ECM sont également décrits. L'invention porte aussi sur des procédés de stérilisation et de décellularisation d'une matière ECM.
PCT/US2012/039450 2011-05-27 2012-05-24 Conduits en matière de matrice extracellulaire et procédés de fabrication et d'utilisation de ces conduits Ceased WO2012166554A2 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CA2835859A CA2835859A1 (fr) 2011-05-27 2012-05-24 Conduits en matiere de matrice extracellulaire et procedes de fabrication et d'utilisation de ces conduits
SG2013083167A SG194878A1 (en) 2011-05-27 2012-05-24 Extracellular matrix material conduits and methods of making and using same
EP12793466.9A EP2714068B1 (fr) 2011-05-27 2012-05-24 Conduits en matière de matrice extracellulaire et procédés de fabrication et d'utilisation de ces conduits
AU2012262554A AU2012262554B2 (en) 2011-05-27 2012-05-24 Extracellular matrix material conduits and methods of making and using same
JP2014512122A JP2014519379A (ja) 2011-05-27 2012-05-24 細胞外マトリックス材料の導管並びにその製造方法及び使用方法
BR112013030482A BR112013030482A2 (pt) 2011-05-27 2012-05-24 método de regeneração de uma válvula atrioventricular e duto de material de matriz extracelular
KR1020137031538A KR20140145954A (ko) 2011-05-27 2012-05-24 세포외 기질 물질 도관 및 이의 제조 및 사용 방법
IL229287A IL229287B (en) 2011-05-27 2013-11-06 Extracellular matrix material conduits and methods of making and using same

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201161490693P 2011-05-27 2011-05-27
US201161490873P 2011-05-27 2011-05-27
US61/490,693 2011-05-27
US61/490,873 2011-05-27
US201161491723P 2011-05-31 2011-05-31
US61/491,723 2011-05-31
US201261650911P 2012-05-23 2012-05-23
US61/650,911 2012-05-23

Publications (3)

Publication Number Publication Date
WO2012166554A2 WO2012166554A2 (fr) 2012-12-06
WO2012166554A8 true WO2012166554A8 (fr) 2014-01-23
WO2012166554A3 WO2012166554A3 (fr) 2014-05-08

Family

ID=47260207

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/039450 Ceased WO2012166554A2 (fr) 2011-05-27 2012-05-24 Conduits en matière de matrice extracellulaire et procédés de fabrication et d'utilisation de ces conduits

Country Status (8)

Country Link
JP (2) JP2014519379A (fr)
KR (1) KR20140145954A (fr)
AU (1) AU2012262554B2 (fr)
BR (1) BR112013030482A2 (fr)
CA (1) CA2835859A1 (fr)
IL (1) IL229287B (fr)
SG (1) SG194878A1 (fr)
WO (1) WO2012166554A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120302499A1 (en) 2011-05-27 2012-11-29 Matheny Robert G Sterilized, acellular extracellular matrix compositions and methods of making thereof
WO2014133543A1 (fr) * 2013-03-01 2014-09-04 Cormatrix Cardiovascular, Inc. Valvule prothétique en deux parties
US11147673B2 (en) 2018-05-22 2021-10-19 Boston Scientific Scimed, Inc. Percutaneous papillary muscle relocation

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4790844A (en) * 1987-01-30 1988-12-13 Yoel Ovil Replacement of cardiac valves in heart surgery
US4902508A (en) 1988-07-11 1990-02-20 Purdue Research Foundation Tissue graft composition
CA2441679A1 (fr) * 1991-05-16 1992-11-26 3F Therapeutics, Inc. Valve cardiaque
US5281422A (en) 1991-09-24 1994-01-25 Purdue Research Foundation Graft for promoting autogenous tissue growth
US5275826A (en) 1992-11-13 1994-01-04 Purdue Research Foundation Fluidized intestinal submucosa and its use as an injectable tissue graft
US5480424A (en) 1993-11-01 1996-01-02 Cox; James L. Heart valve replacement using flexible tubes
US5713950A (en) 1993-11-01 1998-02-03 Cox; James L. Method of replacing heart valves using flexible tubes
US5554389A (en) 1995-04-07 1996-09-10 Purdue Research Foundation Urinary bladder submucosa derived tissue graft
JP2001505807A (ja) * 1996-12-10 2001-05-08 パーデュー・リサーチ・ファウンデーション 人工血管弁
US6933326B1 (en) 1998-06-19 2005-08-23 Lifecell Coporation Particulate acellular tissue matrix
US6579538B1 (en) 1999-12-22 2003-06-17 Acell, Inc. Tissue regenerative compositions for cardiac applications, method of making, and method of use thereof
US7033611B2 (en) 2001-02-23 2006-04-25 Biora Bioex Ab Matrix protein compositions for guided connective tissue growth
AU2003234505A1 (en) * 2002-05-03 2003-11-17 The General Hospital Corporation Involuted endovascular valve and method of construction
US7550004B2 (en) * 2002-08-20 2009-06-23 Cook Biotech Incorporated Endoluminal device with extracellular matrix material and methods
US7087034B2 (en) * 2002-09-19 2006-08-08 Mcpherson William E Vascular shunt with audio flow indication
CO5500017A1 (es) * 2002-09-23 2005-03-31 3F Therapeutics Inc Valvula mitral protesica
WO2005000364A2 (fr) 2003-06-23 2005-01-06 Novasterilis Inc. Procedes et dispositif de sterilisation utilisant un sterilisant supercritique au dioxyde de carbone
DE10340265A1 (de) * 2003-08-29 2005-04-07 Sievers, Hans-Hinrich, Prof. Dr.med. Prothese zum Ersatz der Aorten- und/oder Mitralklappe des Herzens
JP2007105081A (ja) * 2005-10-11 2007-04-26 Japan Health Science Foundation 超臨界二酸化炭素による移植用生体組織の脱細胞処理
US20090157177A1 (en) * 2007-12-18 2009-06-18 Matheny Robert G Sewing Ring for a Prosthetic Tissue Valve

Also Published As

Publication number Publication date
CA2835859A1 (fr) 2012-12-06
JP2017060776A (ja) 2017-03-30
JP2014519379A (ja) 2014-08-14
AU2012262554A1 (en) 2013-11-28
WO2012166554A3 (fr) 2014-05-08
WO2012166554A2 (fr) 2012-12-06
IL229287B (en) 2019-05-30
BR112013030482A2 (pt) 2016-09-27
IL229287A0 (en) 2014-01-30
SG194878A1 (en) 2013-12-30
KR20140145954A (ko) 2014-12-24
AU2012262554B2 (en) 2016-09-15
AU2012262554A8 (en) 2014-02-27

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