WO2012166700A3 - Profilage moléculaire d'un microenvironnement de tumeur létale - Google Patents

Profilage moléculaire d'un microenvironnement de tumeur létale Download PDF

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Publication number
WO2012166700A3
WO2012166700A3 PCT/US2012/039814 US2012039814W WO2012166700A3 WO 2012166700 A3 WO2012166700 A3 WO 2012166700A3 US 2012039814 W US2012039814 W US 2012039814W WO 2012166700 A3 WO2012166700 A3 WO 2012166700A3
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WO
WIPO (PCT)
Prior art keywords
cancer
subject
tumor microenvironment
molecular profiling
useful
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Ceased
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PCT/US2012/039814
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English (en)
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WO2012166700A2 (fr
Inventor
Michael P. Lisanti
Federica Sotgia
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Individual
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Individual
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Publication of WO2012166700A2 publication Critical patent/WO2012166700A2/fr
Publication of WO2012166700A3 publication Critical patent/WO2012166700A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La présente invention concerne des marqueurs biologiques utiles relatifs à des cancers ayant des éléments du stroma. Ces marqueurs biologiques nouvellement identifiés sont utiles en tant que signatures de pronostic pour évaluer un pronostic de cancer chez un sujet ayant un cancer (par exemple, risque de récurrence de cancer, progression d'un cancer chez un sujet ayant un cancer, survie globale du cancer par un patient ayant un cancer). Ils peuvent également être mis en œuvre en tant que procédé de surveillance de l'évolution d'un cancer du sein chez des sujets subissant un traitement pour le cancer ou en tant que procédé de stratification d'un sujet ou d'un groupe de sujets ayant une tumeur cancéreuse pour un essai clinique.
PCT/US2012/039814 2011-05-29 2012-05-29 Profilage moléculaire d'un microenvironnement de tumeur létale Ceased WO2012166700A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161491218P 2011-05-29 2011-05-29
US201161491219P 2011-05-29 2011-05-29
US61/491,219 2011-05-29
US61/491,218 2011-05-29

Publications (2)

Publication Number Publication Date
WO2012166700A2 WO2012166700A2 (fr) 2012-12-06
WO2012166700A3 true WO2012166700A3 (fr) 2013-01-24

Family

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Family Applications (1)

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PCT/US2012/039814 Ceased WO2012166700A2 (fr) 2011-05-29 2012-05-29 Profilage moléculaire d'un microenvironnement de tumeur létale

Country Status (1)

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WO (1) WO2012166700A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101672531B1 (ko) * 2013-04-18 2016-11-17 주식회사 젠큐릭스 조기 유방암 예후 예측 진단용 유전자 마커 및 이의 용도
UY36586A (es) * 2015-03-26 2016-10-31 Bayer Pharma AG Heterociclilmetiltienouracilos y uso de los mismos
CA3063450A1 (fr) 2017-05-19 2018-11-22 Lunella Biotech, Inc. Diagnostic compagnon pour inhibiteurs mitochondriaux
WO2020077552A1 (fr) * 2018-10-17 2020-04-23 上海允英医疗科技有限公司 Procédé et système de prédiction pour un pronostic de tumeur
CN111778336B (zh) * 2020-07-23 2021-02-26 苏州班凯基因科技有限公司 用于肿瘤微环境综合量化评估的基因标志物组合及应用
CN115354078B (zh) * 2022-09-02 2023-07-07 中山大学附属第一医院 骨肉瘤检测标记物及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010096574A1 (fr) * 2009-02-20 2010-08-26 Lisanti Michael P Procédé de diagnostic ou de pronostic d'un néoplasme comprenant la détermination du taux d'expression d'une protéine dans des cellules stromales adjacentes au néoplasme

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010096574A1 (fr) * 2009-02-20 2010-08-26 Lisanti Michael P Procédé de diagnostic ou de pronostic d'un néoplasme comprenant la détermination du taux d'expression d'une protéine dans des cellules stromales adjacentes au néoplasme

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
SOTGIA ET AL.: "Caveolin-1-/- Null Mammary Stromal Fibroblasts Share Characteristics with Human Breast Cancer-Associated Fibroblasts.", AM J PATHOL, vol. 174, no. 3, March 2009 (2009-03-01), pages 746 - 761 *
WITKIEWICZ ET AL.: "Molecular profiling of a lethal tumor microenvironment, as defined by stromal caveolin-1 status in breast cancers.", CELL CYCLE, vol. 10, no. 11, 1 June 2010 (2010-06-01), pages 1794 - 1809, Retrieved from the Internet <URL:http://www.landesbioscience.com/journals/cc/article/15675> *
WITKIEWICZ ET AL.: "''Towards a new ''stromal-based'' classification system for human breast cancer prognosis and therapy''", CELL CYCLE, vol. 8, no. 11, June 2009 (2009-06-01), pages 1654 - 1658 *

Also Published As

Publication number Publication date
WO2012166700A2 (fr) 2012-12-06

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