WO2012166705A3 - Nanofibres et hydrogels supramoléculaires à base de conjugués acide aminé-nucléobase-glucoside - Google Patents

Nanofibres et hydrogels supramoléculaires à base de conjugués acide aminé-nucléobase-glucoside Download PDF

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Publication number
WO2012166705A3
WO2012166705A3 PCT/US2012/039821 US2012039821W WO2012166705A3 WO 2012166705 A3 WO2012166705 A3 WO 2012166705A3 US 2012039821 W US2012039821 W US 2012039821W WO 2012166705 A3 WO2012166705 A3 WO 2012166705A3
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WO
WIPO (PCT)
Prior art keywords
nucleobase
amino acid
supramolecular
hydrogels based
glycoside conjugates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2012/039821
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English (en)
Other versions
WO2012166705A2 (fr
Inventor
Bing Xu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brandeis University
Original Assignee
Brandeis University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brandeis University filed Critical Brandeis University
Publication of WO2012166705A2 publication Critical patent/WO2012166705A2/fr
Publication of WO2012166705A3 publication Critical patent/WO2012166705A3/fr
Anticipated expiration legal-status Critical
Priority to US14/093,974 priority Critical patent/US10093674B2/en
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L31/129—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix containing macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

L'invention concerne des promoteurs d'hydrogel qui comportent une nucléobase, un acide aminé et un glucoside. Ces promoteurs d'hydrogel présentent une résistance accrue aux protéases et peuvent former par auto-assemblage des nanofibres ou des hydrogels supramoléculaires. Ces structures supramoléculaires peuvent être utilisées pour favoriser la croissance de cellules ou pour délivrer une substance à une cellule.
PCT/US2012/039821 2011-05-31 2012-05-29 Nanofibres et hydrogels supramoléculaires à base de conjugués acide aminé-nucléobase-glucoside Ceased WO2012166705A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US14/093,974 US10093674B2 (en) 2011-05-31 2013-12-02 Supramolecular nanofibers and hydrogels based on nucleic acids functionalized with nucleobases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161491544P 2011-05-31 2011-05-31
US61/491,544 2011-05-31

Related Child Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/039822 Continuation-In-Part WO2012166706A2 (fr) 2011-05-31 2012-05-29 Nanofibres et hydrogels supramoléculaires à base d'oligopeptides fonctionnalisés par des nucléobases

Publications (2)

Publication Number Publication Date
WO2012166705A2 WO2012166705A2 (fr) 2012-12-06
WO2012166705A3 true WO2012166705A3 (fr) 2013-02-28

Family

ID=47260243

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/039821 Ceased WO2012166705A2 (fr) 2011-05-31 2012-05-29 Nanofibres et hydrogels supramoléculaires à base de conjugués acide aminé-nucléobase-glucoside

Country Status (1)

Country Link
WO (1) WO2012166705A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10308682B2 (en) 2013-03-06 2019-06-04 Brandeis University Inhibition of tumor growth with aggregates of small molecules
US10232037B2 (en) 2014-02-03 2019-03-19 Brandeis University Supramolecular hydrogel of fMLF-based molecules and use thereof
US10857243B2 (en) 2014-04-09 2020-12-08 Brandeis University Enzymatically responsive magnetic particles and their use
WO2016205459A2 (fr) * 2015-06-16 2016-12-22 The Johns Hopkins University Hydrogels thérapeutiques à base de nanofibres pour le traitement local des maladies liées au cerveau
US12246068B2 (en) 2017-01-06 2025-03-11 Brandeis University Enzymatically activatable peptide-redox modulator conjugates and use thereof
US11839661B2 (en) 2017-08-15 2023-12-12 Brandeis University Rapid formation of supramolecular hydrogels by short peptide and bioactive small molecules
US11834517B2 (en) 2017-09-18 2023-12-05 Brandeis University Branched peptides for enzymatic assembly and mitochondria drug delivery
WO2019055988A1 (fr) 2017-09-18 2019-03-21 Brandeis University Peptides ramifiés pour assemblage enzymatique et administration de médicament à des mitochondries

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5278284A (en) * 1992-05-14 1994-01-11 Miller Brewing Company Protein purification method
US20020081726A1 (en) * 2000-09-25 2002-06-27 Brenda Russell Microfabrication of membranes for the growth of cells
US20080057005A1 (en) * 2005-03-24 2008-03-06 Jean-Marie Lehn Hydrogels for the controlled release of bioactive materials

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5278284A (en) * 1992-05-14 1994-01-11 Miller Brewing Company Protein purification method
US20020081726A1 (en) * 2000-09-25 2002-06-27 Brenda Russell Microfabrication of membranes for the growth of cells
US20080057005A1 (en) * 2005-03-24 2008-03-06 Jean-Marie Lehn Hydrogels for the controlled release of bioactive materials

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LI, X. ET AL.: "Multifunctional, Biocompatible Supramolecular Hydrogelators Consist Only for Nucleobase, Amino Acid, and Glycoside", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 133, 19 September 2011 (2011-09-19), pages 17513 - 17518 *
YANG, Z. ET AL.: "Supramolecular hydrogels based on biofunctional nanofibers of self-assembled small molecules", JOURNAL OF MATERIALS CHEMISTRY, vol. 17, 2007, pages 2385 - 2393 *

Also Published As

Publication number Publication date
WO2012166705A2 (fr) 2012-12-06

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