WO2012168342A9 - Biopassivierende membranstabilisation mittels nitrocarbonsäuren-enthaltenden phospholipiden in zubereitungen und beschichtungen - Google Patents

Biopassivierende membranstabilisation mittels nitrocarbonsäuren-enthaltenden phospholipiden in zubereitungen und beschichtungen Download PDF

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Publication number
WO2012168342A9
WO2012168342A9 PCT/EP2012/060773 EP2012060773W WO2012168342A9 WO 2012168342 A9 WO2012168342 A9 WO 2012168342A9 EP 2012060773 W EP2012060773 W EP 2012060773W WO 2012168342 A9 WO2012168342 A9 WO 2012168342A9
Authority
WO
WIPO (PCT)
Prior art keywords
solutions
biopassivating
preparations
coatings
nitrocarboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2012/060773
Other languages
English (en)
French (fr)
Other versions
WO2012168342A1 (de
Inventor
Ulrich Dietz
Udo Nubbemeyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to BR112013030644A priority Critical patent/BR112013030644A2/pt
Priority to RU2013158673/15A priority patent/RU2013158673A/ru
Priority to CN201280034834.3A priority patent/CN103717211B/zh
Priority to EP12727358.9A priority patent/EP2717864A1/de
Priority to US14/123,816 priority patent/US20140099354A1/en
Publication of WO2012168342A1 publication Critical patent/WO2012168342A1/de
Publication of WO2012168342A9 publication Critical patent/WO2012168342A9/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/124—Disinfecting agents, e.g. antimicrobials
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having alternatively specified atoms bound to the phosphorus atom and not covered by a single one of groups A01N57/10, A01N57/18, A01N57/26, A01N57/34
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds
    • A01N57/12—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds containing acyclic or cycloaliphatic radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/14—Post-treatment to improve physical properties
    • A61L17/145—Coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Agronomy & Crop Science (AREA)
  • Organic Chemistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Materials Engineering (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Die vorliegende Erfindung betrifft Nitrocarbonsäure(n)-enthaltende Phospholipide, mit besagten Verbindungen beschichtete Medizinprodukte wie beispielsweise Stents, Katheterballons, Wundeinlagen oder chirurgisches Nahtmaterial und biopassivierende Zusammensetzungen, Spüllösungen, Imprägnierlösungen, Beschichtungslösungen, Cryoprotektionslösungen, Kältekonservierungsmedien, Lyoprotektionslösungen, Kontrastmittellösungen, Konservierungslösungen und Perfusionslösungen enthaltend diese Verbindungen sowie die Herstellung dieser Lösungen und der beschichteten Medizinprodukte und deren Verwendungen.
PCT/EP2012/060773 2011-06-06 2012-06-06 Biopassivierende membranstabilisation mittels nitrocarbonsäuren-enthaltenden phospholipiden in zubereitungen und beschichtungen Ceased WO2012168342A1 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
BR112013030644A BR112013030644A2 (pt) 2011-06-06 2012-06-06 fosfolipídios contendo ácido(s) nitrocarboxílico(s) da estrutura geral (i), e uso dos mesmos, dispositivo médico e composições biopassivadoras
RU2013158673/15A RU2013158673A (ru) 2011-06-06 2012-06-06 Биопассивирующая стабилизация мембран посредством содержащих нитрокарбоновую кислоту фосфолипидов в препаратах и покрытиях
CN201280034834.3A CN103717211B (zh) 2011-06-06 2012-06-06 在配制剂和涂层中通过含有硝基羧酸的磷脂来实现的生物钝化性膜稳定化
EP12727358.9A EP2717864A1 (de) 2011-06-06 2012-06-06 Biopassivierende membranstabilisation mittels nitrocarbonsäuren-enthaltenden phospholipiden in zubereitungen und beschichtungen
US14/123,816 US20140099354A1 (en) 2011-06-06 2012-06-06 Biopassivating membrane stabilization by means of nitrocarboxylic acid-containing phospholipids in preparations and coatings

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102011103948A DE102011103948A1 (de) 2011-06-06 2011-06-06 Biopassivierende Beschichtung von Gefäßprothesen mit Nitrocarbonsäuren enthaltenden Phospholipiden
DE102011103948.5 2011-06-06

Publications (2)

Publication Number Publication Date
WO2012168342A1 WO2012168342A1 (de) 2012-12-13
WO2012168342A9 true WO2012168342A9 (de) 2013-02-28

Family

ID=46275822

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2012/060773 Ceased WO2012168342A1 (de) 2011-06-06 2012-06-06 Biopassivierende membranstabilisation mittels nitrocarbonsäuren-enthaltenden phospholipiden in zubereitungen und beschichtungen

Country Status (7)

Country Link
US (1) US20140099354A1 (de)
EP (1) EP2717864A1 (de)
CN (1) CN103717211B (de)
BR (1) BR112013030644A2 (de)
DE (1) DE102011103948A1 (de)
RU (1) RU2013158673A (de)
WO (1) WO2012168342A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103435493B (zh) * 2013-09-10 2016-01-20 大连医诺生物有限公司 一种硝基油酸及其衍生物的制备方法
US10874772B2 (en) * 2018-07-12 2020-12-29 Cook Medical Technologies Llc Coated medical device and method of coating such a device
CN109486790B (zh) * 2018-12-10 2021-08-03 南通励成生物工程有限公司 一种以磷脂酶d转化制备磷酯酰丝氨酸的方法
CN110452262A (zh) * 2019-08-22 2019-11-15 深圳上泰生物工程有限公司 血小板激活因子(paf)类似物的合成方法
CN114938646B (zh) * 2019-12-05 2026-03-27 费森尤斯卡比有限责任公司 分析地加瑞克及其相关产物的方法
JP2023533452A (ja) * 2020-06-23 2023-08-03 ユニバーシティ オブ ピッツバーグ － オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 動脈瘤を処置するための求電子化合物および求電子プロドラッグ
CN116583272A (zh) * 2020-10-19 2023-08-11 埃维科生物技术有限公司 包含生育酚磷酸酯和长链甘油三酯或长链脂肪酸的口服大麻素制剂
CN114953465B (zh) * 2022-05-17 2023-04-21 成都信息工程大学 一种基于Marlin固件的3D打印方法
KR102595126B1 (ko) 2022-09-27 2023-10-30 하나제약 주식회사 콜린알포세레이트 에스테르 유도체의 제조방법과 그 용도
DE102022134188B3 (de) 2022-12-20 2024-03-28 Universität Augsburg - Körperschaft des öffentlichen Rechts Verfahren zur in-situ Erfassung von Änderungen eines Lipidsystems bei dessen Lagerung bei einer Lagertemperatur unterhalb von -60 °C
CN118652270B (zh) * 2024-08-20 2024-12-20 北京悦康科创医药科技股份有限公司 阴离子脂质化合物及包含其的脂质组合物和应用

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JP3100783B2 (ja) * 1992-10-15 2000-10-23 キユーピー株式会社 ホスファチジルコリンおよびその製造方法
US6583251B1 (en) * 1997-09-08 2003-06-24 Emory University Modular cytomimetic biomaterials, transport studies, preparation and utilization thereof
US6838452B2 (en) * 2000-11-24 2005-01-04 Vascular Biogenics Ltd. Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
US7731947B2 (en) * 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
CN1897918A (zh) * 2003-11-17 2007-01-17 阿尔萨公司 包含两亲性分子作为混悬载体的组合物和剂型
US8263576B2 (en) * 2006-08-15 2012-09-11 Mayo Foundation For Medical Education And Research Non-natural sphingolipid analogs and uses thereof
US20090048423A1 (en) * 2007-08-15 2009-02-19 Tyco Healthcare Group Lp Phospholipid Copolymers
JP2011519373A (ja) * 2008-05-01 2011-07-07 コンプレクザ インコーポレイテッド ビニル置換脂肪酸
EP2299997A4 (de) * 2008-06-19 2012-01-11 Univ Utah Res Found Verwendung von nitrierten lipiden zur behandlung von nebenwirkungen von toxischen medizinischen therapien
EP2542232A4 (de) * 2009-11-02 2013-08-28 Life Technologies Corp Fettsäurehemmer

Also Published As

Publication number Publication date
US20140099354A1 (en) 2014-04-10
WO2012168342A1 (de) 2012-12-13
CN103717211A (zh) 2014-04-09
RU2013158673A (ru) 2015-07-20
DE102011103948A1 (de) 2012-12-06
EP2717864A1 (de) 2014-04-16
CN103717211B (zh) 2017-11-17
BR112013030644A2 (pt) 2017-12-19

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