WO2012173392A3 - 인플루엔자 바이러스 감염의 예방 또는 치료용 커큐미노이드계 화합물/스테비오사이드 함유 복합체 - Google Patents

인플루엔자 바이러스 감염의 예방 또는 치료용 커큐미노이드계 화합물/스테비오사이드 함유 복합체 Download PDF

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Publication number
WO2012173392A3
WO2012173392A3 PCT/KR2012/004672 KR2012004672W WO2012173392A3 WO 2012173392 A3 WO2012173392 A3 WO 2012173392A3 KR 2012004672 W KR2012004672 W KR 2012004672W WO 2012173392 A3 WO2012173392 A3 WO 2012173392A3
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WIPO (PCT)
Prior art keywords
stevioside
plant extract
prevention
influenza virus
virus infection
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2012/004672
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English (en)
French (fr)
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WO2012173392A9 (ko
WO2012173392A2 (ko
Inventor
이우송
류영배
김영민
박수진
노문철
정형재
권형준
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Korea Research Institute of Bioscience and Biotechnology KRIBB
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Korea Research Institute of Bioscience and Biotechnology KRIBB
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Priority to US14/126,106 priority Critical patent/US10136663B2/en
Publication of WO2012173392A2 publication Critical patent/WO2012173392A2/ko
Publication of WO2012173392A3 publication Critical patent/WO2012173392A3/ko
Publication of WO2012173392A9 publication Critical patent/WO2012173392A9/ko
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/111—Aromatic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/163—Sugars; Polysaccharides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Birds (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
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  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fodder In General (AREA)

Abstract

본 발명은 화학식 1로 표시되는 화합물, 이를 포함하는 식물 추출물, 또는 상기 추출물의 분획물; 및 스테비오사이드(stevioside), 이를 포함하는 식물 추출물, 또는 상기 스테비오사이드를 포함하는 식물 추출물의 분획물을 포함하는 복합체, 상기 복합체를 유효성분으로 포함하는 인플루엔자 바이러스 감염의 예방 또는 치료용 약제학적 조성물, 인플루엔자 바이러스 감염의 예방 또는 개선용 식품 조성물, 살바이러스용 의약외품 조성물, 살바이러스용 사료첨가제, 및 사료에 관한 것이다. 본 발명에 따르면, 화학식 1로 표시되는 화합물, 이를 포함하는 식물 추출물, 또는 상기 추출물의 분획물; 및 스테비오사이드, 이를 포함하는 식물 추출물, 또는 상기 추출물의 분획물의 혼합물은 인플루엔자 바이러스에 대해 살바이러스 및 세포변성억제효과 및 SPF 닭을 이용한 항바이러스 효능을 동시에 나타내므로 인플루엔자 바이러스 감염의 예방 및 치료에 유용하게 사용될 수 있다.
PCT/KR2012/004672 2011-06-13 2012-06-13 인플루엔자 바이러스 감염의 예방 또는 치료용 커큐미노이드계 화합물/스테비오사이드 함유 복합체 Ceased WO2012173392A2 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US14/126,106 US10136663B2 (en) 2011-06-13 2012-06-13 Curcuminoid-based compound/stevioside-containing complex for the prevention and treatment of an influenza virus infection

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020110057139A KR101811848B1 (ko) 2011-06-13 2011-06-13 인플루엔자 바이러스 감염의 예방 또는 치료용 커큐미노이드계 화합물/스테비오사이드 함유 복합체
KR10-2011-0057139 2011-06-13

Publications (3)

Publication Number Publication Date
WO2012173392A2 WO2012173392A2 (ko) 2012-12-20
WO2012173392A3 true WO2012173392A3 (ko) 2013-03-14
WO2012173392A9 WO2012173392A9 (ko) 2013-05-02

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ID=47357599

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PCT/KR2012/004672 Ceased WO2012173392A2 (ko) 2011-06-13 2012-06-13 인플루엔자 바이러스 감염의 예방 또는 치료용 커큐미노이드계 화합물/스테비오사이드 함유 복합체

Country Status (3)

Country Link
US (1) US10136663B2 (ko)
KR (1) KR101811848B1 (ko)
WO (1) WO2012173392A2 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101684462B1 (ko) * 2014-05-02 2016-12-08 한국생명공학연구원 울금 및 스테비아의 혼합물을 유효성분으로 포함하는 뱀장어 생육증진용 사료첨가제 조성물
KR101664452B1 (ko) * 2015-02-06 2016-10-10 고려대학교 산학협력단 봉출 추출물을 함유하는 항바이러스용 조성물
KR102647386B1 (ko) 2023-10-25 2024-03-14 한국생명공학연구원 커큐미노이드계 화합물 및 스테비오사이드 복합체를 포함하는 비만 예방, 개선 또는 치료용 조성물

Citations (3)

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JP2006008594A (ja) * 2004-06-25 2006-01-12 Sato Naohiko インフルエンザの予防方法
JP2008280333A (ja) * 2007-04-10 2008-11-20 Yoshinari Matsui 末期癌等治療用医薬組成物
KR20110004763A (ko) * 2009-07-08 2011-01-14 한국생명공학연구원 울금 추출물을 포함하는 인플루엔자 바이러스 감염의 예방 및 치료용 조성물 및 뉴라미니데이즈 활성의 억제용 조성물

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WO2010061497A1 (ja) 2008-11-27 2010-06-03 学校法人日本大学 抗インフルエンザウイルス剤
KR100962334B1 (ko) * 2009-10-19 2010-06-10 주식회사 중앙백신연구소 울금으로부터 얻은 조류, 돼지 인플루엔자 및 신종플루에 대한 항바이러스제

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006008594A (ja) * 2004-06-25 2006-01-12 Sato Naohiko インフルエンザの予防方法
JP2008280333A (ja) * 2007-04-10 2008-11-20 Yoshinari Matsui 末期癌等治療用医薬組成物
KR20110004763A (ko) * 2009-07-08 2011-01-14 한국생명공학연구원 울금 추출물을 포함하는 인플루엔자 바이러스 감염의 예방 및 치료용 조성물 및 뉴라미니데이즈 활성의 억제용 조성물

Non-Patent Citations (2)

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Title
MANDAL, V. ET AL.: "Microwave assisted extraction of curcumin by sample-solvent dual heating mechanism using Taguchi L9 orthogonal design.", JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS., vol. 46, no. 2, 2008, pages 322 - 327 *
WAKTE, P. S. ET AL.: "Optimization of microwave, ultra-sonic and supercritical carbon dioxide assisted extraction techniques for curcumin from Curcuma longa.", SEPARATION AND PURIFICATION TECHNOLOGY., vol. 79, no. 1, 19 May 2011 (2011-05-19), pages 50 - 55 *

Also Published As

Publication number Publication date
KR20120137953A (ko) 2012-12-24
US20140248382A1 (en) 2014-09-04
WO2012173392A9 (ko) 2013-05-02
US10136663B2 (en) 2018-11-27
WO2012173392A2 (ko) 2012-12-20
KR101811848B1 (ko) 2017-12-22

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