WO2012173846A3 - Macrocycles peptidomimétiques - Google Patents

Macrocycles peptidomimétiques Download PDF

Info

Publication number
WO2012173846A3
WO2012173846A3 PCT/US2012/041181 US2012041181W WO2012173846A3 WO 2012173846 A3 WO2012173846 A3 WO 2012173846A3 US 2012041181 W US2012041181 W US 2012041181W WO 2012173846 A3 WO2012173846 A3 WO 2012173846A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptidomimetic macrocycles
macrocycles
disease
peptidomimetic
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2012/041181
Other languages
English (en)
Other versions
WO2012173846A2 (fr
Inventor
Huw M. Nash
Noriyuki Kawahata
Carl Elkin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rein Therapeutics Inc
Original Assignee
Aileron Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aileron Therapeutics Inc filed Critical Aileron Therapeutics Inc
Publication of WO2012173846A2 publication Critical patent/WO2012173846A2/fr
Publication of WO2012173846A3 publication Critical patent/WO2012173846A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne de nouveaux macrocycles peptidomimétiques et des procédés d'utilisation de tels macrocycles dans le traitement de maladies.
PCT/US2012/041181 2011-06-06 2012-06-06 Macrocycles peptidomimétiques Ceased WO2012173846A2 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201161493979P 2011-06-06 2011-06-06
US61/493,979 2011-06-06
US201161494377P 2011-06-07 2011-06-07
US201161494382P 2011-06-07 2011-06-07
US61/494,377 2011-06-07
US61/494,382 2011-06-07

Publications (2)

Publication Number Publication Date
WO2012173846A2 WO2012173846A2 (fr) 2012-12-20
WO2012173846A3 true WO2012173846A3 (fr) 2013-03-21

Family

ID=47357671

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/041181 Ceased WO2012173846A2 (fr) 2011-06-06 2012-06-06 Macrocycles peptidomimétiques

Country Status (1)

Country Link
WO (1) WO2012173846A2 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0720306A2 (pt) 2006-12-14 2014-02-04 Aileron Therapeutics Inc Sistemas de macrociclização da bis-sufidrila
ES2649941T3 (es) 2007-02-23 2018-01-16 Aileron Therapeutics, Inc. Aminoácidos sustituidos para preparar péptidos macrocíclicos unidos a triazol
US8592377B2 (en) 2007-03-28 2013-11-26 President And Fellows Of Harvard College Stitched polypeptides
CA2737922A1 (fr) 2008-09-22 2010-03-25 Aileron Therapeutics, Inc. Macrocycles peptidomimetiques
BRPI0920899A2 (pt) 2008-11-24 2016-04-26 Aileron Therapeutics Inc macrociclos peptidomiméticos com propriedades melhoradas
US9175047B2 (en) 2009-01-14 2015-11-03 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
CN102712675A (zh) 2009-09-22 2012-10-03 爱勒让治疗公司 拟肽大环化合物
ES2711526T3 (es) 2010-08-13 2019-05-06 Aileron Therapeutics Inc Macrociclos peptidomiméticos
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
BR112014020103A2 (pt) 2012-02-15 2018-10-09 Aileron Therapeutics, Inc. macrociclos peptidomiméticos
EP2819688A4 (fr) 2012-02-15 2015-10-28 Aileron Therapeutics Inc Macrocycles peptidomimétiques réticulés par triazole et par thioéther
WO2014071241A1 (fr) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Acides aminés disubstitués et procédés de préparation et d'utilisation de ceux-ci
EP3197478A4 (fr) 2014-09-24 2018-05-30 Aileron Therapeutics, Inc. Macrocycles peptidomimétiques et leurs utilisations
AU2015320545C1 (en) 2014-09-24 2020-05-14 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof
WO2016154058A1 (fr) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Macrocycles peptidomimétiques et leurs utilisations
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US20170056352A1 (en) 2015-08-25 2017-03-02 Rgenix, Inc. PHARMACEUTICALLY ACCEPTABLE SALTS OF beta-GUANIDINOPROPIONIC ACID WITH IMPROVED PROPERTIES AND USES THEREOF
WO2017044633A1 (fr) 2015-09-10 2017-03-16 Aileron Therapeutics, Inc. Macrocycles peptidomimétiques en tant que modulateurs de mcl-1
WO2018160178A1 (fr) 2017-03-01 2018-09-07 Rgenix, Inc. Sels pharmaceutiquement acceptables d'acide bêta-guanidinopropionique ayant des propriétés améliorées et utilisations de ceux-ci
EP4072561A4 (fr) 2019-12-11 2023-11-29 Inspirna, Inc. Méthodes de traitement du cancer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080262200A1 (en) * 2007-02-23 2008-10-23 Aileron Therapeutics, Inc., A Delaware Corporation Triazole Macrocycle Systems
US20100184047A1 (en) * 2007-03-30 2010-07-22 Oncotherapy Science, Inc. Screening and therapeutic method for nsclc targeting the cdca8-aurkb complex

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080262200A1 (en) * 2007-02-23 2008-10-23 Aileron Therapeutics, Inc., A Delaware Corporation Triazole Macrocycle Systems
US20100184047A1 (en) * 2007-03-30 2010-07-22 Oncotherapy Science, Inc. Screening and therapeutic method for nsclc targeting the cdca8-aurkb complex

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JEYAPRAKASH ET AL.: "Structure of a survivin-borealin-INCENP core complex reveals how chromosomal passengers travel together.", CELL, vol. 131, 2007, pages 271 - 285 *

Also Published As

Publication number Publication date
WO2012173846A2 (fr) 2012-12-20

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