WO2012173846A3 - Macrocycles peptidomimétiques - Google Patents

Macrocycles peptidomimétiques Download PDF

Info

Publication number
WO2012173846A3
WO2012173846A3 PCT/US2012/041181 US2012041181W WO2012173846A3 WO 2012173846 A3 WO2012173846 A3 WO 2012173846A3 US 2012041181 W US2012041181 W US 2012041181W WO 2012173846 A3 WO2012173846 A3 WO 2012173846A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptidomimetic macrocycles
macrocycles
disease
peptidomimetic
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2012/041181
Other languages
English (en)
Other versions
WO2012173846A2 (fr
Inventor
Huw M. Nash
Noriyuki Kawahata
Carl Elkin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rein Therapeutics Inc
Original Assignee
Aileron Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aileron Therapeutics Inc filed Critical Aileron Therapeutics Inc
Publication of WO2012173846A2 publication Critical patent/WO2012173846A2/fr
Publication of WO2012173846A3 publication Critical patent/WO2012173846A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne de nouveaux macrocycles peptidomimétiques et des procédés d'utilisation de tels macrocycles dans le traitement de maladies.
PCT/US2012/041181 2011-06-06 2012-06-06 Macrocycles peptidomimétiques Ceased WO2012173846A2 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201161493979P 2011-06-06 2011-06-06
US61/493,979 2011-06-06
US201161494382P 2011-06-07 2011-06-07
US201161494377P 2011-06-07 2011-06-07
US61/494,382 2011-06-07
US61/494,377 2011-06-07

Publications (2)

Publication Number Publication Date
WO2012173846A2 WO2012173846A2 (fr) 2012-12-20
WO2012173846A3 true WO2012173846A3 (fr) 2013-03-21

Family

ID=47357671

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/041181 Ceased WO2012173846A2 (fr) 2011-06-06 2012-06-06 Macrocycles peptidomimétiques

Country Status (1)

Country Link
WO (1) WO2012173846A2 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2686827C (fr) 2006-12-14 2014-09-16 Aileron Therapeutics, Inc. Systemes de macrocyclisation bis-sulfhydryle
CN109627287A (zh) 2007-02-23 2019-04-16 爱勒让治疗公司 三唑大环系统
EP2508531B1 (fr) 2007-03-28 2016-10-19 President and Fellows of Harvard College Polypeptides piqués
US8524653B2 (en) 2008-09-22 2013-09-03 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
WO2010060112A1 (fr) 2008-11-24 2010-05-27 Aileron Therapeutics, Inc. Macrocycles peptidomimétiques avec propriétés améliorées
EP2376100B1 (fr) 2009-01-14 2017-10-25 Aileron Therapeutics, Inc. Macrocycles peptidomimetiques
CA2774973A1 (fr) 2009-09-22 2011-03-31 Aileron Therapeutics, Inc. Macrocycles peptidomimetiques
SI2603600T1 (sl) 2010-08-13 2019-04-30 Aileron Therapeutics, Inc. Peptidomimetični makrocikli
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
HK1205454A1 (en) 2012-02-15 2015-12-18 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
KR102112373B1 (ko) 2012-02-15 2020-05-18 에일러론 테라퓨틱스 인코포레이티드 펩티드모방체 마크로사이클
WO2014071241A1 (fr) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Acides aminés disubstitués et procédés de préparation et d'utilisation de ceux-ci
JP2018503595A (ja) 2014-09-24 2018-02-08 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ペプチド模倣大環状分子およびその製剤
BR112017005598A2 (pt) 2014-09-24 2017-12-12 Aileron Therapeutics Inc macrociclos peptidomiméticos e usos dos mesmos
WO2016154058A1 (fr) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Macrocycles peptidomimétiques et leurs utilisations
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US20170056352A1 (en) 2015-08-25 2017-03-02 Rgenix, Inc. PHARMACEUTICALLY ACCEPTABLE SALTS OF beta-GUANIDINOPROPIONIC ACID WITH IMPROVED PROPERTIES AND USES THEREOF
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1
WO2018160178A1 (fr) 2017-03-01 2018-09-07 Rgenix, Inc. Sels pharmaceutiquement acceptables d'acide bêta-guanidinopropionique ayant des propriétés améliorées et utilisations de ceux-ci
JP2023505687A (ja) 2019-12-11 2023-02-10 インスピルナ，インコーポレーテッド 癌の処置方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080262200A1 (en) * 2007-02-23 2008-10-23 Aileron Therapeutics, Inc., A Delaware Corporation Triazole Macrocycle Systems
US20100184047A1 (en) * 2007-03-30 2010-07-22 Oncotherapy Science, Inc. Screening and therapeutic method for nsclc targeting the cdca8-aurkb complex

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080262200A1 (en) * 2007-02-23 2008-10-23 Aileron Therapeutics, Inc., A Delaware Corporation Triazole Macrocycle Systems
US20100184047A1 (en) * 2007-03-30 2010-07-22 Oncotherapy Science, Inc. Screening and therapeutic method for nsclc targeting the cdca8-aurkb complex

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JEYAPRAKASH ET AL.: "Structure of a survivin-borealin-INCENP core complex reveals how chromosomal passengers travel together.", CELL, vol. 131, 2007, pages 271 - 285 *

Also Published As

Publication number Publication date
WO2012173846A2 (fr) 2012-12-20

Similar Documents

Publication Publication Date Title
HK1205454A1 (en) Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
MX355543B (es) Macrociclos peptidomiméticos.
PH12014501844B1 (en) Peptidomimetic macrocycles
WO2010083347A3 (fr) Macrocycles peptidomimetiques
WO2013059530A3 (fr) Macrocycles peptidomimétiques
HK1202313A1 (en) Methods and compositions for the treatment and diagnosis of bladder cancer
MX358886B (es) Macrociclos peptidomimeticos.
WO2012166626A8 (fr) Réactifs et procédés pour traiter une maladie dentaire
MX342240B (es) Anticuerpos anti-fgfr4 y metodos de uso.
MX2013015311A (es) Polipeptidos de enlace de pcsk9 y metodos de uso.
HK1209159A1 (en) Methods of decellularizing bone
WO2013056148A3 (fr) Procédés d'utilisation d'antagonistes de scd1
MX2014002053A (es) Anticuerpos anti -mcsp y metodos de uso.
EP2665433A2 (fr) Dispositifs et procédés de traitement de tissus
WO2014138429A3 (fr) Macrocycles peptidomimétiques et leur utilisation dans la régulation de hif1alpha
PH12014500841B1 (en) ANTI-HtrA1 ANTIBODIES AND METHODS OF USE
HK1198689A1 (en) Antibody formulations and methods
PT2763982T (pt) Benzimidazois substituídos para utilização como inibidores da bub1 quinase no tratamento de doenças hiperploriferativas
HK1199100A1 (en) Methods and compositions for the treatment and diagnosis of colorectal cancer
MX340555B (es) Anticuerpos contra il-18r1 y usos de los mismos.
MX336323B (es) Anticuerpos de anti-poliubiquitina y metodos de uso.
WO2013106747A3 (fr) Méthodes et compositions pour le traitement et le diagnostic du cancer de la thyroïde
WO2012106427A3 (fr) Procédés de traitement d'ulcères du pied diabétique
WO2012129299A3 (fr) Instruments médicaux et leurs procédés de fabrication
WO2012064743A3 (fr) Procédés d'amélioration de la fonction cardiaque

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12800645

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC (EPO FORM 1205A DATED 13/02/2014)

122 Ep: pct application non-entry in european phase

Ref document number: 12800645

Country of ref document: EP

Kind code of ref document: A2