WO2013121279A3 - Procédé de préparation d'ertapénem - Google Patents

Procédé de préparation d'ertapénem Download PDF

Info

Publication number
WO2013121279A3
WO2013121279A3 PCT/IB2013/000211 IB2013000211W WO2013121279A3 WO 2013121279 A3 WO2013121279 A3 WO 2013121279A3 IB 2013000211 W IB2013000211 W IB 2013000211W WO 2013121279 A3 WO2013121279 A3 WO 2013121279A3
Authority
WO
WIPO (PCT)
Prior art keywords
ertapenem
prepare
prepare ertapenem
lutidine
methylmorpholine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2013/000211
Other languages
English (en)
Other versions
WO2013121279A2 (fr
Inventor
Shankar Reddy Budidet
Mallikarjuna Reddy Karuru
Sivakumar KURIMISETTY
Rajasekhara Raju KONDURU
Sivakumaran Meenakshisunderam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aurobindo Pharma Ltd
Original Assignee
Aurobindo Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aurobindo Pharma Ltd filed Critical Aurobindo Pharma Ltd
Publication of WO2013121279A2 publication Critical patent/WO2013121279A2/fr
Anticipated expiration legal-status Critical
Publication of WO2013121279A3 publication Critical patent/WO2013121279A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D477/08—Modification of a carboxyl group directly attached in position 2, e.g. esterification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La présente invention concerne un nouveau procédé de préparation d'ertapénem de formule (I) ou de l'un de ses sels.
PCT/IB2013/000211 2012-02-14 2013-02-11 Procédé de préparation d'ertapénem Ceased WO2013121279A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN547CH2012 2012-02-14
IN547/CHE/2012 2012-02-14
IN3084/CHE/2012 2012-07-27
IN3084CH2012 2012-07-27

Publications (2)

Publication Number Publication Date
WO2013121279A2 WO2013121279A2 (fr) 2013-08-22
WO2013121279A3 true WO2013121279A3 (fr) 2014-09-12

Family

ID=47997590

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2013/000211 Ceased WO2013121279A2 (fr) 2012-02-14 2013-02-11 Procédé de préparation d'ertapénem

Country Status (1)

Country Link
WO (1) WO2013121279A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104788453B (zh) * 2014-01-16 2017-02-15 浙江九洲药业股份有限公司 厄他培南单钠盐一锅法制备工艺
US10434089B2 (en) 2017-01-25 2019-10-08 The Johns Hopkins University Avibactam and carbapenems antibacterial agents
CN110698479A (zh) * 2018-07-09 2020-01-17 武汉启瑞药业有限公司 一种厄他培南单钠盐的合成方法
CN113880839A (zh) * 2021-11-01 2022-01-04 石药集团中诺药业（石家庄）有限公司 一种厄他培南钠粗品的合成新方法
CN114105988B (zh) * 2022-01-24 2022-04-29 深圳市海滨制药有限公司 一种厄他培南钠的合成方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5478820A (en) * 1992-02-04 1995-12-26 Zeneca Ltd. Antibiotic compounds
US7071330B2 (en) * 2001-01-16 2006-07-04 Williams John M Process for carbapenem synthesis
US20090312539A1 (en) * 2006-11-20 2009-12-17 Orchid Chemicals & Pharmaceuticals Limited An improved process for the preparation of carbapenem antibiotic
EP2141167A1 (fr) * 2008-07-04 2010-01-06 ACS DOBFAR S.p.A. Procédé de synthèse de carbapenem utilisant du nickel de Raney
EP2388261A2 (fr) * 2010-05-19 2011-11-23 Savior Lifetec Corporation Procédé amélioré pour la préparation de carbapenem en utilisant des intermédiaires de carbapenem et récupération du carbapenem

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5478820A (en) * 1992-02-04 1995-12-26 Zeneca Ltd. Antibiotic compounds
US7071330B2 (en) * 2001-01-16 2006-07-04 Williams John M Process for carbapenem synthesis
US20090312539A1 (en) * 2006-11-20 2009-12-17 Orchid Chemicals & Pharmaceuticals Limited An improved process for the preparation of carbapenem antibiotic
EP2141167A1 (fr) * 2008-07-04 2010-01-06 ACS DOBFAR S.p.A. Procédé de synthèse de carbapenem utilisant du nickel de Raney
EP2388261A2 (fr) * 2010-05-19 2011-11-23 Savior Lifetec Corporation Procédé amélioré pour la préparation de carbapenem en utilisant des intermédiaires de carbapenem et récupération du carbapenem

Also Published As

Publication number Publication date
WO2013121279A2 (fr) 2013-08-22

Similar Documents

Publication Publication Date Title
MX2010007587A (es) Compuestos que comprenden un grupo ciclobutoxi.
IN2015KN00262A (fr)
PH12015500211A1 (en) 4-methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes
CA2830549C (fr) Procedes et compositions pour la preparation de noribogaine a partir de voacangine
MX2011008864A (es) Tetrahidroazolopirazinas sulfoniladas y su uso como productos medicinales.
HK1206635A1 (en) Modified polynucleotides for the production of proteins
WO2011138281A3 (fr) Procédé de production de dithiine-tétracarboxy-diimides
HK1198442A1 (en) Pyrazolopyridine derivatives, preparation process therefor and therapeutic use thereof
WO2011132051A3 (fr) Composés tricycliques en tant qu'inhibiteurs de la phosphodiestérase-10
WO2010102778A3 (fr) 3-aminoisoxazolopyridines substituées en tant que modulateurs de kcnq 2/3
WO2013068850A3 (fr) Procédé pour la préparation de β-c-arylglucosides
PH12014501195A1 (en) Novel 2h-indazoles as ep2, receptor antagonists
MX2014014138A (es) Procedimiento nuevo para la preparacion de acido 2-ciclopentil-6-metoxi-isonicotinico.
GB201100531D0 (en) Functionalised materials, processes for the production and uses thereof
PH12014501712B1 (en) Novel morpholinyl derivatives useful as mogat-2-inhibitors
MX2014004210A (es) Derivados de 2-oxo-piperidinilo.
WO2012140490A3 (fr) Procédé de préparation de dérivé de quinoléine
WO2010079045A3 (fr) Nouveaux sels
WO2014068333A3 (fr) Nouveau procédé
MX350430B (es) Proceso para preparar compuestos acido 4-amino-5-bifenil-4-il-2-hi droximetil-2-metil-pentanoico.
WO2014087208A3 (fr) Procédé de préparation d'alcaftadine
IN2015DN00950A (fr)
WO2012063115A3 (fr) Procédé de préparation de rosuvastatine calcique via un nouvel intermédiaire amine
IL238931A0 (en) Production methods for (1s,4s,5s)-4-bromo-6-oxabicyclo)[3,2,1]octane-7-one
MY168411A (en) Method for preparing compound by novel michael addition reaction using water or various acids as additive

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 13711946

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 13711946

Country of ref document: EP

Kind code of ref document: A2