WO2013125555A1 - Dispositif d'atomisation de liquide - Google Patents

Dispositif d'atomisation de liquide Download PDF

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Publication number
WO2013125555A1
WO2013125555A1 PCT/JP2013/054105 JP2013054105W WO2013125555A1 WO 2013125555 A1 WO2013125555 A1 WO 2013125555A1 JP 2013054105 W JP2013054105 W JP 2013054105W WO 2013125555 A1 WO2013125555 A1 WO 2013125555A1
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WO
WIPO (PCT)
Prior art keywords
liquid
gas
orifice
syringe
pressure source
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2013/054105
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English (en)
Japanese (ja)
Inventor
博良 麻川
良太 久下
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nozzle Network Co Ltd
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Nozzle Network Co Ltd
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Filing date
Publication date
Application filed by Nozzle Network Co Ltd filed Critical Nozzle Network Co Ltd
Priority to JP2014500726A priority Critical patent/JP5971532B2/ja
Publication of WO2013125555A1 publication Critical patent/WO2013125555A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/02—Spray pistols; Apparatus for discharge
    • B05B7/06—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane
    • B05B7/062—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane with only one liquid outlet and at least one gas outlet
    • B05B7/066—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane with only one liquid outlet and at least one gas outlet with an inner liquid outlet surrounded by at least one annular gas outlet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/02—Membranes or pistons acting on the contents inside the container, e.g. follower pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/06—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/06—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump
    • B05B11/062—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump designed for spraying particulate material
    • B05B11/064—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump designed for spraying particulate material the particulate material being stored in several discrete quantities delivered one at a time
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1087—Combination of liquid and air pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/02—Spray pistols; Apparatus for discharge
    • B05B7/04—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge
    • B05B7/0416—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid
    • B05B7/0441—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid with one inner conduit of liquid surrounded by an external conduit of gas upstream the mixing chamber
    • B05B7/0475—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid with one inner conduit of liquid surrounded by an external conduit of gas upstream the mixing chamber with means for deflecting the peripheral gas flow towards the central liquid flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/02—Spray pistols; Apparatus for discharge
    • B05B7/04—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge
    • B05B7/0416—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid
    • B05B7/0483—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid with gas and liquid jets intersecting in the mixing chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/02—Spray pistols; Apparatus for discharge
    • B05B7/08—Spray pistols; Apparatus for discharge with separate outlet orifices, e.g. to form parallel jets, i.e. the axis of the jets being parallel, to form intersecting jets, i.e. the axis of the jets converging but not necessarily intersecting at a point
    • B05B7/0807—Spray pistols; Apparatus for discharge with separate outlet orifices, e.g. to form parallel jets, i.e. the axis of the jets being parallel, to form intersecting jets, i.e. the axis of the jets converging but not necessarily intersecting at a point to form intersecting jets
    • B05B7/0861—Spray pistols; Apparatus for discharge with separate outlet orifices, e.g. to form parallel jets, i.e. the axis of the jets being parallel, to form intersecting jets, i.e. the axis of the jets converging but not necessarily intersecting at a point to form intersecting jets with one single jet constituted by a liquid or a mixture containing a liquid and several gas jets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
    • A61M11/007—Syringe-type or piston-type sprayers or atomisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/08—Inhaling devices inserted into the nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/30—Vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/07—General characteristics of the apparatus having air pumping means
    • A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
    • A61M2205/073—Syringe, piston type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/07—General characteristics of the apparatus having air pumping means
    • A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
    • A61M2205/075—Bulb type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/07—General characteristics of the apparatus having air pumping means
    • A61M2205/078—General characteristics of the apparatus having air pumping means foot operated

Definitions

  • the present invention relates to a liquid atomizing apparatus for atomizing a liquid.
  • an injector atomizer having a cylinder having a spray nozzle at the tip and a piston inserted into the cylinder is known (see, for example, Patent Document 1). Since this spray nozzle is a one-fluid spray nozzle, the average particle diameter to be sprayed was as large as about 25 to 40 ⁇ m.
  • This injector type atomizer is mainly used for the purpose of spraying drugs, vaccines and the like on the mucous membrane in the nostril.
  • the above-mentioned method of spraying and administering a drug has a limited use because of the large spray particle size.
  • the particle size of the spray is large, and the sprayed chemical solution cannot reach the target site in the body. Therefore, there is a demand for reducing the particle size of the spray particles so that the drug reaches the target site, for example, the esophagus, trachea, etc., deeper than the site of the mucosa in the nostril.
  • the present inventor has developed a new miniaturization different from the conventional principle of a general two-fluid nozzle (a gas and a liquid are jetted in the same jetting direction and the liquid is miniaturized by a shearing effect due to a gas-liquid accompanying flow). It is an object of the present invention to provide a liquid atomizing apparatus that can be carried without using a power source and can atomize a liquid with low energy by using the principle.
  • a liquid orifice A cylindrical liquid storage section for storing liquid therein;
  • a manual, foot, mechanical or blown gas pressure source for generating a gas flow for atomizing the liquid;
  • a first gas orifice part and a second gas orifice part for injecting the gas sent from the gas pressure source as two gas streams;
  • the first gas flow ejected from the first gas orifice portion, the second gas flow ejected from the second gas orifice portion, and the liquid exiting from the liquid orifice portion collide with each other to atomize the liquid.
  • a gas-liquid mixing area part which is an area to be made to be
  • the gas pressure source is a manual type, a mechanical type, a foot type, and a blowing type (including exhalation), it is portable and can be used regardless of location. Since no compressor or power supply is used, the device configuration can be simplified and the equipment cost can be reduced.
  • the liquid atomizing device is A piston part movable in the liquid storage part; A gas passage portion in which a part of the gas from the gas pressure source branches and flows, and The gas pressure source causes gas pressure to act from the rear of the piston part, and pushes the piston part to the liquid orifice part of the liquid storage part, thereby ejecting the liquid from the liquid orifice part,
  • the first and second gas orifice portions inject the gas flowing from the gas passage portion into the gas-liquid mixing area portion as respective gas flows, and cause the first gas flow and the second gas flow to collide with each other.
  • the liquid in the liquid storage portion is ejected by a gas action from a single gas pressure source, and the gas flow from the gas pressure source is ejected from two opposing directions to collide with the liquid.
  • the liquid can be atomized (miniaturized). Since the obtained spray particles have a particle diameter smaller than that of the prior art, for example, the spray particles can reach the inner part of the body.
  • FIG. 1A is a front view of the tip outlet 6a of the liquid orifice portion 6.
  • FIG. The first and second gas orifice portions 1 and 2 extend from the left and right sides facing each other toward the tip outlet 6 a of the central liquid orifice portion 6.
  • the liquid 61 in the liquid storage part is pushed out by the piston part and ejected from the liquid orifice part 6.
  • gas flows G1 and G2 are injected from the first and second gas orifices 1 and 2, respectively.
  • FIG. 1B is an enlarged view of the AA cross section of FIG. 1A.
  • FIG. 1C is an enlarged view of the BB cross section of FIG. 1A.
  • the jetted gas flows G1 and G2 collide to form a collision portion W.
  • a portion including the collision portion W is referred to as a collision wall.
  • the liquid L is ejected from the liquid orifice part 6 toward the collision wall (collision part W).
  • collision part W When the liquid L collides with the collision wall, the liquid L is pulverized (atomized) to become a mist F.
  • An area where the gas flows G1 and G2 collide with the liquid flow L and the mist F is generated is indicated by a broken line as a gas-liquid mixing area portion M. 1A to 1C, the gas-liquid mixing area portion M is provided inside the spray outlet portion 3 and forms a recess.
  • the present invention is not particularly limited to this, and the tip position of the spray outlet portion 3 is not limited thereto. May not project from the position of the collision part W (may be retracted). That is, in the present invention, internal gas / liquid mixing in the concave gas / liquid mixing area or external mixing of gas / liquid may be used. After the gas flows G ⁇ b> 1 and G ⁇ b> 2 collide with each other in the gas-liquid mixing area M, the gas flows out from the tip of the spray outlet 3 to the outside of the open space. On the other hand, the liquid 61 in the liquid storage part is pushed out by the piston part and ejected from the liquid orifice part 6 to collide with the gas flow.
  • Reference numeral 3 a indicates an outer surface portion of the spray outlet portion 3.
  • the fog F spreads from the tip of the spray outlet 3 to a wide angle (spreads like a fan) and is sprayed.
  • a spray pattern of fog for example, it is formed in a wide fan shape, and its cross-sectional shape is elliptical or oval. Parallel to the collision surface where the gas flows collide (in the direction in which the collision surface expands), the gas that collided (after the collision) diffuses, and the mist F spreads in this direction in a fan shape and is ejected.
  • Wide angle spraying in which the angle ⁇ in the major axis direction of the spray pattern is 70 ° to 120 ° is possible. Further, not only a wide-angle spray pattern of 70 ° to 120 ° but also a spray angle ⁇ of 70 ° or less is possible. For example, it can be set to 20 ° to 40 °.
  • the liquid storage part is formed with an injection port for injecting the liquid.
  • the liquid exits from the liquid orifice by the siphon action of the first and second gas flows injected from the first and second gas orifices.
  • two gas flows can be generated from a single gas pressure source, and the liquid can be ejected by siphon action of the two gas flows.
  • a member corresponding to the above-described piston portion can be omitted, and the member configuration can be simplified.
  • the liquid storage unit may be constituted by a cartridge that is detachable from the apparatus main body. According to this configuration, it is not necessary to form an injection port, and it is only necessary to mount a used cartridge in the apparatus main body.
  • the form and method of mounting the cartridge are not particularly limited.
  • the gas pressure source includes a syringe and a plunger that moves inside the syringe and pushes the gas inside the syringe to the outside.
  • a disposable syringe syringe, plunger
  • the connection part (method) between the syringe and the liquid atomizer is not particularly limited, and for example, a tube, a connector, a Luer Taper, or the like may be used.
  • the gas pressure source is a balloon pump or a portable inflator.
  • the balloon-type pump and the portable inflator may be connected to the entrance of the syringe, or may be directly connected to the liquid storage unit and the gas passage unit without the syringe.
  • the portable inflator include a bicycle inflator and a balloon inflator.
  • the first gas flow ejected from the first gas orifice portion and the second fluid with respect to the liquid ejected from the tip portion of the liquid orifice portion.
  • Two liquid columns are formed by colliding with the second gas flow ejected from the gas orifice, and the liquid is atomized.
  • FIGS. 3A to 3E Two liquid columns L1 and L2 are formed by causing the gas flows G1 and G2 ejected from the first and second gas orifices 1 and 2 to collide with the liquid flow L ejected from the liquid orifice unit 6. And fog F is generated (FIGS. 3A and 3B).
  • FIG. 3C shows one liquid column in a state where only the liquid flow L is ejected. In this state, two gas streams that collide with each other are caused to collide with the liquid column.
  • one liquid column is separated (vertically divided) to form two liquid columns L1 and L2, and the liquid in the central portion of the liquid column is refined.
  • Fog F F (FIGS. 3A and 3D). This means that two gas flows are sandwiched between one liquid column, the liquid column is split (split), and a liquid film is generated at the center of the liquid column. However, this liquid film is broken and refined. And if one liquid column is made into a small diameter, a liquid film will also become thin and the particle
  • a thin film can be formed with a low energy (low pressure, low flow rate) gas flow, which assists in the fine particle formation of the thin film.
  • the mist can be sprayed at low speed in the atmosphere.
  • the width d1 of the liquid flow L with which the gas flows G1 and G2 collide is smaller than or the same as the width d2 of the gas flow.
  • the width d1 (or diameter) of the liquid flow L there are portions that do not collide with the gas flow (in FIG. 3E, two protruding portions Lb and Lc).
  • the width d2 (or diameter) (d2 / d1) of the gas flows G1 and G2 is, for example, in the range of 0.1 to 0.9, preferably 0. .3 to 0.8, and more preferably 0.4 to 0.7.
  • the liquid film becomes thinner as the liquid flow width d1 is smaller, the effect of miniaturization becomes higher.
  • the gas-liquid mixing area part M is shown with a broken line.
  • the spray direction of the mist F is regulated by the spray outlet portion 3 surrounding the mist F.
  • the spray outlet portion 3 may be formed integrally with a member (gas orifice portions 1 and 2) for forming a gas orifice, or may be formed by a separate member.
  • a spray pattern of fog it forms in the shape of a wide fan, for example, and the cross-sectional shape becomes an ellipse shape or an ellipse shape.
  • the spray angle ⁇ of the fog F is, for example, 20 ° to 90 ° (FIG. 3B).
  • two or three liquid orifice portions are formed in series,
  • the first gas flow injected from the first gas orifice part and the second gas flow injected from the second gas orifice part are sandwiched from both ends of the series of the liquid orifice parts arranged in series. It collides with the liquid exiting from the liquid orifice and atomizes the liquid.
  • the number of holes in the liquid orifice part is two, two, or three from two because the effect of miniaturization is increased. Further, when the number of holes in the liquid orifice part is set to two or three, it is possible to increase the siphon effect by reducing the orifice cross-sectional size (cross-sectional diameter) and to increase the amount of liquid sucked up as a whole.
  • the miniaturization promoting portion described later when the miniaturization promoting portion described later is not provided, this makes it possible to control the average particle diameter of the mist.
  • the structure for finely adjusting the average particle diameter is one, two, or three structures. Is suitable. Examples of the shape of the orifice hole include a circle, an ellipse, a rectangle, a rounded rectangle, and a rounded square.
  • the hole diameters of the plurality of liquid orifice portions may be different or the same, but are preferably the same from the viewpoint of processing and moldability.
  • three, four, five or six liquid orifice portions are formed. Although it may be arranged in series, it may be arranged so that the appearance shape when arranged forms a polygon. In proportion to the increase in the total cross-sectional size of the liquid orifice portion, the collision size between the gas flows (or the collision size between the gas flows and the liquid) increases. Therefore, the size of the device itself is also increased.
  • the liquid atomizing device is provided in a spraying direction of the mist coming out of the gas-liquid mixing area, has the internal space, and further refines the mist in the internal space. It further has a miniaturization promoting part.
  • Examples of the shape of the miniaturization promoting portion having the internal space include a cylindrical shape, a trumpet shape, and an L shape.
  • the gas pressure source is not electrically driven, and is configured to generate a gas pressure (gas flow) by, for example, a manual type, a foot type, or a mechanical type.
  • the gas pressure Pa (MPa) is, for example, in the range of 0.005 to 0.40, preferably 0.01 to 0.30, and more preferably 0.03 to 0.1.
  • the liquid can be atomized with only such low gas energy.
  • the gas pressure Pa (MPa) is, for example, in the range of 0.10 to 0.40.
  • the pressures of the two gas streams are preferably set to be the same or substantially the same, and the flow rates are preferably set to be the same or substantially the same.
  • the cross-sectional shape of the gas flow injected from the gas orifice part is not particularly limited, and examples thereof include a circular shape, an elliptical shape, a rectangular shape, and a polygonal shape.
  • the cross-sectional shape of the gas flow depends on the orifice cross section of the gas orifice portion.
  • the cross-sectional shape of the liquid orifice part is not particularly limited. In the case of a circular cross section, workability is good.
  • the spray outlet part 3 may be formed integrally with a member (gas orifice part 1, 2) for forming a gas orifice part or may be formed by a separate member.
  • the liquid atomizing device may be made disposable, or each component part may be made removable and reused so that it can be cleaned. Moreover, it is preferable that the liquid atomization apparatus has the compactness excellent in portability. Moreover, you may couple
  • an intersection angle between an injection direction axis of the first gas orifice portion and an injection direction axis of the second gas orifice portion is in a range of 90 ° to 180 °.
  • the angle range in which the respective injection direction axes of the first gas orifice part 1 and the second gas orifice part 2 intersect each other is such that the gas injected from the first gas orifice part 1 and the gas flow injected from the second gas orifice part 2 It corresponds to the collision angle.
  • FIG. 2 shows the collision angle ⁇ .
  • the “collision angle ⁇ ” is 80 ° to 220 °, preferably 80 ° to 180 °, more preferably 90 ° to 150 °, and particularly preferably 100 ° to 130 °.
  • the two gas orifices preferably have a structure in which the space on the upstream side (for example, the size of the cross-sectional rectangle, the size of the cross-sectional circle, etc.) is large in the flow direction of the gas flow, and the space becomes smaller toward the downstream.
  • This space may be a gap formed between the inner wall surface of the outer member and the outer wall surface of the inner member, for example.
  • the gas is not particularly limited, and examples thereof include air, clean air (clean air), nitrogen, inert gas, fuel mixed air, oxygen, and the like, and can be appropriately set according to the purpose of use.
  • the liquid is not particularly limited, but a low-viscosity liquid is preferable.
  • cosmetic liquids such as water, ionized water, moisturizing liquid, beauty water, lotion, etc.
  • examples thereof include paints, fuel oils, coating agents, solvents, and resins.
  • FIG. 1B is an enlarged view of the AA cross section of FIG. 1A.
  • 1B is an enlarged view of a BB cross section of FIG. 1A.
  • FIG. It is a schematic diagram for demonstrating the crossing angle formed with two gas injection axes. It is a schematic diagram for demonstrating an example of the cross section of the spray outlet part periphery of another embodiment. It is the schematic diagram seen from the side of FIG. 3A. It is explanatory drawing for demonstrating the atomization mechanism. It is explanatory drawing for demonstrating the atomization mechanism. It is explanatory drawing for demonstrating the width
  • FIG. 1 It is a cross-sectional schematic diagram of the whole liquid atomization apparatus of Embodiment 1.
  • FIG. It is the figure which expanded the liquid atomization apparatus of Embodiment 1.
  • FIG. It is a figure for demonstrating the spraying operation
  • FIG. It is a cross-sectional schematic diagram of the whole liquid atomization apparatus of Embodiment 2.
  • FIG. It is a figure which expanded the liquid atomization apparatus of Embodiment 2.
  • FIG. It is a figure which shows the connection structure of the syringe and nozzle main-body part of another embodiment.
  • FIG. 3 shows the connection structure of the syringe and nozzle main-body part of another embodiment.
  • FIG. 6 is a schematic cross-sectional view taken along the line AA of the liquid atomizing apparatus according to Embodiment 3. It is the figure which expanded the front-end
  • FIG. It is a figure for demonstrating the crossing angle (collision angle) of the injection direction axis
  • FIG. 4 is a schematic cross-sectional view of the entire liquid atomizing apparatus 100.
  • FIG. 5 is an enlarged view of the nozzle main body portion of the liquid atomizing apparatus 100.
  • the liquid atomizing apparatus 100 includes a gas pressure source 130 having a syringe 131 and a plunger 132.
  • the syringe 131 has a female luer lock joint 131a formed on the tip side thereof.
  • the syringe 131 is connected to the nozzle body 30.
  • the nozzle main body 30 is provided with a male luer lock joint 30 a and is connected to the female luer lock joint 131 a of the syringe 131.
  • the nozzle body 30 has a cylindrical cross section, and the liquid storage section 10 having a cylindrical cross section is provided therein.
  • a space is provided between the outer wall surface of the liquid storage unit 10 and the inner wall surface of the nozzle body 30. This space is the gas passage portion R1 and communicates with the internal space of the liquid storage portion 10 through openings 11 and 12 provided behind the liquid storage portion 10 (the liquid orifice portion side is the front). Part of the gas from the gas pressure source 130 is branched from the liquid storage unit 10 through the openings 11 and 12 and flows into the gas passages R1 and R2.
  • the liquid storage unit 10 is arranged inside the nozzle body 30 and fixed with the nozzle tip 20.
  • the nozzle tip portion 20 has a female screw portion 20a at the rear portion thereof.
  • the nozzle tip portion 20 is held down so as to cover the outer wall surface of the tip portion of the liquid storage portion 10, and the female screw portion 20a and the male screw portion 30b of the nozzle body portion 30 are fixed by screws.
  • a packing 60 is provided as a seal member between contact end portions of the nozzle tip portion 20 and the nozzle main body portion 30.
  • the gas flowing through the gas passage portions R1 and R2 flows to the first gas orifice portion 21 and the second gas orifice portion 22 formed in the space between the inner wall surface of the nozzle tip portion 20 and the outer wall surface of the liquid storage portion 10.
  • the first gas orifice portion 21 and the second gas orifice portion 22 are injected as two gas flows.
  • two concave grooves are formed on the outer wall surface of the liquid storage portion 10, and each gas orifice portion is formed by covering the inner wall surface of the nozzle tip portion 20.
  • the crossing angle (collision angle ⁇ ) of the injection direction axes of the first and second gas orifices is 90 °.
  • the collision angle ⁇ is in the range of 80 ° to 180 °.
  • a piston unit 50 that moves inside the liquid storage unit 10 is disposed in the interior of the liquid storage unit 10.
  • a rubber plug 40 is formed at the tip of the piston portion 50.
  • the liquid storage unit 10 has a liquid orifice unit 15 having a diameter smaller than the diameter of the liquid storage unit 10 in the distal direction.
  • a predetermined amount of liquid L is stored in the liquid storage unit 10.
  • the method for storing the liquid L in the liquid storage unit 10 is not particularly limited.
  • the piston L may be removed to inject the liquid L, or the liquid L may be sucked up from the liquid orifice 15 by pulling the piston 50 backward from the tip position.
  • the injection hole may be formed by providing a horizontal hole.
  • the plunger 132 is waiting at a predetermined position in the syringe 131. From this state, the plunger 132 is pushed into the tip (front) of the syringe 131. As a result, the gas in the syringe 131 flows into the liquid storage unit 10. The gas pressure of the inflowing gas acts on the rubber plug 40, and the rubber plug 40 is pushed toward the tip of the liquid storage unit 10. At the same time, gas flows into the gas passage portions R1 and R2 through the open portions 11 and 12 of the liquid storage portion 10. This gas passes through the gas passage portions R1 and R2, flows to the first gas orifice portion 21 and the second gas orifice portion 22, and is injected from the tip thereof.
  • FIG. 6 shows a state in which the rubber stopper 40 reaches the tip of the liquid storage unit 10 and stops.
  • the gas-liquid mixing area part M which is an area in which two gas flows and a liquid collide to perform atomization, is located in front of the orifice axis of the liquid orifice part 15.
  • the nozzle main body 30 is removed from the syringe 131, and the piston 50 is pulled backward, whereby the liquid can be injected again into the liquid storage unit 10.
  • first and second gas orifice portions 21 and 22 is not limited to the above configuration.
  • a groove may be formed on the inner wall surface side of the nozzle tip 20 and a lid may be formed on the outer wall surface of the liquid storage unit 10.
  • connection method between the members is not particularly limited, and may be configured to be detachable, for example, may be connected by screw connection, fitting, or may be bonded by an adhesive. Moreover, when connecting each member, you may interpose sealing members, such as packing.
  • the said liquid atomization apparatus is provided in the spray direction of the mist which comes out from the gas-liquid mixing area part M ahead of the nozzle front-end
  • FIG. 7 is a schematic cross-sectional view of the entire liquid atomizing apparatus.
  • FIG. 8 is an enlarged view of the tip side of the liquid atomizing device.
  • the cover part 70 is provided outside the nozzle body part 30 and the nozzle tip part 20.
  • the front part of the cover part 70 protrudes forward (forward in the spraying direction) from the nozzle tip part 20.
  • a predetermined space is provided from the liquid orifice portion 15 to the tip opening portion 71 of the cover portion 70.
  • a gas-liquid mixing area is formed in this space.
  • the front end opening 71 of the cover part 70 has a shape that is inclined forward in diameter, and this corresponds to a spray outlet part.
  • the piston portion 50 and the rubber plug 40 are not provided.
  • the liquid in the liquid storage part 10 can be pushed out only by the gas pressure without the piston part 50 and the rubber plug 40 being interposed. Since the liquid injected by the surface tension is held inside as the internal diameter of the liquid storage unit 10 is smaller, there may be no rubber stopper.
  • the connecting member is not particularly limited, and can be connected by a connector, a tube, or the like.
  • FIG. 10A is a schematic cross-sectional view of the entire liquid atomizing apparatus 300.
  • FIG. 10B is a schematic cross-sectional view of the liquid atomizing apparatus 300 taken along the line AA.
  • FIG. 10C is an enlarged view of the nozzle tip B portion of the liquid atomizing apparatus 300.
  • the liquid atomizing apparatus 300 has a gas pressure source having a syringe (not shown) and a plunger.
  • the syringe has a female lock joint formed on the tip side thereof.
  • the syringe is connected to the nozzle main body 330.
  • the nozzle body 330 is provided with a male luer lock joint 310 and is connected to a syringe luer lock joint of a syringe.
  • the nozzle body 330 has a cylindrical cross section, and provides a space along the central axis X where the liquid storage unit 340 is disposed.
  • the liquid storage portion 340 has already been arranged along the central axis X of the nozzle body 330.
  • the liquid storage unit 340 is formed with an injection port 341, communicates with the opening 330 a of the nozzle body 330, injects liquid from the opening 330 a, and stores the liquid in the liquid storage unit 340 through the injection port 341. It is configured.
  • a lid or plug (not shown) for closing the opening 330a is provided.
  • the liquid inlet 341 may not be formed in the liquid storage part 340, and the liquid storage part 340 may be configured to be detachable from the nozzle body 330.
  • the nozzle main body 330 has four gas passage portions 331, 332, 333, and 334 formed around the liquid storage portion 340 along the central axis X (see FIGS. 10B and 10C). These gas passage portions are areas where gas from a gas pressure source (not shown) branches and flows.
  • the number of gas passages is not limited to four, and may be 1, 2, 3, 4 or more.
  • a liquid orifice part 350 in which three orifice holes 351, 352, 353 are formed in series is provided at the tip of the liquid storage part 340.
  • Two concave grooves 355 a and 355 b are formed on the outer wall of the liquid orifice portion 350.
  • Two concave grooves 355a and 355b are formed so as to be sandwiched from both ends of the orifice holes arranged in series.
  • a cap 360 on which a spray outlet 362 is formed is connected to the nozzle main body 330 with a packing 370 with a screw.
  • the inner wall surface 361 of the cap 360 and the outer wall surface 357 of the liquid orifice part 350 are in contact with each other up to the position reaching the opening of the spray outlet part 362, and two gas flows R1 and R2 are generated by the two concave grooves 355a and 355b.
  • the two concave grooves 355a and 355b correspond to first and second gas orifice portions, respectively.
  • the gas flowing through the gas passage portions 331, 332, 333, and 334 merges in the space E between the tip of the nozzle body 330 and the inner wall of the side surface of the cap 360, and two gas flows R1 and R2 are generated by the two concave grooves 355a and 355b. Is done.
  • the two gas flows collide with each other in the gas-liquid mixing area M, and the collided gas flows are injected to the outside through the spray outlet 362. Due to the jetting action of this gas flow, the inside of the gas-liquid mixing area M becomes a negative pressure, and the liquid is sucked up from the three orifice holes 351, 352, 353 of the liquid orifice part 350 by the siphon action, and this liquid becomes two gases.
  • the liquid collides with the streams R1 and R2, the liquid is atomized (miniaturized), and the mist is sprayed from the spray outlet 362 to the outside.
  • the intersection angle (collision angle ⁇ 1) of the injection direction axes of the two gas flows generated by the grooves 355a and 355b is 110 °.
  • An angle ⁇ 2 (cross-sectional angle) formed by the inner wall surface 361 of the cap 360 is 120 °.
  • the collision angle ⁇ and the angle formed by the inner wall surface of the nozzle tip 20 are the same, but in the third embodiment, they are different angles.
  • the two gas orifice portions have a structure in which the space on the upstream side is large in the flow direction of the gas flow and the space becomes small as it goes downstream.
  • . ⁇ 2 is preferably in the range of ⁇ 1 + 5 ° to 20 °, for example.
  • increasing the air amount increases the siphon action and increases the spray amount, but tends to increase the average particle diameter of the mist.
  • ⁇ 1 ⁇ 2 it is possible to maintain or reduce the average particle diameter of the mist without increasing the spray amount while keeping the air amount constant and without reducing the refining action.
  • connection method between the members is not particularly limited, and may be configured to be detachable, for example, may be connected by screw connection, fitting, or may be bonded by an adhesive. Moreover, when connecting each member, you may interpose sealing members, such as packing.
  • liquid storage unit 340 and the liquid orifice unit 350 may be integrally configured. Further, the nozzle body 330 and the cap 360 may be provided integrally.
  • the said liquid atomization apparatus has further the refinement
  • Example> The spray characteristics were evaluated using a liquid atomizing apparatus (with a cover) configured as shown in the second embodiment.
  • the amount of water injected into the liquid storage unit is 0.12 ml.
  • the cross-sectional diameter of the liquid orifice portion 15 is ⁇ 0.1 mm, the concave portions (cross-sectional rectangles) of the first and second gas orifice portions are 0.3 mm deep, and the slit width is 0.1 mm. Air was used as the gas.
  • the plunger was pushed all the way to the syringe tip (1 push).
  • the spray amount at that time was 0.12 ml, and the entire amount was extruded and sprayed. Moreover, the spray state was favorable and it was a low speed spray.
  • the average particle size (SMD) of the sprayed mist particles was 6.43 ⁇ m.
  • the average particle size (SMD) was measured with a laser diffraction measuring instrument. The measurement position was 100 mm from the liquid orifice.

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  • Anesthesiology (AREA)
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PCT/JP2013/054105 2012-02-21 2013-02-20 Dispositif d'atomisation de liquide Ceased WO2013125555A1 (fr)

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JP2015219088A (ja) * 2014-05-16 2015-12-07 フェムトディプロイメンツ株式会社 液膜ノズル装置、注射針、注射器、注射器型液膜生成装置、液体の殺菌装置、液体スクリーンの形成装置、液膜ノズル装置の製造方法
WO2017180151A1 (fr) 2016-04-15 2017-10-19 Kaer Biotherapeutics Corporation Buse d'aérosolisation et procédé de fonctionnement d'une telle buse d'aérosolisation
CN107376063A (zh) * 2017-07-04 2017-11-24 浙江医尔仁医疗科技有限公司 中西药靶向雾化装置
IT201600080879A1 (it) * 2016-08-01 2018-02-01 Giorgio Mezzoli Erogatore
JP2018149170A (ja) * 2017-03-14 2018-09-27 ニプロ株式会社 シリンジ型噴出装置
WO2018186277A1 (fr) * 2017-04-04 2018-10-11 ニプロ株式会社 Éjecteur du type seringue
WO2019017176A1 (fr) * 2017-07-21 2019-01-24 スプレーイングシステムスジャパン合同会社 Buse à double fluide
WO2019225226A1 (fr) * 2018-05-24 2019-11-28 ニプロ株式会社 Dispositif d'éjection de type seringue
WO2019228946A1 (fr) * 2018-05-29 2019-12-05 Shl Medical Ag Ensemble pour dispositif de pulvérisation, dispositif de pulvérisation, dispositif d'administration de médicament et procédé
US10661033B2 (en) 2016-04-15 2020-05-26 Kaer Biotherapeutics Corporation Aerosolizing nozzle and method of operating such aerosolizing nozzle
JP2021522920A (ja) * 2018-05-29 2021-09-02 エスエイチエル・メディカル・アーゲー ノズル及びカートリッジ組立体
WO2022003592A1 (fr) * 2020-07-01 2022-01-06 Adl Farmaceutici S.R.L. Atomiseur nasal à seringue
US11278925B2 (en) 2017-04-27 2022-03-22 Aptar France Sas Head for dispensing a fluid product
EP4201457A1 (fr) * 2021-12-22 2023-06-28 Gerresheimer Regensburg GmbH Moyen d'atomisation

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ES2907567T3 (es) * 2017-06-22 2022-04-25 Softhale Nv Dispositivo de inhalación con boquilla multilíquido

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Publication number Priority date Publication date Assignee Title
JP2015219088A (ja) * 2014-05-16 2015-12-07 フェムトディプロイメンツ株式会社 液膜ノズル装置、注射針、注射器、注射器型液膜生成装置、液体の殺菌装置、液体スクリーンの形成装置、液膜ノズル装置の製造方法
CN109562237B (zh) * 2016-04-15 2021-08-27 卡尔生物治疗公司 雾化喷嘴和操作这样的雾化喷嘴的方法
WO2017180151A1 (fr) 2016-04-15 2017-10-19 Kaer Biotherapeutics Corporation Buse d'aérosolisation et procédé de fonctionnement d'une telle buse d'aérosolisation
AU2016402362B2 (en) * 2016-04-15 2022-03-17 Kaer Biotherapeutics Corporation Aerosolizing nozzle and method of operating such aerosolizing nozzle
EP3442628A4 (fr) * 2016-04-15 2020-01-01 KAER Biotherapeutics Corporation Buse d'aérosolisation et procédé de fonctionnement d'une telle buse d'aérosolisation
US10661033B2 (en) 2016-04-15 2020-05-26 Kaer Biotherapeutics Corporation Aerosolizing nozzle and method of operating such aerosolizing nozzle
CN109562237A (zh) * 2016-04-15 2019-04-02 卡尔生物治疗公司 雾化喷嘴和操作这样的雾化喷嘴的方法
IT201600080879A1 (it) * 2016-08-01 2018-02-01 Giorgio Mezzoli Erogatore
JP2018149170A (ja) * 2017-03-14 2018-09-27 ニプロ株式会社 シリンジ型噴出装置
US11638791B2 (en) 2017-04-04 2023-05-02 Nipro Corporation Syringe type ejection device
JP2018175006A (ja) * 2017-04-04 2018-11-15 ニプロ株式会社 シリンジ型噴出装置
WO2018186277A1 (fr) * 2017-04-04 2018-10-11 ニプロ株式会社 Éjecteur du type seringue
US11278925B2 (en) 2017-04-27 2022-03-22 Aptar France Sas Head for dispensing a fluid product
CN107376063B (zh) * 2017-07-04 2020-08-21 浙江医尔仁医疗科技有限公司 中西药靶向雾化装置
CN107376063A (zh) * 2017-07-04 2017-11-24 浙江医尔仁医疗科技有限公司 中西药靶向雾化装置
JP2019018183A (ja) * 2017-07-21 2019-02-07 スプレーイングシステムスジャパン合同会社 二流体ノズル
WO2019017176A1 (fr) * 2017-07-21 2019-01-24 スプレーイングシステムスジャパン合同会社 Buse à double fluide
JP2019201985A (ja) * 2018-05-24 2019-11-28 ニプロ株式会社 シリンジ型噴出装置
WO2019225226A1 (fr) * 2018-05-24 2019-11-28 ニプロ株式会社 Dispositif d'éjection de type seringue
US11975137B2 (en) 2018-05-24 2024-05-07 Nipro Corporation Syringe-shaped spraying device
WO2019228946A1 (fr) * 2018-05-29 2019-12-05 Shl Medical Ag Ensemble pour dispositif de pulvérisation, dispositif de pulvérisation, dispositif d'administration de médicament et procédé
JP2021522920A (ja) * 2018-05-29 2021-09-02 エスエイチエル・メディカル・アーゲー ノズル及びカートリッジ組立体
US12337099B2 (en) 2018-05-29 2025-06-24 Shl Medical Ag Nozzle and cartridge assembly
WO2022003592A1 (fr) * 2020-07-01 2022-01-06 Adl Farmaceutici S.R.L. Atomiseur nasal à seringue
EP4201457A1 (fr) * 2021-12-22 2023-06-28 Gerresheimer Regensburg GmbH Moyen d'atomisation

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