Classifications

• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
  • C11D3/0005—Other compounding ingredients characterised by their effect
  • C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
  • C11D1/008—Polymeric surface-active agents
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
  • C11D1/66—Non-ionic compounds
  • C11D1/825—Mixtures of compounds all of which are non-ionic
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
  • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
  • B65B25/00—Packaging other articles presenting special problems
  • B65B25/008—Packaging other articles presenting special problems packaging of contact lenses
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
  • C11D1/38—Cationic compounds
  • C11D1/42—Amino alcohols or amino ethers
  • C11D1/44—Ethers of polyoxyalkylenes with amino alcohols; Condensation products of epoxyalkanes with amines
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
  • C11D1/66—Non-ionic compounds
  • C11D1/722—Ethers of polyoxyalkylene glycols having mixed oxyalkylene groups; Polyalkoxylated fatty alcohols or polyalkoxylated alkylaryl alcohols with mixed oxyalkylele groups

Definitions

• the present invention relates to a contact lens in a packaging container, a method of manufacturing a contact lens in a packaging container, and a contact lens solution.
• contact lens (CL) wearers have increased.
• Contact lenses are classified into hard contact lenses (HCL) and soft contact lenses (SCL).
• Wearers of soft contact lenses (SCL) with a reduced uncomfortable feeling during wearing thereof have increased.
• the soft contact lenses have a disadvantage in that it is lower in oxygen permeability than the hard contact lenses. This is because a supply of oxygen to an eyeball when a hard contact lens is worn mainly depends on interchange of tears due to lens movement by eye-blinking, but the supply of oxygen due to the interchange of tears is reduced when a soft contact lens is worn.
• the oxygen permeability of a soft contact lens depends on free water included in the lens, and as the water content ratio of a lens becomes higher, the oxygen permeability becomes higher in general. On the other hand, since more moisture of a lens is evaporated with a higher water content ratio of a lens, the evaporated moisture should be compensated for with tears. Accordingly, it is generally said that an eye wearing a soft contact lens is more easily dried than that when an eye wearing a hard contact lens.
• a blister pack (packaging container) has been used to package a soft contact lens from the past.
• the blister pack is configured to receive a soft contact lens and a storage solution (solution) in an indent portion formed in a container body and to air-tightly seal the indent portion with a packaging film detachably bonded to the container body.
• the soft contact lens is stored in a state where it is immersed in the storage solution in the sealed indent portion.
• physiological saline, deionized water, or the like is used as the storage solution.
• a storage solution has been proposed to which a nonionic surfactant is added (see Patent Document 1).
• Patent Document 1 discloses a contact lens packaging solution which contains a poly(oxyethylene) (POE)-poly(oxypropylene) (POP) block copolymer such as poloxamer or poloxamine as the nonionic surfactant.
• POE poly(oxyethylene)
• POP poly(oxypropylene)
• Patent Document 1 describes that excellent wetting characteristics are achieved particularly for a soft contact lens having a high water-containing property (hydrophilic property) by using a POE-POP block copolymer with a weight-average molecular weight of about 4,000 to 30,000.
• a moisture-retaining property greatly varies by combination of the high molecular POE-POP block copolymer with a POE-POP block copolymer, particularly, a low molecular POE-POP block copolymer with a
• the invention also provides a method of manufacturing the contact lens in a packaging container and a contact lens solution.
• a first aspect of the invention is a contact lens in a packaging container
• a second aspect of the invention is a contact lens solution
• a third aspect of the invention is a method of manufacturing a contact lens in a packaging container.
• the invention can provide at least the following means.
• a contact lens in a packaging container including: a container body that has an indent portion; a contact lens and a solution that are received in the indent portion; and a packaging film that is detachably bonded to the container body so as to air-tightly seal the indent portion, wherein the solution contains a nonionic surfactant at a ratio of 0.01 to 10 wt%, and wherein the nonionic surfactant includes two or more types of
• the nonionic surfactant includes one or more types of a high-molecular POE-POP block copolymer and a low-molecular POE-POP block copolymer between which the difference in weight-average molecular weight of a POP group is 1000 or more.
• a nonionic surfactant including two or more types of poly(oxyethylene) (POE)-poly(oxypropylene) (POP) block copolymers at a ratio of 0.01 to 10 wt%.
• nonionic surfactant includes one or more types of a high-molecular POE-POP block copolymer and a low-molecular POE-POP block copolymer between which the difference in
• weight-average molecular weight of a POP group is 1000 or more.
• a method of manufacturing a contact lens in a packaging container including: immersing a contact lens in a solution that contains a nonionic surfactant including two or more types of poly(oxyethylene) (POE)-poly(oxypropylene) (POP) block copolymers at a ratio of 0.01 to 10 wt%; and detachably bonding a packaging film, which receives the contact lens and the solution in an indent portion formed in a container body and air-tightly seals the indent portion, to the container body.
• a nonionic surfactant including two or more types of poly(oxyethylene) (POE)-poly(oxypropylene) (POP) block copolymers at a ratio of 0.01 to 10 wt%
• the contact lens in a packaging container it is possible to suppress moisture loss from the lens surface when the contact lens is worn and thus to enhance a moisture-retaining property of the lens surface. Accordingly, for example, even when a soft contact lens having a high water-containing property is used, it is possible to suppress drying of an eye wearing the soft contact lens and to achieve a comfortable wearing sensation with a small feeling of dryness.
• a contact lens in a packaging container In the method of manufacturing a contact lens in a packaging container according to the invention, it is possible to manufacture a contact lens in a packaging container, which can suppress moisture loss from the lens surface when a contact lens is worn and enhance a moisture-retaining property of the lens surface.
• the contact lens solution according to the invention for manufacturing, washing, storing, or packaging of a contact lens, it is possible to suppress moisture loss from the lens surface when the contact lens is worn and thus to enhance a
• FIG. 1 is a partially-exploded cross-sectional view illustrating an example of a contact lens in a packaging container according to the invention.
• FIG. 2 is a graph in which various poloxamers (Pluronics) are marked in a grid shape.
• FIG 3 is a graph in which various reverse POE-POP block copolymers (RPE) are marked in a grid shape.
• FIG 4 is a graph illustrating measurement results (absolute values) of Samples 1 to 6 in an example.
• FIG 5 is a graph illustrating measurement results (absolute values) of Samples 7 to 15 in the example.
• FIG 6 is a graph illustrating measurement results (relative values) of Samples 1 to 6 in the example.
• FIG. 7 is a graph illustrating measurement results (relative values) of Samples 7 to 15 in the example.
• FIG. 8 is a graph illustrating measurement results (relative values) of Samples 16 to 20 in the example.
• FIG. 9 is a graph illustrating measurement results (relative values) of Samples 22 to 28 in the example.
• FIG. 10 is a graph illustrating measurement results (relative values) of Samples 30 to 39 in the example.
• FIG 11 is a graph illustrating analysis results (absolute values) of Samples 40 to 43 in the example.
• FIG. 1 An example of a contact lens in a packaging container according to a first embodiment of the invention is shown in FIG. 1.
• a contact lens CL is packaged with a packaging container called blister pack 1.
• the blister pack 1 includes a container body 2 and a packaging film 3 bonded to the container body 2.
• the container body 2 has a spherical indent portion 4 and receives a contact lens CL and a storage solution (solution) S in the indent portion 4.
• the material of the container body 2 is not particularly limited, and examples thereof include plastic materials such as a polyalkylene resin, a polyvinyl chloride (PVC) resin, and a polyamide resin.
• plastic materials such as a polyalkylene resin, a polyvinyl chloride (PVC) resin, and a polyamide resin.
• PVC polyvinyl chloride
• the shape of the container body 2 is not particularly limited as long as the indent portion 4 receiving the contact lens CL can be formed therein.
• the shape of the indent portion 4 is not particularly limited, and examples thereof include a spherical shape, a polyhedral shape, a cubic shape, and a rectangular parallelepiped shape.
• the packaging film 3 is detachably bonded to the container body 2 to cover the indent portion 4 of the container body 2.
• the indent portion 4 is air-tightly sealed with the packaging film 3.
• the material of the packaging film 3 is not particularly limited, and examples thereof include a resin film and a laminated film in which a resin film and a metal foil are laminated and bonded.
• the contact lens CL is stored in the sealed indent portion 4 in a state where it is immersed in the storage solution S. By detaching the packaging film 3, the contact lens CL can be taken out from the indent portion 4 for use.
• Examples of the product type of the contact lens in a packaging container according to the first embodiment include three types described below.
• the first type is a disposable type in which a contact lens CL is hardly cared in a duration of use and is discarded after being used for about a day to one week.
• the second type is a frequent replacement type in which a contact lens is slightly cared such as being washing if necessary in a duration of use and is used for about two weeks.
• the third type is a planned replacement type in which a contact lens CL is sufficiently cared in a duration of use and is used for about one month or three months.
• a contact lens CL to which the first embodiment can be applied is not particularly limited and an example thereof is a water-containing soft contact lens (SCL) containing relatively much moisture and including a gel-like synthetic polymer compound (hydrogel) called PHEMA (polyhydroxy ethylmethacrylate).
• SCL water-containing soft contact lens
• PHEMA gel-like synthetic polymer compound
• MPC 2-methacryloyloxyethylphosphoryl chlorine
• PEG polyethylene glycol
• Another example of the soft contact lens is a lens formed of an amphoteric ion material.
• soft contact lenses can be classified into four types depending on presence or absence of ionic properties. That is, the soft contact lenses are classified into a high water content type in which the water content ratio of a lens is 50% or more and a low water content type in which the water content ratio of a lens is less than 50%, and the respective types are classified into an ionic type and a nonionic type. By this classification, the soft contact lenses are classified into four groups of Group I (low water content and nonionic), Group II (high water content and nonionic), Group III (low water content and ionic), and Group IV (high water content and ionic).
• Group I low water content and nonionic
• Group II high water content and nonionic
• Group III low water content and ionic
• Group IV high water content and ionic
• Examples of the material of such a soft contact lens include etafilcon A, polymacon, genfilcon A, lenefilcon A, bafilcon, acofilcon A, acquafilcon A, alofilcon A, alphafilcon A, amifilcon A, astifilcon A, atalafilcon A, bisfilcon A, bufilcon A, crofilcon A, cyclofilcon A,balilcon A, deltafilcon A, deltafilcon B, dimefilcon A, drooxifilcon A, epsifilcon A, esterifilcon A, focofilcon A, galyfilcon A, govafilcon A, hefilcon A, hefilcon B, hefilcon D, hilafilcon A, hilafilcon B, hixoifilcon A, hioxifilcon B, hioxifilcon C, hydrofilcon A, licryfilcon A, licryfilcon B, lidofilcon B, lidofilcon A
• the solvent of the storage solution S is not particularly limited as long as it is a solvent in which a nonionic surfactant is soluble, and examples thereof include physiological saline and deionized water.
• the storage solution S contains a nonionic surfactant at a ratio of 0.01 to 10 mass% (wt%), and the nonionic surfactant includes two or more types of
• the total concentration of two or more types of nonionic surfactants in the storage solution S is not particularly limited as long as it is in a range of 0.01 to 10 wt%, and the total concentration may be in a range of 0.05 to 8.0 wt%, may be in a range of 0.10 to 7.0 wt%, may be in a range of 0.20 to 6.0 wt%, may be in a range of 0.30 to 5.0 wt%, may be in a range of 0.40 to 5.0 wt%, may be in a range of 0.
• 50 to 4.5 wt% may be in a range of 0.60 to 4.5 wt%, may be in a range of 0.70 to 4.0 wt%, may be in a range of 0.80 to 3.5 wt%, may be in a range of 0.90 to 3.0 wt%, may be in a range of 1.0 to 2.5 wt%, or may be in a range of 1.10 to 2.0 wt%.
• the lower limit value of the range is equal to or more than 0.30 wt%, it is possible to further reduce moisture loss from the lens surface during wearing the contact lens, which is preferable.
• the upper limit value of the range is equal to or less than 3.0 wt%, it is possible to further reduce an influence (burden) to an eye wearing the contact lens, which is preferable.
• the nonionic surfactant includes one or more types of a high-molecular
• the upper limit of the difference in weight-average molecular weight is not particularly limited, but may be considered to be, for example, 50,000 or less.
• the difference in weight-average molecular weight may be 40,000 or less, may be 30,000 or less, may be 20,000 or less, may be 15,000 or less, may be 12,500 or less, and may be 10,000 or less.
• a copolymer of which the weight-average molecular weight is 4,000 or more and the weight ratio of a POE group (poly(oxyethylene) block) to the overall molecule is 40% or more as the high-molecular POE-POP block copolymer and a copolymer of which the weight-average molecular weight is 3,000 or less and the weight ratio of the POE group to the overall molecule is 40% or less as the low-molecular POE-POP block copolymer may be combined.
• the upper limit of the weight ratio of the POE group to the overall molecule of the high-molecular POE-POP block copolymer is not particularly limited, and may be 90 wt% or less or may be 80 wt% or less.
• the range of the weight ratio is not particularly limited as long as it is 40 wt% or more.
• a copolymer to be used may be selected from a range of 40 to 90 wt%
• a copolymer to be used may be selected from a range of 50 to 90 wt%
• a copolymer to be used may be selected from a range of 60 to 80 wt%
• a copolymer to be used may be selected from a range of 70 to 80 wt%.
• the block copolymer can be selected from any of the ranges, but by using a high-molecular POE-POP block copolymer of which the weight ratio is selected from the range of 70 to 80 wt%, it is possible to suppress moisture loss from the lens and to further enhance a moisture-retaining property of the lens.
• the upper limit of the weight ratio of the POE group to the overall molecule of the low-molecular POE-POP block copolymer is not particularly limited, and may be 5 wt% or more or may be 10 wt% or more.
• the range of the weight ratio is not particularly limited as long as it is 40 wt% or less.
• a copolymer to be used may be selected from a range of 5 to 40 wt%
• a copolymer to be used may be selected from a range of 10 to 40 wt%
• a copolymer to be used may be selected from a range of 20 to 40 wt%
• a copolymer to be used may be selected from a range of 30 to 40 wt%.
• the block copolymer can be selected from any of the ranges, but by using a low-molecular POE-POP block copolymer of which the weight ratio is selected from the range of 20 to 40 wt%, it is possible to suppress moisture loss from the lens and to further enhance a moisture-retaining property of the lens.
• an example of an appropriate combination of the weight ratio of the POE group to the overall molecule of the high-molecular POE-POP block copolymer and the weight ratio of the POE group to the overall molecule of the low-molecular POE-POP block copolymer include a combination in which the weight ratio of the high-molecular POE-POP block copolymer is in a range of 70 to 80 wt% and the weight ratio of the low-molecular POE-POP block copolymer is in a range of 20 to 40 wt%.
• the upper limit of the weight-average molecular weight of the high-molecular POE-POP block copolymer is not particularly limited, and can be considered to be, for example, 50,000 or less.
• the weight-average molecular weight of the high-molecular POE-POP block copolymer may be selected from a range of 4,000 to 40,000, may be selected from a range of 4,500 to 30,000, may be selected from a range of 5,000 to 25,000, may be selected from a range of 6,000 to 20,000, and may be selected from a range of 7,000 to 16,000.
• the block copolymer can be selected from any of the ranges, but by employing the high-molecular POE-POP block copolymer selected from the range of 7,000 to 16,000, it is possible to suppress moisture loss from the lens and to further enhance a moisture-retaining property of the lens.
• the lower limit of the weight-average molecular weight of the low-molecular POE-POP block copolymer is not particularly limited, and can be considered to be, for example, 300 or more.
• the weight-average molecular weight of the low-molecular POE-POP block copolymer may be selected from a range of 300 to 3,000, may be selected from a range of 450 to 3,000, may be selected from a range of 600 to 3,000, may be selected from a range of 750 to 3,000, may be selected from a range of 1,000 to 3,000, may be selected from a range of 1,500 to 3,000, and may be selected from a range of 2,000 to 3,000.
• the block copolymer can be selected from any of the ranges, but by employing the low-molecular POE-POP block copolymer selected from the range of 1,000 to 3,000, it is possible to suppress moisture loss from the lens and to further enhance a moisture-reining property of the lens.
• an example of an appropriate combination of the weight-average molecular weight of the high-molecular POE-POP block copolymer and the weight-average molecular weight of the low-molecular POE-POP block copolymer is a combination in which the weight-average molecular weight of the high-molecular POE-POP block copolymer is in a range of 7,000 to 16,000 and the weight-average molecular weight of the low-molecular POE-POP block copolymer is in a range of 1 ,000 to 3,000.
• an example of an appropriate combination of the high-molecular POE-POP block copolymer and the low-molecular POE-POP block copolymer is a combination in which the weight ratio and the average molecular weight of the high-molecular POE-POP block copolymer are in a range of 70 to 80 wt% and in a range of 7,000 to 16,000, respectively, and the weight ratio and the average molecular weight of the low-molecular POE-POP block copolymer are in a range of 20 to 40 wt% and in a range of 1,000 to 3,000, respectively.
• the content ratio (content rate) of the high-molecular type is larger than the content ratio (content rate) of the low-molecular type, it is possible to suppress moisture loss from the lens and to further enhance a moisture-retaining property of the lens.
• the concentration of the high-molecular POE-POP block copolymer in the storage solution S is not particularly limited as long as it is in a range of 0.01 to less than 10 wt%, and the concentration may be in a range of 0.05 to 8.0 wt%, may be in a range of 0.10 to 7.0 wt%, may be in a range of 0.20 to 6.0 wt%, may be in a range of 0.30 to 5.0 wt%, may be in a range of 0.40 to 5.0 wt%, may be in a range of 0.
• 50 to 4.5 wt% may be in a range of 0.60 to 4.5 wt%, may be in a range of 0.70 to 4.0 wt%, may be in a range of 0.80 to 3.5 wt%, may be in a range of 0.90 to 3.0 wt%, may be in a range of 1.0 to 2.5 wt%, or may be in a range of 1.10 to 2.0 wt%.
• the lower limit value of the range is equal to or more than 0.30 wt%, it is possible to further reduce moisture loss from the lens surface during wearing the contact lens, which is preferable.
• the upper limit value of the range is equal to or less than 3.0 wt%, it is possible to further reduce an influence (burden) to an eye wearing the contact lens, which is preferable.
• the concentration of the low-molecular POE-POP block copolymer in the storage solution S is not particularly limited as long as it is in a range of 0.01 to less than 10 wt%, and the concentration may be in a range of 0.05 to 8.0 wt%, may be in a range of 0.10 to 7.0 wt%, may be in a range of 0.20 to 6.0 wt%, may be in a range of 0.30 to 5.0 wt%, may be in a range of 0.40 to 5.0 wt%, may be in a range of 0.
• 50 to 4.5 wt% may be in a range of 0.60 to 4.5 wt%, may be in a range of 0.70 to 4.0 wt%, may be in a range of 0.80 to 3.5 wt%, may be in a range of 0.90 to 3.0 wt%, may be in a range of 1.0 to 2.5 wt%, or may be in a range of 1.10 to 2.0 wt%.
• the lower limit value of the range is equal to or more than 0.30 wt%, it is possible to further reduce moisture loss from the lens surface during wearing the contact lens, which is preferable.
• the upper limit value of the range is equal to or less than 3.0 wt%, it is possible to further reduce an influence (burden) to an eye wearing the contact lens, which is preferable.
• a name of poloxamer is known as a generic name of a commercially-available POE-POP block copolymer.
• the first two numbers added subsequently to the head character of the model number of the trade name represents the weight-average molecular weight of a POP groiip, and the third number represents the weight ratio of the POE group to the overall molecule.
• the POE-POP block copolymer is available from BASF SE. Pluronic or
• Lutrol registered trademark
• BASF SE Lutrol
• the first number of the trade name represents the weight-average molecular weight [-] of the POP group
• the second number represents the weight ratio [%] of the POE group to the overall molecule.
• L of the head represents liquid
• P represents paste
• F represents flakes.
• RPE represents a reverse type.
• FIG. 2 A graph in which various poloxamers (Pluronics) are marked in a grid shape where the horizontal axis represents the weight ratio [%] of the POE group to the overall molecule and the vertical axis represents the weight-average molecular weight [-] of the POP group is shown in FIG. 2.
• the POE-POP block copolymers include a block copolymer called reverse type.
• General POE-POP block copolymers (poloxamer) other than the reverse type have a structure in which a POE group as a hydrophilic group is disposed on the outside of the POP group (poly(oxypropylene) block) as a hydrophobic group present inside a molecule by adding propylene oxide to propylene glycol and then adding ethylene oxide thereto. That is, a general POE-POP block copolymer has a connection in the order of POE block-POP block-POE block.
• reverse-type POE-POP block copolymers are also called meroxapol and have a structure in which a POP group as a hydrophobic group is disposed on the outside of the POE group as a hydrophilic group present inside a molecule by adding ethylene oxide to propylene glycol and then adding propylene oxide thereto. That is, a reverse-type POE-POP block copolymer has a connection in the order of POP block-POE block-POP block.
• RPE reverse-type POE-POP block copolymers
• the POE-POP block copolymers include a copolymer called Tetronic type.
• Tetronic-type POE-POP block copolymer is also called poloxamine and has a structure in which propylene oxide is added to ethylene diamine and then ethylene oxide is added thereto.
• both a straight chain type having a straight chain structure and a branch type having a branched structure can be used.
• branched-chain POE-POP block copolymer examples include TR1307
• TR304 (with a weight-average molecular weight of 1,300 and a POE weight ratio of 40%), TR908 (with a weight-average molecular weight of 22,500 and a POE weight ratio of 80%), TR1508 (with a weight-average molecular weight of 26,600 and a POE weight ratio of 80%), TR1107 (with a weight-average molecular weight of 14,500 and a POE weight ratio of 70%), TR707 (with a weight-average molecular weight of 12,000 and a POE weight ratio of 70%), TR1504 (with a weight-average molecular weight of 12,500 and a POE weight ratio of 40%), TR1304 (with a weight-average molecular weight of 10,500 and a POE weight ratio of 40%), TR504 (with a weight-average molecular weight of 3,000 and a POE weight ratio of 40%), TR704 (with a weight-average molecular weight-average molecular weight of a weight-average molecular weight of 18,600 and a PO
• TR701 with a weight-average molecular weight of 2,750 and a POE weight ratio of 10%
• TR1101 with a weight-average molecular weight of 5,600 and a POE weight ratio of 10%
• TRl 102 with a weight-average molecular weight of 6,300 and a POE weight ratio of 20%
• TRl 301 with a weight-average molecular weight of 6,800 and a POE weight ratio of 10%
• TRl 302 with a weight-average molecular weight of 7,800 and a POE weight ratio of 20%
• TRl 502 with a weight-average molecular weight of 9,000 and a POE weight ratio of 20%
• TRl 501 with a weight-average molecular weight of 7,900 and a POE weight ratio of 10%
• low-molecular POE-POP block copolymer among known POE-POP block copolymers can be combined for use.
• one or more types of Pluronic F68 (with a weight-average molecular weight of 8,400 and a POE weight ratio of 80%), Pluronic F87 (with a weight-average molecular weight of 7,900 and a POE weight ratio of 70%), Lutrol F87 (with a weight-average molecular weight of 7,700 and a POE weight ratio of 70%), Pluronic F88 (with a weight-average molecular weight of 10,800 and a POE weight ratio of 80%), Pluronic F98 (with a weight-average molecular weight of 13,000 and a POE weight ratio of 80%), Pluronic F108 (with a weight-average molecular weight of 14,600 and a POE weight ratio of 80%), Lutrol F108 (with a weight-average molecular weight of 14,400 and a POE weight ratio of 80%), Pluronic F127 (with a weight-average molecular weight of 11,500 and
• Pluronic RPE1720 (with a weight-average molecular weight of 2,200 and a POE weight ratio of 20%), Pluronic RPE1740 (with a weight-average molecular weight of 2,700 and a POE weight ratio of 40%), Pluronic RPE2035 (with a weight-average molecular weight of 4,100 and a POE weight ratio of 35%), Pluronic RPE2520 (with a weight-average molecular weight of 3,100 and a POE weight ratio of 20%), Pluronic RPE2525 (with a weight-average molecular weight of 2,000 and a POE weight ratio of 25%), Pluronic RPE3110 (with a weight-average molecular weight of 3,500 and a POE weight ratio of 10%), PE3100 (with a weight-average molecular weight of 1 ,000 and a POE weight ratio of 10%), Pluronic L31 (with a weight-
• the first embodiment by employing the combination of the high-molecular POE-POP block copolymer and the low-molecular POE-POP block copolymer, it is possible to suppress moisture loss from the contact lens CL and to achieve an excellent moisture-retaining property (wetting property).
• the storage solution S in the first embodiment can be suitably used for a high water-content soft contact lenses (Groups II and IV) formed of the above-mentioned hydrogel out of the above-mentioned contact lenses CL. That is, by employing the storage solution S in the first embodiment, it is possible to enhance the
• the storage solution S may further contain a menthol. Both a diastereomer and an enantiomer of the menthol can be used, but 1-menthol can be preferably used.
• a menthol By containing the menthol in the storage solution S, it is possible to suppress moisture loss from the lens and to further enhance a moisture-retaining property of the lens. One reason thereof is that the amount of nonionic surfactant adsorbed onto the surface of the contact lens increases.
• the amount of nonionic surfactant adsorbed onto the contact lens can increase by blending the 1-menthol into the storage solution S, it is possible to improve surface characteristics as well as the moisture-retaining property (wetting property) of the contact lens.
• the surface characteristics are characteristics of reducing a burden to an eye during wearing. By improving the surface characteristics, it is possible to reduce an uncomfortable feeling due to unnecessary friction between the lens and the eye during wearing.
• the types, concentrations, and combinations of the nonionic surfactants coexisting in the storage solution S are not particularly limited, and can be appropriately selected, for example, from the
• menthol be contained in the storage solution S with the suitable types, concentrations, and combinations of the nonionic surfactants.
• the concentration of menthol in the storage solution S is not particularly limited, may be selected from a range of 0.001 to 1.0 wt%, may be selected from a range of 0.005 to 0.5 wt%, may be selected from a range of 0.01 to 0.25 wt%, and may be selected from a range of 0.025 to 0.10 wt%. In the range of 0.01 to 0.25 wt% or the range of 0.025 to 0.10 wt% among these concentration ranges, it is possible to suppress moisture loss from the lens and to further improve a moisture-retaining property of the lens.
• the stimulation to the eye during wearing the contact lens CL may be excessively strong.
• water-soluble polymer such as polyvinyl alcohol (PVA), polyvinyl pyrrolidone (PVP), and Na hyaluronate as a water-retaining component.
• PVA polyvinyl alcohol
• PVP polyvinyl pyrrolidone
• Na hyaluronate Na hyaluronate
• the contact lens in a packaging container since a contact lens CL is stored in the indent portion 4 sealed with the packaging film 3 of the container body 2 in a state where it is immersed in the storage solution S, the nonionic surfactant contained in the storage solution S acts on the contact lens CL and it is thus possible to suppress moisture loss from the lens surface during wearing the contact lens CL and to improve the moisture-retaining property of the surface.
• the shape of the packaging container is not limited to the shape having one indent portion 4, like the blister pack 1 shown in FIG. 1, but a shape having plural indent portions 4 and a shape in which plural blister packs 1 are packaged can be used.
• the solution (storage solution S) according to the first embodiment is not limited to an application of packaging and storing a contact lens CL in the contact lens in a packaging container.
• the solution can be used and sold as contact lens solutions which can be used for caring such as temporary storage, washing, disinfection, and sterilization of a contact lens CL.
• a method of bringing the contact lens into contact with the solution a method of temporarily taking out the worn contact lens and immersing the contact lens in the container containing the solution can be exemplified.
• a method of dropping the solution onto the worn contact lens that is, a method of using the solution as eye drops, can be used.
• the contact lens and the solution can come in contact with each other, thereby achieving the above-mentioned effect.
• the time in which the contact lens and the solution are in contact with each other is not particularly limited, but may be, for example, about 30 minutes to 120 hours.
• the solution (storage solution S) according to the first embodiment can be used to manufacture a contact lens in a packaging container.
• the solution when peeling off (detaching) a contact lens from a mold after molding a resin material into a contact lens using a known molding process, the solution may be injected between the mold and the contact lens.
• the solution can reduce the adsorption of the contact lens to the mold and thus can detach the contact lens from the mold while protecting the contact lens.
• the contact lens can be heated in a state where the contact lens is immersed in the solution.
• a sterilization process such as an autoclaving process can be performed in this state. That is, the process using the solution (storage solution S) may be performed in the course of manufacturing a contact lens CL.
• a process using the solution can be performed in the process of high-pressure sterilization by swelling.
• the solution contains two or more types of nonionic surfactants, it is possible to improve the moisture-retaining property (wetting property) of the contact lens by bringing the contact lens into contact with the solution in the course of manufacturing.
• moisture-retaining property wetting property
• the contact lens in a packaging container it is possible to further improve the moisture-retaining property and the surface characteristics of the contact lens by performing a process of bringing the contact lens into contact with the solution having menthol added thereto.
• the content of menthol in the solution is not particularly limited, and can be adjusted, for example, within a range of 0.01 to 10.0 wt%. This range may be 0.01 to 5.0 wt%, may be 0.01 to 3.0 wt%, may be 0.01 to 1.0 wt%, may be 0.01 to 0.50 wt%, may be 0.01 to 0.25 wt%, or may be 0.01 to 0.10 wt%.
• the menthol concentration in the solution coming in contact with the contact lens can be set to be relatively high.
• the menthol concentration in the solution used in a state where the contact lens is immersed therein in a packaging container be set so as not to excessively increase the stimulation to an eye during wearing.
• the moisture-retaining property of a contact lens was evaluated using a storage solution prepared as follows. Specifically, by adding and dissolving RPE1740 (Sample 1), L64 (Sample 2), F87 (Sample 3), F108 (Sample 4), RPE1740 and F87 (Sample 5), and L64 and F108 (Sample 6) at a ratio of 1.0 wt% to and in an ISO physiological saline (0.8300 g of sodium chloride, 0.5993 g of sodium hydrogenphosphate (dodecahydrate), 0.0528 g of sodium hydrogenphosphate (dehydrate), and an appropriate amount of purified water in 100 ml), storage solutions of Samples 1 to 6 were prepared.
• the ratio of RPE1740 and F87 in Sample 5 and the ratio of L64 and F108 in Sample 6 were 1:1. That is, the concentration of RPE1740 and the concentration of F87 in Sample 5 were 1.0 wt% (2.0 wt% in total), and the concentration L64 and the concentration of F 108 in Sample 6 were 1.0 wt% (2.0 wt% in total).
• the transpiration rates of the test lenses immersed in the storage solutions of Samples 1 to 6 were measured.
• the transpiration rate was measured in the following order of (1) to (5).
• the base was raised to match the center of the contact lens with an electrode of a moisture meter (model: SKICON-200, made by IBS Corporation).
• the value ( ⁇ 8: micro Siemens) of electric conductivity every 30 seconds was measured and the slope variation per unit time [ ⁇ 8/ ⁇ ⁇ ] was calculated. This measurement was performed four times in total and the average value thereof was calculated.
• Samples 1 to 4 were processed with the storage solutions which do not satisfy the conditions of the invention and in which a high molecular type or a low molecular type alone (only one type) out of the POE-POP block copolymers as the nonionic surfactant is contained.
• Samples 5 and 6 are smaller in transpiration rate than Samples 1 to 4 and exhibit an excellent moisture-retaining property (wetting property).
• the transpiration rates of the test lenses immersed in the storage solutions of Samples 7 to 15 were measured.
• the transpiration rates of the test lenses washed with the ISO physiological saline before they were immersed in the storage solutions of Samples 7 to 15 were measured in the same way.
• Samples 12 to 15 were processed with the storage solutions which satisfy the conditions of the invention and in which a high molecular type and a low molecular type out of the POE-POP block copolymers as the nonionic surfactant are combined and contained.
• Samples 7 to 11 were processed with the storage solutions which do not satisfy the conditions of the invention and in which a high molecular type or a low molecular type alone (only one type) out of the POE-POP block copolymers as the nonionic surfactant is contained.
• Samples 12 to 15 are smaller in transpiration rate than Samples 7 to 11 and exhibit an excellent moisture-retaining property (wetting property).
• the contact lens immersed in the storage solution according to the invention since the contact lens immersed in the storage solution according to the invention has the excellent moisture-retaining property (wetting property), it is possible to suppress moisture loss from the lens surface.
• Table 1 absolute value corresponds to Table 3 (relative value)
• FIG. 4 absolute value corresponds to FIG. 6 (relative value)
• Table 2 absolute value corresponds to Table 4 (relative value)
• FIG. 5 absolute value corresponds to FIG 7 (relative value).
• the concentrations of the surfactants in the storage solutions were as follows.
• the surfactant was contained by a concentration of 1.0 wt% in the storage solutions (Samples 16 to 20) containing only one type of nonionic surfactant.
• the content ratio (weight ratio) of the surfactants in the storage solutions (Samples 22 to 28) containing two types of nonionic surfactants was 1:1 and the surfactants were contained by a concentration of 0.5 wt% (1.0 wt% in total).
• the concentrations of the surfactants in the storage solutions are the same as described in parentheses (% in the table represents wt%) in Table 7. As shown in Table 7, for example, in the storage solution of Sample 38, RPE1740 was contained by a concentration of 0.01 wt%, F87 was contained by a concentration of 1.0 wt%, and the nonionic surfactants were contained by a concentration of 1.01 wt% in total.
• the weight ratios of the high-molecular surfactant and the low-molecular surfactant contained in the storage solutions of the samples are described together in Table 7.
• Samples 32, 33, 37, 38, and 39 are smaller in transpiration rate (unit: S/min) than the reference example and have an excellent moisture-retaining property.
• F87 which is a high molecular type is preferably contained by more than 0.01 wt% in the storage solutions and more preferably by about 0.1 wt%.
• the total concentration of RPE1740 which is a low molecular type and F87 which is a high molecular type is preferably contained by more than 0.2 wt% in the storage solutions and more preferably by more than 1.0 wt%.
• the content of the high molecular type of nonionic surfactant in the storage solutions is preferably more than the content of the low molecular type of nonionic surfactant.
• concentrations of the surfactants and the 1-menthol in the storage solutions are the same as described in parentheses (% in the table represents wt%) in Table 8.
• nonionic surfactant polyxamer
• RI differential refractive index detector
• G3000SW made by Tosoh Corporation having a guard column as a column was used, the column temperature was set to 30°C, a mixed solution of 0.02 mol/L of sodium dihydrogen-phosphate solution and acetonitrile (mixing ratio of 7:3) was used as a mobile phase, the flow rate was set to about 0.5 ml/min, and the amount of sample injected was set to 50 ⁇ .
• a solution in which poloxamer was dissolved by 1 wt% in an ISO physiological saline was used as a standard solution.
• a sample not using a lens was prepared and was subjected to the same treatment as the sample solutions to calculate an adsorbed amount as a blank.
• Samples 42 and 43 by blending menthol into the content lens solution (storage solution), it is possible to obtain a pleasant cooling sensation during wearing and to further reduce an uncomfortable feeling due to unnecessary friction based on the lens and the eye during wearing.
• the contact lens in a packaging container, the method of manufacturing a contact lens in a packaging container, and the contact lens solution according to the invention can be widely used for applications such as manufacturing, storage, and packaging of a contact lens.

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• 2013
  • 2013-03-04 WO PCT/JP2013/056551 patent/WO2013129706A1/fr not_active Ceased

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