WO2013149769A1 - Dispositif d'injection comprenant un entraînement amélioré à tige de piston - Google Patents

Dispositif d'injection comprenant un entraînement amélioré à tige de piston Download PDF

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Publication number
WO2013149769A1
WO2013149769A1 PCT/EP2013/053959 EP2013053959W WO2013149769A1 WO 2013149769 A1 WO2013149769 A1 WO 2013149769A1 EP 2013053959 W EP2013053959 W EP 2013053959W WO 2013149769 A1 WO2013149769 A1 WO 2013149769A1
Authority
WO
WIPO (PCT)
Prior art keywords
piston rod
housing
drive member
gear
toothing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2013/053959
Other languages
German (de)
English (en)
Inventor
Markus Frantz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tecpharma Licensing AG
Original Assignee
Tecpharma Licensing AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tecpharma Licensing AG filed Critical Tecpharma Licensing AG
Publication of WO2013149769A1 publication Critical patent/WO2013149769A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533Dosing mechanisms, i.e. setting a dose
    • A61M5/31545Setting modes for dosing
    • A61M5/31548Mechanically operated dose setting member
    • A61M5/3155Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31551Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566Means improving security or handling thereof
    • A61M5/31573Accuracy improving means
    • A61M5/31575Accuracy improving means using scaling up or down transmissions, e.g. gearbox
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31585Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button

Definitions

  • the invention relates to an injection device for administering a liquid product, in particular a medicament, such as insulin for diabetes therapy.
  • a liquid product in particular a medicament, such as insulin for diabetes therapy.
  • the invention relates to a drive mechanism for such an injection device.
  • injection devices are known in which a threaded piston rod is rotated relative to a housing to displace a piston of a product container for dispensing the product.
  • the piston rod is in threaded engagement with the housing or with respect to the housing fixed member. Due to the threaded engagement, rotation of the piston rod causes it to be screwed in the dispensing direction and displace the piston.
  • a drive member is rotated, which is axially fixed with respect to the housing and extending in parallel to the longitudinal direction of the piston rod, engages formed by the piston rod longitudinal guides.
  • the piston rod has two different threads, one of which is in engagement with the housing or a housing-fixed member and the other is in engagement with a drive member , which in a product distribution with respect to the housing rotationally fixed, but axially displaceable.
  • the thread of the threaded engagement between the drive member and the piston rod has a pitch that is large enough that no Self-locking between the drive member and piston rod is.
  • the axial movement of the drive member relative to the housing causes the piston rod to rotate, thereby screwing in the dispensing direction due to threaded engagement with the housing or housing-fixed member.
  • the invention is based on a drive mechanism for an injection device for administering a liquid medicament.
  • the drive mechanism has a housing.
  • the housing is preferably sleeve-shaped and / or elongated.
  • the housing is intended to receive a piston rod drive.
  • the housing can optionally accommodate a product container or even form the product container.
  • the housing can be one or more parts.
  • the housing may form a proximal housing part which receives the piston rod drive.
  • the housing may further include a product container holder, which holds the product container, such. B. a carpule, receives and is connected to the housing or the proximal housing part. This connection can be such that the product container holder and the housing or the proximal housing part after connection inseparable, that is only solvable by destruction of fasteners.
  • Such a solution is particularly advantageous in disposable injection devices which are disposed of as a whole after the product contained in the product container is completely discharged.
  • the product container holder can also be releasably secured to the housing, whereby it is possible to use the drive mechanism, if necessary, multiple times, that is to replace an empty product container with a filled product container.
  • the housing preferably serves to be gripped by the user of the device.
  • the housing may have a substantially cylindrical shape.
  • the housing may, for. B. a pointing device, in particular a window, by means of which or by which a currently set dose, preferably from a scale of a dose setting element, can be read.
  • the drive mechanism further includes a piston rod having a longitudinal axis.
  • the piston rod is movable along its longitudinal axis and relative to the housing in the discharge direction, in particular in the product container in order to move a slidably received in the product container piston for displacement of the product from the product container.
  • the piston rod comprises a toothing, which extends advantageously around the longitudinal axis or the circumference of the piston rod.
  • the toothing may have a plurality of teeth, each extending along the longitudinal axis.
  • the teeth of the toothing may be arranged alternately with tooth spaces formed between adjacent teeth around the circumference of the piston rod.
  • the toothing may be a straight toothing in which the teeth are arranged substantially parallel to the longitudinal axis of the piston rod.
  • the toothing may alternatively be a helical toothing, in which the teeth with a slope at least partially wind around the longitudinal axis.
  • the piston rod further includes a guide in addition to the toothing.
  • the leadership is different from the gearing.
  • the guide may be along, in particular parallel to the longitudinal axis of the piston rod extended longitudinal guide, such as in the form of a guide groove or a flattened edge, especially when the toothing is a helical toothing.
  • the guide may be a thread, wherein the toothing may be a straight or helical toothing. If the toothing is a helical toothing, it has, in particular, a different pitch than the thread forming the guide, for example a greater or smaller pitch and / or an opposite or a same direction of rotation.
  • the thread may be an external thread and / or have a pitch which is so large that a self-locking or no self-locking occurs, in particular when the piston rod is acted upon by a force acting along its longitudinal axis.
  • the guide can be superimposed on the toothing.
  • the teeth and the guide can cross each other.
  • the guide and toothing can be arranged at different positions relative to the longitudinal axis of the piston rod.
  • the guide can be arranged proximally of the toothing or vice versa.
  • the threaded portion of the proximal end of the piston rod and the teeth may be disposed in the region of the distal end of the piston rod.
  • the thread can be arranged in a region of the piston rod having a larger outer diameter than the region with the toothing. This area may preferably be formed at the proximal end of the piston rod.
  • the drive mechanism further includes a piston rod drive comprising at least one drive member and at least one gear.
  • the at least one gear is in particular arranged kinematically between the drive member and the piston rod and preferably mediates a rotation of the drive member to the piston rod.
  • the drive member may be designed sleeve-shaped and / or preferably surrounding the piston rod.
  • the drive member may be in contact with the piston rod, in particular engage in the leadership of the piston rod.
  • it can be arranged between the piston rod and the drive member engaging in the leadership of the piston rod intermediate sleeve which is rotatable and preferably axially fixed relative to the drive member, in particular so connected to the drive member, this embodiment is advantageous if the guide is a longitudinal guide ,
  • the at least one gear engages in the toothing, in particular external toothing, the piston rod or - in other words - meshes with the toothing of the piston rod.
  • the preferred external toothing of the at least one gear and the toothing of the piston rod are coordinated so that a rotational movement of the gear around its associated gear axis, on which the gear is arranged, a rotational movement of the piston rod, on which the gear rolls, in particular opposite direction as the gear causes.
  • the tooth forms for such gears are familiar to the expert.
  • the gear axis of rotation of the respective gear is offset from the longitudinal axis of the piston rod, in particular radially spaced from and / or parallel to the longitudinal axis.
  • the drive member and the at least one gear are preferably rotatable relative to each other but axially fixed with respect to the longitudinal axis.
  • the drive member may be arranged not displaceable relative to the housing in the longitudinal direction of the piston rod.
  • the drive member is axially fixed both at a dose setting and during a dose release, preferably permanently relative to the housing.
  • the at least one gear can perform rotational movements relative to the housing and preferably relative to each other.
  • gear converts or mediates movement of the drive member into movement of the piston rod.
  • the gear may cause movement, in particular rotation of the piston rod relative to the housing and the drive member.
  • the drive member rotates relative to the housing and relative to the piston rod, wherein the piston rod also moves relative to the housing and the drive member due to the action of the at least one gear, vorzweise rotates and axially moved, thus screwed.
  • the piston rod Due to the interaction of the drive member with the piston rod via the at least one gear and the guide, the piston rod is moved along its longitudinal axis relative to the drive member and / or the housing and / or the at least one gear during rotation of the drive member relative to the housing, in particular in the dispensing direction , Due to the fact that upon rotation of the drive member, the piston rod rotates both relative to the housing and relative to the drive member, an even finer distribution of the adjusted product dose compared to the devices of the prior Technique can be achieved, in particular to an even greater extent when the guide is threaded.
  • the piston rod is moved along its longitudinal axis relative to the drive member and the housing respectively, especially in the dispensing direction and especially administered or distributed a set product dose.
  • the at least one gear part of a planetary gear such as. B. be a planetary gear that meshes with a ring gear and the piston rod or their teeth.
  • the piston rod thus assumes the role of the planetary gears usual sun gear.
  • the planetary gear can, in particular with its circumference, roll both on the ring gear and on the toothing of the piston rod.
  • Planetary gears as such should be known in the art, the terms sun gear, ring gear, planetary gear and planet carrier Termini are technici.
  • the gear which is referred to below as a planetary gear, on a planet carrier and on a spaced-apart from the longitudinal axis of the piston rod axis of rotation, in particular Planetenradwindachse be arranged.
  • the Planetenradwindachse is preferably stationary with respect to the planet carrier.
  • the planetary carrier or the planetary gear may form a planetary pin on which the planetary gear is rotatably arranged relative to the planetary carrier and which forms the Planetenraddeckachse.
  • the planet carrier may be rotatable in embodiments about the longitudinal axis of the piston rod, which may thus also be referred to as a planet carrier rotation axis.
  • the planetary gear can rotate about two axes, namely about the axis on which it sits (Planetenradcardachse) and about the longitudinal axis of the piston rod (planet carrier rotation axis).
  • the planetary gear may rotate at least about the Planetenradwindachse.
  • the planetary gear more than one planetary gear such. B. have three or four planet gears, in particular uniformly over the circumference of the sun gear can be distributed.
  • the planet gears may preferably be arranged on a common planet carrier, ie, that the Planetenrad loftachsen, on each of which sits at least one planetary gear, may be stationary relative to each other.
  • Several planet wheels have the advantage of centering the sun gear radially and securing it against movement of the sun gear transverse to the longitudinal axis of the piston rod.
  • the planet carrier rotatably connected to the drive member and the ring gear rotatably connected to the housing, wherein the piston rod forms the sun gear or acts as a sun gear. This causes the drive member and the piston rod to rotate in the same direction of rotation when the drive member is rotated relative to the housing.
  • the planet carrier rotatably connected to the housing and the ring gear rotatably connected to the drive member, wherein the piston rod forms the sun gear or acts as a sun gear. This causes the drive member and the piston rod to rotate in opposite directions of rotation when the drive member is rotated relative to the housing.
  • the at least one gear can have a first external toothing with a first pitch circle diameter and a second outer toothing with a second pitch circle diameter, wherein the first pitch circle diameter is greater or smaller than the second pitch circle diameter.
  • the first outer toothing is preferably rotationally fixed relative to the second outer toothing, in particular permanently, d. H. also when the at least one gear and / or the drive member is rotated.
  • the rotational movement of the drive member is converted via the first outer toothing in a rotational movement of the at least one gear and this gear via its second outer toothing, which engages in the toothing of the piston rod, the piston rod drives.
  • the axis of rotation on which the at least one gear is arranged with respect to the housing fixed ie, that this axis of rotation can not rotate in particular about the longitudinal axis of the piston rod.
  • the drive mechanism has a dose setting mechanism in generally preferred embodiments.
  • the dose setting mechanism may, for. B. be designed as described in WO 99/38554 to Figures 15 to 17.
  • the dose setting mechanism may include a non-self-locking Schaub connection along which an injection button in which a dose setting element, in particular limb, or the injection button itself is rotated relative to the housing and unscrewed from the proximal end of the housing to about this proximal end to survive a distance determined by the angle of this rotation.
  • the screwing movement Upon axial retraction of the injection button, the screwing movement converts this axial movement into a rotation of the drive member.
  • the screwing movement also converts this axial movement into a rotation of the at least one gear and into a rotation of the piston rod.
  • the dose setting element is configured as indicated in EP 1 819 382 B1.
  • the dose setting mechanism may comprise a dose setting member in the form of a dosing button axially fixed relative to the housing, which is rotated relative to the housing for dose adjustment. Rotation of the dose setting member relative to the housing causes rotation of a dose indicating drum relative to the housing.
  • the dose indicating drum is threadable in the housing, in particular received by threaded engagement with the housing. As the dose setting knob rotates, the dose indicating drum is threaded along the housing with the dose to be administered displayed in a window of the housing.
  • the dose display drum is screwed back to the value zero, during which the rotational movement required for the drive mechanism according to the invention is transmitted to the drive member, which in turn rotates relative to the housing, whereby the at least one gear and the piston rod rotate.
  • the drive mechanism may comprise a spring which is tensioned in the setting of the desired product dose and emits their spring energy to the drive member in the form of a rotation of the drive member for a product distribution.
  • the drive mechanism on an actuating button, the actuation of which causes the energy stored in the spring is delivered to the drive member, whereby this is rotated relative to the housing, whereby also rotate the at least one gear and the piston rod.
  • the drive mechanism may comprise a unidirectional clutch which permits rotation of the drive member or guide member in a rotational direction and locks in the opposite direction of rotation.
  • the permissible direction of rotation may be that by means of which the piston rod is moved in the dispensing direction or distal direction of the drive mechanism.
  • the unidirectional coupling can be designed as a ratchet z. B. between the housing and drive member or preferably between the drive member and piston rod can be arranged.
  • the unidirectional coupling in particular the ratchet, may have a resilient arm which engages in a toothing.
  • the resilient arm may be formed, for example, on the drive member and engage in the toothing of the piston rod, which also meshes with the at least one gear, or engage in a toothing of an intermediate sleeve which may be disposed between the drive member and the piston rod.
  • the toothing of the intermediate sleeve is preferably an outer toothing, wherein the intermediate sleeve is preferably non-rotatably connected to the piston rod.
  • the intermediate sleeve may for example have an internal toothing, with which it engages in the toothing of the piston rod for producing the rotationally fixed connection.
  • the teeth of the outer toothing of the intermediate sleeve may preferably be configured as a sawtooth or each have a flat and a steep edge.
  • the arm can slide in a rotational direction over the flat flank of a tooth and be blocked in the opposite direction of rotation by the steep flank, whereby the unidirectional coupling is effected.
  • the resilient arm may alternatively be formed on the rotationally fixed (see previous paragraph) connected to the piston rod intermediate sleeve and engage in an internal toothing of the drive member.
  • the resilient arm formed on the drive member can engage in an internal toothing of the housing or a housing-fixed element.
  • the teeth of the internal toothing can preferably be designed as a sawtooth or each have a flat and a steep edge.
  • the arm can slide in a rotational direction over the flat flank of a tooth and be blocked in the opposite direction of rotation by the steep flank, whereby the unidirectional coupling is effected.
  • the resilient arm may be formed on the housing or a housing-fixed element and engage in an outer toothing of the drive member.
  • the teeth of the outer toothing of the drive sleeve may preferably be designed as a sawtooth or each having a flat and a steep edge.
  • the arm can slide in a rotational direction over the flat flank of a tooth and be blocked in the opposite direction of rotation by the steep flank, whereby the unidirectional coupling is effected.
  • the unidirectional clutch may be designed so that an initial resistance set large enough to withstand a torque applied to the clutch by the dose setting must be overcome before any rotation occurs.
  • the dose setting mechanism is coupled to the drive member so as to prevent rotation of the drive member at the dose setting and to effect the dose distribution.
  • the dose setting mechanism is coupled to the drive member so as to prevent rotation of the drive member at the dose setting and to effect the dose distribution.
  • z. Example, via a clutch, a dose display drum and the drive member for the distribution in relation to each other rotatory determined, in particular by pressing an operating button, so that the dose display drum and the drive member rotate together, in particular are relatively rotatable relative to each other.
  • the clutch may be open at the dose setting so that the drive member is rotationally decoupled from the dose indicating drum.
  • the drive mechanism may optionally include a mechanism for inhibiting the setting of a dose exceeding the amount of drug in the product container, wherein a dose is adjusted by rotation, particularly a dosing member or dose setting member or dosing knob of a dose setting mechanism.
  • the mechanism may comprise a limiter, which is arranged kinematically between drive member and dosing member, in particular a dose display drum.
  • the limiter and the drive member may be coupled such that relative rotation, particularly during dose adjustment, between the dose setting member and the drive member causes the limiter to move to a stop position in which the limiter inhibits the setting of a dose corresponding to the dose Amount of a product in the product container exceeds. Examples of correspondingly suitable limiters are disclosed in WO 2010/149209 or in WO 01/19434 A1, in particular in FIG.
  • FIG. 2 shows a first embodiment of a drive mechanism according to the invention
  • FIG. 3 shows a second embodiment of a device according to the invention
  • Figure 4 shows a third embodiment of an inventive
  • Figure 5 shows a fourth embodiment of an inventive
  • FIG. 6 shows a piston rod for the invention described herein
  • Figure 7 shows an alternative piston rod for the embodiments of the invention described herein.
  • a drive mechanism which have preferred embodiments of a piston rod drive.
  • Such a piston rod drive can be integrated in the device of the figures la to lc.
  • a manually operable injection device In the known from the prior art device of the figures la to lc is a manually operable injection device.
  • the device comprises a dose setting mechanism, which is at least one dosing member 2 in the form of a Dosierknopfs, in particular rotationally and axially fixed to a dose display drum 21 is connected.
  • the dosing member 2 is for adjusting the product dose to be administered with respect to a housing 1 rotatable, in particular screwed. To increase the dosage, the dosing member 2 is unscrewed from the proximal end of the housing 1. To reduce the dosage, the dosing member 2 is screwed back into the housing 1. In general, it can be stated that the dosing member 2 can be screwed back and forth relative to the housing 1 for setting the dose.
  • the dosing member 2 for the screwing movement, has a thread which is in engagement with a thread of the housing 1.
  • the thread pitch is such that no self-locking occurs when the dosing member 2 is loaded or operated with a force acting in the dispensing direction.
  • the housing 1 has a window 14 in which the product dose set by the dose setting mechanism is displayed.
  • the dose display drum 21 has on its outer periphery a scale with the various adjustable product cans, which extends helically in accordance with the thread pitch of the thread 11. For the dose setting, a portion of the scale, namely the scale value corresponding to the desired product dose, is displayed in window 14.
  • the injection device from the figures la to lc further comprises a first coupling member 3, which is non-rotatably, but axially displaceably connected to a drive member 5.
  • a connection can be z. B. by means of a groove extending along the longitudinal axis of the injection device realize.
  • the particular sleeve-shaped first coupling member 3 has a toothing 31, which rests in a toothing 22 which is formed on the dosing member 2.
  • the first coupling member 3 is rotationally fixed with respect to the housing 1.
  • the toothing 22 is rotated relative to the toothing 31.
  • the toothing 22 and the toothing 31 form an axial coupling.
  • a trained at the proximal end of the device actuator button 4 is pressed, in particular with the thumb of the user's hand, which surrounds the housing 1.
  • the thereby acting in the distal direction of the user force on the actuator button 4 is transmitted to the toothing 31, which is pressed into the toothing 22, whereby the dosing member 2 and the first coupling member 3 are rotatably coupled relative to each other.
  • the dosing member 2 is screwed back into the housing 1.
  • the first coupling member 3 is rotated relative to the housing 1.
  • the coupling member 3 takes with the drive member 5, which also rotates.
  • the drive mechanisms according to the invention can be combined not only with the device shown in Figures la to lc, but in principle with any device in which an actuation of the drive mechanism for a product distribution causes rotation of the drive member 5. If the drive mechanism is provided with a dose setting mechanism, it is preferable that the drive member 5 is not rotated in the dose setting movements of the dose setting mechanism relative to the housing 1. In particular, a rotation of the drive member 5 can take place only when operating the drive mechanism for a product distribution.
  • the invention can also be advantageous z. B. in devices such as those used in US 5,104,380 A, WO 2007/017052 AI.
  • the drive energy is not provided manually deviating from the device of Figures la to lc, but by a spring which is either stretched or stretched at a dose setting and is connected to the drive member 5 that the or at least a part of stored spring energy upon actuation of an actuating element or operating knob 4, the drive member 5 rotates or rotates for the product distribution.
  • This type of device also allows for combination with a dose indicating drum 21.
  • the spring may preferably be a torsion or torsion spring.
  • the drive mechanisms according to the invention shown in Figures 2 to 5 have as essential features a piston rod 6, and a piston rod drive comprising a drive member 5 and a gear 95 on.
  • the gear 95 is arranged kinematically between the drive member 5 and the piston rod 6.
  • the particular sleeve-shaped drive member 5 is rotatable relative to the housing 1 and preferably axially fixed.
  • the drive mechanism is configured such that the drive member
  • the drive member 5 is not rotated relative to the housing 1 or the drive member 5 is rotatably relative to the housing 1.
  • the drive member 5 is arranged in the housing 1 so that it is movable only in a single direction of rotation, d. H. in the opposite direction of rotation is not rotatable.
  • the drive mechanism may have a unidirectional clutch 52, the z. B. is designed as a ratchet.
  • the unidirectional clutch 52 may include an arm or ratchet arm that engages circumferentially extending teeth.
  • the unidirectional clutch 52 may, for. B. between the housing 1 and the drive member 5 ( Figures 2 and 5) or between the drive member 5 and the piston rod 6 ( Figures 3 and 4) act.
  • This assignment of differently configured couplings 52 to the embodiments of Figures 2 to 5 is merely exemplary.
  • the clutches 52 of FIGS. 2 to 5 can be arbitrarily combined with the arrangements of the gears 95 of these figures.
  • the resilient arm of the coupling 52 is formed on the drive member 5 and engages in, for example, a sawtooth-shaped internal toothing of the housing 1 or a housing-fixed insert.
  • the resilient arm of the clutch 52 is formed on a part, in particular a ring or the drive member 5, which is connected to the drive member 5 in a rotationally fixed manner and engages in the external toothing with which the gearwheel 95 meshes.
  • an intermediate sleeve may be formed (not shown), which is rotatably connected to the piston rod 6 and has a preferably sawtooth-shaped external toothing, in which engages the resilient arm of the clutch 52.
  • the resilient arm of the clutch 52 is formed on a part rotatably connected to the piston rod 6, in particular a ring or intermediate sleeve, and engages in a preferably sawtooth-shaped internal toothing of the drive member 5.
  • the resilient arm of the clutch 52 is formed on a part rotatably connected to the housing 1, in particular housing insert, which can optionally form a planet carrier 91, and engages in a preferably sawtooth-shaped external toothing of the drive member 5.
  • a piston rod 6 according to FIGS. 6 or 7 or from FIG. 1c can be used.
  • a solid rod is shown, it may also be formed as a sleeve, i. H. it does not necessarily have to be massive.
  • the toothing 65 is a spur toothing and provided for the meshing engagement with the at least one gear 95.
  • the gearing 95 is disposed distally of the thread 63 provided for threaded engagement with the drive member 5.
  • the thread 63 may be referred to generally as a guide.
  • the piston rod 6, where the thread 63 is arranged a larger outer diameter have as where the toothing 65 is arranged.
  • the thread 63 is formed on a section enlarged from the outside diameter, in particular a head, which is arranged on the proximal end of the piston rod 6.
  • the thread forming the guide 63 and the toothing 65 which is formed as a straight toothing, superimposed, d. H. arranged at the same axial positions.
  • the thread 63 and the toothing 65 intersect.
  • the toothing 65 is provided for the meshing engagement with the at least one gear 95.
  • the thread 63 is provided for threaded engagement with the drive member 5.
  • the drive mechanisms according to the invention from FIGS. 2 to 5 have at least one toothed wheel 95 in common, which is arranged kinematically between the drive member 5 and the piston rod 6 and is in meshing engagement with the toothing 65 of the piston rod 6.
  • the gear 95 is arranged to cause movement of the piston rod 6 relative to the housing 1 and the drive member 5 upon rotation of the drive member 5 relative to the housing 1, particularly during or during dose rejection upon actuation of the drive mechanism. Due to the interference of the drive member 5 and the at least one gear 95 with the piston rod 6 and the relative rotation between the drive member 5 and the piston rod 6, the piston rod 6 is moved along its longitudinal axis relative to the drive member 5 and the at least one gear 95, in particular also relatively to the housing 1.
  • the piston rod 6 is displaced or moved into the product container 8 and / or pushed against the piston slidably received in the product container 8, which is then displaced in the distal direction relative to the product container 8 and into the product container 8 contained product from the product container 8 displaced.
  • the rotation which performs the piston rod 6 relative to the drive member 5, and the threaded engagement of the drive member 5 in the thread 63, the piston rod 6 is screwed to the drive member 5 along.
  • the transmission comprising the at least one gearwheel 95 from FIGS. 2 to 4 is based on at least one planetary gearbox 9.
  • the gearbox in particular the gearwheel 95 from FIG. 5, does not require a planetary gearbox 9.
  • a planetary gear 9 generally comprises a sun gear whose function in the examples shown takes over the piston rod 95, a ring gear 94 and a planetary gear disposed between ring gear 94 and piston rod 6, ie the gear 95 which has a toothing over its outer circumference which engages with the teeth of the ring gear 94 and the toothing 65 of the piston rod 6 is.
  • the planetary gear 9 has at least one planetary gear 95, although it is preferred that over the circumference of several planetary gears 95, such. B. two, three or four planetary gears 95 are arranged in particular evenly distributed. In the figures 2 to 4 z. B. four planetary gears arranged over the circumference, but only two of which are visible.
  • the planetary gear 95 is disposed on a Planetenrad loftachse about which it is rotatable and which is spaced from the longitudinal axis of the piston rod 6. Further, the planetary gear 95 is disposed on a planet carrier 91. At the planet carrier 91, the other planetary gears 95 of the planetary gear 9 are preferably arranged.
  • the planetary gear axis 95 of the planetary gear 95 which is spaced from the longitudinal axis of the piston rod 6, is formed by a carrier pin which is arranged on the planet carrier 91 and / or can be integral with the planet carrier 91.
  • the planetary gear 95 may form the support pin 92 itself, wherein the support pin 92 z. B. can be rotatably mounted on the planet carrier 91.
  • the ring gear 94 is of a housing-fixed, d. H. formed axially and rotationally fixed to the housing 1 connected insert.
  • the gear 95 meshes with the toothing 65 of the piston rod 6.
  • the planet carrier 91 is rotatably connected to the drive member 5, in particular in one piece with the drive member. 5
  • the planetary gear 95 Upon rotation of the drive member 5 relative to the housing 1, the planetary gear 95 is rotated about the longitudinal axis of the piston rod 6, which may also be referred to as a planet carrier rotation axis, and about its Planetenrad loftachse on which it is arranged. In this case, the planetary gear 95 rolls on the ring gear 94, whereby the piston rod 6 relative to the housing. 1 and the drive member 5 is rotated. With respect to the housing 1, the drive member 5 and the piston rod 6 rotate in the same direction of rotation, relative to the housing 1, the piston rod 6 rotates at a magnitude higher angular velocity than the drive member fifth
  • the ring gear 94 is rotatably connected to the drive member 5, in particular in one piece with the drive member 5.
  • the gear 95 meshes with the toothing 65 of the piston rod 6.
  • the planet carrier 91 is fixed to the housing, d. H. rotatably and axially connected to the housing 1.
  • the ring gear 94 rolls on the planetary gear 95, which is about its Planetenrad loftachse on which it is arranged and which is fixed with respect to the housing 1 rotates, whereby the piston rod 6 relative to the housing 1 and the drive member 5 is twisted.
  • the drive member 5 and the piston rod 6 rotate in opposite directions of rotation.
  • the piston rod 6 can rotate with a magnitude higher angular velocity than the drive member. 5
  • the gear 95 has a first toothing 97a and a second toothing 97b, wherein the first toothing 97a has a smaller pitch circle diameter than the second toothing 97b.
  • the first toothing 97a and the second toothing 97b are rotatable relative to each other, in particular integrally connected to each other.
  • the gear 95 is seated on a rotation axis, which is arranged radially spaced from the axis of rotation of the piston rod 6.
  • the axis of rotation is formed by a support pin 92, which is fixed to the housing, in particular rotationally and axially fixed with respect to the housing 1 is arranged.
  • the support pin 92 is formed on a housing-fixed insert 91, which is snapped in the example shown with the housing 1. Alternatively, this insert 91 could also be glued or welded to the housing 1.
  • An external toothing is rotatably connected to the drive member 5, in particular integrally formed on the drive member 5. This intermeshing meshes with the first toothing 97a of the gear 95.
  • the second toothing 97b meshes with the toothing 65 of the piston rod 6.

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PCT/EP2013/053959 2012-04-05 2013-02-27 Dispositif d'injection comprenant un entraînement amélioré à tige de piston Ceased WO2013149769A1 (fr)

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DE102012103002.2 2012-04-05
DE102012103002 2012-04-05

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Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5104380A (en) 1988-04-18 1992-04-14 Robert Charles Turner Syringe with dose metering device
WO1999038554A1 (fr) 1998-01-30 1999-08-05 Novo Nordisk A/S Seringue d'injection
WO2001019434A1 (fr) 1999-09-16 2001-03-22 Novo Nordisk A/S Limiteur de dosage
WO2004078239A1 (fr) 2003-03-03 2004-09-16 Dca Design International Ltd. Mecanisme d'entrainement pour dispositifs de distribution de medicaments
WO2004089450A1 (fr) * 2003-04-10 2004-10-21 Dca Design International Ltd. Mecanismes de commande utilise dans des systemes pour administrer des medicaments
WO2007017052A1 (fr) 2005-07-27 2007-02-15 Novo Nordisk A/S Mecanisme de dosage pour un dispositif d'injection permettant de limiter un dosage correspondant a la quantite de medicament restante
EP1974760A1 (fr) * 2007-03-29 2008-10-01 Jürgen Schmidt-Evers Pen-Injecteur par un injection liquide, particulier insulin
EP1819382B1 (fr) 2004-10-21 2009-10-14 Novo Nordisk A/S Dispositif d'injection a ressort de torsion et affichage rotatif
WO2010110712A1 (fr) * 2009-03-24 2010-09-30 Istvan Bartha Dispositif d'administration d'un médicament liquide
WO2010149209A1 (fr) 2009-06-23 2010-12-29 Tecpharma Licensing Ag Dispositif d'injection muni d'un mécanisme de dosage pour limiter un réglage de dose
WO2011003762A1 (fr) * 2009-06-30 2011-01-13 Sanofi-Aventis Deutschland Gmbh Mécanisme d’entraînement et dispositif de délivrance de médicaments

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5104380A (en) 1988-04-18 1992-04-14 Robert Charles Turner Syringe with dose metering device
WO1999038554A1 (fr) 1998-01-30 1999-08-05 Novo Nordisk A/S Seringue d'injection
WO2001019434A1 (fr) 1999-09-16 2001-03-22 Novo Nordisk A/S Limiteur de dosage
WO2004078239A1 (fr) 2003-03-03 2004-09-16 Dca Design International Ltd. Mecanisme d'entrainement pour dispositifs de distribution de medicaments
WO2004089450A1 (fr) * 2003-04-10 2004-10-21 Dca Design International Ltd. Mecanismes de commande utilise dans des systemes pour administrer des medicaments
EP1819382B1 (fr) 2004-10-21 2009-10-14 Novo Nordisk A/S Dispositif d'injection a ressort de torsion et affichage rotatif
WO2007017052A1 (fr) 2005-07-27 2007-02-15 Novo Nordisk A/S Mecanisme de dosage pour un dispositif d'injection permettant de limiter un dosage correspondant a la quantite de medicament restante
EP1974760A1 (fr) * 2007-03-29 2008-10-01 Jürgen Schmidt-Evers Pen-Injecteur par un injection liquide, particulier insulin
WO2010110712A1 (fr) * 2009-03-24 2010-09-30 Istvan Bartha Dispositif d'administration d'un médicament liquide
WO2010149209A1 (fr) 2009-06-23 2010-12-29 Tecpharma Licensing Ag Dispositif d'injection muni d'un mécanisme de dosage pour limiter un réglage de dose
WO2011003762A1 (fr) * 2009-06-30 2011-01-13 Sanofi-Aventis Deutschland Gmbh Mécanisme d’entraînement et dispositif de délivrance de médicaments

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