WO2013178802A3 - Microparticles and a system and method for the synthesis of microparticles - Google Patents

Microparticles and a system and method for the synthesis of microparticles Download PDF

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Publication number
WO2013178802A3
WO2013178802A3 PCT/EP2013/061302 EP2013061302W WO2013178802A3 WO 2013178802 A3 WO2013178802 A3 WO 2013178802A3 EP 2013061302 W EP2013061302 W EP 2013061302W WO 2013178802 A3 WO2013178802 A3 WO 2013178802A3
Authority
WO
WIPO (PCT)
Prior art keywords
microparticles
phase
dispersed
emulsion
fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2013/061302
Other languages
French (fr)
Other versions
WO2013178802A2 (en
Inventor
Gil Lee
James O'mahony
Mark Platt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University College Dublin
Original Assignee
University College Dublin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University College Dublin filed Critical University College Dublin
Priority to US14/404,575 priority Critical patent/US10005677B2/en
Priority to EP13726776.1A priority patent/EP2854776B1/en
Publication of WO2013178802A2 publication Critical patent/WO2013178802A2/en
Publication of WO2013178802A3 publication Critical patent/WO2013178802A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5094—Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G49/00—Compounds of iron
    • C01G49/02—Oxides; Hydroxides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/4105—Methods of emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/43—Mixing liquids with liquids; Emulsifying using driven stirrers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/80—After-treatment of the mixture
    • B01F23/804—Drying the mixture
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/712—Feed mechanisms for feeding fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • B01J13/043—Drying and spraying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
    • B01J13/125—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution by evaporation of the solvent
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/0036—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties showing low dimensional magnetism, i.e. spin rearrangements due to a restriction of dimensions, e.g. showing giant magnetoresistivity
    • H01F1/0045—Zero dimensional, e.g. nanoparticles, soft nanoparticles for medical/biological use
    • H01F1/0054—Coated nanoparticles, e.g. nanoparticles coated with organic surfactant
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/90—Heating or cooling systems
    • B01F2035/99—Heating
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/60—Particles characterised by their size
    • C01P2004/61—Micrometer sized, i.e. from 1-100 micrometer
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2006/00—Physical properties of inorganic compounds
    • C01P2006/42—Magnetic properties

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Power Engineering (AREA)
  • Molecular Biology (AREA)
  • Colloid Chemistry (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

There is provided a method of producing microparticles using an emulsion based synthesis route including: Providing a first fluid phase and a second fluid phase, wherein the first fluid phase is a continuous phase and the second fluid phase is a dispersed phase comprising a dispersed material, wherein the continuous phase is immiscible with the dispersed phase; Mixing the first continuous phase and the second dispersed phase in the presence of a surfactant in a shear device to form an emulsion of droplets of controllable size and having a narrow drop size distribution; Drying the emulsion to form microparticles of controllable size and having narrow size distribution, and wherein the microparticles may comprise spherical, crumpled, dimpled, porous or hollow microparticles morphology. Also provided is a system including shear device and drying arrangement. Also provided are microparticles of controllable size and morphology formed by the method.
PCT/EP2013/061302 2012-05-31 2013-05-31 Microparticles and a system and method for the synthesis of microparticles Ceased WO2013178802A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US14/404,575 US10005677B2 (en) 2012-05-31 2013-05-31 Microparticles and a system and method for the synthesis of microparticles
EP13726776.1A EP2854776B1 (en) 2012-05-31 2013-05-31 System and method for the synthesis of microparticles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1209681.4A GB2502577A (en) 2012-05-31 2012-05-31 Microparticles and a device and method for the production thereof
GB1209681.4 2012-05-31

Publications (2)

Publication Number Publication Date
WO2013178802A2 WO2013178802A2 (en) 2013-12-05
WO2013178802A3 true WO2013178802A3 (en) 2014-02-27

Family

ID=46582119

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2013/061302 Ceased WO2013178802A2 (en) 2012-05-31 2013-05-31 Microparticles and a system and method for the synthesis of microparticles

Country Status (4)

Country Link
US (1) US10005677B2 (en)
EP (1) EP2854776B1 (en)
GB (1) GB2502577A (en)
WO (1) WO2013178802A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6558830B2 (en) * 2012-06-15 2019-08-14 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム High-throughput sequencing of multiple transcripts
US10293325B2 (en) 2013-12-11 2019-05-21 University Of Massachusetts Core-shell multi-layer particles
US10513733B2 (en) 2015-03-23 2019-12-24 Board Of Regents, The University Of Texas System High throughout sequencing of paired VH and VL transcripts from B cells secreting antigen-specific antibodies
WO2017199123A1 (en) 2016-05-17 2017-11-23 Ecole Polytechnique Federale De Lausanne (Epfl) Device and methods for shell phase removal of core-shell capsules
JP2018019686A (en) * 2016-07-20 2018-02-08 コニカミノルタ株式会社 Gelatin particles, method of producing gelatin particles, gelatin particle-containing cell, method of producing gelatin particle-containing cell and cell structure
CN111032134B (en) * 2017-06-30 2024-02-13 阿维塔斯有限公司 electrospray catheter
WO2019084538A1 (en) 2017-10-27 2019-05-02 Board Of Regents, The University Of Texas System Tumor specific antibodies and t-cell receptors and methods of identifying the same
US11583924B2 (en) * 2018-12-31 2023-02-21 Tata Consultancy Services Limited Synthesis of nano particles
CN109650974B (en) * 2019-01-14 2021-07-09 湖南大学 A method for reducing nitrogen loss in composting process and improving fertilizer efficiency of composting products by using iron oxide nanomaterials
CN110164703B (en) * 2019-06-21 2021-07-09 江苏科技大学 Porous Fe3O4/C polyhedral material, preparation method and application thereof
KR102474965B1 (en) 2019-07-01 2022-12-07 오크우드 레버러토리즈, 엘엘씨 Systems and methods for preparing microspheres and emulsions
CN111359551B (en) * 2020-03-24 2022-04-26 北京唯公医疗技术有限公司 Magnetic polymer microsphere and preparation method thereof
CN113024733B (en) * 2021-03-15 2022-04-01 华东理工大学 Preparation method of porous material
US20250114753A1 (en) * 2022-01-25 2025-04-10 The Trustees Of The University Of Pennsylvania Nanocrystal superparticles through a source-sink emulsion system
CN114534590B (en) * 2022-02-26 2023-06-09 四川大学 Rotary sleeve microfluidic device and method for controllably preparing monodisperse double emulsion
WO2025101814A1 (en) * 2023-11-07 2025-05-15 Magnostics Limited Uniform multi-layer silica coated porous/mesoporus magnetic beads, methods of making and uses thereof
CN118479950A (en) * 2024-05-17 2024-08-13 南京理工大学 High-frequency preparation system and method for energetic microspheres based on pulse gas injection
CN120267901B (en) * 2025-04-03 2025-11-18 宁波慈北医疗器械有限公司 Preparation method of composite microsphere for medical beauty injection filler

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070172426A1 (en) * 2005-10-24 2007-07-26 Lee Gil U Polymer coated microparticles
US20090311295A1 (en) * 2006-05-12 2009-12-17 Edith Mathiowitz Particles with high uniform loading of nanoparticles and methods of preparation thereof
US20110204533A1 (en) * 2009-12-22 2011-08-25 Gary Winchester Emulsion-Based Process for Preparing Microparticles and Workhead Assembly for Use with Same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070172426A1 (en) * 2005-10-24 2007-07-26 Lee Gil U Polymer coated microparticles
US20090311295A1 (en) * 2006-05-12 2009-12-17 Edith Mathiowitz Particles with high uniform loading of nanoparticles and methods of preparation thereof
US20110204533A1 (en) * 2009-12-22 2011-08-25 Gary Winchester Emulsion-Based Process for Preparing Microparticles and Workhead Assembly for Use with Same

Also Published As

Publication number Publication date
EP2854776A2 (en) 2015-04-08
US20150183655A1 (en) 2015-07-02
GB201209681D0 (en) 2012-07-18
GB2502577A (en) 2013-12-04
EP2854776B1 (en) 2020-02-12
US10005677B2 (en) 2018-06-26
WO2013178802A2 (en) 2013-12-05

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