WO2014008223A3 - Inhibiteurs d'acide gras synthase - Google Patents

Inhibiteurs d'acide gras synthase Download PDF

Info

Publication number
WO2014008223A3
WO2014008223A3 PCT/US2013/049010 US2013049010W WO2014008223A3 WO 2014008223 A3 WO2014008223 A3 WO 2014008223A3 US 2013049010 W US2013049010 W US 2013049010W WO 2014008223 A3 WO2014008223 A3 WO 2014008223A3
Authority
WO
WIPO (PCT)
Prior art keywords
fatty acid
acid synthase
synthase inhibitors
inhibitors
fas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2013/049010
Other languages
English (en)
Other versions
WO2014008223A2 (fr
Inventor
Nicholas David ADAMS
Amita M. Chaudhari
Terence John Kiesow
Allison K. MCSHERRY
Michael Lee Moore
Cynthia Ann Parrish
Alexander Joseph Reif
Lance Howard Ridgers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline LLC
Original Assignee
GlaxoSmithKline LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GlaxoSmithKline LLC filed Critical GlaxoSmithKline LLC
Publication of WO2014008223A2 publication Critical patent/WO2014008223A2/fr
Publication of WO2014008223A3 publication Critical patent/WO2014008223A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne de nouvelles pipéridines spirocycliques selon la formule (I), qui sont des inhibiteurs d'acides gras synthase (FAS), des compositions pharmaceutiques les contenant, leurs procédés de préparation et leur utilisation dans une thérapie de traitement de cancers.
PCT/US2013/049010 2012-07-03 2013-07-02 Inhibiteurs d'acide gras synthase Ceased WO2014008223A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261667609P 2012-07-03 2012-07-03
US61/667,609 2012-07-03

Publications (2)

Publication Number Publication Date
WO2014008223A2 WO2014008223A2 (fr) 2014-01-09
WO2014008223A3 true WO2014008223A3 (fr) 2014-02-27

Family

ID=49882587

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2013/049010 Ceased WO2014008223A2 (fr) 2012-07-03 2013-07-02 Inhibiteurs d'acide gras synthase

Country Status (1)

Country Link
WO (1) WO2014008223A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SMT202200396T1 (it) 2017-12-13 2022-11-18 Lupin Ltd Composti eterociclici biciclici sostituiti come inibitori di prmt5
WO2020048826A1 (fr) * 2018-09-03 2020-03-12 Bayer Aktiengesellschaft Composés de la 1-oxa-3,9-diazaspiro[5.5]undécan-2-one substituée en position 5

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4353900A (en) * 1981-10-19 1982-10-12 Syntex (U.S.A.) Inc. 9-(Arylalkyl or aroylalkyl)-1-oxa-4,9-diazaspiro(5.5)undecan-3-ones
US20030171373A1 (en) * 1995-09-29 2003-09-11 Fisher Matthew J. Spiro compounds as inhibitors of fibrinogen-dependent platelet aggregation
US20090131418A1 (en) * 2001-12-28 2009-05-21 Acadia Pharamceuticals, Inc. Spiroazacyclic compounds as monoamine receptor modulators

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4353900A (en) * 1981-10-19 1982-10-12 Syntex (U.S.A.) Inc. 9-(Arylalkyl or aroylalkyl)-1-oxa-4,9-diazaspiro(5.5)undecan-3-ones
US20030171373A1 (en) * 1995-09-29 2003-09-11 Fisher Matthew J. Spiro compounds as inhibitors of fibrinogen-dependent platelet aggregation
US20090131418A1 (en) * 2001-12-28 2009-05-21 Acadia Pharamceuticals, Inc. Spiroazacyclic compounds as monoamine receptor modulators

Also Published As

Publication number Publication date
WO2014008223A2 (fr) 2014-01-09

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